2AF0A

Structure of the regulator of g-protein signaling domain of rgs2
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
146
structure length
146
Chain Sequence
ADLGTENLYFQSMKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule keywords Regulator of G-protein signaling 2
molecule tags Signaling protein
source organism Homo sapiens
total genus 51
structure length 146
sequence length 146
ec nomenclature
pdb deposition date 2005-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2af0A02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2af0A01
3V5WA 2ODEB 2IHBB 5HE2A 2BT2A 1FQKB 2EBZA 5HE0A 2OJ4A 4TNDA 4TNBA 2JNUA 3PSCA 3PVUA 1FQIA 2BV1A 2IK8B 2CRPA 2V4ZB 4MK0A 3C7LA 3UZTA 1AGRE 4PNKA 2OWIA 1EZYA 3KRWA 5HE1A 5DO9B 3NYNA 3CIKA 4EKDB 2IHDA 3C7KB 3NYOA 5HE3A 2DLVA 2GTPC 3KRXA 1OMWA 2D9JA 1EZTA 1FQJB 1DK8A 2JM5A 1EMUA 3PVWA 2BCJA 1CMZA 2AF0A
chains in the Genus database with same CATH superfamily
3V5WA 2ODEB 2IHBB 5HE2A 2BT2A 1FQKB 4HTEA 2EBZA 5HE0A 2OJ4A 4TNDA 4TNBA 2JNUA 3PSCA 3PVUA 1FQIA 2BV1A 2IK8B 2CRPA 2V4ZB 4MK0A 3C7LA 3UZTA 1AGRE 4PNKA 2OWIA 1EZYA 3KRWA 5HE1A 5DO9B 3NYNA 3CIKA 4EKDB 2IHDA 3C7KB 3NYOA 5HE3A 2DLVA 3QYFA 2GTPC 3KRXA 1OMWA 2D9JA 1EZTA 1FQJB 1DK8A 2JM5A 1EMUA 3PVWA 2BCJA 1CMZA 2AF0A 3I5QA 5REQB
chains in the Genus database with same CATH topology
3V5WA 2ODEB 2IHBB 5HE2A 2BT2A 1FQKB 2EBZA 5HE0A 2OJ4A 4TNDA 4TNBA 2JNUA 3PSCA 3PVUA 1FQIA 2BV1A 2IK8B 2CRPA 2V4ZB 4MK0A 3C7LA 3UZTA 1AGRE 4PNKA 2OWIA 1EZYA 3KRWA 5HE1A 5DO9B 3NYNA 3CIKA 4EKDB 2IHDA 3C7KB 3NYOA 5HE3A 2DLVA 3QYFA 2GTPC 3KRXA 1OMWA 2D9JA 1EZTA 1FQJB 1DK8A 2JM5A 1EMUA 3PVWA 2BCJA 1CMZA 2AF0A 5REQB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3V5W A;  2ODE B;  2IHB B;  5HE2 A;  2BT2 A;  1FQK B;  2EBZ A;  5HE0 A;  2OJ4 A;  4TND A;  4TNB A;  2JNU A;  3PSC A;  3PVU A;  1FQI A;  2BV1 A;  2IK8 B;  2CRP A;  2V4Z B;  4MK0 A;  3C7L A;  3UZT A;  1AGR E;  4PNK A;  2OWI A;  1EZY A;  3KRW A;  5HE1 A;  5DO9 B;  3NYN A;  3CIK A;  4EKD B;  2IHD A;  3C7K B;  3NYO A;  5HE3 A;  2DLV A;  2GTP C;  3KRX A;  1OMW A;  2D9J A;  1EZT A;  1FQJ B;  1DK8 A;  2JM5 A;  1EMU A;  3PVW A;  2BCJ A;  1CMZ A;  2AF0 A; 
#chains in the Genus database with same CATH topology
 3V5W A;  2ODE B;  2IHB B;  5HE2 A;  2BT2 A;  1FQK B;  4HTE A;  2EBZ A;  5HE0 A;  2OJ4 A;  4TND A;  4TNB A;  2JNU A;  3PSC A;  3PVU A;  1FQI A;  2BV1 A;  2IK8 B;  2CRP A;  2V4Z B;  4MK0 A;  3C7L A;  3UZT A;  1AGR E;  4PNK A;  2OWI A;  1EZY A;  3KRW A;  5HE1 A;  5DO9 B;  3NYN A;  3CIK A;  4EKD B;  2IHD A;  3C7K B;  3NYO A;  5HE3 A;  2DLV A;  3QYF A;  2GTP C;  3KRX A;  1OMW A;  2D9J A;  1EZT A;  1FQJ B;  1DK8 A;  2JM5 A;  1EMU A;  3PVW A;  2BCJ A;  1CMZ A;  2AF0 A;  3I5Q A;  5REQ B; 
#chains in the Genus database with same CATH homology
 3V5W A;  2ODE B;  2IHB B;  5HE2 A;  2BT2 A;  1FQK B;  2EBZ A;  5HE0 A;  2OJ4 A;  4TND A;  4TNB A;  2JNU A;  3PSC A;  3PVU A;  1FQI A;  2BV1 A;  2IK8 B;  2CRP A;  2V4Z B;  4MK0 A;  3C7L A;  3UZT A;  1AGR E;  4PNK A;  2OWI A;  1EZY A;  3KRW A;  5HE1 A;  5DO9 B;  3NYN A;  3CIK A;  4EKD B;  2IHD A;  3C7K B;  3NYO A;  5HE3 A;  2DLV A;  3QYF A;  2GTP C;  3KRX A;  1OMW A;  2D9J A;  1EZT A;  1FQJ B;  1DK8 A;  2JM5 A;  1EMU A;  3PVW A;  2BCJ A;  1CMZ A;  2AF0 A;  5REQ B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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