5HSUA

Fluorine substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines
rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
total genus 56
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hsuA00
3QG2A 3QL3A 3QLYA 1RX2A 1DG5A 5HQYA 4NX6A 2ANQA 4LAEX 4RGCA 1DYJA 2AZNA 1PD8A 1RG7A 5HF2X 4FGHA 1RX4A 3NZDA 3F0XX 2HXVA 1M78A 1IA3A 3FRDX 3FS6A 4DP3A 2FZJA 4X5IA 3EELA 3NRRA 3IX9A 3F8YA 3SRUX 3GYFA 3KGYA 3I8AX 4ELFA 4KEBA 3FREX 5U27A 1E26A 4KFJA 4PDJA 3F0UX 3JWMA 1DDRA 2BLBA 3SR5X 1HFQA 3SQYX 1ZDRA 3RG9A 5CCCA 3D80A 1CD2A 3CL9A 4M6KA 4XRBA 3TQ9A 3TQBA 3TQ8A 4ELEA 1LY4A 3NZCX 3UM6A 1S3UA 1HFRA 1QZFA 3K74A 1DYIA 2H2QA 2LF1A 3Q1HA 3INVA 1YHOA 4GH8A 1LUDA 4M6LA 2W3WA 4QJCA 1U71A 4KNEA 4G8ZX 4XT7A 3JWKA 1J3KA 3DRCA 1MVSA 2FZIA 3EIGA 2BLCA 1DDSA 1DR3A 1D1GA 3JWCA 1RB3A 3JSUA 3NXRA 2XW7A 3NXVA 5HVEA 3UM8A 4HA7A 4FGGA 2INQA 1DRFA 1LY3A 4XECX 3QLXA 2W3MA 1KLKA 1AOEA 4PSTA 3QLRA 2QK8A 4KM0A 4P3QA 7DFRA 3N0HA 2W9HA 2ITHA 2W9GA 4IXED 3FQZA 4H95A 4KJLA 3SRSX 1U70A 5HVBA 4Q0DA 3QLSA 3M08A 2OIPA 3NZ9X 1AO8A 1S3YA 5EAJA 1DREA 3D84X 3DG8A 1IA4A 3QFXA 3NXXA 4I13A 1VDRA 3QL0A 1DR6A 3F0SX 4H98A 2FZHA 1OHJA 2L28A 4LAGX 3FL9A 1PDBA 3FYVX 3KY8A 3SH2A 1S3VA 1DRHA 5E8QA 3DL6A 4PSYA 3KJRA 1DHFA 4QLEA 4QLFA 3JWFA 3GHCA 3SAIA 3S7AA 3SGYA 3IRNA 3FRBX 4PTHA 3SRRX 3EX8A 4LEKX 8DFRA 3R33A 3ROAA 4M7VA 4HOGA 1DR5A 3IA5A 4LAHX 3I3RA 3JTWA 4IXFX 3FQFA 5HQZA 3JW5A 4KJKA 1M7AA 5JA3A 4FHBA 4DPHA 3SRWX 5FDAA 4M2XA 1DG8A 1RX9A 3TQAA 1RX8A 3QLWA 3KJSA 3KFYA 3DFRA 1AI9A 4OR7A 1M79A 4EIZA 1DAJA 3FQVA 3JVXA 4KAKA 4KBNA 4M7UA 3NTZA 4XT6A 3F8ZA 2GD9A 1DRAA 4IXGX 1RH3A 4ELHA 1RX6A 2DHFA 3VCOA 2BLAA 3FYWX 3OCHA 5CC9A 4P66A 3GI2A 4X5GA 5U26A 3ZPGA 1J3IA 3DAUA 3SRQX 1DRBA 2JYBA 3NU0A 3CSEA 1DYRA 4H97A 1S3WA 1RX5A 3EEMA 1BZFA 2D5NA 3FRAX 3IROA 3K47A 3FL8A 3S3VA 5HT5A 3GHWA 2HQPA 3QYLA 4QI9A 4KM2A 3TD8A 1DYHA 1BOZA 2BL9A 1DR2A 2C2TA 2W3AA 4G95A 3NXOA 4CD2A 3NZ6X 4TU5X 4KL9A 4DDRA 4P68A 1DF7A 1MVTA 3K45A 1DISA 4H96A 3FY8X 4PSSA 3ZPCA 1DLRA 5JG0X 2DRCA 1PD9A 1RB2A 3HBBA 4DPDA 4ELGA 3S9UA 5HT4A 1RX3A 2W9SA 1IA1A 1RC4A 1KMSA 1JOMA 3CD2A 4XE6X 4EIGA 4EJ1A 3EEJA 2O7PA 4Q67A 5DFRA 5HI6A 3LG4A 3FQ0A 1RX7A 1DG7A 2CD2A 3F0QX 4KY4A 3HJ3A 3FQOA 3F0VX 3QYOA 3IRMA 1J3JA 4XT4A 4XT5A 4KYAA 5HSRA 1RA8A 1DLSA 1DR1A 3SA1A 2C2SA 1RA9A 1RA2A 5ECCA 4HA9A 4QLGA 3OAFA 2KGKA 2W9TA 1RA3A 4HOFA 3DL5A 1DR7A 3GHVA 4Q6AA 3NZAX 1HFPA 1JOLA 2B3ZA 2W3BA 4PTJA 3F91A 4P3RA 3DGAA 5HUIA 1DR4A 4X5JA 1RD7A 1DHIA 1VJ3A 3CLBA 3JW3A 3UM5A 5DXVA 2D0KA 5ECXA 3RO9A 3QLZA 4X5FA 3NXTA 3NXYA 2ZZAA 4KY8A 2HM9A 3DATA 4ECKA 5HSUA 2ANOA 6DFRA 3M09A 4X5HA 3EEKA 1RA1A 4KLXA 1TDRA 4KD7A 4OSGA 4G3MA 1IA2A 1KMVA 3SA2A 2OBCA 3QGTA 1U72A 1OHKA 4XT8A 1RE7A 3F0BX 2P4GA 3FY9X 3NZBX 3FQCA 5HPBA 4QHVA 1RX1A 4HOEA 5HF0X 4ELBA 4Q0EA 2CIGA 4DFRA 1DIUA 2G6VA 4I1NA 4NX7A 1CZ3A 2W3VA 4M6JA 1SEJA 3K2HA 4QJZD 4KJJA 3FRFX 3IA4A 1JUVA 3E0BA 1RF7A 1DHJA 4EILA 3L3RA
