2KQPA

Nmr structure of proinsulin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
86
structure length
86
Chain Sequence
FVNQHLCGSDLVEALYLVCGERGFFYTKPTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
pubmed doi rcsb
molecule keywords Insulin
molecule tags Hormone
source organism Homo sapiens
total genus 11
structure length 86
sequence length 86
ec nomenclature
pdb deposition date 2009-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2kqpA00
3GF1A 1BQTA 2DSRI 1B9GA 2GF1A 1WQJI 5L3MA 2DSQC 6INSE 1EFEA 2LWZA 1SJUA 5L3NA 1IGLA 5L3LA 2JZQA 2KQPA 3KR3D 1GZRB 1H02B 1ZEIA 1IMXA 2DSPI 1GZZB 4XSSB 3LRIA 1TGRA 2KJIA 2L29B 1GZYB 1H59A 1PMXA
chains in the Genus database with same CATH superfamily
3GF1A 3F2CA 1BQTA 2DSRI 1B9GA 2GF1A 1WQJI 3F2DA 5L3MA 2DSQC 6INSE 1EFEA 2LWZA 1SJUA 5L3NA 1IGLA 5L3LA 2JZQA 2KQPA 2L14B 3KR3D 1GZRB 1H02B 1ZEIA 1IMXA 2DSPI 1GZZB 4XSSB 3LRIA 1TGRA 2KJIA 2L29B 1GZYB 1H59A 1PMXA 3F2BA
chains in the Genus database with same CATH topology
3GF1A 1BQTA 2DSRI 1B9GA 2GF1A 1WQJI 5L3MA 2DSQC 6INSE 1EFEA 2LWZA 1SJUA 5L3NA 1IGLA 5L3LA 2JZQA 2KQPA 3KR3D 1GZRB 1H02B 1ZEIA 1IMXA 2DSPI 1GZZB 4XSSB 3LRIA 1TGRA 2KJIA 2L29B 1GZYB 1H59A 1PMXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GF1 A;  1BQT A;  2DSR I;  1B9G A;  2GF1 A;  1WQJ I;  5L3M A;  2DSQ C;  6INS E;  1EFE A;  2LWZ A;  1SJU A;  5L3N A;  1IGL A;  5L3L A;  2JZQ A;  2KQP A;  3KR3 D;  1GZR B;  1H02 B;  1ZEI A;  1IMX A;  2DSP I;  1GZZ B;  4XSS B;  3LRI A;  1TGR A;  2KJI A;  2L29 B;  1GZY B;  1H59 A;  1PMX A; 
#chains in the Genus database with same CATH topology
 3GF1 A;  3F2C A;  1BQT A;  2DSR I;  1B9G A;  2GF1 A;  1WQJ I;  3F2D A;  5L3M A;  2DSQ C;  6INS E;  1EFE A;  2LWZ A;  1SJU A;  5L3N A;  1IGL A;  5L3L A;  2JZQ A;  2KQP A;  2L14 B;  3KR3 D;  1GZR B;  1H02 B;  1ZEI A;  1IMX A;  2DSP I;  1GZZ B;  4XSS B;  3LRI A;  1TGR A;  2KJI A;  2L29 B;  1GZY B;  1H59 A;  1PMX A;  3F2B A; 
#chains in the Genus database with same CATH homology
 3GF1 A;  1BQT A;  2DSR I;  1B9G A;  2GF1 A;  1WQJ I;  5L3M A;  2DSQ C;  6INS E;  1EFE A;  2LWZ A;  1SJU A;  5L3N A;  1IGL A;  5L3L A;  2JZQ A;  2KQP A;  3KR3 D;  1GZR B;  1H02 B;  1ZEI A;  1IMX A;  2DSP I;  1GZZ B;  4XSS B;  3LRI A;  1TGR A;  2KJI A;  2L29 B;  1GZY B;  1H59 A;  1PMX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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