4DDRA

Human dihydrofolate reductase complexed with nadph and p218
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
pubmed doi rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
total genus 56
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2012-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4ddrA00
1RC4A 3Q1HA 4TU5X 4H95A 5EAJA 4I1NA 4G95A 1HFPA 2D0KA 3FQFA 1IA3A 5CCCA 1QZFA 3FRBX 3FQ0A 4H98A 1DR5A 4DPDA 4KM0A 4QHVA 3NZ6X 5HUIA 4X5FA 3F8YA 3DG8A 2INQA 4OR7A 3EEKA 3HBBA 2XW7A 1AI9A 1RX1A 3NRRA 3TQBA 4XECX 3INVA 1RX2A 2BLCA 3SH2A 3NZBX 4FHBA 1ZDRA 4P3RA 6DFRA 4P66A 3GHVA 1MVTA 2L28A 4EJ1A 2KGKA 3FQOA 1DR7A 3QLXA 3GHCA 3F8ZA 3NXVA 3TQAA 2W3MA 4Q6AA 1DDSA 1CD2A 4M7UA 4X5IA 4XRBA 4QLFA 3QLSA 2BLBA 3QL0A 5CC9A 4KY8A 4KFJA 3FREX 1LY3A 3QL3A 2H2QA 2W3AA 2ZZAA 4H97A 2HQPA 3EEJA 2OIPA 3NZCX 5DFRA 3KJRA 1RX4A 4ELEA 3EX8A 1IA4A 3SR5X 3RG9A 1PDBA 2ANOA 3FQZA 4EILA 3NU0A 2B3ZA 3JWFA 3GYFA 4QLGA 1DDRA 2W3WA 1JOLA 1JOMA 4X5GA 5DXVA 4IXFX 5HT4A 3FS6A 3IRMA 4HOGA 1RX8A 3S9UA 4DPHA 3R33A 4ELFA 3DATA 3CLBA 3NXRA 5HF2X 1RA3A 3OAFA 3TQ8A 4LAGX 4XT7A 1MVSA 3ZPGA 3FL9A 5JG0X 4M7VA 3K45A 3M08A 8DFRA 3NXXA 3FRFX 1RD7A 3JVXA 5HSUA 3FQCA 3JW5A 4H96A 3DL6A 1RB3A 1DR4A 1BZFA 3K47A 1VDRA 1RX7A 1AO8A 1DRAA 1J3IA 1BOZA 2C2TA 4ELHA 5U26A 4KD7A 4NX7A 1S3VA 4HOFA 3TQ9A 1RA8A 1RF7A 1DR6A 4HOEA 5HSRA 2HM9A 1S3WA 3DL5A 2HXVA 3QYLA 4CD2A 1KMSA 3JWMA 4IXGX 1DHFA 3SRRX 2W9TA 3ROAA 3S7AA 1DYHA 3HJ3A 3JSUA 1M78A 4Q67A 3QYOA 1OHKA 2W3VA 3E0BA 5HVEA 3IA5A 3JWCA 1IA2A 1U72A 3SAIA 3DRCA 1CZ3A 3FY9X 1PD8A 1DRHA 4XT5A 3FY8X 1HFQA 4PTHA 4XT8A 4PSTA 3UM6A 7DFRA 2C2SA 3L3RA 4QJCA 4P3QA 3KGYA 4PSSA 4FGGA 4GH8A 1IA1A 3FL8A 2AZNA 2BLAA 1YHOA 2W9GA 2JYBA 3F0XX 1DYJA 3D84X 5HVBA 4KM2A 1E26A 4DDRA 3QG2A 1RG7A 3GHWA 4XE6X 4X5HA 4Q0DA 4HA7A 1J3JA 3FRDX 2FZJA 3F0QX 4QI9A 2ANQA 3IROA 4OSGA 1TDRA 2FZHA 4ELGA 3F91A 5E8QA 2DRCA 1DRBA 4X5JA 4EIZA 4XT6A 4Q0EA 1SEJA 4KJLA 3DAUA 1OHJA 4ELBA 1DR1A 3KJSA 4KBNA 1HFRA 1DLRA 1RA1A 4PSYA 2D5NA 3FRAX 1RX3A 2GD9A 5HPBA 1S3UA 2DHFA 3SGYA 4KNEA 2O7PA 3F0BX 3QLYA 5HI6A 5HQYA 4P68A 1DAJA 4FGHA 1LY4A 3JWKA 2ITHA 3NXYA 3CSEA 3CD2A 2P4GA 4ECKA 3NTZA 1DF7A 3QFXA 4QJZD 3IRNA 4M6KA 4IXED 4KJJA 4XT4A 1RH3A 2BL9A 3UM8A 2QK8A 1DLSA 3TD8A 1RA2A 1KMVA 3QGTA 3DGAA 1DISA 4KY4A 5ECXA 4LAHX 1S3YA 3KFYA 2LF1A 1M7AA 3SQYX 1RX5A 5FDAA 1DYRA 4LAEX 1DR2A 3NXOA 1DHIA 1KLKA 3NZAX 1DG8A 3IA4A 3LG4A 1AOEA 3FYVX 3KY8A 3RO9A 1JUVA 3VCOA 3M09A 4KAKA 4G3MA 3QLZA 5U27A 2W9HA 3I8AX 3SA2A 1DREA 1DR3A 4PTJA 3I3RA 5ECCA 1DHJA 1DRFA 1D1GA 3QLRA 4HA9A 4NX6A 3GI2A 4QLEA 3EELA 4LEKX 1DG5A 4M2XA 3SRWX 5HF0X 3N0HA 