chains in the Genus database with same CATH superfamily
3QG2A 3QL3A 3QLYA 1RX2A 1DG5A 5HQYA 4NX6A 2ANQA 4LAEX 4RGCA 1DYJA 2AZNA 1PD8A 1RG7A 5HF2X 4FGHA 1RX4A 3NZDA 3F0XX 2HXVA 1M78A 1IA3A 3FRDX 3FS6A 4DP3A 2FZJA 4X5IA 3EELA 3NRRA 3IX9A 3F8YA 3SRUX 3GYFA 3KGYA 3I8AX 4ELFA 4KEBA 3FREX 5U27A 1E26A 4KFJA 4PDJA 3F0UX 3JWMA 1DDRA 2BLBA 3SR5X 1HFQA 3SQYX 1ZDRA 3RG9A 5CCCA 3D80A 1CD2A 3CL9A 4M6KA 4XRBA 3TQ9A 3TQBA 3TQ8A 4ELEA 1LY4A 3NZCX 3UM6A 1S3UA 1HFRA 1QZFA 3K74A 1DYIA 2H2QA 2LF1A 3Q1HA 3INVA 1YHOA 4GH8A 1LUDA 4M6LA 2W3WA 4QJCA 1U71A 4KNEA 4G8ZX 4XT7A 3JWKA 1J3KA 3DRCA 1MVSA 2FZIA 3EIGA 2BLCA 1DDSA 1DR3A 1D1GA 3JWCA 1RB3A 3JSUA 3NXRA 2XW7A 3NXVA 5HVEA 3UM8A 4HA7A 4FGGA 2INQA 1DRFA 1LY3A 4XECX 3QLXA 2W3MA 1KLKA 1AOEA 4PSTA 3QLRA 2QK8A 4KM0A 4P3QA 7DFRA 3N0HA 2W9HA 2ITHA 2W9GA 4IXED 3FQZA 4H95A 4KJLA 3SRSX 1U70A 5HVBA 4Q0DA 3QLSA 3M08A 2OIPA 3NZ9X 1AO8A 1S3YA 5EAJA 1DREA 3D84X 3DG8A 1IA4A 3QFXA 3NXXA 4I13A 1VDRA 3QL0A 1DR6A 3F0SX 4H98A 2FZHA 1OHJA 2L28A 4LAGX 3FL9A 1PDBA 3FYVX 3KY8A 3SH2A 1S3VA 1DRHA 5E8QA 3DL6A 4PSYA 3KJRA 1DHFA 4QLEA 4QLFA 3JWFA 3GHCA 3SAIA 3S7AA 3SGYA 3IRNA 3FRBX 4PTHA 3SRRX 3EX8A 4LEKX 8DFRA 3R33A 3ROAA 4M7VA 4HOGA 1DR5A 3IA5A 4LAHX 3I3RA 3JTWA 4IXFX 3FQFA 5HQZA 3JW5A 4KJKA 1M7AA 5JA3A 4FHBA 4DPHA 3SRWX 5FDAA 4M2XA 1DG8A 1RX9A 3TQAA 1RX8A 3QLWA 3KJSA 3KFYA 3DFRA 1AI9A 4OR7A 1M79A 4EIZA 1DAJA 3FQVA 3JVXA 4KAKA 4KBNA 4M7UA 3NTZA 4XT6A 3F8ZA 2GD9A 1DRAA 4IXGX 1RH3A 4ELHA 1RX6A 2DHFA 3VCOA 2BLAA 3FYWX 3OCHA 5CC9A 4P66A 3GI2A 4X5GA 5U26A 3ZPGA 1J3IA 3DAUA 3SRQX 1DRBA 2JYBA 3NU0A 3CSEA 1DYRA 4H97A 1S3WA 1RX5A 3EEMA 1BZFA 2D5NA 3FRAX 3IROA 3K47A 3FL8A 3S3VA 5HT5A 3GHWA 2HQPA 3QYLA 4QI9A 4KM2A 3TD8A 1DYHA 1BOZA 2BL9A 1DR2A 2C2TA 2W3AA 4G95A 3NXOA 4CD2A 3NZ6X 4TU5X 4KL9A 4DDRA 4P68A 1DF7A 1MVTA 3K45A 1DISA 4H96A 3FY8X 4PSSA 3ZPCA 1DLRA 5JG0X 2DRCA 1PD9A 1RB2A 3HBBA 4DPDA 4ELGA 3S9UA 5HT4A 1RX3A 2W9SA 1IA1A 1RC4A 1KMSA 1JOMA 3CD2A 4XE6X 4EIGA 4EJ1A 3EEJA 2O7PA 4Q67A 5DFRA 5HI6A 3LG4A 3FQ0A 1RX7A 1DG7A 2CD2A 3F0QX 4KY4A 3HJ3A 3FQOA 3F0VX 3QYOA 3IRMA 1J3JA 4XT4A 4XT5A 4KYAA 5HSRA 1RA8A 1DLSA 1DR1A 3SA1A 2C2SA 1RA9A 1RA2A 5ECCA 4HA9A 4QLGA 3OAFA 2KGKA 2W9TA 1RA3A 4HOFA 3DL5A 1DR7A 3GHVA 4Q6AA 3NZAX 1HFPA 1JOLA 2B3ZA 2W3BA 4PTJA 3F91A 4P3RA 3DGAA 5HUIA 1DR4A 