2GTPC

Crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
132
structure length
132
Chain Sequence
VLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule keywords Guanine nucleotide-binding protein G(i), alpha-1 subunit
molecule tags Signaling protein
source organism Homo sapiens
total genus 46
structure length 132
sequence length 132
chains with identical sequence D
ec nomenclature
pdb deposition date 2006-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2gtpC02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2gtpC01
3NYOA 3V5WA 2JM5A 5HE2A 2BV1A 1EZTA 2IHDA 1FQIA 2BCJA 1FQKB 3PVWA 5HE3A 5DO9B 1EZYA 3KRXA 3C7LA 1OMWA 5HE1A 3PSCA 3UZTA 1FQJB 2AF0A 2IK8B 2GTPC 2JNUA 2BT2A 1DK8A 3CIKA 1CMZA 1AGRE 4MK0A 3NYNA 4EKDB 3PVUA 1EMUA 2D9JA 2ODEB 2DLVA 2EBZA 2V4ZB 5HE0A 2CRPA 3C7KB 2IHBB 3KRWA 2OJ4A 4PNKA 4TNBA 4TNDA 2OWIA
chains in the Genus database with same CATH superfamily
3NYOA 3V5WA 2JM5A 5HE2A 2BV1A 1EZTA 2IHDA 1FQIA 2BCJA 1FQKB 3PVWA 5HE3A 5DO9B 1EZYA 3KRXA 3C7LA 1OMWA 5HE1A 3PSCA 3UZTA 1FQJB 4HTEA 2AF0A 2IK8B 5REQB 2GTPC 2JNUA 2BT2A 1DK8A 3CIKA 1CMZA 1AGRE 4MK0A 3NYNA 4EKDB 3PVUA 1EMUA 2D9JA 2ODEB 3QYFA 2DLVA 2EBZA 2V4ZB 5HE0A 4PNKA 2CRPA 3C7KB 2IHBB 3KRWA 2OJ4A 3I5QA 4TNBA 4TNDA 2OWIA
chains in the Genus database with same CATH topology
3NYOA 3V5WA 2JM5A 5HE2A 2BV1A 1EZTA 2IHDA 1FQIA 2BCJA 1FQKB 3PVWA 5HE3A 5DO9B 1EZYA 3KRXA 3C7LA 1OMWA 5HE1A 3PSCA 3UZTA 1FQJB 2AF0A 2IK8B 5REQB 2GTPC 2JNUA 2BT2A 1DK8A 3CIKA 1CMZA 1AGRE 4MK0A 3NYNA 4EKDB 3PVUA 1EMUA 2D9JA 2ODEB 3QYFA 2DLVA 2EBZA 2V4ZB 5HE0A 2CRPA 3C7KB 2IHBB 3KRWA 2OJ4A 4PNKA 4TNBA 4TNDA 2OWIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NYO A;  3V5W A;  2JM5 A;  5HE2 A;  2BV1 A;  1EZT A;  2IHD A;  1FQI A;  2BCJ A;  1FQK B;  3PVW A;  5HE3 A;  5DO9 B;  1EZY A;  3KRX A;  3C7L A;  1OMW A;  5HE1 A;  3PSC A;  3UZT A;  1FQJ B;  2AF0 A;  2IK8 B;  2GTP C;  2JNU A;  2BT2 A;  1DK8 A;  3CIK A;  1CMZ A;  1AGR E;  4MK0 A;  3NYN A;  4EKD B;  3PVU A;  1EMU A;  2D9J A;  2ODE B;  2DLV A;  2EBZ A;  2V4Z B;  5HE0 A;  2CRP A;  3C7K B;  2IHB B;  3KRW A;  2OJ4 A;  4PNK A;  4TNB A;  4TND A;  2OWI A; 
#chains in the Genus database with same CATH topology
 3NYO A;  3V5W A;  2JM5 A;  5HE2 A;  2BV1 A;  1EZT A;  2IHD A;  1FQI A;  2BCJ A;  1FQK B;  3PVW A;  5HE3 A;  5DO9 B;  1EZY A;  3KRX A;  3C7L A;  1OMW A;  5HE1 A;  3PSC A;  3UZT A;  1FQJ B;  4HTE A;  2AF0 A;  2IK8 B;  5REQ B;  2GTP C;  2JNU A;  2BT2 A;  1DK8 A;  3CIK A;  1CMZ A;  1AGR E;  4MK0 A;  3NYN A;  4EKD B;  3PVU A;  1EMU A;  2D9J A;  2ODE B;  3QYF A;  2DLV A;  2EBZ A;  2V4Z B;  5HE0 A;  4PNK A;  2CRP A;  3C7K B;  2IHB B;  3KRW A;  2OJ4 A;  3I5Q A;  4TNB A;  4TND A;  2OWI A; 
#chains in the Genus database with same CATH homology
 3NYO A;  3V5W A;  2JM5 A;  5HE2 A;  2BV1 A;  1EZT A;  2IHD A;  1FQI A;  2BCJ A;  1FQK B;  3PVW A;  5HE3 A;  5DO9 B;  1EZY A;  3KRX A;  3C7L A;  1OMW A;  5HE1 A;  3PSC A;  3UZT A;  1FQJ B;  2AF0 A;  2IK8 B;  5REQ B;  2GTP C;  2JNU A;  2BT2 A;  1DK8 A;  3CIK A;  1CMZ A;  1AGR E;  4MK0 A;  3NYN A;  4EKD B;  3PVU A;  1EMU A;  2D9J A;  2ODE B;  3QYF A;  2DLV A;  2EBZ A;  2V4Z B;  5HE0 A;  2CRP A;  3C7K B;  2IHB B;  3KRW A;  2OJ4 A;  4PNK A;  4TNB A;  4TND A;  2OWI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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