2L29B

Complex structure of e4 mutant human igf2r domain 11 bound to igf-ii
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
67
structure length
67
Chain Sequence
AYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
pubmed doi rcsb
molecule keywords Insulin-like growth factor 2 receptor variant
molecule tags Transport protein
source organism Homo sapiens
total genus 13
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2010-08-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2l29B00
2DSRI 5L3MA 1H59A 2L29B 2KJIA 3KR3D 2DSQC 1IMXA 1GZYB 1EFEA 2KQPA 1PMXA 1IGLA 6INSE 1ZEIA 1H02B 1SJUA 3GF1A 1B9GA 1BQTA 2DSPI 5L3NA 1TGRA 2LWZA 4XSSB 1GZZB 2GF1A 3LRIA 1GZRB 5L3LA 2JZQA 1WQJI
chains in the Genus database with same CATH superfamily
2DSRI 5L3MA 1H59A 2L29B 2KJIA 3KR3D 2DSQC 1IMXA 1GZYB 1EFEA 2KQPA 3F2DA 1PMXA 1IGLA 6INSE 1ZEIA 1H02B 1SJUA 3GF1A 1B9GA 1BQTA 2DSPI 5L3NA 1TGRA 2LWZA 4XSSB 1GZZB 2GF1A 3LRIA 1GZRB 2L14B 5L3LA 2JZQA 1WQJI 3F2CA 3F2BA
chains in the Genus database with same CATH topology
2DSRI 5L3MA 1H59A 2L29B 2KJIA 3KR3D 2DSQC 1IMXA 1GZYB 1EFEA 2KQPA 1PMXA 1IGLA 6INSE 1ZEIA 1H02B 1SJUA 3GF1A 1B9GA 1BQTA 2DSPI 5L3NA 1TGRA 2LWZA 4XSSB 1GZZB 2GF1A 3LRIA 1GZRB 5L3LA 2JZQA 1WQJI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DSR I;  5L3M A;  1H59 A;  2L29 B;  2KJI A;  3KR3 D;  2DSQ C;  1IMX A;  1GZY B;  1EFE A;  2KQP A;  1PMX A;  1IGL A;  6INS E;  1ZEI A;  1H02 B;  1SJU A;  3GF1 A;  1B9G A;  1BQT A;  2DSP I;  5L3N A;  1TGR A;  2LWZ A;  4XSS B;  1GZZ B;  2GF1 A;  3LRI A;  1GZR B;  5L3L A;  2JZQ A;  1WQJ I; 
#chains in the Genus database with same CATH topology
 2DSR I;  5L3M A;  1H59 A;  2L29 B;  2KJI A;  3KR3 D;  2DSQ C;  1IMX A;  1GZY B;  1EFE A;  2KQP A;  3F2D A;  1PMX A;  1IGL A;  6INS E;  1ZEI A;  1H02 B;  1SJU A;  3GF1 A;  1B9G A;  1BQT A;  2DSP I;  5L3N A;  1TGR A;  2LWZ A;  4XSS B;  1GZZ B;  2GF1 A;  3LRI A;  1GZR B;  2L14 B;  5L3L A;  2JZQ A;  1WQJ I;  3F2C A;  3F2B A; 
#chains in the Genus database with same CATH homology
 2DSR I;  5L3M A;  1H59 A;  2L29 B;  2KJI A;  3KR3 D;  2DSQ C;  1IMX A;  1GZY B;  1EFE A;  2KQP A;  1PMX A;  1IGL A;  6INS E;  1ZEI A;  1H02 B;  1SJU A;  3GF1 A;  1B9G A;  1BQT A;  2DSP I;  5L3N A;  1TGR A;  2LWZ A;  4XSS B;  1GZZ B;  2GF1 A;  3LRI A;  1GZR B;  5L3L A;  2JZQ A;  1WQJ I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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