2KQPA

Nmr structure of proinsulin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
86
structure length
86
Chain Sequence
FVNQHLCGSDLVEALYLVCGERGFFYTKPTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
pubmed doi rcsb
molecule keywords Insulin
molecule tags Hormone
source organism Homo sapiens
total genus 11
structure length 86
sequence length 86
ec nomenclature
pdb deposition date 2009-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2kqpA00
3LRIA 1GZZB 3GF1A 2L29B 1GZYB 1EFEA 1IGLA 1WQJI 2DSQC 2KQPA 2DSRI 2GF1A 1H59A 1TGRA 1GZRB 1B9GA 5L3LA 6INSE 1H02B 2DSPI 4XSSB 1ZEIA 3KR3D 5L3NA 1IMXA 2JZQA 2KJIA 1PMXA 1SJUA 2LWZA 5L3MA 1BQTA
chains in the Genus database with same CATH superfamily
3LRIA 1GZZB 3GF1A 2L29B 1GZYB 1EFEA 1IGLA 1WQJI 2DSQC 3F2BA 2KQPA 2DSRI 2GF1A 1H59A 1TGRA 1GZRB 1B9GA 5L3LA 6INSE 1H02B 2DSPI 4XSSB 1ZEIA 3F2CA 3KR3D 5L3NA 1IMXA 2JZQA 2L14B 2KJIA 3F2DA 1PMXA 1SJUA 2LWZA 5L3MA 1BQTA
chains in the Genus database with same CATH topology
3LRIA 1GZZB 3GF1A 2L29B 1GZYB 1EFEA 1IGLA 1WQJI 2DSQC 2KQPA 2DSRI 2GF1A 1H59A 1TGRA 1GZRB 1B9GA 5L3LA 6INSE 1H02B 2DSPI 4XSSB 1ZEIA 3KR3D 5L3NA 1IMXA 2JZQA 2KJIA 1PMXA 1SJUA 2LWZA 5L3MA 1BQTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LRI A;  1GZZ B;  3GF1 A;  2L29 B;  1GZY B;  1EFE A;  1IGL A;  1WQJ I;  2DSQ C;  2KQP A;  2DSR I;  2GF1 A;  1H59 A;  1TGR A;  1GZR B;  1B9G A;  5L3L A;  6INS E;  1H02 B;  2DSP I;  4XSS B;  1ZEI A;  3KR3 D;  5L3N A;  1IMX A;  2JZQ A;  2KJI A;  1PMX A;  1SJU A;  2LWZ A;  5L3M A;  1BQT A; 
#chains in the Genus database with same CATH topology
 3LRI A;  1GZZ B;  3GF1 A;  2L29 B;  1GZY B;  1EFE A;  1IGL A;  1WQJ I;  2DSQ C;  3F2B A;  2KQP A;  2DSR I;  2GF1 A;  1H59 A;  1TGR A;  1GZR B;  1B9G A;  5L3L A;  6INS E;  1H02 B;  2DSP I;  4XSS B;  1ZEI A;  3F2C A;  3KR3 D;  5L3N A;  1IMX A;  2JZQ A;  2L14 B;  2KJI A;  3F2D A;  1PMX A;  1SJU A;  2LWZ A;  5L3M A;  1BQT A; 
#chains in the Genus database with same CATH homology
 3LRI A;  1GZZ B;  3GF1 A;  2L29 B;  1GZY B;  1EFE A;  1IGL A;  1WQJ I;  2DSQ C;  2KQP A;  2DSR I;  2GF1 A;  1H59 A;  1TGR A;  1GZR B;  1B9G A;  5L3L A;  6INS E;  1H02 B;  2DSP I;  4XSS B;  1ZEI A;  3KR3 D;  5L3N A;  1IMX A;  2JZQ A;  2KJI A;  1PMX A;  1SJU A;  2LWZ A;  5L3M A;  1BQT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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