4KEBA 5HQZA 3QLWA 3F0SX 2CIGA 1LUDA 3SRQX 1RE7A 1VJ3A 4DP3A 4G8ZX 3NXTA 3DFRA 3OCHA 3D80A 1DIUA 3SA1A 4KYAA 1RA9A 4KJKA 3EEMA 2W3BA 1DG7A 3JW3A 3FQVA 4RGCA 3UM5A 5JA3A 3K2HA 1U70A 3SRSX 4KLXA 5HT5A 3K74A 3NZ9X 1U71A 1RB2A 1RX6A 4M6LA 3FYWX 4I13A 3CL9A 2G6VA 1J3KA 1DYIA 1M79A 4M6JA 3F0UX 2FZIA 3SRUX 1PD9A 4DFRA 4KL9A 2CD2A 1RX9A 2W9SA 3EIGA 4EIGA 3JTWA 3S3VA 3ZPCA 3NZDA 3IX9A 4PDJA 2OBCA 3F0VX
chains in the Genus database with same CATH superfamily
1RC4A 3Q1HA 4TU5X 4H95A 5EAJA 4I1NA 4G95A 1HFPA 2D0KA 3FQFA 1IA3A 5CCCA 1QZFA 3FRBX 3FQ0A 4H98A 1DR5A 4DPDA 4KM0A 4QHVA 3NZ6X 5HUIA 4X5FA 3F8YA 3DG8A 2INQA 4OR7A 3EEKA 3HBBA 2XW7A 1AI9A 1RX1A 3NRRA 3TQBA 4XECX 3INVA 1RX2A 2BLCA 3SH2A 3NZBX 4FHBA 1ZDRA 4P3RA 6DFRA 4P66A 3GHVA 1MVTA 2L28A 4EJ1A 2KGKA 3FQOA 1DR7A 3QLXA 3GHCA 3F8ZA 3NXVA 3TQAA 2W3MA 4Q6AA 1DDSA 1CD2A 4M7UA 4X5IA 4XRBA 4QLFA 3QLSA 2BLBA 3QL0A 5CC9A 4KY8A 4KFJA 3FREX 1LY3A 3QL3A 2H2QA 2W3AA 2ZZAA 4H97A 2HQPA 3EEJA 2OIPA 3NZCX 5DFRA 3KJRA 1RX4A 4ELEA 3EX8A 1IA4A 3SR5X 3RG9A 1PDBA 2ANOA 3FQZA 4EILA 3NU0A 2B3ZA 3JWFA 3GYFA 4QLGA 1DDRA 2W3WA 1JOLA 1JOMA 4X5GA 5DXVA 4IXFX 5HT4A 3FS6A 3IRMA 4HOGA 1RX8A 3S9UA 4DPHA 3R33A 4ELFA 3DATA 3CLBA 3NXRA 5HF2X 1RA3A 3OAFA 3TQ8A 4LAGX 4XT7A 1MVSA 3ZPGA 3FL9A 5JG0X 4M7VA 3K45A 3M08A 8DFRA 3NXXA 3FRFX 1RD7A 3JVXA 5HSUA 3FQCA 3JW5A 4H96A 3DL6A 1RB3A 1DR4A 1BZFA 3K47A 1VDRA 1RX7A 1AO8A 1DRAA 1J3IA 1BOZA 2C2TA 4ELHA 5U26A 4KD7A 4NX7A 1S3VA 4HOFA 3TQ9A 1RA8A 1RF7A 1DR6A 4HOEA 5HSRA 2HM9A 1S3WA 3DL5A 2HXVA 3QYLA 4CD2A 1KMSA 3JWMA 4IXGX 1DHFA 3SRRX 2W9TA 3ROAA 3S7AA 1DYHA 3HJ3A 3JSUA 1M78A 4Q67A 3QYOA 1OHKA 2W3VA 3E0BA 5HVEA 3IA5A 3JWCA 1IA2A 1U72A 3SAIA 3DRCA 1CZ3A 3FY9X 1PD8A 1DRHA 4XT5A 3FY8X 1HFQA 4PTHA 4XT8A 4PSTA 3UM6A 7DFRA 2C2SA 3L3RA 4QJCA 4P3QA 3KGYA 4PSSA 4FGGA 4GH8A 1IA1A 3FL8A 2AZNA 2BLAA 1YHOA 2W9GA 2JYBA 3F0XX 1DYJA 3D84X 5HVBA 4KM2A 1E26A 4DDRA 3QG2A 1RG7A 3GHWA 4XE6X 4X5HA 4Q0DA 4HA7A 1J3JA 3FRDX 2FZJA 3F0QX 4QI9A 2ANQA 3IROA 4OSGA 1TDRA 2FZHA 4ELGA 3F91A 5E8QA 2DRCA 1DRBA 4X5JA 4EIZA 4XT6A 4Q0EA 1SEJA 4KJLA 3DAUA 1OHJA 4ELBA 1DR1A 3KJSA 4KBNA 1HFRA 1DLRA 1RA1A 4PSYA 2D5NA 3FRAX 1RX3A 2GD9A 5HPBA 1S3UA 2DHFA 3SGYA 4KNEA 2O7PA 3F0BX 3QLYA 5HI6A 5HQYA 4P68A 1DAJA 4FGHA 1LY4A 3JWKA 2ITHA 3NXYA 3CSEA 3CD2A 2P4GA 4ECKA 3NTZA 1DF7A 3QFXA 4QJZD 3IRNA 4M6KA 4IXED 4KJJA 4XT4A 1RH3A 2BL9A 3UM8A 2QK8A 1DLSA 3TD8A 1RA2A 1KMVA 3QGTA 3DGAA 1DISA 4KY4A 5ECXA 4LAHX 1S3YA 3KFYA 2LF1A 1M7AA 3SQYX 1RX5A 5FDAA 1DYRA 4LAEX 1DR2A 3NXOA 1DHIA 1KLKA 3NZAX 1DG8A 3IA4A 3LG4A 1AOEA 3FYVX 3KY8A 3RO9A 1JUVA 3VCOA 3M09A 4KAKA 4G3MA 3QLZA 5U27A 2W9HA 3I8AX 3SA2A 1DREA 1DR3A 4PTJA 3I3RA 5ECCA 1DHJA 1DRFA 1D1GA 3QLRA 4HA9A 4NX6A 3GI2A 4QLEA 3EELA 4LEKX 1DG5A 4M2XA 3SRWX 5HF0X 3N0HA 4KEBA 5HQZA 3QLWA 3F0SX 2CIGA 1LUDA 3SRQX 1RE7A 1VJ3A 4DP3A 4G8ZX 3NXTA 3DFRA 3OCHA 3D80A 1DIUA 3SA1A 4KYAA 1RA9A 4KJKA 3EEMA 2W3BA 1DG7A 3JW3A 3FQVA 4RGCA 3UM5A 5JA3A 3K2HA 1U70A 3SRSX 4KLXA 5HT5A 3K74A 3NZ9X 1U71A 1RB2A 1RX6A 4M6LA 3FYWX 4I13A 3CL9A 2G6VA 1J3KA 1DYIA 1M79A 4M6JA 3F0UX 2FZIA 3SRUX 1PD9A 4DFRA 4KL9A 2CD2A 1RX9A 2W9SA 3EIGA 4EIGA 3JTWA 3S3VA 3ZPCA 3NZDA 3IX9A 4PDJA 2OBCA 3F0VX
chains in the Genus database with same CATH topology
1RC4A 3Q1HA 4TU5X 4H95A 5EAJA 4I1NA 4G95A 1HFPA 2D0KA 3FQFA 1IA3A 5CCCA 1QZFA 3FRBX 3FQ0A 4H98A 1DR5A 4DPDA 4KM0A 4QHVA 3NZ6X 5HUIA 4X5FA 3F8YA 3DG8A 2INQA 4OR7A 3EEKA 3HBBA 2XW7A 1AI9A 1RX1A 3NRRA 3TQBA 4XECX 3INVA 1RX2A 2BLCA 3SH2A 3NZBX 4FHBA 1ZDRA 4P3RA 6DFRA 4P66A 3GHVA 1MVTA 2L28A 4EJ1A 2KGKA 3FQOA 1DR7A 3QLXA 3GHCA 3F8ZA 3NXVA 3TQAA 2W3MA 4Q6AA 1DDSA 1CD2A 4M7UA 4X5IA 4XRBA 4QLFA 3QLSA 2BLBA 3QL0A 5CC9A 4KY8A 4KFJA 3FREX 1LY3A 3QL3A 2H2QA 2W3AA 2ZZAA 4H97A 2HQPA 3EEJA 2OIPA 3NZCX 5DFRA 3KJRA 1RX4A 4ELEA 3EX8A 1IA4A 3SR5X 3RG9A 1PDBA 2ANOA 3FQZA 4EILA 3NU0A 2B3ZA 3JWFA 3GYFA 4QLGA 1DDRA 2W3WA 1JOLA 1JOMA 4X5GA 5DXVA 4IXFX 5HT4A 3FS6A 3IRMA 4HOGA 1RX8A 3S9UA 4DPHA 3R33A 4ELFA 3DATA 3CLBA 3NXRA 5HF2X 1RA3A 3OAFA 3TQ8A 4LAGX 4XT7A 1MVSA 3ZPGA 3FL9A 5JG0X 4M7VA 3K45A 3M08A 8DFRA 3NXXA 3FRFX 1RD7A 3JVXA 5HSUA 3FQCA 3JW5A 4H96A 3DL6A 1RB3A 1DR4A 1BZFA 3K47A 1VDRA 1RX7A 1AO8A 1DRAA 1J3IA 1BOZA 2C2TA 4ELHA 5U26A 4KD7A 4NX7A 1S3VA 4HOFA 3TQ9A 1RA8A 1RF7A 1DR6A 4HOEA 5HSRA 2HM9A 1S3WA 3DL5A 2HXVA 3QYLA 4CD2A 1KMSA 3JWMA 4IXGX 1DHFA 3SRRX 2W9TA 3ROAA 3S7AA 1DYHA 3HJ3A 3JSUA 1M78A 4Q67A 3QYOA 1OHKA 2W3VA 3E0BA 5HVEA 3IA5A 3JWCA 1IA2A 1U72A 3SAIA 3DRCA 1CZ3A 3FY9X 1PD8A 1DRHA 4XT5A 3FY8X 1HFQA 4PTHA 4XT8A 4PSTA 3UM6A 7DFRA 2C2SA 3L3RA 4QJCA 4P3QA 3KGYA 4PSSA 4FGGA 4GH8A 1IA1A 3FL8A 2AZNA 2BLAA 1YHOA 2W9GA 2JYBA 3F0XX 1DYJA 3D84X 5HVBA 4KM2A 1E26A 4DDRA 3QG2A 1RG7A 3GHWA 4XE6X 4X5HA 4Q0DA 4HA7A 1J3JA 3FRDX 2FZJA 3F0QX 4QI9A 2ANQA 3IROA 4OSGA 1TDRA 2FZHA 4ELGA 3F91A 5E8QA 2DRCA 1DRBA 4X5JA 4EIZA 4XT6A 4Q0EA 1SEJA 4KJLA 3DAUA 1OHJA 4ELBA 1DR1A 3KJSA 4KBNA 1HFRA 1DLRA 1RA1A 4PSYA 2D5NA 3FRAX 1RX3A 2GD9A 5HPBA 1S3UA 2DHFA 3SGYA 4KNEA 2O7PA 3F0BX 3QLYA 5HI6A 5HQYA 4P68A 1DAJA 4FGHA 1LY4A 3JWKA 2ITHA 3NXYA 3CSEA 3CD2A 2P4GA 4ECKA 3NTZA 1DF7A 3QFXA 4QJZD 3IRNA 4M6KA 4IXED 4KJJA 4XT4A 1RH3A 2BL9A 3UM8A 2QK8A 1DLSA 3TD8A 1RA2A 1KMVA 3QGTA 3DGAA 1DISA 4KY4A 5ECXA 4LAHX 1S3YA 3KFYA 2LF1A 1M7AA 3SQYX 1RX5A 5FDAA 1DYRA 4LAEX 1DR2A 3NXOA 1DHIA 1KLKA 3NZAX 1DG8A 3IA4A 3LG4A 1AOEA 3FYVX 3KY8A 3RO9A 1JUVA 3VCOA 3M09A 4KAKA 4G3MA 3QLZA 5U27A 2W9HA 3I8AX 3SA2A 1DREA 1DR3A 4PTJA 3I3RA 5ECCA 1DHJA 1DRFA 1D1GA 3QLRA 4HA9A 4NX6A 3GI2A 4QLEA 3EELA 4LEKX 1DG5A 4M2XA 3SRWX 5HF0X 3N0HA 4KEBA 5HQZA 3QLWA 3F0SX 2CIGA 1LUDA 3SRQX 1RE7A 1VJ3A 4DP3A 4G8ZX 3NXTA 3DFRA 3OCHA 3D80A 1DIUA 3SA1A 4KYAA 1RA9A 4KJKA 3EEMA 2W3BA 1DG7A 3JW3A 3FQVA 4RGCA 3UM5A 5JA3A 3K2HA 1U70A 3SRSX 4KLXA 5HT5A 3K74A 3NZ9X 1U71A 1RB2A 1RX6A 4M6LA 3FYWX 4I13A 3CL9A 2G6VA 1J3KA 1DYIA 1M79A 4M6JA 3F0UX 2FZIA 3SRUX 1PD9A 4DFRA 4KL9A 2CD2A 1RX9A 2W9SA 3EIGA 4EIGA 3JTWA 3S3VA 3ZPCA 3NZDA 3IX9A 4PDJA 2OBCA 3F0VX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RC4 A;  3Q1H A;  4TU5 X;  4H95 A;  5EAJ A;  4I1N A;  4G95 A;  1HFP A;  2D0K A;  3FQF A;  1IA3 A;  5CCC A;  1QZF A;  3FRB X;  3FQ0 A;  4H98 A;  1DR5 A;  4DPD A;  4KM0 A;  4QHV A;  3NZ6 X;  5HUI A;  4X5F A;  3F8Y A;  3DG8 A;  2INQ A;  4OR7 A;  3EEK A;  3HBB A;  2XW7 A;  1AI9 A;  1RX1 A;  3NRR A;  3TQB A;  4XEC X;  3INV A;  1RX2 A;  2BLC A;  3SH2 A;  3NZB X;  4FHB A;  1ZDR A;  4P3R A;  6DFR A;  4P66 A;  3GHV A;  1MVT A;  2L28 A;  4EJ1 A;  2KGK A;  3FQO A;  1DR7 A;  3QLX A;  3GHC A;  3F8Z A;  3NXV A;  3TQA A;  2W3M A;  4Q6A A;  1DDS A;  1CD2 A;  4M7U A;  4X5I A;  4XRB A;  4QLF A;  3QLS A;  2BLB A;  3QL0 A;  5CC9 A;  4KY8 A;  4KFJ A;  3FRE X;  1LY3 A;  3QL3 A;  2H2Q A;  2W3A A;  2ZZA A;  4H97 A;  2HQP A;  3EEJ A;  2OIP A;  3NZC X;  5DFR A;  3KJR A;  1RX4 A;  4ELE A;  3EX8 A;  1IA4 A;  3SR5 X;  3RG9 A;  1PDB A;  2ANO A;  3FQZ A;  4EIL A;  3NU0 A;  2B3Z A;  3JWF A;  3GYF A;  4QLG A;  1DDR A;  2W3W A;  1JOL A;  1JOM A;  4X5G A;  5DXV A;  4IXF X;  5HT4 A;  3FS6 A;  3IRM A;  4HOG A;  1RX8 A;  3S9U A;  4DPH A;  3R33 A;  4ELF A;  3DAT A;  3CLB A;  3NXR A;  5HF2 X;  1RA3 A;  3OAF A;  3TQ8 A;  4LAG X;  4XT7 A;  1MVS A;  3ZPG A;  3FL9 A;  5JG0 X;  4M7V A;  3K45 A;  3M08 A;  8DFR A;  3NXX A;  3FRF X;  1RD7 A;  3JVX A;  5HSU A;  3FQC A;  3JW5 A;  4H96 A;  3DL6 A;  1RB3 A;  1DR4 A;  1BZF A;  3K47 A;  1VDR A;  1RX7 A;  1AO8 A;  1DRA A;  1J3I A;  1BOZ A;  2C2T A;  4ELH A;  5U26 A;  4KD7 A;  4NX7 A;  1S3V A;  4HOF A;  3TQ9 A;  1RA8 A;  1RF7 A;  1DR6 A;  4HOE A;  5HSR A;  2HM9 A;  1S3W A;  3DL5 A;  2HXV A;  3QYL A;  4CD2 A;  1KMS A;  3JWM A;  4IXG X;  1DHF A;  3SRR X;  2W9T A;  3ROA A;  3S7A A;  1DYH A;  3HJ3 A;  3JSU A;  1M78 A;  4Q67 A;  3QYO A;  1OHK A;  2W3V A;  3E0B A;  5HVE A;  3IA5 A;  3JWC A;  1IA2 A;  1U72 A;  3SAI A;  3DRC A;  1CZ3 A;  3FY9 X;  1PD8 A;  1DRH A;  4XT5 A;  3FY8 X;  1HFQ A;  4PTH A;  4XT8 A;  4PST A;  3UM6 A;  7DFR A;  2C2S A;  3L3R A;  4QJC A;  4P3Q A;  3KGY A;  4PSS A;  4FGG A;  4GH8 A;  1IA1 A;  3FL8 A;  2AZN A;  2BLA A;  1YHO A;  2W9G A;  2JYB A;  3F0X X;  1DYJ A;  3D84 X;  5HVB A;  4KM2 A;  1E26 A;  4DDR A;  3QG2 A;  1RG7 A;  3GHW A;  4XE6 X;  4X5H A;  4Q0D A;  4HA7 A;  1J3J A;  3FRD X;  2FZJ A;  3F0Q X;  4QI9 A;  2ANQ A;  3IRO A;  4OSG A;  1TDR A;  2FZH A;  4ELG A;  3F91 A;  5E8Q A;  2DRC A;  1DRB A;  4X5J A;  4EIZ A;  4XT6 A;  4Q0E A;  1SEJ A;  4KJL A;  3DAU A;  1OHJ A;  4ELB A;  1DR1 A;  3KJS A;  4KBN A;  1HFR A;  1DLR A;  1RA1 A;  4PSY A;  2D5N A;  3FRA X;  1RX3 A;  2GD9 A;  5HPB A;  1S3U A;  2DHF A;  3SGY A;  4KNE A;  2O7P A;  3F0B X;  3QLY A;  5HI6 A;  5HQY A;  4P68 A;  1DAJ A;  4FGH A;  1LY4 A;  3JWK A;  2ITH A;  3NXY A;  3CSE A;  3CD2 A;  2P4G A;  4ECK A;  3NTZ A;  1DF7 A;  3QFX A;  4QJZ D;  3IRN A;  4M6K A;  4IXE D;  4KJJ A;  4XT4 A;  1RH3 A;  2BL9 A;  3UM8 A;  2QK8 A;  1DLS A;  3TD8 A;  1RA2 A;  1KMV A;  3QGT A;  3DGA A;  1DIS A;  4KY4 A;  5ECX A;  4LAH X;  1S3Y A;  3KFY A;  2LF1 A;  1M7A A;  3SQY X;  1RX5 A;  5FDA A;  1DYR A;  4LAE X;  1DR2 A;  3NXO A;  1DHI A;  1KLK A;  3NZA X;  1DG8 A;  3IA4 A;  3LG4 A;  1AOE A;  3FYV X;  3KY8 A;  3RO9 A;  1JUV A;  3VCO A;  3M09 A;  4KAK A;  4G3M A;  3QLZ A;  5U27 A;  2W9H A;  3I8A X;  3SA2 A;  1DRE A;  1DR3 A;  4PTJ A;  3I3R A;  5ECC A;  1DHJ A;  1DRF A;  1D1G A;  3QLR A;  4HA9 A;  4NX6 A;  3GI2 A;  4QLE A;  3EEL A;  4LEK X;  1DG5 A;  4M2X A;  3SRW X;  5HF0 X;  3N0H A;  4KEB A;  5HQZ A;  3QLW A;  3F0S X;  2CIG A;  1LUD A;  3SRQ X;  1RE7 A;  1VJ3 A;  4DP3 A;  4G8Z X;  3NXT A;  3DFR A;  3OCH A;  3D80 A;  1DIU A;  3SA1 A;  4KYA A;  1RA9 A;  4KJK A;  3EEM A;  2W3B A;  1DG7 A;  3JW3 A;  3FQV A;  4RGC A;  3UM5 A;  5JA3 A;  3K2H A;  1U70 A;  3SRS X;  4KLX A;  5HT5 A;  3K74 A;  3NZ9 X;  1U71 A;  1RB2 A;  1RX6 A;  4M6L A;  3FYW X;  4I13 A;  3CL9 A;  2G6V A;  1J3K A;  1DYI A;  1M79 A;  4M6J A;  3F0U X;  2FZI A;  3SRU X;  1PD9 A;  4DFR A;  4KL9 A;  2CD2 A;  1RX9 A;  2W9S A;  3EIG A;  4EIG A;  3JTW A;  3S3V A;  3ZPC A;  3NZD A;  3IX9 A;  4PDJ A;  2OBC A;  3F0V X; 
#chains in the Genus database with same CATH topology
 1RC4 A;  3Q1H A;  4TU5 X;  4H95 A;  5EAJ A;  4I1N A;  4G95 A;  1HFP A;  2D0K A;  3FQF A;  1IA3 A;  5CCC A;  1QZF A;  3FRB X;  3FQ0 A;  4H98 A;  1DR5 A;  4DPD A;  4KM0 A;  4QHV A;  3NZ6 X;  5HUI A;  4X5F A;  3F8Y A;  3DG8 A;  2INQ A;  4OR7 A;  3EEK A;  3HBB A;  2XW7 A;  1AI9 A;  1RX1 A;  3NRR A;  3TQB A;  4XEC X;  3INV A;  1RX2 A;  2BLC A;  3SH2 A;  3NZB X;  4FHB A;  1ZDR A;  4P3R A;  6DFR A;  4P66 A;  3GHV A;  1MVT A;  2L28 A;  4EJ1 A;  2KGK A;  3FQO A;  1DR7 A;  3QLX A;  3GHC A;  3F8Z A;  3NXV A;  3TQA A;  2W3M A;  4Q6A A;  1DDS A;  1CD2 A;  4M7U A;  4X5I A;  4XRB A;  4QLF A;  3QLS A;  2BLB A;  3QL0 A;  5CC9 A;  4KY8 A;  4KFJ A;  3FRE X;  1LY3 A;  3QL3 A;  2H2Q A;  2W3A A;  2ZZA A;  4H97 A;  2HQP A;  3EEJ A;  2OIP A;  3NZC X;  5DFR A;  3KJR A;  1RX4 A;  4ELE A;  3EX8 A;  1IA4 A;  3SR5 X;  3RG9 A;  1PDB A;  2ANO A;  3FQZ A;  4EIL A;  3NU0 A;  2B3Z A;  3JWF A;  3GYF A;  4QLG A;  1DDR A;  2W3W A;  1JOL A;  1JOM A;  4X5G A;  5DXV A;  4IXF X;  5HT4 A;  3FS6 A;  3IRM A;  4HOG A;  1RX8 A;  3S9U A;  4DPH A;  3R33 A;  4ELF A;  3DAT A;  3CLB A;  3NXR A;  5HF2 X;  1RA3 A;  3OAF A;  3TQ8 A;  4LAG X;  4XT7 A;  1MVS A;  3ZPG A;  3FL9 A;  5JG0 X;  4M7V A;  3K45 A;  3M08 A;  8DFR A;  3NXX A;  3FRF X;  1RD7 A;  3JVX A;  5HSU A;  3FQC A;  3JW5 A;  4H96 A;  3DL6 A;  1RB3 A;  1DR4 A;  1BZF A;  3K47 A;  1VDR A;  1RX7 A;  1AO8 A;  1DRA A;  1J3I A;  1BOZ A;  2C2T A;  4ELH A;  5U26 A;  4KD7 A;  4NX7 A;  1S3V A;  4HOF A;  3TQ9 A;  1RA8 A;  1RF7 A;  1DR6 A;  4HOE A;  5HSR A;  2HM9 A;  1S3W A;  3DL5 A;  2HXV A;  3QYL A;  4CD2 A;  1KMS A;  3JWM A;  4IXG X;  1DHF A;  3SRR X;  2W9T A;  3ROA A;  3S7A A;  1DYH A;  3HJ3 A;  3JSU A;  1M78 A;  4Q67 A;  3QYO A;  1OHK A;  2W3V A;  3E0B A;  5HVE A;  3IA5 A;  3JWC A;  1IA2 A;  1U72 A;  3SAI A;  3DRC A;  1CZ3 A;  3FY9 X;  1PD8 A;  1DRH A;  4XT5 A;  3FY8 X;  1HFQ A;  4PTH A;  4XT8 A;  4PST A;  3UM6 A;  7DFR A;  2C2S A;  3L3R A;  4QJC A;  4P3Q A;  3KGY A;  4PSS A;  4FGG A;  4GH8 A;  1IA1 A;  3FL8 A;  2AZN A;  2BLA A;  1YHO A;  2W9G A;  2JYB A;  3F0X X;  1DYJ A;  3D84 X;  5HVB A;  4KM2 A;  1E26 A;  4DDR A;  3QG2 A;  1RG7 A;  3GHW A;  4XE6 X;  4X5H A;  4Q0D A;  4HA7 A;  1J3J A;  3FRD X;  2FZJ A;  3F0Q X;  4QI9 A;  2ANQ A;  3IRO A;  4OSG A;  1TDR A;  2FZH A;  4ELG A;  3F91 A;  5E8Q A;  2DRC A;  1DRB A;  4X5J A;  4EIZ A;  4XT6 A;  4Q0E A;  1SEJ A;  4KJL A;  3DAU A;  1OHJ A;  4ELB A;  1DR1 A;  3KJS A;  4KBN A;  1HFR A;  1DLR A;  1RA1 A;  4PSY A;  2D5N A;  3FRA X;  1RX3 A;  2GD9 A;  5HPB A;  1S3U A;  2DHF A;  3SGY A;  4KNE A;  2O7P A;  3F0B X;  3QLY A;  5HI6 A;  5HQY A;  4P68 A;  1DAJ A;  4FGH A;  1LY4 A;  3JWK A;  2ITH A;  3NXY A;  3CSE A;  3CD2 A;  2P4G A;  4ECK A;  3NTZ A;  1DF7 A;  3QFX A;  4QJZ D;  3IRN A;  4M6K A;  4IXE D;  4KJJ A;  4XT4 A;  1RH3 A;  2BL9 A;  3UM8 A;  2QK8 A;  1DLS A;  3TD8 A;  1RA2 A;  1KMV A;  3QGT A;  3DGA A;  1DIS A;  4KY4 A;  5ECX A;  4LAH X;  1S3Y A;  3KFY A;  2LF1 A;  1M7A A;  3SQY X;  1RX5 A;  5FDA A;  1DYR A;  4LAE X;  1DR2 A;  3NXO A;  1DHI A;  1KLK A;  3NZA X;  1DG8 A;  3IA4 A;  3LG4 A;  1AOE A;  3FYV X;  3KY8 A;  3RO9 A;  1JUV A;  3VCO A;  3M09 A;  4KAK A;  4G3M A;  3QLZ A;  5U27 A;  2W9H A;  3I8A X;  3SA2 A;  1DRE A;  1DR3 A;  4PTJ A;  3I3R A;  5ECC A;  1DHJ A;  1DRF A;  1D1G A;  3QLR A;  4HA9 A;  4NX6 A;  3GI2 A;  4QLE A;  3EEL A;  4LEK X;  1DG5 A;  4M2X A;  3SRW X;  5HF0 X;  3N0H A;  4KEB A;  5HQZ A;  3QLW A;  3F0S X;  2CIG A;  1LUD A;  3SRQ X;  1RE7 A;  1VJ3 A;  4DP3 A;  4G8Z X;  3NXT A;  3DFR A;  3OCH A;  3D80 A;  1DIU A;  3SA1 A;  4KYA A;  1RA9 A;  4KJK A;  3EEM A;  2W3B A;  1DG7 A;  3JW3 A;  3FQV A;  4RGC A;  3UM5 A;  5JA3 A;  3K2H A;  1U70 A;  3SRS X;  4KLX A;  5HT5 A;  3K74 A;  3NZ9 X;  1U71 A;  1RB2 A;  1RX6 A;  4M6L A;  3FYW X;  4I13 A;  3CL9 A;  2G6V A;  1J3K A;  1DYI A;  1M79 A;  4M6J A;  3F0U X;  2FZI A;  3SRU X;  1PD9 A;  4DFR A;  4KL9 A;  2CD2 A;  1RX9 A;  2W9S A;  3EIG A;  4EIG A;  3JTW A;  3S3V A;  3ZPC A;  3NZD A;  3IX9 A;  4PDJ A;  2OBC A;  3F0V X; 
#chains in the Genus database with same CATH homology
 1RC4 A;  3Q1H A;  4TU5 X;  4H95 A;  5EAJ A;  4I1N A;  4G95 A;  1HFP A;  2D0K A;  3FQF A;  1IA3 A;  5CCC A;  1QZF A;  3FRB X;  3FQ0 A;  4H98 A;  1DR5 A;  4DPD A;  4KM0 A;  4QHV A;  3NZ6 X;  5HUI A;  4X5F A;  3F8Y A;  3DG8 A;  2INQ A;  4OR7 A;  3EEK A;  3HBB A;  2XW7 A;  1AI9 A;  1RX1 A;  3NRR A;  3TQB A;  4XEC X;  3INV A;  1RX2 A;  2BLC A;  3SH2 A;  3NZB X;  4FHB A;  1ZDR A;  4P3R A;  6DFR A;  4P66 A;  3GHV A;  1MVT A;  2L28 A;  4EJ1 A;  2KGK A;  3FQO A;  1DR7 A;  3QLX A;  3GHC A;  3F8Z A;  3NXV A;  3TQA A;  2W3M A;  4Q6A A;  1DDS A;  1CD2 A;  4M7U A;  4X5I A;  4XRB A;  4QLF A;  3QLS A;  2BLB A;  3QL0 A;  5CC9 A;  4KY8 A;  4KFJ A;  3FRE X;  1LY3 A;  3QL3 A;  2H2Q A;  2W3A A;  2ZZA A;  4H97 A;  2HQP A;  3EEJ A;  2OIP A;  3NZC X;  5DFR A;  3KJR A;  1RX4 A;  4ELE A;  3EX8 A;  1IA4 A;  3SR5 X;  3RG9 A;  1PDB A;  2ANO A;  3FQZ A;  4EIL A;  3NU0 A;  2B3Z A;  3JWF A;  3GYF A;  4QLG A;  1DDR A;  2W3W A;  1JOL A;  1JOM A;  4X5G A;  5DXV A;  4IXF X;  5HT4 A;  3FS6 A;  3IRM A;  4HOG A;  1RX8 A;  3S9U A;  4DPH A;  3R33 A;  4ELF A;  3DAT A;  3CLB A;  3NXR A;  5HF2 X;  1RA3 A;  3OAF A;  3TQ8 A;  4LAG X;  4XT7 A;  1MVS A;  3ZPG A;  3FL9 A;  5JG0 X;  4M7V A;  3K45 A;  3M08 A;  8DFR A;  3NXX A;  3FRF X;  1RD7 A;  3JVX A;  5HSU A;  3FQC A;  3JW5 A;  4H96 A;  3DL6 A;  1RB3 A;  1DR4 A;  1BZF A;  3K47 A;  1VDR A;  1RX7 A;  1AO8 A;  1DRA A;  1J3I A;  1BOZ A;  2C2T A;  4ELH A;  5U26 A;  4KD7 A;  4NX7 A;  1S3V A;  4HOF A;  3TQ9 A;  1RA8 A;  1RF7 A;  1DR6 A;  4HOE A;  5HSR A;  2HM9 A;  1S3W A;  3DL5 A;  2HXV A;  3QYL A;  4CD2 A;  1KMS A;  3JWM A;  4IXG X;  1DHF A;  3SRR X;  2W9T A;  3ROA A;  3S7A A;  1DYH A;  3HJ3 A;  3JSU A;  1M78 A;  4Q67 A;  3QYO A;  1OHK A;  2W3V A;  3E0B A;  5HVE A;  3IA5 A;  3JWC A;  1IA2 A;  1U72 A;  3SAI A;  3DRC A;  1CZ3 A;  3FY9 X;  1PD8 A;  1DRH A;  4XT5 A;  3FY8 X;  1HFQ A;  4PTH A;  4XT8 A;  4PST A;  3UM6 A;  7DFR A;  2C2S A;  3L3R A;  4QJC A;  4P3Q A;  3KGY A;  4PSS A;  4FGG A;  4GH8 A;  1IA1 A;  3FL8 A;  2AZN A;  2BLA A;  1YHO A;  2W9G A;  2JYB A;  3F0X X;  1DYJ A;  3D84 X;  5HVB A;  4KM2 A;  1E26 A;  4DDR A;  3QG2 A;  1RG7 A;  3GHW A;  4XE6 X;  4X5H A;  4Q0D A;  4HA7 A;  1J3J A;  3FRD X;  2FZJ A;  3F0Q X;  4QI9 A;  2ANQ A;  3IRO A;  4OSG A;  1TDR A;  2FZH A;  4ELG A;  3F91 A;  5E8Q A;  2DRC A;  1DRB A;  4X5J A;  4EIZ A;  4XT6 A;  4Q0E A;  1SEJ A;  4KJL A;  3DAU A;  1OHJ A;  4ELB A;  1DR1 A;  3KJS A;  4KBN A;  1HFR A;  1DLR A;  1RA1 A;  4PSY A;  2D5N A;  3FRA X;  1RX3 A;  2GD9 A;  5HPB A;  1S3U A;  2DHF A;  3SGY A;  4KNE A;  2O7P A;  3F0B X;  3QLY A;  5HI6 A;  5HQY A;  4P68 A;  1DAJ A;  4FGH A;  1LY4 A;  3JWK A;  2ITH A;  3NXY A;  3CSE A;  3CD2 A;  2P4G A;  4ECK A;  3NTZ A;  1DF7 A;  3QFX A;  4QJZ D;  3IRN A;  4M6K A;  4IXE D;  4KJJ A;  4XT4 A;  1RH3 A;  2BL9 A;  3UM8 A;  2QK8 A;  1DLS A;  3TD8 A;  1RA2 A;  1KMV A;  3QGT A;  3DGA A;  1DIS A;  4KY4 A;  5ECX A;  4LAH X;  1S3Y A;  3KFY A;  2LF1 A;  1M7A A;  3SQY X;  1RX5 A;  5FDA A;  1DYR A;  4LAE X;  1DR2 A;  3NXO A;  1DHI A;  1KLK A;  3NZA X;  1DG8 A;  3IA4 A;  3LG4 A;  1AOE A;  3FYV X;  3KY8 A;  3RO9 A;  1JUV A;  3VCO A;  3M09 A;  4KAK A;  4G3M A;  3QLZ A;  5U27 A;  2W9H A;  3I8A X;  3SA2 A;  1DRE A;  1DR3 A;  4PTJ A;  3I3R A;  5ECC A;  1DHJ A;  1DRF A;  1D1G A;  3QLR A;  4HA9 A;  4NX6 A;  3GI2 A;  4QLE A;  3EEL A;  4LEK X;  1DG5 A;  4M2X A;  3SRW X;  5HF0 X;  3N0H A;  4KEB A;  5HQZ A;  3QLW A;  3F0S X;  2CIG A;  1LUD A;  3SRQ X;  1RE7 A;  1VJ3 A;  4DP3 A;  4G8Z X;  3NXT A;  3DFR A;  3OCH A;  3D80 A;  1DIU A;  3SA1 A;  4KYA A;  1RA9 A;  4KJK A;  3EEM A;  2W3B A;  1DG7 A;  3JW3 A;  3FQV A;  4RGC A;  3UM5 A;  5JA3 A;  3K2H A;  1U70 A;  3SRS X;  4KLX A;  5HT5 A;  3K74 A;  3NZ9 X;  1U71 A;  1RB2 A;  1RX6 A;  4M6L A;  3FYW X;  4I13 A;  3CL9 A;  2G6V A;  1J3K A;  1DYI A;  1M79 A;  4M6J A;  3F0U X;  2FZI A;  3SRU X;  1PD9 A;  4DFR A;  4KL9 A;  2CD2 A;  1RX9 A;  2W9S A;  3EIG A;  4EIG A;  3JTW A;  3S3V A;  3ZPC A;  3NZD A;  3IX9 A;  4PDJ A;  2OBC A;  3F0V X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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