2DSRI

Structural basis for the inhibition of insulin-like growth factors by igf binding proteins
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
63
structure length
60
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTGYGSSAPQTGIVDECCFRSCDLRRLEMYCAPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
pubmed doi rcsb
molecule keywords Insulin-like growth factor-binding protein 4
molecule tags Protein binding/hormone/growth factor
source organism Homo sapiens
total genus 16
structure length 60
sequence length 63
ec nomenclature
pdb deposition date 2006-07-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2dsrI00
6INSE 1H59A 3KR3D 2KQPA 1IGLA 1GZZB 1ZEIA 2DSRI 1SJUA 2DSPI 2DSQC 2LWZA 1PMXA 1H02B 1GZYB 1IMXA 2L29B 2GF1A 4XSSB 1EFEA 3GF1A 5L3NA 1B9GA 1WQJI 2JZQA 5L3MA 3LRIA 2KJIA 1GZRB 5L3LA 1BQTA 1TGRA
chains in the Genus database with same CATH superfamily
6INSE 1H59A 3KR3D 2KQPA 1IGLA 1GZZB 1ZEIA 2DSRI 1SJUA 2DSPI 2DSQC 2LWZA 1PMXA 1H02B 1GZYB 1IMXA 2L29B 2GF1A 4XSSB 3F2BA 1EFEA 3GF1A 3F2DA 5L3NA 1B9GA 2L14B 1WQJI 3F2CA 2JZQA 5L3MA 3LRIA 2KJIA 1GZRB 5L3LA 1BQTA 1TGRA
chains in the Genus database with same CATH topology
6INSE 1H59A 3KR3D 2KQPA 1IGLA 1GZZB 1ZEIA 2DSRI 1SJUA 2DSPI 2DSQC 2LWZA 1PMXA 1H02B 1GZYB 1IMXA 2L29B 2GF1A 4XSSB 1EFEA 3GF1A 5L3NA 1B9GA 1WQJI 2JZQA 5L3MA 3LRIA 2KJIA 1GZRB 5L3LA 1BQTA 1TGRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 6INS E;  1H59 A;  3KR3 D;  2KQP A;  1IGL A;  1GZZ B;  1ZEI A;  2DSR I;  1SJU A;  2DSP I;  2DSQ C;  2LWZ A;  1PMX A;  1H02 B;  1GZY B;  1IMX A;  2L29 B;  2GF1 A;  4XSS B;  1EFE A;  3GF1 A;  5L3N A;  1B9G A;  1WQJ I;  2JZQ A;  5L3M A;  3LRI A;  2KJI A;  1GZR B;  5L3L A;  1BQT A;  1TGR A; 
#chains in the Genus database with same CATH topology
 6INS E;  1H59 A;  3KR3 D;  2KQP A;  1IGL A;  1GZZ B;  1ZEI A;  2DSR I;  1SJU A;  2DSP I;  2DSQ C;  2LWZ A;  1PMX A;  1H02 B;  1GZY B;  1IMX A;  2L29 B;  2GF1 A;  4XSS B;  3F2B A;  1EFE A;  3GF1 A;  3F2D A;  5L3N A;  1B9G A;  2L14 B;  1WQJ I;  3F2C A;  2JZQ A;  5L3M A;  3LRI A;  2KJI A;  1GZR B;  5L3L A;  1BQT A;  1TGR A; 
#chains in the Genus database with same CATH homology
 6INS E;  1H59 A;  3KR3 D;  2KQP A;  1IGL A;  1GZZ B;  1ZEI A;  2DSR I;  1SJU A;  2DSP I;  2DSQ C;  2LWZ A;  1PMX A;  1H02 B;  1GZY B;  1IMX A;  2L29 B;  2GF1 A;  4XSS B;  1EFE A;  3GF1 A;  5L3N A;  1B9G A;  1WQJ I;  2JZQ A;  5L3M A;  3LRI A;  2KJI A;  1GZR B;  5L3L A;  1BQT A;  1TGR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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