2JZQA

Design of an active ultra-stable single-chain insulin analog 20 structures
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
57
structure length
57
Chain Sequence
FVNQHLCGSDLVEALYLVCGERGFFYTDPTGGGPRRGIVEQCCHSICSLYQLENYCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
pubmed doi rcsb
molecule tags Hormone
molecule keywords Insulin
total genus 9
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2008-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2jzqA00
1TGRA 5L3NA 1GZZB 1ZEIA 1PMXA 5L3LA 1B9GA 1GZRB 2DSPI 1GZYB 2KQPA 1H59A 1IGLA 2DSQC 4XSSB 2L29B 2GF1A 2JZQA 1EFEA 1SJUA 1WQJI 2LWZA 3LRIA 1H02B 3GF1A 6INSE 1BQTA 2DSRI 3KR3D 1IMXA 5L3MA 2KJIA
chains in the Genus database with same CATH superfamily
1TGRA 5L3NA 1GZZB 1ZEIA 1PMXA 5L3LA 2L14B 1B9GA 1GZRB 2DSPI 1GZYB 2KQPA 1H59A 1IGLA 2DSQC 4XSSB 3F2DA 3F2CA 2L29B 2GF1A 2JZQA 3F2BA 1EFEA 1SJUA 1WQJI 2LWZA 3LRIA 1H02B 3GF1A 6INSE 1BQTA 2DSRI 3KR3D 1IMXA 5L3MA 2KJIA
chains in the Genus database with same CATH topology
1TGRA 5L3NA 1GZZB 1ZEIA 1PMXA 5L3LA 1B9GA 1GZRB 2DSPI 1GZYB 2KQPA 1H59A 1IGLA 2DSQC 4XSSB 2L29B 2GF1A 2JZQA 1EFEA 1SJUA 1WQJI 2LWZA 3LRIA 1H02B 3GF1A 6INSE 1BQTA 2DSRI 3KR3D 1IMXA 5L3MA 2KJIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TGR A;  5L3N A;  1GZZ B;  1ZEI A;  1PMX A;  5L3L A;  1B9G A;  1GZR B;  2DSP I;  1GZY B;  2KQP A;  1H59 A;  1IGL A;  2DSQ C;  4XSS B;  2L29 B;  2GF1 A;  2JZQ A;  1EFE A;  1SJU A;  1WQJ I;  2LWZ A;  3LRI A;  1H02 B;  3GF1 A;  6INS E;  1BQT A;  2DSR I;  3KR3 D;  1IMX A;  5L3M A;  2KJI A; 
#chains in the Genus database with same CATH topology
 1TGR A;  5L3N A;  1GZZ B;  1ZEI A;  1PMX A;  5L3L A;  2L14 B;  1B9G A;  1GZR B;  2DSP I;  1GZY B;  2KQP A;  1H59 A;  1IGL A;  2DSQ C;  4XSS B;  3F2D A;  3F2C A;  2L29 B;  2GF1 A;  2JZQ A;  3F2B A;  1EFE A;  1SJU A;  1WQJ I;  2LWZ A;  3LRI A;  1H02 B;  3GF1 A;  6INS E;  1BQT A;  2DSR I;  3KR3 D;  1IMX A;  5L3M A;  2KJI A; 
#chains in the Genus database with same CATH homology
 1TGR A;  5L3N A;  1GZZ B;  1ZEI A;  1PMX A;  5L3L A;  1B9G A;  1GZR B;  2DSP I;  1GZY B;  2KQP A;  1H59 A;  1IGL A;  2DSQ C;  4XSS B;  2L29 B;  2GF1 A;  2JZQ A;  1EFE A;  1SJU A;  1WQJ I;  2LWZ A;  3LRI A;  1H02 B;  3GF1 A;  6INS E;  1BQT A;  2DSR I;  3KR3 D;  1IMX A;  5L3M A;  2KJI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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