1TWRA

Crystal structures of ferrous and ferrous-no forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
214
structure length
214
Chain Sequence
PQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Heme oxygenase 1
total genus 90
structure length 214
sequence length 214
chains with identical sequence B
ec nomenclature ec 1.14.14.18: Heme oxygenase (biliverdin-producing).
pdb deposition date 2004-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01126 Heme_oxygenase Heme oxygenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.910.10 Mainly Alpha Up-down Bundle Heme Oxygenase; Chain A Heme oxygenase-like 1twrA00
1XK2A 3NO6A 1WWMA 3IBXA 3OQLA 4GOHA 4WWZA 2RGZA 1WZDA 1P3UA 4WD4A 1V8XA 1XK3A 3I8RA 1WOVA 1J2CA 4MECA 4WWJA 1J02A 1SK7A 1XK1A 4GPFA 1XJZA 4G7PA 1N3UA 1IW1A 1YAFA 1OZLA 3HOKA 2A2MA 1WOXA 4GPHA 1WOWA 1T5PA 1WNWA 1OZRA 3I9TA 1OZWA 1S13A 1TWNA 4NY7A 1WZGA 3BJDA 1WZFA 3B5OA 3MVUA 4G99A 3HLXA 4RAJA 1TYHA 1NI6A 1WNVA 1Z72A 1DVGA 2E7EA 1N45A 1WE1A 2QPPA 1TO9B 1OZEA 2Q4XA 1IX4A 3HMLA 2A2OA 1TWRA 5BTQA 4LQXA 1IW0A 1IRMA 3TGMA 2GM7A 4FN6A 1TO9A 1YAKA 4G98A 1J77A 2QCXA 2QZCA 3HNHA 3B5PA 1OTWA 4G7TA 3MOOA 1P3VA 1OYLA 2Q32A 2Z68A 2GM8A 4G7LA 4G8UA 4WX0A 1WNXA 3RM5A 2F2GA 3CZYA 1VGIA 1OYKA 2ZVUA 1P3TA 1RCWA 3K4FA 1DVEA 1RTWA 1ULXA 1IX3A 3DDEA 1XK0A 1IVJA 1UDDA 1S8CA 4G7UA 4G8WA 2RD3A 3I9UA 4GPCA 4WMHA 4G8PA 1OTVA 2DY5A 1UBBA 2A6BA
chains in the Genus database with same CATH superfamily
1XK2A 3NO6A 1WWMA 3IBXA 3OQLA 4GOHA 4WWZA 2RGZA 1WZDA 1P3UA 4WD4A 1V8XA 2LCUA 1XK3A 3I8RA 1WOVA 1J2CA 4MECA 4WWJA 1J02A 1SK7A 1XK1A 4GPFA 1XJZA 4G7PA 1N3UA 1IW1A 1YAFA 1OZLA 3HOKA 2A2MA 1WOXA 4GPHA 1WOWA 1T5PA 1WNWA 1OZRA 3I9TA 1OZWA 1S13A 1TWNA 4NY7A 1WZGA 3BJDA 1WZFA 3B5OA 3MVUA 4G99A 3HLXA 4RAJA 1TYHA 1NI6A 1WNVA 1Z72A 1DVGA 2E7EA 1N45A 1WE1A 2QPPA 1TO9B 1OZEA 2Q4XA 1IX4A 3HMLA 2A2OA 1TWRA 5BTQA 4LQXA 1IW0A 1IRMA 3TGMA 2GM7A 4FN6A 1TO9A 1YAKA 4G98A 1J77A 2QCXA 2QZCA 3HNHA 3B5PA 1OTWA 4G7TA 3MOOA 1P3VA 1OYLA 2Q32A 2Z68A 2GM8A 4G7LA 4G8UA 4WX0A 1WNXA 3RM5A 2F2GA 3CZYA 1VGIA 1OYKA 2ZVUA 1P3TA 1RCWA 3K4FA 1DVEA 1RTWA 1ULXA 1IX3A 3DDEA 1XK0A 1IVJA 1UDDA 1S8CA 4G7UA 4G8WA 2RD3A 3I9UA 4GPCA 4WMHA 4G8PA 1OTVA 2DY5A 1UBBA 2A6BA
chains in the Genus database with same CATH topology