4X5JA 1RD7A 1DHIA 1VJ3A 3CLBA 3JW3A 3UM5A 5DXVA 2D0KA 5ECXA 3RO9A 3QLZA 4X5FA 3NXTA 3NXYA 2ZZAA 4KY8A 2HM9A 3DATA 4ECKA 5HSUA 2ANOA 6DFRA 3M09A 4X5HA 3EEKA 1RA1A 4KLXA 1TDRA 4KD7A 4OSGA 4G3MA 1IA2A 1KMVA 3SA2A 2OBCA 3QGTA 1U72A 1OHKA 4XT8A 1RE7A 3F0BX 2P4GA 3FY9X 3NZBX 3FQCA 5HPBA 4QHVA 1RX1A 4HOEA 5HF0X 4ELBA 4Q0EA 2CIGA 4DFRA 1DIUA 2G6VA 4I1NA 4NX7A 1CZ3A 2W3VA 4M6JA 1SEJA 3K2HA 4QJZD 4KJJA 3FRFX 3IA4A 1JUVA 3E0BA 1RF7A 1DHJA 4EILA 3L3RA
chains in the Genus database with same CATH topology
3QG2A 3QL3A 3QLYA 1RX2A 1DG5A 5HQYA 4NX6A 2ANQA 4LAEX 4RGCA 1DYJA 2AZNA 1PD8A 1RG7A 5HF2X 4FGHA 1RX4A 3NZDA 3F0XX 2HXVA 1M78A 1IA3A 3FRDX 3FS6A 4DP3A 2FZJA 4X5IA 3EELA 3NRRA 3IX9A 3F8YA 3SRUX 3GYFA 3KGYA 3I8AX 4ELFA 4KEBA 3FREX 5U27A 1E26A 4KFJA 4PDJA 3F0UX 3JWMA 1DDRA 2BLBA 3SR5X 1HFQA 3SQYX 1ZDRA 3RG9A 5CCCA 3D80A 1CD2A 3CL9A 4M6KA 4XRBA 3TQ9A 3TQBA 3TQ8A 4ELEA 1LY4A 3NZCX 3UM6A 1S3UA 1HFRA 1QZFA 3K74A 1DYIA 2H2QA 2LF1A 3Q1HA 3INVA 1YHOA 4GH8A 1LUDA 4M6LA 2W3WA 4QJCA 1U71A 4KNEA 4G8ZX 4XT7A 3JWKA 1J3KA 3DRCA 1MVSA 2FZIA 3EIGA 2BLCA 1DDSA 1DR3A 1D1GA 3JWCA 1RB3A 3JSUA 3NXRA 2XW7A 3NXVA 5HVEA 3UM8A 4HA7A 4FGGA 2INQA 1DRFA 1LY3A 4XECX 3QLXA 2W3MA 1KLKA 1AOEA 4PSTA 3QLRA 2QK8A 4KM0A 4P3QA 7DFRA 3N0HA 2W9HA 2ITHA 2W9GA 4IXED 3FQZA 4H95A 4KJLA 3SRSX 1U70A 5HVBA 4Q0DA 3QLSA 3M08A 2OIPA 3NZ9X 1AO8A 1S3YA 5EAJA 1DREA 3D84X 3DG8A 1IA4A 3QFXA 3NXXA 4I13A 1VDRA 3QL0A 1DR6A 3F0SX 4H98A 2FZHA 1OHJA 2L28A 4LAGX 3FL9A 1PDBA 3FYVX 3KY8A 3SH2A 1S3VA 1DRHA 5E8QA 3DL6A 4PSYA 3KJRA 1DHFA 4QLEA 4QLFA 3JWFA 3GHCA 3SAIA 3S7AA 3SGYA 3IRNA 3FRBX 4PTHA 3SRRX 3EX8A 4LEKX 8DFRA 3R33A 3ROAA 4M7VA 4HOGA 1DR5A 3IA5A 4LAHX 3I3RA 3JTWA 4IXFX 3FQFA 5HQZA 3JW5A 4KJKA 1M7AA 5JA3A 4FHBA 4DPHA 3SRWX 5FDAA 4M2XA 1DG8A 1RX9A 3TQAA 1RX8A 3QLWA 3KJSA 3KFYA 3DFRA 1AI9A 4OR7A 1M79A 4EIZA 1DAJA 3FQVA 3JVXA 4KAKA 4KBNA 4M7UA 3NTZA 4XT6A 3F8ZA 2GD9A 1DRAA 4IXGX 1RH3A 4ELHA 1RX6A 2DHFA 3VCOA 2BLAA 3FYWX 3OCHA 5CC9A 4P66A 3GI2A 4X5GA 5U26A 3ZPGA 1J3IA 3DAUA 3SRQX 1DRBA 2JYBA 3NU0A 3CSEA 1DYRA 4H97A 1S3WA 1RX5A 3EEMA 1BZFA 2D5NA 3FRAX 3IROA 3K47A 3FL8A 3S3VA 5HT5A 3GHWA 2HQPA 3QYLA 4QI9A 4KM2A 3TD8A 1DYHA 1BOZA 2BL9A 1DR2A 2C2TA 2W3AA 4G95A 3NXOA 4CD2A 3NZ6X 4TU5X 4KL9A 4DDRA 4P68A 1DF7A 1MVTA 3K45A 1DISA 4H96A 3FY8X 4PSSA 3ZPCA 1DLRA 5JG0X 2DRCA 1PD9A 1RB2A 3HBBA 4DPDA 4ELGA 3S9UA 5HT4A 1RX3A 2W9SA 1IA1A 1RC4A 1KMSA 1JOMA 3CD2A 4XE6X 4EIGA 4EJ1A 3EEJA 2O7PA 4Q67A 5DFRA 5HI6A 3LG4A 3FQ0A 1RX7A 1DG7A 2CD2A 3F0QX 4KY4A 3HJ3A 3FQOA 3F0VX 3QYOA 3IRMA 1J3JA 4XT4A 4XT5A 4KYAA 5HSRA 1RA8A 1DLSA 1DR1A 3SA1A 2C2SA 1RA9A 