2VPMA

Trypanothione synthetase
Total Genus 180
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
180
sequence length
637
structure length
600
Chain Sequence
HMSSLQRASVSFNKPGHIPFGAVQGYAPGGVPAYSNKHDHYFSGERNIEDNIFFGFKYQCVEFARRWLLVRKGLLLPDVNWACHIFQLKEVRDAATTESFAVLQVRNGTTTKPEADALLVYPSTDANPVGHVGTITEVGDDYVCVADQNYRFHKWESSCAYKLKLDHRDGIWTIIDDIDADEIEIPLGWLTFPGRANRPEGAPPVALHPSLHFKEPPKPYLLRRNFLPTESKANWLDMNNPAERLFVEEFGMVVSYYESNHEFHLRCVAYGTQLHAIFMEATAQVIESDEKLRLFAIPEEFWPRIRHSWKYQQTYISGRFDFAFNNETGEVKCFEYNADSASTLLECGLIQQKWAESVGLDKQDTRGSGFAVERNLKMAWANSGATGRVHFCVDEEREEQYTALYCMQAAEAVGLEGKLCILFDEFRFDDNGHVVDSDGVRVRNVWKTWMWESAITDYYAAREERGENWKPSPKDKVRLCDLLLGDDWEILYFEPMWKVIPSNKAILPMIYHNHPEHPAILKAEYELTDELRKHGYAKKPIVNMIYQQLFELKKQDDYYAIIGGWMIGDAFSGTGIREDKSVITGVDSPFAAVRIKTDKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
pubmed doi rcsb
molecule tags Ligase
source organism Leishmania major
molecule keywords TRYPANOTHIONE SYNTHETASE
total genus 180
structure length 600
sequence length 637
chains with identical sequence B
ec nomenclature ec 6.3.1.9: Trypanothione synthase.
pdb deposition date 2008-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03738 GSP_synth Glutathionylspermidine synthase preATP-grasp
A PF05257 CHAP CHAP domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1720.10 Alpha Beta Alpha-Beta Complex endopeptidase fold (from Nostoc punctiforme) endopeptidase domain like (from Nostoc punctiforme) 2vpmA01
2IF6A 4FGIA 4EQAA 4HPEA 4FGEA 2FG0A 2IOBA 4JXBA 3PBCA 4LJ1A 4CT3A 3VPJA 2LRJA 4HZBA 3PVQA 4FGDA 4CGKA 3NPFA 4R0KA 4Q4TA 2K3AA 3I86A 4HZ9A 4OLKA 3O98A 3H41A 3PBIA 3S0QA 4F4MA 2XIVA 2EVRA 4F0WA 3A2ZA 3NE0A 2IO7A 2IO8A 3GT2A 4EQ8A 3KW0A 2K1GA 4EOBA 2VPSA 2VOBA 4F0VA 2HBWA 2IO9A 4FDYA 4FQBA 4CSHA 4Q4NA 3A30A 2VPMA 3M1UA 4FQAA 3VPIA 4Q4GX 2IOAA 3A2YA
chains in the Genus database with same CATH superfamily
2IF6A 4FGIA 4EQAA 4HPEA 4FGEA 2FG0A 2IOBA 4JXBA 3PBCA 4LJ1A 4CT3A 3VPJA 2LRJA 4HZBA 3PVQA 4FGDA 4CGKA 3NPFA 4HFFA 2WP7A 4Q4TA 4R0KA 2K3AA 3I86A 4HZ9A 4J32A 3O98A 4J30A 4OLKA 3H41A 3PBIA 3S0QA 4F4MA 2XIVA 4HFLA 2EVRA 4F0WA 3A2ZA 3NE0A 2IO7A 2IO8A 3GT2A 4EQ8A 3KW0A 2K1GA 4EOBA 2VPSA 2VOBA 4F0VA 2HBWA 2IO9A 4JURA 4FDYA 4FQBA 4CSHA 4HFKA 4Q4NA 3A30A 2VPMA 3M1UA 4FQAA 3EBQA 3VPIA 4Q4GX 2IOAA 3A2YA
chains in the Genus database with same CATH topology
2IF6A 4FGIA 4EQAA 4HPEA 4FGEA 2FG0A 2IOBA 4JXBA 3PBCA 4LJ1A 4CT3A 3VPJA 2LRJA 4HZBA 3PVQA 4FGDA 4CGKA 3NPFA 4R0KA 4Q4TA 2K3AA 3I86A 4HZ9A 4OLKA 3O98A 3H41A 3PBIA 3S0QA 4F4MA 2XIVA 2EVRA 4F0WA 3A2ZA 3NE0A 2IO7A 2IO8A 3GT2A 4EQ8A 3KW0A 2K1GA 4EOBA 2VPSA 2VOBA 4F0VA 2HBWA 2IO9A 4FDYA 4FQBA 4CSHA 4Q4NA 3A30A 2VPMA 3M1UA 4FQAA 3VPIA 4Q4GX 2IOAA 3A2YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IF6 A;  4FGI A;  4EQA A;  4HPE A;  4FGE A;  2FG0 A;  2IOB A;  4JXB A;  3PBC A;  4LJ1 A;  4CT3 A;  3VPJ A;  2LRJ A;  4HZB A;  3PVQ A;  4FGD A;  4CGK A;  3NPF A;  4R0K A;  4Q4T A;  2K3A A;  3I86 A;  4HZ9 A;  4OLK A;  3O98 A;  3H41 A;  3PBI A;  3S0Q A;  4F4M A;  2XIV A;  2EVR A;  4F0W A;  3A2Z A;  3NE0 A;  2IO7 A;  2IO8 A;  3GT2 A;  4EQ8 A;  3KW0 A;  2K1G A;  4EOB A;  2VPS A;  2VOB A;  4F0V A;  2HBW A;  2IO9 A;  4FDY A;  4FQB A;  4CSH A;  4Q4N A;  3A30 A;  2VPM A;  3M1U A;  4FQA A;  3VPI A;  4Q4G X;  2IOA A;  3A2Y A; 
#chains in the Genus database with same CATH topology
 2IF6 A;  4FGI A;  4EQA A;  4HPE A;  4FGE A;  2FG0 A;  2IOB A;  4JXB A;  3PBC A;  4LJ1 A;  4CT3 A;  3VPJ A;  2LRJ A;  4HZB A;  3PVQ A;  4FGD A;  4CGK A;  3NPF A;  4HFF A;  2WP7 A;  4Q4T A;  4R0K A;  2K3A A;  3I86 A;  4HZ9 A;  4J32 A;  3O98 A;  4J30 A;  4OLK A;  3H41 A;  3PBI A;  3S0Q A;  4F4M A;  2XIV A;  4HFL A;  2EVR A;  4F0W A;  3A2Z A;  3NE0 A;  2IO7 A;  2IO8 A;  3GT2 A;  4EQ8 A;  3KW0 A;  2K1G A;  4EOB A;  2VPS A;  2VOB A;  4F0V A;  2HBW A;  2IO9 A;  4JUR A;  4FDY A;  4FQB A;  4CSH A;  4HFK A;  4Q4N A;  3A30 A;  2VPM A;  3M1U A;  4FQA A;  3EBQ A;  3VPI A;  4Q4G X;  2IOA A;  3A2Y A; 
#chains in the Genus database with same CATH homology
 2IF6 A;  4FGI A;  4EQA A;  4HPE A;  4FGE A;  2FG0 A;  2IOB A;  4JXB A;  3PBC A;  4LJ1 A;  4CT3 A;  3VPJ A;  2LRJ A;  4HZB A;  3PVQ A;  4FGD A;  4CGK A;  3NPF A;  4R0K A;  4Q4T A;  2K3A A;  3I86 A;  4HZ9 A;  4OLK A;  3O98 A;  3H41 A;  3PBI A;  3S0Q A;  4F4M A;  2XIV A;  2EVR A;  4F0W A;  3A2Z A;  3NE0 A;  2IO7 A;  2IO8 A;  3GT2 A;  4EQ8 A;  3KW0 A;  2K1G A;  4EOB A;  2VPS A;  2VOB A;  4F0V A;  2HBW A;  2IO9 A;  4FDY A;  4FQB A;  4CSH A;  4Q4N A;  3A30 A;  2VPM A;  3M1U A;  4FQA A;  3VPI A;  4Q4G X;  2IOA A;  3A2Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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