1XK2A 3NO6A 1WWMA 3IBXA 3OQLA 4GOHA 4WWZA 2RGZA 1WZDA 1P3UA 4WD4A 1V8XA 1XK3A 3I8RA 1WOVA 1J2CA 4MECA 4WWJA 1J02A 1SK7A 1XK1A 4GPFA 1XJZA 4G7PA 1N3UA 1IW1A 1YAFA 1OZLA 3HOKA 2A2MA 1WOXA 4GPHA 1WOWA 1T5PA 1WNWA 1OZRA 3I9TA 1OZWA 1S13A 1TWNA 4NY7A 1WZGA 3BJDA 1WZFA 3B5OA 3MVUA 4G99A 3HLXA 4RAJA 1TYHA 1NI6A 1WNVA 1Z72A 1DVGA 2E7EA 1N45A 1WE1A 2QPPA 1TO9B 1OZEA 2Q4XA 1IX4A 3HMLA 2A2OA 1TWRA 5BTQA 4LQXA 1IW0A 1IRMA 3TGMA 2GM7A 4FN6A 1TO9A 1YAKA 4G98A 1J77A 2QCXA 2QZCA 3HNHA 3B5PA 1OTWA 4G7TA 3MOOA 1P3VA 1OYLA 2Q32A 2Z68A 2GM8A 4G7LA 4G8UA 4WX0A 1WNXA 3RM5A 2F2GA 3CZYA 1VGIA 1OYKA 2ZVUA 1P3TA 1RCWA 3K4FA 1DVEA 1RTWA 1ULXA 1IX3A 3DDEA 1XK0A 1IVJA 1UDDA 1S8CA 4G7UA 4G8WA 2RD3A 3I9UA 4GPCA 4WMHA 4G8PA 1OTVA 2DY5A 1UBBA 2A6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XK2 A;  3NO6 A;  1WWM A;  3IBX A;  3OQL A;  4GOH A;  4WWZ A;  2RGZ A;  1WZD A;  1P3U A;  4WD4 A;  1V8X A;  1XK3 A;  3I8R A;  1WOV A;  1J2C A;  4MEC A;  4WWJ A;  1J02 A;  1SK7 A;  1XK1 A;  4GPF A;  1XJZ A;  4G7P A;  1N3U A;  1IW1 A;  1YAF A;  1OZL A;  3HOK A;  2A2M A;  1WOX A;  4GPH A;  1WOW A;  1T5P A;  1WNW A;  1OZR A;  3I9T A;  1OZW A;  1S13 A;  1TWN A;  4NY7 A;  1WZG A;  3BJD A;  1WZF A;  3B5O A;  3MVU A;  4G99 A;  3HLX A;  4RAJ A;  1TYH A;  1NI6 A;  1WNV A;  1Z72 A;  1DVG A;  2E7E A;  1N45 A;  1WE1 A;  2QPP A;  1TO9 B;  1OZE A;  2Q4X A;  1IX4 A;  3HML A;  2A2O A;  1TWR A;  5BTQ A;  4LQX A;  1IW0 A;  1IRM A;  3TGM A;  2GM7 A;  4FN6 A;  1TO9 A;  1YAK A;  4G98 A;  1J77 A;  2QCX A;  2QZC A;  3HNH A;  3B5P A;  1OTW A;  4G7T A;  3MOO A;  1P3V A;  1OYL A;  2Q32 A;  2Z68 A;  2GM8 A;  4G7L A;  4G8U A;  4WX0 A;  1WNX A;  3RM5 A;  2F2G A;  3CZY A;  1VGI A;  1OYK A;  2ZVU A;  1P3T A;  1RCW A;  3K4F A;  1DVE A;  1RTW A;  1ULX A;  1IX3 A;  3DDE A;  1XK0 A;  1IVJ A;  1UDD A;  1S8C A;  4G7U A;  4G8W A;  2RD3 A;  3I9U A;  4GPC A;  4WMH A;  4G8P A;  1OTV A;  2DY5 A;  1UBB A;  2A6B A; 
#chains in the Genus database with same CATH topology