1RA2A 5ECCA 4HA9A 4QLGA 3OAFA 2KGKA 2W9TA 1RA3A 4HOFA 3DL5A 1DR7A 3GHVA 4Q6AA 3NZAX 1HFPA 1JOLA 2B3ZA 2W3BA 4PTJA 3F91A 4P3RA 3DGAA 5HUIA 1DR4A 4X5JA 1RD7A 1DHIA 1VJ3A 3CLBA 3JW3A 3UM5A 5DXVA 2D0KA 5ECXA 3RO9A 3QLZA 4X5FA 3NXTA 3NXYA 2ZZAA 4KY8A 2HM9A 3DATA 4ECKA 5HSUA 2ANOA 6DFRA 3M09A 4X5HA 3EEKA 1RA1A 4KLXA 1TDRA 4KD7A 4OSGA 4G3MA 1IA2A 1KMVA 3SA2A 2OBCA 3QGTA 1U72A 1OHKA 4XT8A 1RE7A 3F0BX 2P4GA 3FY9X 3NZBX 3FQCA 5HPBA 4QHVA 1RX1A 4HOEA 5HF0X 4ELBA 4Q0EA 2CIGA 4DFRA 1DIUA 2G6VA 4I1NA 4NX7A 1CZ3A 2W3VA 4M6JA 1SEJA 3K2HA 4QJZD 4KJJA 3FRFX 3IA4A 1JUVA 3E0BA 1RF7A 1DHJA 4EILA 3L3RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QG2 A;  3QL3 A;  3QLY A;  1RX2 A;  1DG5 A;  5HQY A;  4NX6 A;  2ANQ A;  4LAE X;  4RGC A;  1DYJ A;  2AZN A;  1PD8 A;  1RG7 A;  5HF2 X;  4FGH A;  1RX4 A;  3NZD A;  3F0X X;  2HXV A;  1M78 A;  1IA3 A;  3FRD X;  3FS6 A;  4DP3 A;  2FZJ A;  4X5I A;  3EEL A;  3NRR A;  3IX9 A;  3F8Y A;  3SRU X;  3GYF A;  3KGY A;  3I8A X;  4ELF A;  4KEB A;  3FRE X;  5U27 A;  1E26 A;  4KFJ A;  4PDJ A;  3F0U X;  3JWM A;  1DDR A;  2BLB A;  3SR5 X;  1HFQ A;  3SQY X;  1ZDR A;  3RG9 A;  5CCC A;  3D80 A;  1CD2 A;  3CL9 A;  4M6K A;  4XRB A;  3TQ9 A;  3TQB A;  3TQ8 A;  4ELE A;  1LY4 A;  3NZC X;  3UM6 A;  1S3U A;  1HFR A;  1QZF A;  3K74 A;  1DYI A;  2H2Q A;  2LF1 A;  3Q1H A;  3INV A;  1YHO A;  4GH8 A;  1LUD A;  4M6L A;  2W3W A;  4QJC A;  1U71 A;  4KNE A;  4G8Z X;  4XT7 A;  3JWK A;  1J3K A;  3DRC A;  1MVS A;  2FZI A;  3EIG A;  2BLC A;  1DDS A;  1DR3 A;  1D1G A;  3JWC A;  1RB3 A;  3JSU A;  3NXR A;  2XW7 A;  3NXV A;  5HVE A;  3UM8 A;  4HA7 A;  4FGG A;  2INQ A;  1DRF A;  1LY3 A;  4XEC X;  3QLX A;  2W3M A;  1KLK A;  1AOE A;  4PST A;  3QLR A;  2QK8 A;  4KM0 A;  4P3Q A;  7DFR A;  3N0H A;  2W9H A;  2ITH A;  2W9G A;  4IXE D;  3FQZ A;  4H95 A;  4KJL A;  3SRS X;  1U70 A;  5HVB A;  4Q0D A;  3QLS A;  3M08 A;  2OIP A;  3NZ9 X;  1AO8 A;  1S3Y A;  5EAJ A;  1DRE A;  3D84 X;  3DG8 A;  1IA4 A;  3QFX A;  3NXX A;  4I13 A;  1VDR A;  3QL0 A;  1DR6 A;  3F0S X;  4H98 A;  2FZH A;  1OHJ A;  2L28 A;  4LAG X;  3FL9 A;  1PDB A;  3FYV X;  3KY8 A;  3SH2 A;  1S3V A;  1DRH A;  5E8Q A;  3DL6 A;  4PSY A;  3KJR A;  1DHF A;  4QLE A;  4QLF A;  3JWF A;  3GHC A;  3SAI A;  3S7A A;  3SGY A;  3IRN A;  3FRB X;  4PTH A;  3SRR X;  3EX8 A;  4LEK X;  8DFR A;  3R33 A;  3ROA A;  4M7V A;  4HOG A;  1DR5 A;  3IA5 A;  4LAH X;  3I3R A;  3JTW A;  4IXF X;  3FQF A;  5HQZ A;  3JW5 A;  4KJK A;  1M7A A;  5JA3 A;  4FHB A;  4DPH A;  3SRW X;  5FDA A;  4M2X A;  1DG8 A;  1RX9 A;  3TQA A;  1RX8 A;  3QLW A;  3KJS A;  3KFY A;  3DFR A;  1AI9 A;  4OR7 A;  1M79 A;  4EIZ A;  1DAJ A;  3FQV A;  3JVX A;  4KAK A;  4KBN A;  4M7U A;  3NTZ A;  4XT6 A;  3F8Z A;  2GD9 A;  1DRA A;  4IXG X;  1RH3 A;  4ELH A;  1RX6 A;  2DHF A;  3VCO A;  2BLA A;  3FYW X;  3OCH A;  5CC9 A;  4P66 A;  3GI2 A;  4X5G A;  5U26 A;  3ZPG A;  1J3I A;  3DAU A;  3SRQ X;  1DRB A;  2JYB A;  3NU0 A;  3CSE A;  1DYR A;  4H97 A;  1S3W A;  1RX5 A;  3EEM A;  1BZF A;  2D5N A;  3FRA X;  3IRO A;  3K47 A;  3FL8 A;  3S3V A;  5HT5 A;  3GHW A;  2HQP A;  3QYL A;  4QI9 A;  4KM2 A;  3TD8 A;  1DYH A;  1BOZ A;  2BL9 A;  1DR2 A;  2C2T A;  2W3A A;  4G95 A;  3NXO A;  4CD2 A;  3NZ6 X;  4TU5 X;  4KL9 A;  4DDR A;  4P68 A;  1DF7 A;  1MVT A;  3K45 A;  1DIS A;  4H96 A;  3FY8 X;  4PSS A;  3ZPC A;  1DLR A;  5JG0 X;  2DRC A;  1PD9 A;  1RB2 A;  3HBB A;  4DPD A;  4ELG A;  3S9U A;  5HT4 A;  1RX3 A;  2W9S A;  1IA1 A;  1RC4 A;  1KMS A;  1JOM A;  3CD2 A;  4XE6 X;  4EIG A;  4EJ1 A;  3EEJ A;  2O7P A;  4Q67 A;  5DFR A;  5HI6 A;  3LG4 A;  3FQ0 A;  1RX7 A;  1DG7 A;  2CD2 A;  3F0Q X;  4KY4 A;  3HJ3 A;  3FQO A;  3F0V X;  3QYO A;  3IRM A;  1J3J A;  4XT4 A;  4XT5 A;  4KYA A;  5HSR A;  1RA8 A;  1DLS A;  1DR1 A;  3SA1 A;  2C2S A;  1RA9 A;  1RA2 A;  5ECC A;  4HA9 A;  4QLG A;  3OAF A;  2KGK A;  2W9T A;  1RA3 A;  4HOF A;  3DL5 A;  1DR7 A;  3GHV A;  4Q6A A;  3NZA X;  1HFP A;  1JOL A;  2B3Z A;  2W3B A;  4PTJ A;  3F91 A;  4P3R A;  3DGA A;  5HUI A;  1DR4 A;  4X5J A;  1RD7 A;  1DHI A;  1VJ3 A;  3CLB A;  3JW3 A;  3UM5 A;  5DXV A;  2D0K A;  5ECX A;  3RO9 A;  3QLZ A;  4X5F A;  3NXT A;  3NXY A;  2ZZA A;  4KY8 A;  2HM9 A;  3DAT A;  4ECK A;  5HSU A;  2ANO A;  6DFR A;  3M09 A;  4X5H A;  3EEK A;  1RA1 A;  4KLX A;  1TDR A;  4KD7 A;  4OSG A;  4G3M A;  1IA2 A;  1KMV A;  3SA2 A;  2OBC A;  3QGT A;  1U72 A;  1OHK A;  4XT8 A;  1RE7 A;  3F0B X;  2P4G A;  3FY9 X;  3NZB X;  3FQC A;  5HPB A;  4QHV A;  1RX1 A;  4HOE A;  5HF0 X;  4ELB A;  4Q0E A;  2CIG A;  4DFR A;  1DIU A;  2G6V A;  4I1N A;  4NX7 A;  1CZ3 A;  2W3V A;  4M6J A;  1SEJ A;  3K2H A;  4QJZ D;  4KJJ A;  3FRF X;  3IA4 A;  1JUV A;  3E0B A;  1RF7 A;  1DHJ A;  4EIL A;  3L3R A; 
#chains in the Genus database with same CATH topology
 3QG2 A;  3QL3 A;  3QLY A;  1RX2 A;  1DG5 A;  5HQY A;  4NX6 A;  2ANQ A;  4LAE X;  4RGC A;  1DYJ A;  2AZN A;  1PD8 A;  1RG7 A;  5HF2 X;  4FGH A;  1RX4 A;  3NZD A;  3F0X X;  2HXV A;  1M78 A;  1IA3 A;  3FRD X;  3FS6 A;  4DP3 A;  2FZJ A;  4X5I A;  3EEL A;  3NRR A;  3IX9 A;  3F8Y A;  3SRU X;  3GYF A;  3KGY A;  3I8A X;  4ELF A;  4KEB A;  3FRE X;  5U27 A;  1E26 A;  4KFJ A;  4PDJ A;  3F0U X;  3JWM A;  1DDR A;  2BLB A;  3SR5 X;  