2AF0A

Structure of the regulator of g-protein signaling domain of rgs2
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
146
structure length
146
Chain Sequence
ADLGTENLYFQSMKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Regulator of G-protein signaling 2
total genus 51
structure length 146
sequence length 146
ec nomenclature
pdb deposition date 2005-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2af0A02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2af0A01
1FQJB 5HE2A 1FQIA 1OMWA 2BT2A 2BV1A 2DLVA 2JM5A 5HE1A 2EBZA 3KRXA 3C7KB 1CMZA 2JNUA 4PNKA 2ODEB 1DK8A 2BCJA 2IK8B 3KRWA 1FQKB 2OWIA 3CIKA 5HE3A 3NYOA 3PSCA 4TNBA 2AF0A 5DO9B 4TNDA 4EKDB 2V4ZB 2IHBB 1EZTA 1AGRE 2IHDA 3NYNA 5HE0A 2GTPC 3UZTA 2CRPA 4MK0A 2D9JA 1EZYA 3C7LA 3PVUA 3V5WA 1EMUA 2OJ4A 3PVWA
chains in the Genus database with same CATH superfamily
1FQJB 5HE2A 1FQIA 1OMWA 2BT2A 2BV1A 2DLVA 2JM5A 5HE1A 2EBZA 3KRXA 3C7KB 1CMZA 2JNUA 4PNKA 3QYFA 2ODEB 1DK8A 2BCJA 2IK8B 3KRWA 1FQKB 2OWIA 3CIKA 5HE3A 4HTEA 3NYOA 3PSCA 4TNBA 2AF0A 5DO9B 4TNDA 4EKDB 2V4ZB 2IHBB 1EZTA 1AGRE 2IHDA 3NYNA 5REQB 5HE0A 2GTPC 3UZTA 2CRPA 4MK0A 2D9JA 1EZYA 3C7LA 3PVUA 3V5WA 1EMUA 2OJ4A 3I5QA 3PVWA
chains in the Genus database with same CATH topology
1FQJB 5HE2A 1FQIA 1OMWA 2BT2A 2BV1A 2DLVA 2JM5A 5HE1A 2EBZA 3KRXA 3C7KB 1CMZA 2JNUA 4PNKA 3QYFA 2ODEB 1DK8A 2BCJA 2IK8B 3KRWA 1FQKB 2OWIA 3CIKA 5HE3A 3NYOA 3PSCA 4TNBA 2AF0A 5DO9B 4TNDA 4EKDB 2V4ZB 2IHBB 1EZTA 1AGRE 2IHDA 3NYNA 5REQB 5HE0A 2GTPC 3UZTA 2CRPA 4MK0A 2D9JA 1EZYA 3C7LA 3PVUA 3V5WA 1EMUA 2OJ4A 3PVWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FQJ B;  5HE2 A;  1FQI A;  1OMW A;  2BT2 A;  2BV1 A;  2DLV A;  2JM5 A;  5HE1 A;  2EBZ A;  3KRX A;  3C7K B;  1CMZ A;  2JNU A;  4PNK A;  2ODE B;  1DK8 A;  2BCJ A;  2IK8 B;  3KRW A;  1FQK B;  2OWI A;  3CIK A;  5HE3 A;  3NYO A;  3PSC A;  4TNB A;  2AF0 A;  5DO9 B;  4TND A;  4EKD B;  2V4Z B;  2IHB B;  1EZT A;  1AGR E;  2IHD A;  3NYN A;  5HE0 A;  2GTP C;  3UZT A;  2CRP A;  4MK0 A;  2D9J A;  1EZY A;  3C7L A;  3PVU A;  3V5W A;  1EMU A;  2OJ4 A;  3PVW A; 
#chains in the Genus database with same CATH topology
 1FQJ B;  5HE2 A;  1FQI A;  1OMW A;  2BT2 A;  2BV1 A;  2DLV A;  2JM5 A;  5HE1 A;  2EBZ A;  3KRX A;  3C7K B;  1CMZ A;  2JNU A;  4PNK A;  3QYF A;  2ODE B;  1DK8 A;  2BCJ A;  2IK8 B;  3KRW A;  1FQK B;  2OWI A;  3CIK A;  5HE3 A;  4HTE A;  3NYO A;  3PSC A;  4TNB A;  2AF0 A;  5DO9 B;  4TND A;  4EKD B;  2V4Z B;  2IHB B;  1EZT A;  1AGR E;  2IHD A;  3NYN A;  5REQ B;  5HE0 A;  2GTP C;  3UZT A;  2CRP A;  4MK0 A;  2D9J A;  1EZY A;  3C7L A;  3PVU A;  3V5W A;  1EMU A;  2OJ4 A;  3I5Q A;  3PVW A; 
#chains in the Genus database with same CATH homology
 1FQJ B;  5HE2 A;  1FQI A;  1OMW A;  2BT2 A;  2BV1 A;  2DLV A;  2JM5 A;  5HE1 A;  2EBZ A;  3KRX A;  3C7K B;  1CMZ A;  2JNU A;  4PNK A;  3QYF A;  2ODE B;  1DK8 A;  2BCJ A;  2IK8 B;  3KRW A;  1FQK B;  2OWI A;  3CIK A;  5HE3 A;  3NYO A;  3PSC A;  4TNB A;  2AF0 A;  5DO9 B;  4TND A;  4EKD B;  2V4Z B;  2IHB B;  1EZT A;  1AGR E;  2IHD A;  3NYN A;  5REQ B;  5HE0 A;  2GTP C;  3UZT A;  2CRP A;  4MK0 A;  2D9J A;  1EZY A;  3C7L A;  3PVU A;  3V5W A;  1EMU A;  2OJ4 A;  3PVW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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