2IOAA

E. coli bifunctional glutathionylspermidine synthetase/amidase incomplex with mg2+ and adp and phosphinate inhibitor
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
sequence length
609
structure length
589
Chain Sequence
APFGTLLGYAPGGVAIYSSDYVFRSYIDDEYMGHKWQCVEFARRFLFLNYGVVFTDVGMAWEIFSLRFLREVVNDNILPLQAFPNGSPRAPVAGALLIWDKGGEFKDTGHVAIITQLHGNKVRIAEQNVIHSPLPQGQQWTRELEMVVENGCYTLKDTFDDTTILGWMIQTEDTEYSLPQPEIAGELLKISGARLENKGQFDGKWLDEKDPLQNAYVQANGQVINQDPYHYYTITESAEQELIKATNELHLMYLHATDKVLKDDNLLALFDIPKILWPRLRLSWQRRRHHMITGRMDFCMDERGLKVYEYNADSASCHTEAGLILERWAEQGYKGNGFNPAEGLINELAGAWKHSRARPFVHIMQDKDIEENYHAQFMEQALHQAGFETRILRGLDELGWQLIDGEGRLVNCVWKTWAWETAFDQIREVFAAVPIRTGHPQNEVRLIDVLLRPEVLVFEPLWTVIPGNKAILPILWSLFPHHRYLLDTDFTVNDELVKTGYAVKPIAGRCGSNIDLVSHHEEVLDKTSGKFAEQKNIYQQLWCLPKVDGKYIQVCTFTVGGNYGGTCLRGDESLVIKKESDIEPLIVVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase
pubmed doi rcsb
molecule tags Ligase, hydrolase
source organism Escherichia coli
molecule keywords Bifunctional glutathionylspermidine synthetase/amidase
total genus 155
structure length 589
sequence length 609
chains with identical sequence B
ec nomenclature ec 3.5.1.78: Glutathionylspermidine amidase.
pdb deposition date 2006-10-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03738 GSP_synth Glutathionylspermidine synthase preATP-grasp
A PF05257 CHAP CHAP domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1720.10 Alpha Beta Alpha-Beta Complex endopeptidase fold (from Nostoc punctiforme) endopeptidase domain like (from Nostoc punctiforme) 2ioaA01
4CT3A 3H41A 4FQBA 4FDYA 4Q4TA 2K3AA 3M1UA 4FQAA 3PBCA 4F0WA 4HZ9A 3PVQA 4HPEA 4FGIA 3KW0A 3A2ZA 4OLKA 3O98A 4F0VA 2LRJA 3A30A 3VPIA 2IOBA 4Q4NA 4EOBA 4EQAA 3A2YA 3GT2A 2XIVA 2IO8A 2VPSA 2IOAA 4LJ1A 3I86A 4Q4GX 3S0QA 4R0KA 3NE0A 4HZBA 4JXBA 3NPFA 2IO7A 4FGDA 3VPJA 2VOBA 4CGKA 4EQ8A 2K1GA 2FG0A 2IF6A 2EVRA 4CSHA 4FGEA 3PBIA 4F4MA 2IO9A 2HBWA 2VPMA
chains in the Genus database with same CATH superfamily
4HFLA 2WP7A 4CT3A 3H41A 4FQBA 4FDYA 4Q4TA 2K3AA 3M1UA 4FQAA 3EBQA 3PBCA 4F0WA 4HZ9A 3PVQA 4HPEA 4FGIA 3KW0A 3A2ZA 4HFFA 4J32A 3O98A 4OLKA 2LRJA 3A30A 3VPIA 4F0VA 2IOBA 4Q4NA 4EOBA 4JURA 4EQAA 3A2YA 3GT2A 2XIVA 2IO8A 2VPSA 2IOAA 4LJ1A 3I86A 4Q4GX 3S0QA 4HFKA 4R0KA 3NE0A 4HZBA 4JXBA 3NPFA 2IO7A 4FGDA 3VPJA 2VOBA 4CGKA 4EQ8A 2K1GA 2FG0A 2IF6A 2EVRA 4CSHA 4FGEA 3PBIA 4F4MA 4J30A 2IO9A 2HBWA 2VPMA
