2DSQC

Structural basis for the inhibition of insulin-like growth factors by igf binding proteins
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
51
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTTGIVDECCFRSCDLRRLEMYCAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
pubmed doi rcsb
molecule tags Protein binding/hormone/growth factor
source organism Homo sapiens
molecule keywords Insulin-like growth factor-binding protein 4
total genus 15
structure length 51
sequence length 62
chains with identical sequence I
ec nomenclature
pdb deposition date 2006-07-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2dsqC00
2JZQA 1H59A 2LWZA 3LRIA 1IMXA 3KR3D 4XSSB 1IGLA 1ZEIA 1BQTA 1GZYB 2DSQC 3GF1A 2KJIA 1GZRB 1PMXA 1SJUA 2GF1A 1WQJI 6INSE 1EFEA 5L3NA 1B9GA 5L3MA 2KQPA 1GZZB 2DSRI 2L29B 1H02B 2DSPI 1TGRA 5L3LA
chains in the Genus database with same CATH superfamily
2L14B 2JZQA 1H59A 2LWZA 3LRIA 1IMXA 3KR3D 4XSSB 1IGLA 1ZEIA 3F2DA 1BQTA 1GZYB 2DSQC 3GF1A 2KJIA 1GZRB 1PMXA 1SJUA 2GF1A 1WQJI 6INSE 1EFEA 5L3NA 1B9GA 5L3MA 3F2CA 3F2BA 2KQPA 1GZZB 2DSRI 2L29B 1H02B 2DSPI 1TGRA 5L3LA
chains in the Genus database with same CATH topology
2JZQA 1H59A 2LWZA 3LRIA 1IMXA 3KR3D 4XSSB 1IGLA 1ZEIA 1BQTA 1GZYB 2DSQC 3GF1A 2KJIA 1GZRB 1PMXA 1SJUA 2GF1A 1WQJI 6INSE 1EFEA 5L3NA 1B9GA 5L3MA 2KQPA 1GZZB 2DSRI 2L29B 1H02B 2DSPI 1TGRA 5L3LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JZQ A;  1H59 A;  2LWZ A;  3LRI A;  1IMX A;  3KR3 D;  4XSS B;  1IGL A;  1ZEI A;  1BQT A;  1GZY B;  2DSQ C;  3GF1 A;  2KJI A;  1GZR B;  1PMX A;  1SJU A;  2GF1 A;  1WQJ I;  6INS E;  1EFE A;  5L3N A;  1B9G A;  5L3M A;  2KQP A;  1GZZ B;  2DSR I;  2L29 B;  1H02 B;  2DSP I;  1TGR A;  5L3L A; 
#chains in the Genus database with same CATH topology
 2L14 B;  2JZQ A;  1H59 A;  2LWZ A;  3LRI A;  1IMX A;  3KR3 D;  4XSS B;  1IGL A;  1ZEI A;  3F2D A;  1BQT A;  1GZY B;  2DSQ C;  3GF1 A;  2KJI A;  1GZR B;  1PMX A;  1SJU A;  2GF1 A;  1WQJ I;  6INS E;  1EFE A;  5L3N A;  1B9G A;  5L3M A;  3F2C A;  3F2B A;  2KQP A;  1GZZ B;  2DSR I;  2L29 B;  1H02 B;  2DSP I;  1TGR A;  5L3L A; 
#chains in the Genus database with same CATH homology
 2JZQ A;  1H59 A;  2LWZ A;  3LRI A;  1IMX A;  3KR3 D;  4XSS B;  1IGL A;  1ZEI A;  1BQT A;  1GZY B;  2DSQ C;  3GF1 A;  2KJI A;  1GZR B;  1PMX A;  1SJU A;  2GF1 A;  1WQJ I;  6INS E;  1EFE A;  5L3N A;  1B9G A;  5L3M A;  2KQP A;  1GZZ B;  2DSR I;  2L29 B;  1H02 B;  2DSP I;  1TGR A;  5L3L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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