2GTPC

Crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
132
structure length
132
Chain Sequence
VLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Guanine nucleotide-binding protein G(i), alpha-1 subunit
total genus 46
structure length 132
sequence length 132
chains with identical sequence D
ec nomenclature
pdb deposition date 2006-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2gtpC02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2gtpC01
2D9JA 1FQIA 3PVWA 5HE1A 2BT2A 3CIKA 5DO9B 2V4ZB 1CMZA 3C7KB 4TNDA 2JM5A 2BV1A 3NYOA 2AF0A 2ODEB 3PVUA 2IHDA 3NYNA 2IHBB 4MK0A 1FQKB 4PNKA 3C7LA 2EBZA 1EMUA 2CRPA 1OMWA 2GTPC 1DK8A 2DLVA 3PSCA 1FQJB 5HE2A 2OJ4A 2JNUA 4EKDB 2BCJA 4TNBA 2OWIA 3UZTA 5HE0A 3KRWA 5HE3A 1EZYA 1EZTA 3V5WA 3KRXA 2IK8B 1AGRE
chains in the Genus database with same CATH superfamily
2D9JA 4HTEA 1FQIA 3PVWA 5HE1A 2BT2A 3CIKA 5DO9B 2V4ZB 1CMZA 3C7KB 4TNDA 2JM5A 2BV1A 3NYOA 5REQB 2AF0A 2ODEB 3PVUA 2IHDA 3NYNA 2IHBB 4MK0A 1FQKB 4PNKA 3C7LA 2EBZA 1EMUA 2CRPA 1OMWA 2GTPC 1DK8A 2DLVA 3PSCA 1FQJB 3QYFA 5HE2A 2OJ4A 2JNUA 3I5QA 2BCJA 4EKDB 4TNBA 2OWIA 3UZTA 5HE0A 3KRWA 5HE3A 1EZYA 1EZTA 3V5WA 3KRXA 2IK8B 1AGRE
chains in the Genus database with same CATH topology
2D9JA 1FQIA 3PVWA 5HE1A 2BT2A 3CIKA 5DO9B 2V4ZB 1CMZA 3C7KB 4TNDA 2JM5A 2BV1A 3NYOA 5REQB 2AF0A 2ODEB 3PVUA 2IHDA 3NYNA 2IHBB 4MK0A 1FQKB 4PNKA 3C7LA 2EBZA 1EMUA 2CRPA 1OMWA 2GTPC 1DK8A 2DLVA 3PSCA 1FQJB 3QYFA 5HE2A 2OJ4A 2JNUA 4EKDB 2BCJA 4TNBA 2OWIA 3UZTA 5HE0A 3KRWA 5HE3A 1EZYA 1EZTA 3V5WA 3KRXA 2IK8B 1AGRE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D9J A;  1FQI A;  3PVW A;  5HE1 A;  2BT2 A;  3CIK A;  5DO9 B;  2V4Z B;  1CMZ A;  3C7K B;  4TND A;  2JM5 A;  2BV1 A;  3NYO A;  2AF0 A;  2ODE B;  3PVU A;  2IHD A;  3NYN A;  2IHB B;  4MK0 A;  1FQK B;  4PNK A;  3C7L A;  2EBZ A;  1EMU A;  2CRP A;  1OMW A;  2GTP C;  1DK8 A;  2DLV A;  3PSC A;  1FQJ B;  5HE2 A;  2OJ4 A;  2JNU A;  4EKD B;  2BCJ A;  4TNB A;  2OWI A;  3UZT A;  5HE0 A;  3KRW A;  5HE3 A;  1EZY A;  1EZT A;  3V5W A;  3KRX A;  2IK8 B;  1AGR E; 
#chains in the Genus database with same CATH topology
 2D9J A;  4HTE A;  1FQI A;  3PVW A;  5HE1 A;  2BT2 A;  3CIK A;  5DO9 B;  2V4Z B;  1CMZ A;  3C7K B;  4TND A;  2JM5 A;  2BV1 A;  3NYO A;  5REQ B;  2AF0 A;  2ODE B;  3PVU A;  2IHD A;  3NYN A;  2IHB B;  4MK0 A;  1FQK B;  4PNK A;  3C7L A;  2EBZ A;  1EMU A;  2CRP A;  1OMW A;  2GTP C;  1DK8 A;  2DLV A;  3PSC A;  1FQJ B;  3QYF A;  5HE2 A;  2OJ4 A;  2JNU A;  3I5Q A;  2BCJ A;  4EKD B;  4TNB A;  2OWI A;  3UZT A;  5HE0 A;  3KRW A;  5HE3 A;  1EZY A;  1EZT A;  3V5W A;  3KRX A;  2IK8 B;  1AGR E; 
#chains in the Genus database with same CATH homology
 2D9J A;  1FQI A;  3PVW A;  5HE1 A;  2BT2 A;  3CIK A;  5DO9 B;  2V4Z B;  1CMZ A;  3C7K B;  4TND A;  2JM5 A;  2BV1 A;  3NYO A;  5REQ B;  2AF0 A;  2ODE B;  3PVU A;  2IHD A;  3NYN A;  2IHB B;  4MK0 A;  1FQK B;  4PNK A;  3C7L A;  2EBZ A;  1EMU A;  2CRP A;  1OMW A;  2GTP C;  1DK8 A;  2DLV A;  3PSC A;  1FQJ B;  3QYF A;  5HE2 A;  2OJ4 A;  2JNU A;  4EKD B;  2BCJ A;  4TNB A;  2OWI A;  3UZT A;  5HE0 A;  3KRW A;  5HE3 A;  1EZY A;  1EZT A;  3V5W A;  3KRX A;  2IK8 B;  1AGR E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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