3T6G | Genus

Total Genus 123

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	123
sequence length	313
structure length	299
Chain Sequence	TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGSTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLESEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAV

Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

loadScript /static/js/j2s/core/package.js

loadScript /static/js/j2s/core/corejmol.z.js

loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__9161394446271096__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet0__9161394446271096__)

vwrOptions:

{ "name":"jmolApplet0","applet":true,"documentBase":"https://genus.fuw.edu.pl/view/3T6G/A/","platform":"J.awtjs2d.Platform","fullName":"jmolApplet0__9161394446271096__","codePath":"https:/static/js/j2s/","display":"jmolApplet0_canvas2d","signedApplet":"true","appletReadyCallback":"Jmol._readyCallback","statusListener":"[J.appletjs.Jmol object]","syncId":"9161394446271096","bgcolor":"white" }

setting document base to "https://genus.fuw.edu.pl/view/3T6G/A/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

Jmol getValue DRAGDROPCallback null

Jmol getValue ECHOCallback null

Jmol getValue ERRORCallback null

Jmol getValue EVALCallback null

Jmol getValue HOVERCallback null

Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback null

Jmol getValue MEASURECallback null

Jmol getValue MESSAGECallback null

Jmol getValue MINIMIZATIONCallback null

Jmol getValue SERVICECallback null

Jmol getValue PICKCallback null

Jmol getValue RESIZECallback null

Jmol getValue SCRIPTCallback null

Jmol getValue SYNCCallback null

Jmol getValue STRUCTUREMODIFIEDCallback null

Jmol getValue doTranslate null

language=en_US

Jmol getValue popupMenu null

Jmol getValue script null

Jmol getValue loadInline null

Jmol getValue load null

Jmol applet jmolApplet0__9161394446271096__ ready

script 1 started

platformSpeed = 8

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Signaling protein, cell adhesion
source organism	Homo sapiens
publication title	NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. pubmed doi rcsb
molecule keywords	SH2 domain-containing protein 3C
total genus	123
structure length	299
sequence length	313
chains with identical sequence	C
ec nomenclature
pdb deposition date	2011-07-28

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00617	RasGEF	RasGEF domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.840.10	Mainly Alpha	Orthogonal Bundle	Son of Sevenless (SoS) protein; Chain S, domain 2	Ras guanine-nucleotide exchange factors catalytic domain	3t6gA00

4NYIS 3QXLA 3T6AA 2BYVE 4US0S 4MGKE 1XD4A 3T6GA 4URYS 4URVS 4US1S 1XD2C 4JGWA 4F7ZA 4MGIE 4URWS 4NYMS 4URUS 4L9MA 1NVVS 1NVUS 2II0A 3KSYA 2IJES 4MH0E 4MGYE 4URZS 1NVXS 4URXS 4MGZE 3CF6E 4US2S 5CM9A 5CM8A 4NYJS 1BKDS 1NVWS
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4NYI S;  3QXL A;  3T6A A;  2BYV E;  4US0 S;  4MGK E;  1XD4 A;  3T6G A;  4URY S;  4URV S;  4US1 S;  1XD2 C;  4JGW A;  4F7Z A;  4MGI E;  4URW S;  4NYM S;  4URU S;  4L9M A;  1NVV S;  1NVU S;  2II0 A;  3KSY A;  2IJE S;  4MH0 E;  4MGY E;  4URZ S;  1NVX S;  4URX S;  4MGZ E;  3CF6 E;  4US2 S;  5CM9 A;  5CM8 A;  4NYJ S;  1BKD S;  1NVW S; 
#chains in the Genus database with same CATH topology
 4NYI S;  3QXL A;  3T6A A;  2BYV E;  4US0 S;  4MGK E;  1XD4 A;  3T6G A;  4URY S;  4URV S;  4US1 S;  1XD2 C;  4JGW A;  4F7Z A;  4MGI E;  4URW S;  4NYM S;  4URU S;  4L9M A;  1NVV S;  1NVU S;  2II0 A;  3KSY A;  2IJE S;  4MH0 E;  4MGY E;  4URZ S;  1NVX S;  4URX S;  4MGZ E;  3CF6 E;  4US2 S;  5CM9 A;  5CM8 A;  4NYJ S;  1BKD S;  1NVW S; 
#chains in the Genus database with same CATH homology
 4NYI S;  3QXL A;  3T6A A;  2BYV E;  4US0 S;  4MGK E;  1XD4 A;  3T6G A;  4URY S;  4URV S;  4US1 S;  1XD2 C;  4JGW A;  4F7Z A;  4MGI E;  4URW S;  4NYM S;  4URU S;  4L9M A;  1NVV S;  1NVU S;  2II0 A;  3KSY A;  2IJE S;  4MH0 E;  4MGY E;  4URZ S;  1NVX S;  4URX S;  4MGZ E;  3CF6 E;  4US2 S;  5CM9 A;  5CM8 A;  4NYJ S;  1BKD S;  1NVW S;

...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)

...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

3T6GA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations