4XSSB

Insulin-like growth factor i in complex with site 1 of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
61
structure length
47
Chain Sequence
ETLCGAELVDALQFVCGDRGFYFNTGIVDECCFRSCDLRRLEMYCAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
pubmed doi rcsb
molecule tags Hormone/hormone receptor
source organism Homo sapiens
molecule keywords Insulin-like growth factor I
total genus 12
structure length 47
sequence length 61
ec nomenclature
pdb deposition date 2015-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 4xssB00
6INSE 5L3LA 2KQPA 2GF1A 2DSPI 1IMXA 2KJIA 2DSQC 2DSRI 1B9GA 1GZRB 1PMXA 1EFEA 1IGLA 3GF1A 3LRIA 1H59A 1GZZB 1WQJI 2LWZA 1H02B 5L3MA 1BQTA 1GZYB 4XSSB 1TGRA 2L29B 3KR3D 1ZEIA 1SJUA 5L3NA 2JZQA
chains in the Genus database with same CATH superfamily
2L14B 6INSE 5L3LA 3F2DA 2KQPA 2GF1A 2DSPI 1IMXA 2KJIA 2DSQC 2DSRI 1B9GA 1GZRB 1PMXA 1EFEA 1IGLA 3GF1A 3LRIA 1H59A 1GZZB 1WQJI 2LWZA 1H02B 5L3MA 1BQTA 1GZYB 4XSSB 1TGRA 2L29B 3KR3D 3F2BA 3F2CA 1ZEIA 1SJUA 5L3NA 2JZQA
chains in the Genus database with same CATH topology
6INSE 5L3LA 2KQPA 2GF1A 2DSPI 1IMXA 2KJIA 2DSQC 2DSRI 1B9GA 1GZRB 1PMXA 1EFEA 1IGLA 3GF1A 3LRIA 1H59A 1GZZB 1WQJI 2LWZA 1H02B 5L3MA 1BQTA 1GZYB 4XSSB 1TGRA 2L29B 3KR3D 1ZEIA 1SJUA 5L3NA 2JZQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 6INS E;  5L3L A;  2KQP A;  2GF1 A;  2DSP I;  1IMX A;  2KJI A;  2DSQ C;  2DSR I;  1B9G A;  1GZR B;  1PMX A;  1EFE A;  1IGL A;  3GF1 A;  3LRI A;  1H59 A;  1GZZ B;  1WQJ I;  2LWZ A;  1H02 B;  5L3M A;  1BQT A;  1GZY B;  4XSS B;  1TGR A;  2L29 B;  3KR3 D;  1ZEI A;  1SJU A;  5L3N A;  2JZQ A; 
#chains in the Genus database with same CATH topology
 2L14 B;  6INS E;  5L3L A;  3F2D A;  2KQP A;  2GF1 A;  2DSP I;  1IMX A;  2KJI A;  2DSQ C;  2DSR I;  1B9G A;  1GZR B;  1PMX A;  1EFE A;  1IGL A;  3GF1 A;  3LRI A;  1H59 A;  1GZZ B;  1WQJ I;  2LWZ A;  1H02 B;  5L3M A;  1BQT A;  1GZY B;  4XSS B;  1TGR A;  2L29 B;  3KR3 D;  3F2B A;  3F2C A;  1ZEI A;  1SJU A;  5L3N A;  2JZQ A; 
#chains in the Genus database with same CATH homology
 6INS E;  5L3L A;  2KQP A;  2GF1 A;  2DSP I;  1IMX A;  2KJI A;  2DSQ C;  2DSR I;  1B9G A;  1GZR B;  1PMX A;  1EFE A;  1IGL A;  3GF1 A;  3LRI A;  1H59 A;  1GZZ B;  1WQJ I;  2LWZ A;  1H02 B;  5L3M A;  1BQT A;  1GZY B;  4XSS B;  1TGR A;  2L29 B;  3KR3 D;  1ZEI A;  1SJU A;  5L3N A;  2JZQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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