4JGW | Genus

Total Genus 135

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	135
sequence length	463
structure length	396
Chain Sequence	EEEASVSVWDEEEDGATFTVTSRQYRPLDPLAPLPPPRSSRRLRAGTLEALVRHLLDARTAGADMMFTPALLATHRAFTSTPALFGLVADRLEALESYPPGELERTTGVAISVLSTWLASHPEDFGSEVKGQLDRLESFLLRTGYSADLIRNLRARDSPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWLCPSVRATVTQFNKVAGAVVSSVLGATSIGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGETTRDSLRVFSSLCQIFSRELLTGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAILSELLRLQKECRGYDLRPNSDIQQWLQGLQPLTEAQSHRVSCEVEP

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein
source organism	Mus musculus
publication title	The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation. pubmed doi rcsb
molecule keywords	Ral guanine nucleotide dissociation stimulator-like 2
total genus	135
structure length	396
sequence length	463
chains with identical sequence	B
ec nomenclature
pdb deposition date	2013-03-04

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00617	RasGEF	RasGEF domain
A	PF00618	RasGEF_N	RasGEF N-terminal motif

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.840.10	Mainly Alpha	Orthogonal Bundle	Son of Sevenless (SoS) protein; Chain S, domain 2	Ras guanine-nucleotide exchange factors catalytic domain	4jgwA02
1.20.870.10	Mainly Alpha	Up-down Bundle	Son of sevenless (SoS) protein; Chain S, domain 1	Son of sevenless (SoS) protein Chain: S domain 1	4jgwA01

4MH0E 1BKDS 3QXLA 4L9MA 4URZS 2II0A 4URUS 4US0S 4MGIE 3CF6E 1NVWS 4URXS 3KSYA 4URYS 3T6AA 5CM9A 4MGKE 5CM8A 4US1S 3T6GA 4US2S 2BYVE 1NVXS 4NYJS 2IJES 4MGZE 1NVVS 1NVUS 4URWS 4JGWA 4URVS 4NYMS 1XD4A 4NYIS 4MGYE 4F7ZA 1XD2C
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4MH0 E;  1BKD S;  3QXL A;  4L9M A;  4URZ S;  2II0 A;  4URU S;  4US0 S;  4MGI E;  3CF6 E;  1NVW S;  4URX S;  3KSY A;  4URY S;  3T6A A;  5CM9 A;  4MGK E;  5CM8 A;  4US1 S;  3T6G A;  4US2 S;  2BYV E;  1NVX S;  4NYJ S;  2IJE S;  4MGZ E;  1NVV S;  1NVU S;  4URW S;  4JGW A;  4URV S;  4NYM S;  1XD4 A;  4NYI S;  4MGY E;  4F7Z A;  1XD2 C; 
#chains in the Genus database with same CATH topology
 4MH0 E;  1BKD S;  3QXL A;  4L9M A;  4URZ S;  2II0 A;  4URU S;  4US0 S;  4MGI E;  3CF6 E;  1NVW S;  4URX S;  3KSY A;  4URY S;  3T6A A;  5CM9 A;  4MGK E;  5CM8 A;  4US1 S;  3T6G A;  4US2 S;  2BYV E;  1NVX S;  4NYJ S;  2IJE S;  4MGZ E;  1NVV S;  1NVU S;  4URW S;  4JGW A;  4URV S;  4NYM S;  1XD4 A;  4NYI S;  4MGY E;  4F7Z A;  1XD2 C; 
#chains in the Genus database with same CATH homology
 4MH0 E;  1BKD S;  3QXL A;  4L9M A;  4URZ S;  2II0 A;  4URU S;  4US0 S;  4MGI E;  3CF6 E;  1NVW S;  4URX S;  3KSY A;  4URY S;  3T6A A;  5CM9 A;  4MGK E;  5CM8 A;  4US1 S;  3T6G A;  4US2 S;  2BYV E;  1NVX S;  4NYJ S;  2IJE S;  4MGZ E;  1NVV S;  1NVU S;  4URW S;  4JGW A;  4URV S;  4NYM S;  1XD4 A;  4NYI S;  4MGY E;  4F7Z A;  1XD2 C;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4JGWA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations