2IOAA

E. coli bifunctional glutathionylspermidine synthetase/amidase incomplex with mg2+ and adp and phosphinate inhibitor
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
sequence length
609
structure length
589
Chain Sequence
APFGTLLGYAPGGVAIYSSDYVFRSYIDDEYMGHKWQCVEFARRFLFLNYGVVFTDVGMAWEIFSLRFLREVVNDNILPLQAFPNGSPRAPVAGALLIWDKGGEFKDTGHVAIITQLHGNKVRIAEQNVIHSPLPQGQQWTRELEMVVENGCYTLKDTFDDTTILGWMIQTEDTEYSLPQPEIAGELLKISGARLENKGQFDGKWLDEKDPLQNAYVQANGQVINQDPYHYYTITESAEQELIKATNELHLMYLHATDKVLKDDNLLALFDIPKILWPRLRLSWQRRRHHMITGRMDFCMDERGLKVYEYNADSASCHTEAGLILERWAEQGYKGNGFNPAEGLINELAGAWKHSRARPFVHIMQDKDIEENYHAQFMEQALHQAGFETRILRGLDELGWQLIDGEGRLVNCVWKTWAWETAFDQIREVFAAVPIRTGHPQNEVRLIDVLLRPEVLVFEPLWTVIPGNKAILPILWSLFPHHRYLLDTDFTVNDELVKTGYAVKPIAGRCGSNIDLVSHHEEVLDKTSGKFAEQKNIYQQLWCLPKVDGKYIQVCTFTVGGNYGGTCLRGDESLVIKKESDIEPLIVVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase
pubmed doi rcsb
molecule tags Ligase, hydrolase
source organism Escherichia coli
molecule keywords Bifunctional glutathionylspermidine synthetase/amidase
total genus 155
structure length 589
sequence length 609
chains with identical sequence B
ec nomenclature ec 3.5.1.78: Glutathionylspermidine amidase.
pdb deposition date 2006-10-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03738 GSP_synth Glutathionylspermidine synthase preATP-grasp
A PF05257 CHAP CHAP domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1720.10 Alpha Beta Alpha-Beta Complex endopeptidase fold (from Nostoc punctiforme) endopeptidase domain like (from Nostoc punctiforme) 2ioaA01
3A30A 4CT3A 2LRJA 3S0QA 4JXBA 4R0KA 4EOBA 3PBIA 4FGIA 2IF6A 3A2ZA 4LJ1A 2IO8A 4OLKA 2VPMA 2IOBA 3H41A 4HZ9A 3VPIA 2IOAA 3GT2A 2HBWA 4CSHA 4FQAA 4HZBA 4F0VA 4HPEA 3PVQA 3O98A 2VOBA 4Q4NA 2VPSA 4FQBA 2K3AA 3A2YA 2K1GA 3VPJA 4FDYA 2FG0A 3NPFA 4FGDA 3M1UA 4F0WA 3I86A 2EVRA 3PBCA 4EQ8A 2IO9A 4F4MA 2IO7A 4FGEA 3KW0A 4Q4TA 3NE0A 4CGKA 2XIVA 4Q4GX 4EQAA
chains in the Genus database with same CATH superfamily
3A30A 4CT3A 2WP7A 2LRJA 3S0QA 4JXBA 4R0KA 4EOBA 3PBIA 4FGIA 2IF6A 3A2ZA 4LJ1A 2IO8A 4OLKA 2VPMA 2IOBA 3H41A 4HZ9A 3VPIA 2IOAA 3GT2A 2HBWA 4CSHA 4FQAA 4HZBA 4HFFA 4F0VA 4HFLA 4HPEA 3PVQA 3O98A 2VOBA 4Q4NA 2VPSA 3EBQA 4HFKA 4FQBA 4J30A 2K3AA 3A2YA 2K1GA 3VPJA 4FDYA 2FG0A 4J32A 3NPFA 4FGDA 3M1UA 4F0WA 3I86A 2EVRA 3PBCA 4EQ8A 2IO9A 4F4MA 2IO7A 4FGEA 3KW0A 4Q4TA 3NE0A 4CGKA 2XIVA 4Q4GX 4EQAA 4JURA
