2V4ZB

The crystal structure of the human g-protein subunit alpha (gnai3) in complex with an engineered regulator of g-protein signaling type 2 domain (rgs2)
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
128
structure length
122
Chain Sequence
PSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFSEENIEFWLACEDFKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNATSGCFTTAQKRVYSLMENDSYPRFLKSEFYQDLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2).
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords GUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA
total genus 41
structure length 122
sequence length 128
ec nomenclature
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2v4zB02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2v4zB01
1DK8A 1FQIA 2GTPC 2OWIA 1FQKB 3PVWA 3V5WA 4PNKA 1EZYA 2D9JA 2JM5A 1FQJB 2EBZA 1EZTA 1OMWA 2OJ4A 2DLVA 5HE0A 3CIKA 2BT2A 2JNUA 2AF0A 3C7KB 3KRXA 1CMZA 5HE1A 5HE2A 2V4ZB 2IK8B 5DO9B 4EKDB 3PVUA 4TNDA 2BV1A 3UZTA 2CRPA 3PSCA 3C7LA 2ODEB 5HE3A 1EMUA 4TNBA 2IHBB 3KRWA 4MK0A 3NYNA 1AGRE 2BCJA 3NYOA 2IHDA
chains in the Genus database with same CATH superfamily
1DK8A 1FQIA 5REQB 2GTPC 2OWIA 1FQKB 3PVWA 3V5WA 4PNKA 1EZYA 2D9JA 2JM5A 1FQJB 2EBZA 1EZTA 1OMWA 2OJ4A 2DLVA 5HE0A 3CIKA 2BT2A 2JNUA 3I5QA 2AF0A 3C7KB 3QYFA 3KRXA 1CMZA 5HE1A 5HE2A 2V4ZB 2IK8B 5DO9B 4EKDB 3PVUA 4TNDA 2BV1A 3UZTA 2CRPA 3PSCA 3C7LA 2ODEB 5HE3A 1EMUA 4HTEA 4TNBA 2IHBB 3KRWA 4MK0A 3NYNA 1AGRE 2BCJA 3NYOA 2IHDA
chains in the Genus database with same CATH topology
1DK8A 1FQIA 5REQB 2GTPC 2OWIA 1FQKB 3PVWA 3V5WA 4PNKA 1EZYA 2D9JA 2JM5A 1FQJB 2EBZA 1EZTA 1OMWA 2OJ4A 2DLVA 5HE0A 3CIKA 2BT2A 2JNUA 2AF0A 3C7KB 3QYFA 3KRXA 1CMZA 5HE1A 5HE2A 2V4ZB 2IK8B 5DO9B 4EKDB 3PVUA 4TNDA 2BV1A 3UZTA 2CRPA 3PSCA 3C7LA 2ODEB 5HE3A 1EMUA 4TNBA 2IHBB 3KRWA 4MK0A 3NYNA 1AGRE 2BCJA 3NYOA 2IHDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DK8 A;  1FQI A;  2GTP C;  2OWI A;  1FQK B;  3PVW A;  3V5W A;  4PNK A;  1EZY A;  2D9J A;  2JM5 A;  1FQJ B;  2EBZ A;  1EZT A;  1OMW A;  2OJ4 A;  2DLV A;  5HE0 A;  3CIK A;  2BT2 A;  2JNU A;  2AF0 A;  3C7K B;  3KRX A;  1CMZ A;  5HE1 A;  5HE2 A;  2V4Z B;  2IK8 B;  5DO9 B;  4EKD B;  3PVU A;  4TND A;  2BV1 A;  3UZT A;  2CRP A;  3PSC A;  3C7L A;  2ODE B;  5HE3 A;  1EMU A;  4TNB A;  2IHB B;  3KRW A;  4MK0 A;  3NYN A;  1AGR E;  2BCJ A;  3NYO A;  2IHD A; 
#chains in the Genus database with same CATH topology
 1DK8 A;  1FQI A;  5REQ B;  2GTP C;  2OWI A;  1FQK B;  3PVW A;  3V5W A;  4PNK A;  1EZY A;  2D9J A;  2JM5 A;  1FQJ B;  2EBZ A;  1EZT A;  1OMW A;  2OJ4 A;  2DLV A;  5HE0 A;  3CIK A;  2BT2 A;  2JNU A;  3I5Q A;  2AF0 A;  3C7K B;  3QYF A;  3KRX A;  1CMZ A;  5HE1 A;  5HE2 A;  2V4Z B;  2IK8 B;  5DO9 B;  4EKD B;  3PVU A;  4TND A;  2BV1 A;  3UZT A;  2CRP A;  3PSC A;  3C7L A;  2ODE B;  5HE3 A;  1EMU A;  4HTE A;  4TNB A;  2IHB B;  3KRW A;  4MK0 A;  3NYN A;  1AGR E;  2BCJ A;  3NYO A;  2IHD A; 
#chains in the Genus database with same CATH homology
 1DK8 A;  1FQI A;  5REQ B;  2GTP C;  2OWI A;  1FQK B;  3PVW A;  3V5W A;  4PNK A;  1EZY A;  2D9J A;  2JM5 A;  1FQJ B;  2EBZ A;  1EZT A;  1OMW A;  2OJ4 A;  2DLV A;  5HE0 A;  3CIK A;  2BT2 A;  2JNU A;  2AF0 A;  3C7K B;  3QYF A;  3KRX A;  1CMZ A;  5HE1 A;  5HE2 A;  2V4Z B;  2IK8 B;  5DO9 B;  4EKD B;  3PVU A;  4TND A;  2BV1 A;  3UZT A;  2CRP A;  3PSC A;  3C7L A;  2ODE B;  5HE3 A;  1EMU A;  4TNB A;  2IHB B;  3KRW A;  4MK0 A;  3NYN A;  1AGR E;  2BCJ A;  3NYO A;  2IHD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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