2KJIA

A divergent ins protein in c. elegans structurally resemble insulin and activates the human insulin receptor
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
50
structure length
50
Chain Sequence
GETRACGRKLISLVMAVCGDLCNPQEGKDIATECCGNQCSDDYIRSACCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insulin worms its way into the spotlight.
pubmed doi rcsb
molecule tags Hormone
source organism Caenorhabditis elegans
molecule keywords Probable insulin-like peptide beta-type 5
total genus 9
structure length 50
sequence length 50
ec nomenclature
pdb deposition date 2009-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03488 Ins_beta Nematode insulin-related peptide beta type
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2kjiA00
1ZEIA 1EFEA 1GZRB 5L3LA 1B9GA 2LWZA 1GZZB 1BQTA 6INSE 1IGLA 1H02B 1TGRA 1PMXA 2DSQC 2GF1A 2DSPI 1SJUA 2JZQA 2L29B 5L3MA 4XSSB 3GF1A 2DSRI 3LRIA 2KQPA 1IMXA 5L3NA 1WQJI 3KR3D 1GZYB 2KJIA 1H59A
chains in the Genus database with same CATH superfamily
1ZEIA 1EFEA 1GZRB 5L3LA 2L14B 1B9GA 2LWZA 1GZZB 1BQTA 6INSE 1IGLA 3F2CA 3F2BA 1H02B 1TGRA 1PMXA 2DSQC 2GF1A 2DSPI 1SJUA 2JZQA 3F2DA 2L29B 5L3MA 4XSSB 3GF1A 2DSRI 3LRIA 2KQPA 1IMXA 5L3NA 1WQJI 3KR3D 1GZYB 2KJIA 1H59A
chains in the Genus database with same CATH topology
1ZEIA 1EFEA 1GZRB 5L3LA 1B9GA 2LWZA 1GZZB 1BQTA 6INSE 1IGLA 1H02B 1TGRA 1PMXA 2DSQC 2GF1A 2DSPI 1SJUA 2JZQA 2L29B 5L3MA 4XSSB 3GF1A 2DSRI 3LRIA 2KQPA 1IMXA 5L3NA 1WQJI 3KR3D 1GZYB 2KJIA 1H59A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZEI A;  1EFE A;  1GZR B;  5L3L A;  1B9G A;  2LWZ A;  1GZZ B;  1BQT A;  6INS E;  1IGL A;  1H02 B;  1TGR A;  1PMX A;  2DSQ C;  2GF1 A;  2DSP I;  1SJU A;  2JZQ A;  2L29 B;  5L3M A;  4XSS B;  3GF1 A;  2DSR I;  3LRI A;  2KQP A;  1IMX A;  5L3N A;  1WQJ I;  3KR3 D;  1GZY B;  2KJI A;  1H59 A; 
#chains in the Genus database with same CATH topology
 1ZEI A;  1EFE A;  1GZR B;  5L3L A;  2L14 B;  1B9G A;  2LWZ A;  1GZZ B;  1BQT A;  6INS E;  1IGL A;  3F2C A;  3F2B A;  1H02 B;  1TGR A;  1PMX A;  2DSQ C;  2GF1 A;  2DSP I;  1SJU A;  2JZQ A;  3F2D A;  2L29 B;  5L3M A;  4XSS B;  3GF1 A;  2DSR I;  3LRI A;  2KQP A;  1IMX A;  5L3N A;  1WQJ I;  3KR3 D;  1GZY B;  2KJI A;  1H59 A; 
#chains in the Genus database with same CATH homology
 1ZEI A;  1EFE A;  1GZR B;  5L3L A;  1B9G A;  2LWZ A;  1GZZ B;  1BQT A;  6INS E;  1IGL A;  1H02 B;  1TGR A;  1PMX A;  2DSQ C;  2GF1 A;  2DSP I;  1SJU A;  2JZQ A;  2L29 B;  5L3M A;  4XSS B;  3GF1 A;  2DSR I;  3LRI A;  2KQP A;  1IMX A;  5L3N A;  1WQJ I;  3KR3 D;  1GZY B;  2KJI A;  1H59 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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