The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
174
|
sequence length |
481
|
structure length |
468
|
Chain Sequence |
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
pubmed doi rcsb |
| molecule keywords |
GTPase HRas
|
| molecule tags |
Signaling protein
|
| source organism |
Homo sapiens
|
| total genus |
174
|
| structure length |
468
|
| sequence length |
481
|
| ec nomenclature | |
| pdb deposition date | 2013-12-10 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| S | PF00617 | RasGEF | RasGEF domain |
| S | PF00618 | RasGEF_N | RasGEF N-terminal motif |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Son of Sevenless (SoS) protein; Chain S, domain 2 | Ras guanine-nucleotide exchange factors catalytic domain | ||
| Mainly Alpha | Up-down Bundle | Son of sevenless (SoS) protein; Chain S, domain 1 | Son of sevenless (SoS) protein Chain: S domain 1 |
#chains in the Genus database with same CATH superfamily 4MGK E; 4JGW A; 1NVX S; 1NVW S; 2IJE S; 2BYV E; 4MGI E; 2II0 A; 3CF6 E; 4MGY E; 4MH0 E; 5CM8 A; 4URZ S; 3KSY A; 4URW S; 4URY S; 4NYJ S; 1NVV S; 4URV S; 4US2 S; 4URU S; 4MGZ E; 3QXL A; 4F7Z A; 4URX S; 1BKD S; 3T6A A; 4L9M A; 4NYI S; 3T6G A; 4US0 S; 4US1 S; 1XD4 A; 5CM9 A; 1NVU S; 4NYM S; 1XD2 C; #chains in the Genus database with same CATH topology 4MGK E; 4JGW A; 1NVX S; 1NVW S; 2IJE S; 2BYV E; 4MGI E; 2II0 A; 3CF6 E; 4MGY E; 4MH0 E; 5CM8 A; 4URZ S; 3KSY A; 4URW S; 4URY S; 4NYJ S; 1NVV S; 4URV S; 4US2 S; 4URU S; 4MGZ E; 3QXL A; 4F7Z A; 4URX S; 1BKD S; 3T6A A; 4L9M A; 4NYI S; 3T6G A; 4US0 S; 4US1 S; 1XD4 A; 5CM9 A; 1NVU S; 4NYM S; 1XD2 C; #chains in the Genus database with same CATH homology 4MGK E; 4JGW A; 1NVX S; 1NVW S; 2IJE S; 2BYV E; 4MGI E; 2II0 A; 3CF6 E; 4MGY E; 4MH0 E; 5CM8 A; 4URZ S; 3KSY A; 4URW S; 4URY S; 4NYJ S; 1NVV S; 4URV S; 4US2 S; 4URU S; 4MGZ E; 3QXL A; 4F7Z A; 4URX S; 1BKD S; 3T6A A; 4L9M A; 4NYI S; 3T6G A; 4US0 S; 4US1 S; 1XD4 A; 5CM9 A; 1NVU S; 4NYM S; 1XD2 C;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