 1XK2 A;  3NO6 A;  1WWM A;  3IBX A;  3OQL A;  4GOH A;  4WWZ A;  2RGZ A;  1WZD A;  1P3U A;  4WD4 A;  1V8X A;  2LCU A;  1XK3 A;  3I8R A;  1WOV A;  1J2C A;  4MEC A;  4WWJ A;  1J02 A;  1SK7 A;  1XK1 A;  4GPF A;  1XJZ A;  4G7P A;  1N3U A;  1IW1 A;  1YAF A;  1OZL A;  3HOK A;  2A2M A;  1WOX A;  4GPH A;  1WOW A;  1T5P A;  1WNW A;  1OZR A;  3I9T A;  1OZW A;  1S13 A;  1TWN A;  4NY7 A;  1WZG A;  3BJD A;  1WZF A;  3B5O A;  3MVU A;  4G99 A;  3HLX A;  4RAJ A;  1TYH A;  1NI6 A;  1WNV A;  1Z72 A;  1DVG A;  2E7E A;  1N45 A;  1WE1 A;  2QPP A;  1TO9 B;  1OZE A;  2Q4X A;  1IX4 A;  3HML A;  2A2O A;  1TWR A;  5BTQ A;  4LQX A;  1IW0 A;  1IRM A;  3TGM A;  2GM7 A;  4FN6 A;  1TO9 A;  1YAK A;  4G98 A;  1J77 A;  2QCX A;  2QZC A;  3HNH A;  3B5P A;  1OTW A;  4G7T A;  3MOO A;  1P3V A;  1OYL A;  2Q32 A;  2Z68 A;  2GM8 A;  4G7L A;  4G8U A;  4WX0 A;  1WNX A;  3RM5 A;  2F2G A;  3CZY A;  1VGI A;  1OYK A;  2ZVU A;  1P3T A;  1RCW A;  3K4F A;  1DVE A;  1RTW A;  1ULX A;  1IX3 A;  3DDE A;  1XK0 A;  1IVJ A;  1UDD A;  1S8C A;  4G7U A;  4G8W A;  2RD3 A;  3I9U A;  4GPC A;  4WMH A;  4G8P A;  1OTV A;  2DY5 A;  1UBB A;  2A6B A; 
#chains in the Genus database with same CATH homology
 1XK2 A;  3NO6 A;  1WWM A;  3IBX A;  3OQL A;  4GOH A;  4WWZ A;  2RGZ A;  1WZD A;  1P3U A;  4WD4 A;  1V8X A;  1XK3 A;  3I8R A;  1WOV A;  1J2C A;  4MEC A;  4WWJ A;  1J02 A;  1SK7 A;  1XK1 A;  4GPF A;  1XJZ A;  4G7P A;  1N3U A;  1IW1 A;  1YAF A;  1OZL A;  3HOK A;  2A2M A;  1WOX A;  4GPH A;  1WOW A;  1T5P A;  1WNW A;  1OZR A;  3I9T A;  1OZW A;  1S13 A;  1TWN A;  4NY7 A;  1WZG A;  3BJD A;  1WZF A;  3B5O A;  3MVU A;  4G99 A;  3HLX A;  4RAJ A;  1TYH A;  1NI6 A;  1WNV A;  1Z72 A;  1DVG A;  2E7E A;  1N45 A;  1WE1 A;  2QPP A;  1TO9 B;  1OZE A;  2Q4X A;  1IX4 A;  3HML A;  2A2O A;  1TWR A;  5BTQ A;  4LQX A;  1IW0 A;  1IRM A;  3TGM A;  2GM7 A;  4FN6 A;  1TO9 A;  1YAK A;  4G98 A;  1J77 A;  2QCX A;  2QZC A;  3HNH A;  3B5P A;  1OTW A;  4G7T A;  3MOO A;  1P3V A;  1OYL A;  2Q32 A;  2Z68 A;  2GM8 A;  4G7L A;  4G8U A;  4WX0 A;  1WNX A;  3RM5 A;  2F2G A;  3CZY A;  1VGI A;  1OYK A;  2ZVU A;  1P3T A;  1RCW A;  3K4F A;  1DVE A;  1RTW A;  1ULX A;  1IX3 A;  3DDE A;  1XK0 A;  1IVJ A;  1UDD A;  1S8C A;  4G7U A;  4G8W A;  2RD3 A;  3I9U A;  4GPC A;  4WMH A;  4G8P A;  1OTV A;  2DY5 A;  1UBB A;  2A6B A; 
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similar chains in the Genus database (?% sequence similarity)
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