2OWIA

Solution structure of the rgs domain from human rgs18
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
134
structure length
134
Chain Sequence
SMVSPEEAVKWGESFDKLLSHRDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Regulator of G-protein signaling 18
publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
source organism Homo sapiens
total genus 48
structure length 134
sequence length 134
ec nomenclature
pdb deposition date 2007-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2owiA02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2owiA01
2BCJA 4TNDA 3PVWA 2IHBB 4TNBA 5HE3A 1FQIA 2OJ4A 4MK0A 2IHDA 1FQKB 2IK8B 1EMUA 2JM5A 2EBZA 2JNUA 2D9JA 3CIKA 3UZTA 1EZTA 4PNKA 1OMWA 2V4ZB 5HE1A 1AGRE 3NYNA 4EKDB 1DK8A 5HE2A 5DO9B 2GTPC 3C7LA 2ODEB 2OWIA 2CRPA 3KRWA 3PVUA 3NYOA 2AF0A 1FQJB 3V5WA 2BV1A 1EZYA 2BT2A 3C7KB 5HE0A 2DLVA 3PSCA 1CMZA 3KRXA
chains in the Genus database with same CATH superfamily
5REQB 2BCJA 4TNDA 3PVWA 2IHBB 4TNBA 5HE3A 1FQIA 2OJ4A 4MK0A 2IHDA 3QYFA 1FQKB 2IK8B 1EMUA 2JM5A 2EBZA 2JNUA 2D9JA 3CIKA 3UZTA 1EZTA 4PNKA 1OMWA 2V4ZB 5HE1A 1AGRE 3I5QA 3NYNA 4EKDB 1DK8A 5HE2A 5DO9B 2GTPC 3C7LA 2ODEB 2OWIA 2CRPA 3KRWA 3PVUA 3NYOA 2AF0A 1FQJB 3V5WA 2BV1A 1EZYA 2BT2A 3C7KB 5HE0A 2DLVA 3PSCA 4HTEA 1CMZA 3KRXA
chains in the Genus database with same CATH topology
5REQB 2BCJA 4TNDA 3PVWA 2IHBB 4TNBA 5HE3A 1FQIA 2OJ4A 4MK0A 2IHDA 3QYFA 1FQKB 2IK8B 1EMUA 2JM5A 2EBZA 2JNUA 2D9JA 3CIKA 3UZTA 1EZTA 4PNKA 1OMWA 2V4ZB 5HE1A 1AGRE 3NYNA 4EKDB 1DK8A 5HE2A 5DO9B 2GTPC 3C7LA 2ODEB 2OWIA 2CRPA 3KRWA 3PVUA 3NYOA 2AF0A 1FQJB 3V5WA 2BV1A 1EZYA 2BT2A 3C7KB 5HE0A 2DLVA 3PSCA 1CMZA 3KRXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BCJ A;  4TND A;  3PVW A;  2IHB B;  4TNB A;  5HE3 A;  1FQI A;  2OJ4 A;  4MK0 A;  2IHD A;  1FQK B;  2IK8 B;  1EMU A;  2JM5 A;  2EBZ A;  2JNU A;  2D9J A;  3CIK A;  3UZT A;  1EZT A;  4PNK A;  1OMW A;  2V4Z B;  5HE1 A;  1AGR E;  3NYN A;  4EKD B;  1DK8 A;  5HE2 A;  5DO9 B;  2GTP C;  3C7L A;  2ODE B;  2OWI A;  2CRP A;  3KRW A;  3PVU A;  3NYO A;  2AF0 A;  1FQJ B;  3V5W A;  2BV1 A;  1EZY A;  2BT2 A;  3C7K B;  5HE0 A;  2DLV A;  3PSC A;  1CMZ A;  3KRX A; 
#chains in the Genus database with same CATH topology
 5REQ B;  2BCJ A;  4TND A;  3PVW A;  2IHB B;  4TNB A;  5HE3 A;  1FQI A;  2OJ4 A;  4MK0 A;  2IHD A;  3QYF A;  1FQK B;  2IK8 B;  1EMU A;  2JM5 A;  2EBZ A;  2JNU A;  2D9J A;  3CIK A;  3UZT A;  1EZT A;  4PNK A;  1OMW A;  2V4Z B;  5HE1 A;  1AGR E;  3I5Q A;  3NYN A;  4EKD B;  1DK8 A;  5HE2 A;  5DO9 B;  2GTP C;  3C7L A;  2ODE B;  2OWI A;  2CRP A;  3KRW A;  3PVU A;  3NYO A;  2AF0 A;  1FQJ B;  3V5W A;  2BV1 A;  1EZY A;  2BT2 A;  3C7K B;  5HE0 A;  2DLV A;  3PSC A;  4HTE A;  1CMZ A;  3KRX A; 
#chains in the Genus database with same CATH homology
 5REQ B;  2BCJ A;  4TND A;  3PVW A;  2IHB B;  4TNB A;  5HE3 A;  1FQI A;  2OJ4 A;  4MK0 A;  2IHD A;  3QYF A;  1FQK B;  2IK8 B;  1EMU A;  2JM5 A;  2EBZ A;  2JNU A;  2D9J A;  3CIK A;  3UZT A;  1EZT A;  4PNK A;  1OMW A;  2V4Z B;  5HE1 A;  1AGR E;  3NYN A;  4EKD B;  1DK8 A;  5HE2 A;  5DO9 B;  2GTP C;  3C7L A;  2ODE B;  2OWI A;  2CRP A;  3KRW A;  3PVU A;  3NYO A;  2AF0 A;  1FQJ B;  3V5W A;  2BV1 A;  1EZY A;  2BT2 A;  3C7K B;  5HE0 A;  2DLV A;  3PSC A;  1CMZ A;  3KRX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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