3QXLA

Crystal structure of the cdc25 domain from ral-specific guanine-nucleotide exchange factor ralgps1a
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
245
structure length
245
Chain Sequence
FDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.
pubmed doi rcsb
molecule keywords Ras-specific guanine nucleotide-releasing factor RalGPS1
molecule tags Signaling protein
source organism Homo sapiens
total genus 102
structure length 245
sequence length 245
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 3qxlA00
1XD2C 3CF6E 5CM8A 3T6AA 4URVS 4MGYE 4URUS 1NVWS 1XD4A 1NVXS 4US0S 4MGIE 4MGZE 5CM9A 4F7ZA 4URZS 4NYIS 3KSYA 4URXS 3QXLA 4US2S 2BYVE 4URWS 4MGKE 4US1S 4MH0E 4NYJS 4URYS 1NVUS 4L9MA 4NYMS 2IJES 1NVVS 2II0A 1BKDS 4JGWA 3T6GA
chains in the Genus database with same CATH superfamily
1XD2C 3CF6E 5CM8A 3T6AA 4URVS 4MGYE 4URUS 1NVWS 1XD4A 1NVXS 4US0S 4MGIE 4MGZE 5CM9A 4F7ZA 4URZS 4NYIS 3KSYA 4URXS 3QXLA 4US2S 2BYVE 4URWS 4MGKE 4US1S 4MH0E 4NYJS 4URYS 1NVUS 4L9MA 4NYMS 2IJES 1NVVS 2II0A 1BKDS 4JGWA 3T6GA
chains in the Genus database with same CATH topology
1XD2C 3CF6E 5CM8A 3T6AA 4URVS 4MGYE 4URUS 1NVWS 1XD4A 1NVXS 4US0S 4MGIE 4MGZE 5CM9A 4F7ZA 4URZS 4NYIS 3KSYA 4URXS 3QXLA 4US2S 2BYVE 4URWS 4MGKE 4US1S 4MH0E 4NYJS 4URYS 1NVUS 4L9MA 4NYMS 2IJES 1NVVS 2II0A 1BKDS 4JGWA 3T6GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XD2 C;  3CF6 E;  5CM8 A;  3T6A A;  4URV S;  4MGY E;  4URU S;  1NVW S;  1XD4 A;  1NVX S;  4US0 S;  4MGI E;  4MGZ E;  5CM9 A;  4F7Z A;  4URZ S;  4NYI S;  3KSY A;  4URX S;  3QXL A;  4US2 S;  2BYV E;  4URW S;  4MGK E;  4US1 S;  4MH0 E;  4NYJ S;  4URY S;  1NVU S;  4L9M A;  4NYM S;  2IJE S;  1NVV S;  2II0 A;  1BKD S;  4JGW A;  3T6G A; 
#chains in the Genus database with same CATH topology
 1XD2 C;  3CF6 E;  5CM8 A;  3T6A A;  4URV S;  4MGY E;  4URU S;  1NVW S;  1XD4 A;  1NVX S;  4US0 S;  4MGI E;  4MGZ E;  5CM9 A;  4F7Z A;  4URZ S;  4NYI S;  3KSY A;  4URX S;  3QXL A;  4US2 S;  2BYV E;  4URW S;  4MGK E;  4US1 S;  4MH0 E;  4NYJ S;  4URY S;  1NVU S;  4L9M A;  4NYM S;  2IJE S;  1NVV S;  2II0 A;  1BKD S;  4JGW A;  3T6G A; 
#chains in the Genus database with same CATH homology
 1XD2 C;  3CF6 E;  5CM8 A;  3T6A A;  4URV S;  4MGY E;  4URU S;  1NVW S;  1XD4 A;  1NVX S;  4US0 S;  4MGI E;  4MGZ E;  5CM9 A;  4F7Z A;  4URZ S;  4NYI S;  3KSY A;  4URX S;  3QXL A;  4US2 S;  2BYV E;  4URW S;  4MGK E;  4US1 S;  4MH0 E;  4NYJ S;  4URY S;  1NVU S;  4L9M A;  4NYM S;  2IJE S;  1NVV S;  2II0 A;  1BKD S;  4JGW A;  3T6G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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