chains in the Genus database with same CATH topology
4CT3A 3H41A 4FQBA 4FDYA 4Q4TA 2K3AA 3M1UA 4FQAA 3PBCA 4F0WA 4HZ9A 3PVQA 4HPEA 4FGIA 3KW0A 3A2ZA 4OLKA 3O98A 4F0VA 2LRJA 3A30A 3VPIA 2IOBA 4Q4NA 4EOBA 4EQAA 3A2YA 3GT2A 2XIVA 2IO8A 2VPSA 2IOAA 4LJ1A 3I86A 4Q4GX 3S0QA 4R0KA 3NE0A 4HZBA 4JXBA 3NPFA 2IO7A 4FGDA 3VPJA 2VOBA 4CGKA 4EQ8A 2K1GA 2FG0A 2IF6A 2EVRA 4CSHA 4FGEA 3PBIA 4F4MA 2IO9A 2HBWA 2VPMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CT3 A;  3H41 A;  4FQB A;  4FDY A;  4Q4T A;  2K3A A;  3M1U A;  4FQA A;  3PBC A;  4F0W A;  4HZ9 A;  3PVQ A;  4HPE A;  4FGI A;  3KW0 A;  3A2Z A;  4OLK A;  3O98 A;  4F0V A;  2LRJ A;  3A30 A;  3VPI A;  2IOB A;  4Q4N A;  4EOB A;  4EQA A;  3A2Y A;  3GT2 A;  2XIV A;  2IO8 A;  2VPS A;  2IOA A;  4LJ1 A;  3I86 A;  4Q4G X;  3S0Q A;  4R0K A;  3NE0 A;  4HZB A;  4JXB A;  3NPF A;  2IO7 A;  4FGD A;  3VPJ A;  2VOB A;  4CGK A;  4EQ8 A;  2K1G A;  2FG0 A;  2IF6 A;  2EVR A;  4CSH A;  4FGE A;  3PBI A;  4F4M A;  2IO9 A;  2HBW A;  2VPM A; 
#chains in the Genus database with same CATH topology
 4HFL A;  2WP7 A;  4CT3 A;  3H41 A;  4FQB A;  4FDY A;  4Q4T A;  2K3A A;  3M1U A;  4FQA A;  3EBQ A;  3PBC A;  4F0W A;  4HZ9 A;  3PVQ A;  4HPE A;  4FGI A;  3KW0 A;  3A2Z A;  4HFF A;  4J32 A;  3O98 A;  4OLK A;  2LRJ A;  3A30 A;  3VPI A;  4F0V A;  2IOB A;  4Q4N A;  4EOB A;  4JUR A;  4EQA A;  3A2Y A;  3GT2 A;  2XIV A;  2IO8 A;  2VPS A;  2IOA A;  4LJ1 A;  3I86 A;  4Q4G X;  3S0Q A;  4HFK A;  4R0K A;  3NE0 A;  4HZB A;  4JXB A;  3NPF A;  2IO7 A;  4FGD A;  3VPJ A;  2VOB A;  4CGK A;  4EQ8 A;  2K1G A;  2FG0 A;  2IF6 A;  2EVR A;  4CSH A;  4FGE A;  3PBI A;  4F4M A;  4J30 A;  2IO9 A;  2HBW A;  2VPM A; 
#chains in the Genus database with same CATH homology
 4CT3 A;  3H41 A;  4FQB A;  4FDY A;  4Q4T A;  2K3A A;  3M1U A;  4FQA A;  3PBC A;  4F0W A;  4HZ9 A;  3PVQ A;  4HPE A;  4FGI A;  3KW0 A;  3A2Z A;  4OLK A;  3O98 A;  4F0V A;  2LRJ A;  3A30 A;  3VPI A;  2IOB A;  4Q4N A;  4EOB A;  4EQA A;  3A2Y A;  3GT2 A;  2XIV A;  2IO8 A;  2VPS A;  2IOA A;  4LJ1 A;  3I86 A;  4Q4G X;  3S0Q A;  4R0K A;  3NE0 A;  4HZB A;  4JXB A;  3NPF A;  2IO7 A;  4FGD A;  3VPJ A;  2VOB A;  4CGK A;  4EQ8 A;  2K1G A;  2FG0 A;  2IF6 A;  2EVR A;  4CSH A;  4FGE A;  3PBI A;  4F4M A;  2IO9 A;  2HBW A;  2VPM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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