1HFQ A;  3SQY X;  1ZDR A;  3RG9 A;  5CCC A;  3D80 A;  1CD2 A;  3CL9 A;  4M6K A;  4XRB A;  3TQ9 A;  3TQB A;  3TQ8 A;  4ELE A;  1LY4 A;  3NZC X;  3UM6 A;  1S3U A;  1HFR A;  1QZF A;  3K74 A;  1DYI A;  2H2Q A;  2LF1 A;  3Q1H A;  3INV A;  1YHO A;  4GH8 A;  1LUD A;  4M6L A;  2W3W A;  4QJC A;  1U71 A;  4KNE A;  4G8Z X;  4XT7 A;  3JWK A;  1J3K A;  3DRC A;  1MVS A;  2FZI A;  3EIG A;  2BLC A;  1DDS A;  1DR3 A;  1D1G A;  3JWC A;  1RB3 A;  3JSU A;  3NXR A;  2XW7 A;  3NXV A;  5HVE A;  3UM8 A;  4HA7 A;  4FGG A;  2INQ A;  1DRF A;  1LY3 A;  4XEC X;  3QLX A;  2W3M A;  1KLK A;  1AOE A;  4PST A;  3QLR A;  2QK8 A;  4KM0 A;  4P3Q A;  7DFR A;  3N0H A;  2W9H A;  2ITH A;  2W9G A;  4IXE D;  3FQZ A;  4H95 A;  4KJL A;  3SRS X;  1U70 A;  5HVB A;  4Q0D A;  3QLS A;  3M08 A;  2OIP A;  3NZ9 X;  1AO8 A;  1S3Y A;  5EAJ A;  1DRE A;  3D84 X;  3DG8 A;  1IA4 A;  3QFX A;  3NXX A;  4I13 A;  1VDR A;  3QL0 A;  1DR6 A;  3F0S X;  4H98 A;  2FZH A;  1OHJ A;  2L28 A;  4LAG X;  3FL9 A;  1PDB A;  3FYV X;  3KY8 A;  3SH2 A;  1S3V A;  1DRH A;  5E8Q A;  3DL6 A;  4PSY A;  3KJR A;  1DHF A;  4QLE A;  4QLF A;  3JWF A;  3GHC A;  3SAI A;  3S7A A;  3SGY A;  3IRN A;  3FRB X;  4PTH A;  3SRR X;  3EX8 A;  4LEK X;  8DFR A;  3R33 A;  3ROA A;  4M7V A;  4HOG A;  1DR5 A;  3IA5 A;  4LAH X;  3I3R A;  3JTW A;  4IXF X;  3FQF A;  5HQZ A;  3JW5 A;  4KJK A;  1M7A A;  5JA3 A;  4FHB A;  4DPH A;  3SRW X;  5FDA A;  4M2X A;  1DG8 A;  1RX9 A;  3TQA A;  1RX8 A;  3QLW A;  3KJS A;  3KFY A;  3DFR A;  1AI9 A;  4OR7 A;  1M79 A;  4EIZ A;  1DAJ A;  3FQV A;  3JVX A;  4KAK A;  4KBN A;  4M7U A;  3NTZ A;  4XT6 A;  3F8Z A;  2GD9 A;  1DRA A;  4IXG X;  1RH3 A;  4ELH A;  1RX6 A;  2DHF A;  3VCO A;  2BLA A;  3FYW X;  3OCH A;  5CC9 A;  4P66 A;  3GI2 A;  4X5G A;  5U26 A;  3ZPG A;  1J3I A;  3DAU A;  3SRQ X;  1DRB A;  2JYB A;  3NU0 A;  3CSE A;  1DYR A;  4H97 A;  1S3W A;  1RX5 A;  3EEM A;  1BZF A;  2D5N A;  3FRA X;  3IRO A;  3K47 A;  3FL8 A;  3S3V A;  5HT5 A;  3GHW A;  2HQP A;  3QYL A;  4QI9 A;  4KM2 A;  3TD8 A;  1DYH A;  1BOZ A;  2BL9 A;  1DR2 A;  2C2T A;  2W3A A;  4G95 A;  3NXO A;  4CD2 A;  3NZ6 X;  4TU5 X;  4KL9 A;  4DDR A;  4P68 A;  1DF7 A;  1MVT A;  3K45 A;  1DIS A;  4H96 A;  3FY8 X;  4PSS A;  3ZPC A;  1DLR A;  5JG0 X;  2DRC A;  1PD9 A;  1RB2 A;  3HBB A;  4DPD A;  4ELG A;  3S9U A;  5HT4 A;  1RX3 A;  2W9S A;  1IA1 A;  1RC4 A;  1KMS A;  1JOM A;  3CD2 A;  4XE6 X;  4EIG A;  4EJ1 A;  3EEJ A;  2O7P A;  4Q67 A;  5DFR A;  5HI6 A;  3LG4 A;  3FQ0 A;  1RX7 A;  1DG7 A;  2CD2 A;  3F0Q X;  4KY4 A;  3HJ3 A;  3FQO A;  3F0V X;  3QYO A;  3IRM A;  1J3J A;  4XT4 A;  4XT5 