|
50
|
186
|
5hpbA |
Human dihydrofolate reductase complex with nadph and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5hqyA |
Human dihydrofolate reductase complex with nadph and 5-methyl-6-(2',3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
56
|
186
|
5hsuA |
Fluorine substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5huiA |
6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl) |
|
55
|
186
|
5hqzA |
Fluorine substituted 5-methyl-6-(4'-trifluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
54
|
186
|
8dfrA |
Refined crystal structures of chicken liver dihydrofolate reductase. 3 angstroms apo-enzyme and 1.7 angstroms nadph holo-enzyme complex |
|
40
|
159
|
7dfrA |
Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state |
|
42
|
159
|
6e4eA |
Crystal structure of dihydrofolate reductase from staphylococcus aureus mw2 bound to nadp and p218 |
|
42
|
159
|
6ddpA |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta-nadph and 3'-[(2r)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid |
|
41
|
159
|
6ddsA |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta-nadph and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid |
|
57
|
186
|
6davA |
Crystal structure of human dhfr complexed with nadp and n10formyltetrahydrofolate |
|
44
|
159
|
6ddwA |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta-nadph and n-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-l-glutamic acid |
|
53
|
186
|
6de4A |
Homo sapiens dihydrofolate reductase complexed with beta-nadph and 3'-[(2r)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid |
|
40
|
159
|
6dfrA |
Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state |
|
38
|
155
|
6cxmA |
Crystal structure of a dihydrofolate reductase from mycobacterium smegmatis in complex with nadp and p218 |
|
158
|
564
|
6aogA |
Crystal structure of toxoplasma gondii ts-dhfr complexed with nadph, dump, pddf, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine) |
|
154
|
564
|
6aoiA |
Crystal structure of toxoplasma gondii ts-dhfr complexed with nadph, dump, pddf, and 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine (trc-2528) |
|
144
|
564
|
6aohA |
Crystal structure of toxoplasma gondii ts-dhfr complexed with nadph, dump, pddf, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (trc-2533) |
|
44
|
160
|
5z6jA |
High-pressure crystal structure analysis of m20 loop closed dhfr at 220 mpa |
|
36
|
160
|
5z6mA |
High-pressure crystal structure analysis of m20 loop closed dhfr at 800 mpa |
|
46
|
160
|
5z6fA |
High-pressure crystal structure analysis of dhfr(0.1 mpa) |
|
44
|
160
|
5z6kA |
High-pressure crystal structure analysis of m20 loop closed dhfr at 400 mpa |
|
41
|
160
|
5z6lA |
High-pressure crystal structure analysis of m20 loop closed dhfr at 650 mpa |
|
45
|
159
|
5cc9A |
L28f e.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate |
|
44
|
159
|
5cccA |
Wild-type e.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate |
|
42
|
159
|
4qleA |
Crystal structure of i14a dhfr mutant complexed with folate and nadp+ |
|
46
|
159
|
4eizA |
Structure of nb113 bound to apodhfr |
|
108
|
608
|
4eckA |
Crystal structure of the toxoplasma gondii ts-dhfr |
|
42
|
166
|
4elfA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
44
|
159
|
4ej1A |
Binding of nb113 camelid antibody fragment with the binary dhfr:folate complex |
|
182
|
606
|
4dp3A |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with p218 and nadph |
|
41
|
166
|
4elhA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
173
|
606
|
4dphA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with p65 and nadph |
|
40
|
166
|
4elbA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
171
|
563
|
4eilA |
Crystal structure of the loop truncated toxoplasma gondii ts-dhfr |
|
44
|
166
|
4eleA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
174
|
605
|
4dpdA |
Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts), dhf complex, nadp+, dump |
|
40
|
166
|
4elgA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
42
|
159
|
4eigA |
Ca1698 camel antibody fragment in complex with dhfr |
|
56
|
186
|
4ddrA |
Human dihydrofolate reductase complexed with nadph and p218 |
|
116
|
285
|
4d3dA |
Structure of imine reductase bcsired from bacillus cereus bag3x2 |
|
96
|
285
|
4d3sA |
Imine reductase from nocardiopsis halophila |
|
43
|
159
|
4dfrA |
Crystal structures of escherichia coli and lactobacillus casei dihydrofolate reductase refined at 1.7 angstroms resolution. i. general features and binding of methotrexate |
|
114
|
284
|
4d3fA |
Bcsired from bacillus cereus in complex with nadph |
|
56
|
202
|
4cd2A |
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and nadp+ |
|
46
|
183
|
3vcoA |
Schistosoma mansoni dihydrofolate reductase |
|
168
|
608
|
3um6A |
Double mutant (a16v+s108t) plasmodium falciparum dhfr-ts (t9/94) complexed with cycloguanil, nadph and dump |
|
177
|
608
|
3um5A |
Double mutant (a16v+s108t) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts-t9/94) complexed with pyrimethamine, nadph, and dump |
|
43
|
160
|
3tqaA |
Structure of the dihydrofolate reductase (fola) from coxiella burnetii in complex with nadph |
|
41
|
160
|
3tq9A |
Structure of the dihydrofolate reductase (fola) from coxiella burnetii in complex with methotrexate |
