2DSPI

Structural basis for the inhibition of insulin-like growth factors by igf binding proteins
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
67
structure length
57
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTQTGIVDECCFRSCDLRRLEMYCAPLKPAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
pubmed doi rcsb
molecule tags Protein binding/hormone/growth factor
source organism Homo sapiens
molecule keywords Insulin-like growth factor-binding protein 4
total genus 12
structure length 57
sequence length 67
ec nomenclature
pdb deposition date 2006-07-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2dspI00
3LRIA 1EFEA 1B9GA 2JZQA 6INSE 5L3LA 1GZZB 3KR3D 4XSSB 2DSQC 1WQJI 5L3MA 1PMXA 1IMXA 1GZYB 3GF1A 1ZEIA 2GF1A 2DSRI 1H02B 2KJIA 1GZRB 1SJUA 1BQTA 1IGLA 5L3NA 2DSPI 1H59A 2KQPA 1TGRA 2L29B 2LWZA
chains in the Genus database with same CATH superfamily
3F2CA 3LRIA 1EFEA 1B9GA 2JZQA 2L14B 6INSE 5L3LA 1GZZB 3KR3D 4XSSB 2DSQC 1WQJI 5L3MA 1PMXA 1IMXA 1GZYB 3GF1A 1ZEIA 2GF1A 2DSRI 1H02B 2KJIA 1GZRB 3F2BA 1SJUA 1BQTA 1IGLA 3F2DA 5L3NA 2DSPI 1H59A 2KQPA 1TGRA 2L29B 2LWZA
chains in the Genus database with same CATH topology
3LRIA 1EFEA 1B9GA 2JZQA 6INSE 5L3LA 1GZZB 3KR3D 4XSSB 2DSQC 1WQJI 5L3MA 1PMXA 1IMXA 1GZYB 3GF1A 1ZEIA 2GF1A 2DSRI 1H02B 2KJIA 1GZRB 1SJUA 1BQTA 1IGLA 5L3NA 2DSPI 1H59A 2KQPA 1TGRA 2L29B 2LWZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LRI A;  1EFE A;  1B9G A;  2JZQ A;  6INS E;  5L3L A;  1GZZ B;  3KR3 D;  4XSS B;  2DSQ C;  1WQJ I;  5L3M A;  1PMX A;  1IMX A;  1GZY B;  3GF1 A;  1ZEI A;  2GF1 A;  2DSR I;  1H02 B;  2KJI A;  1GZR B;  1SJU A;  1BQT A;  1IGL A;  5L3N A;  2DSP I;  1H59 A;  2KQP A;  1TGR A;  2L29 B;  2LWZ A; 
#chains in the Genus database with same CATH topology
 3F2C A;  3LRI A;  1EFE A;  1B9G A;  2JZQ A;  2L14 B;  6INS E;  5L3L A;  1GZZ B;  3KR3 D;  4XSS B;  2DSQ C;  1WQJ I;  5L3M A;  1PMX A;  1IMX A;  1GZY B;  3GF1 A;  1ZEI A;  2GF1 A;  2DSR I;  1H02 B;  2KJI A;  1GZR B;  3F2B A;  1SJU A;  1BQT A;  1IGL A;  3F2D A;  5L3N A;  2DSP I;  1H59 A;  2KQP A;  1TGR A;  2L29 B;  2LWZ A; 
#chains in the Genus database with same CATH homology
 3LRI A;  1EFE A;  1B9G A;  2JZQ A;  6INS E;  5L3L A;  1GZZ B;  3KR3 D;  4XSS B;  2DSQ C;  1WQJ I;  5L3M A;  1PMX A;  1IMX A;  1GZY B;  3GF1 A;  1ZEI A;  2GF1 A;  2DSR I;  1H02 B;  2KJI A;  1GZR B;  1SJU A;  1BQT A;  1IGL A;  5L3N A;  2DSP I;  1H59 A;  2KQP A;  1TGR A;  2L29 B;  2LWZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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