A;  4KYA A;  5HSR A;  1RA8 A;  1DLS A;  1DR1 A;  3SA1 A;  2C2S A;  1RA9 A;  1RA2 A;  5ECC A;  4HA9 A;  4QLG A;  3OAF A;  2KGK A;  2W9T A;  1RA3 A;  4HOF A;  3DL5 A;  1DR7 A;  3GHV A;  4Q6A A;  3NZA X;  1HFP A;  1JOL A;  2B3Z A;  2W3B A;  4PTJ A;  3F91 A;  4P3R A;  3DGA A;  5HUI A;  1DR4 A;  4X5J A;  1RD7 A;  1DHI A;  1VJ3 A;  3CLB A;  3JW3 A;  3UM5 A;  5DXV A;  2D0K A;  5ECX A;  3RO9 A;  3QLZ A;  4X5F A;  3NXT A;  3NXY A;  2ZZA A;  4KY8 A;  2HM9 A;  3DAT A;  4ECK A;  5HSU A;  2ANO A;  6DFR A;  3M09 A;  4X5H A;  3EEK A;  1RA1 A;  4KLX A;  1TDR A;  4KD7 A;  4OSG A;  4G3M A;  1IA2 A;  1KMV A;  3SA2 A;  2OBC A;  3QGT A;  1U72 A;  1OHK A;  4XT8 A;  1RE7 A;  3F0B X;  2P4G A;  3FY9 X;  3NZB X;  3FQC A;  5HPB A;  4QHV A;  1RX1 A;  4HOE A;  5HF0 X;  4ELB A;  4Q0E A;  2CIG A;  4DFR A;  1DIU A;  2G6V A;  4I1N A;  4NX7 A;  1CZ3 A;  2W3V A;  4M6J A;  1SEJ A;  3K2H A;  4QJZ D;  4KJJ A;  3FRF X;  3IA4 A;  1JUV A;  3E0B A;  1RF7 A;  1DHJ A;  4EIL A;  3L3R A; 
#chains in the Genus database with same CATH homology
 3QG2 A;  3QL3 A;  3QLY A;  1RX2 A;  1DG5 A;  5HQY A;  4NX6 A;  2ANQ A;  4LAE X;  4RGC A;  1DYJ A;  2AZN A;  1PD8 A;  1RG7 A;  5HF2 X;  4FGH A;  1RX4 A;  3NZD A;  3F0X X;  2HXV A;  1M78 A;  1IA3 A;  3FRD X;  3FS6 A;  4DP3 A;  2FZJ A;  4X5I A;  3EEL A;  3NRR A;  3IX9 A;  3F8Y A;  3SRU X;  3GYF A;  3KGY A;  3I8A X;  4ELF A;  4KEB A;  3FRE X;  5U27 A;  1E26 A;  4KFJ A;  4PDJ A;  3F0U X;  3JWM A;  1DDR A;  2BLB A;  3SR5 X;  1HFQ A;  3SQY X;  1ZDR A;  3RG9 A;  5CCC A;  3D80 A;  1CD2 A;  3CL9 A;  4M6K A;  4XRB A;  3TQ9 A;  3TQB A;  3TQ8 A;  4ELE A;  1LY4 A;  3NZC X;  3UM6 A;  1S3U A;  1HFR A;  1QZF A;  3K74 A;  1DYI A;  2H2Q A;  2LF1 A;  3Q1H A;  3INV A;  1YHO A;  4GH8 A;  1LUD A;  4M6L A;  2W3W A;  4QJC A;  1U71 A;  4KNE A;  4G8Z X;  4XT7 A;  3JWK A;  1J3K A;  3DRC A;  1MVS A;  2FZI A;  3EIG A;  2BLC A;  1DDS A;  1DR3 A;  1D1G A;  3JWC A;  1RB3 A;  3JSU A;  3NXR A;  2XW7 A;  3NXV A;  5HVE A;  3UM8 A;  4HA7 A;  4FGG A;  2INQ A;  1DRF A;  1LY3 A;  4XEC X;  3QLX A;  2W3M A;  1KLK A;  1AOE A;  4PST A;  3QLR A;  2QK8 A;  4KM0 A;  4P3Q A;  7DFR A;  3N0H A;  2W9H A;  2ITH A;  2W9G A;  4IXE D;  3FQZ A;  4H95 A;  4KJL A;  3SRS X;  1U70 A;  5HVB A;  4Q0D A;  3QLS A;  3M08 A;  2OIP A;  3NZ9 X;  1AO8 A;  1S3Y A;  5EAJ A;  1DRE A;  3D84 X;  3DG8 A;  1IA4 A;  3QFX A;  3NXX A;  4I13 A;  1VDR A;  3QL0 A;  1DR6 A;  3F0S X;  4H98 A;  2FZH A;  1OHJ A;  2L28 A;  4LAG X;  3FL9 A;  1PDB A;  3FYV X;  3KY8 A;  3SH2 A;  1S3V A;  1DRH A;  5E8Q A;  3DL6 A;  4PSY A;  3KJR A;  1DHF A;  4QLE A;  