chains in the Genus database with same CATH topology
3A30A 4CT3A 2LRJA 3S0QA 4JXBA 4R0KA 4EOBA 3PBIA 4FGIA 2IF6A 3A2ZA 4LJ1A 2IO8A 4OLKA 2VPMA 2IOBA 3H41A 4HZ9A 3VPIA 2IOAA 3GT2A 2HBWA 4CSHA 4FQAA 4HZBA 4F0VA 4HPEA 3PVQA 3O98A 2VOBA 4Q4NA 2VPSA 4FQBA 2K3AA 3A2YA 2K1GA 3VPJA 4FDYA 2FG0A 3NPFA 4FGDA 3M1UA 4F0WA 3I86A 2EVRA 3PBCA 4EQ8A 2IO9A 4F4MA 2IO7A 4FGEA 3KW0A 4Q4TA 3NE0A 4CGKA 2XIVA 4Q4GX 4EQAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A30 A;  4CT3 A;  2LRJ A;  3S0Q A;  4JXB A;  4R0K A;  4EOB A;  3PBI A;  4FGI A;  2IF6 A;  3A2Z A;  4LJ1 A;  2IO8 A;  4OLK A;  2VPM A;  2IOB A;  3H41 A;  4HZ9 A;  3VPI A;  2IOA A;  3GT2 A;  2HBW A;  4CSH A;  4FQA A;  4HZB A;  4F0V A;  4HPE A;  3PVQ A;  3O98 A;  2VOB A;  4Q4N A;  2VPS A;  4FQB A;  2K3A A;  3A2Y A;  2K1G A;  3VPJ A;  4FDY A;  2FG0 A;  3NPF A;  4FGD A;  3M1U A;  4F0W A;  3I86 A;  2EVR A;  3PBC A;  4EQ8 A;  2IO9 A;  4F4M A;  2IO7 A;  4FGE A;  3KW0 A;  4Q4T A;  3NE0 A;  4CGK A;  2XIV A;  4Q4G X;  4EQA A; 
#chains in the Genus database with same CATH topology
 3A30 A;  4CT3 A;  2WP7 A;  2LRJ A;  3S0Q A;  4JXB A;  4R0K A;  4EOB A;  3PBI A;  4FGI A;  2IF6 A;  3A2Z A;  4LJ1 A;  2IO8 A;  4OLK A;  2VPM A;  2IOB A;  3H41 A;  4HZ9 A;  3VPI A;  2IOA A;  3GT2 A;  2HBW A;  4CSH A;  4FQA A;  4HZB A;  4HFF A;  4F0V A;  4HFL A;  4HPE A;  3PVQ A;  3O98 A;  2VOB A;  4Q4N A;  2VPS A;  3EBQ A;  4HFK A;  4FQB A;  4J30 A;  2K3A A;  3A2Y A;  2K1G A;  3VPJ A;  4FDY A;  2FG0 A;  4J32 A;  3NPF A;  4FGD A;  3M1U A;  4F0W A;  3I86 A;  2EVR A;  3PBC A;  4EQ8 A;  2IO9 A;  4F4M A;  2IO7 A;  4FGE A;  3KW0 A;  4Q4T A;  3NE0 A;  4CGK A;  2XIV A;  4Q4G X;  4EQA A;  4JUR A; 
#chains in the Genus database with same CATH homology
 3A30 A;  4CT3 A;  2LRJ A;  3S0Q A;  4JXB A;  4R0K A;  4EOB A;  3PBI A;  4FGI A;  2IF6 A;  3A2Z A;  4LJ1 A;  2IO8 A;  4OLK A;  2VPM A;  2IOB A;  3H41 A;  4HZ9 A;  3VPI A;  2IOA A;  3GT2 A;  2HBW A;  4CSH A;  4FQA A;  4HZB A;  4F0V A;  4HPE A;  3PVQ A;  3O98 A;  2VOB A;  4Q4N A;  2VPS A;  4FQB A;  2K3A A;  3A2Y A;  2K1G A;  3VPJ A;  4FDY A;  2FG0 A;  3NPF A;  4FGD A;  3M1U A;  4F0W A;  3I86 A;  2EVR A;  3PBC A;  4EQ8 A;  2IO9 A;  4F4M A;  2IO7 A;  4FGE A;  3KW0 A;  4Q4T A;  3NE0 A;  4CGK A;  2XIV A;  4Q4G X;  4EQA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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