4QLF A;  3JWF A;  3GHC A;  3SAI A;  3S7A A;  3SGY A;  3IRN A;  3FRB X;  4PTH A;  3SRR X;  3EX8 A;  4LEK X;  8DFR A;  3R33 A;  3ROA A;  4M7V A;  4HOG A;  1DR5 A;  3IA5 A;  4LAH X;  3I3R A;  3JTW A;  4IXF X;  3FQF A;  5HQZ A;  3JW5 A;  4KJK A;  1M7A A;  5JA3 A;  4FHB A;  4DPH A;  3SRW X;  5FDA A;  4M2X A;  1DG8 A;  1RX9 A;  3TQA A;  1RX8 A;  3QLW A;  3KJS A;  3KFY A;  3DFR A;  1AI9 A;  4OR7 A;  1M79 A;  4EIZ A;  1DAJ A;  3FQV A;  3JVX A;  4KAK A;  4KBN A;  4M7U A;  3NTZ A;  4XT6 A;  3F8Z A;  2GD9 A;  1DRA A;  4IXG X;  1RH3 A;  4ELH A;  1RX6 A;  2DHF A;  3VCO A;  2BLA A;  3FYW X;  3OCH A;  5CC9 A;  4P66 A;  3GI2 A;  4X5G A;  5U26 A;  3ZPG A;  1J3I A;  3DAU A;  3SRQ X;  1DRB A;  2JYB A;  3NU0 A;  3CSE A;  1DYR A;  4H97 A;  1S3W A;  1RX5 A;  3EEM A;  1BZF A;  2D5N A;  3FRA X;  3IRO A;  3K47 A;  3FL8 A;  3S3V A;  5HT5 A;  3GHW A;  2HQP A;  3QYL A;  4QI9 A;  4KM2 A;  3TD8 A;  1DYH A;  1BOZ A;  2BL9 A;  1DR2 A;  2C2T A;  2W3A A;  4G95 A;  3NXO A;  4CD2 A;  3NZ6 X;  4TU5 X;  4KL9 A;  4DDR A;  4P68 A;  1DF7 A;  1MVT A;  3K45 A;  1DIS A;  4H96 A;  3FY8 X;  4PSS A;  3ZPC A;  1DLR A;  5JG0 X;  2DRC A;  1PD9 A;  1RB2 A;  3HBB A;  4DPD A;  4ELG A;  3S9U A;  5HT4 A;  1RX3 A;  2W9S A;  1IA1 A;  1RC4 A;  1KMS A;  1JOM A;  3CD2 A;  4XE6 X;  4EIG A;  4EJ1 A;  3EEJ A;  2O7P A;  4Q67 A;  5DFR A;  5HI6 A;  3LG4 A;  3FQ0 A;  1RX7 A;  1DG7 A;  2CD2 A;  3F0Q X;  4KY4 A;  3HJ3 A;  3FQO A;  3F0V X;  3QYO A;  3IRM A;  1J3J A;  4XT4 A;  4XT5 A;  4KYA A;  5HSR A;  1RA8 A;  1DLS A;  1DR1 A;  3SA1 A;  2C2S A;  1RA9 A;  1RA2 A;  5ECC A;  4HA9 A;  4QLG A;  3OAF A;  2KGK A;  2W9T A;  1RA3 A;  4HOF A;  3DL5 A;  1DR7 A;  3GHV A;  4Q6A A;  3NZA X;  1HFP A;  1JOL A;  2B3Z A;  2W3B A;  4PTJ A;  3F91 A;  4P3R A;  3DGA A;  5HUI A;  1DR4 A;  4X5J A;  1RD7 A;  1DHI A;  1VJ3 A;  3CLB A;  3JW3 A;  3UM5 A;  5DXV A;  2D0K A;  5ECX A;  3RO9 A;  3QLZ A;  4X5F A;  3NXT A;  3NXY A;  2ZZA A;  4KY8 A;  2HM9 A;  3DAT A;  4ECK A;  5HSU A;  2ANO A;  6DFR A;  3M09 A;  4X5H A;  3EEK A;  1RA1 A;  4KLX A;  1TDR A;  4KD7 A;  4OSG A;  4G3M A;  1IA2 A;  1KMV A;  3SA2 A;  2OBC A;  3QGT A;  1U72 A;  1OHK A;  4XT8 A;  1RE7 A;  3F0B X;  2P4G A;  3FY9 X;  3NZB X;  3FQC A;  5HPB A;  4QHV A;  1RX1 A;  4HOE A;  5HF0 X;  4ELB A;  4Q0E A;  2CIG A;  4DFR A;  1DIU A;  2G6V A;  4I1N A;  4NX7 A;  1CZ3 A;  2W3V A;  4M6J A;  1SEJ A;  3K2H A;  4QJZ D;  4KJJ A;  3FRF X;  3IA4 A;  1JUV A;  3E0B A;  1RF7 A;  1DHJ A;  4EIL A;  3L3R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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