2GTPC

Crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
132
structure length
132
Chain Sequence
VLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule keywords Guanine nucleotide-binding protein G(i), alpha-1 subunit
molecule tags Signaling protein
source organism Homo sapiens
total genus 46
structure length 132
sequence length 132
chains with identical sequence D
ec nomenclature
pdb deposition date 2006-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2gtpC02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2gtpC01
2OWIA 2ODEB 3CIKA 5DO9B 3C7LA 4EKDB 3C7KB 4PNKA 1FQJB 2JM5A 1OMWA 2V4ZB 1EZYA 1FQIA 2IHBB 3UZTA 3NYNA 1FQKB 2CRPA 4MK0A 1AGRE 2AF0A 2IK8B 3KRXA 3PVUA 4TNDA 2BT2A 3KRWA 5HE1A 2JNUA 1EMUA 5HE0A 2OJ4A 3PVWA 5HE3A 2D9JA 1EZTA 1CMZA 2IHDA 2DLVA 5HE2A 3V5WA 3PSCA 2GTPC 1DK8A 2BCJA 2EBZA 2BV1A 3NYOA 4TNBA
chains in the Genus database with same CATH superfamily
2OWIA 2ODEB 3CIKA 5DO9B 3C7LA 4EKDB 3C7KB 4PNKA 1FQJB 2JM5A 5REQB 1OMWA 2V4ZB 1EZYA 1FQIA 2IHBB 3UZTA 3NYNA 1FQKB 2CRPA 4MK0A 1AGRE 2AF0A 2IK8B 3KRXA 3PVUA 4TNDA 2BT2A 3KRWA 5HE1A 2JNUA 1EMUA 5HE0A 2OJ4A 3PVWA 5HE3A 2D9JA 1EZTA 1CMZA 2IHDA 2DLVA 5HE2A 3V5WA 3PSCA 2GTPC 3QYFA 1DK8A 2BCJA 2EBZA 3I5QA 2BV1A 3NYOA 4HTEA 4TNBA
chains in the Genus database with same CATH topology
2OWIA 2ODEB 3CIKA 5DO9B 3C7LA 4EKDB 3C7KB 4PNKA 1FQJB 2JM5A 5REQB 1OMWA 2V4ZB 1EZYA 1FQIA 2IHBB 3UZTA 3NYNA 1FQKB 2CRPA 4MK0A 1AGRE 2AF0A 2IK8B 3KRXA 3PVUA 4TNDA 2BT2A 3KRWA 5HE1A 2JNUA 1EMUA 5HE0A 2OJ4A 3PVWA 5HE3A 2D9JA 1EZTA 1CMZA 2IHDA 2DLVA 5HE2A 3V5WA 3PSCA 2GTPC 3QYFA 1DK8A 2BCJA 2EBZA 2BV1A 3NYOA 4TNBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OWI A;  2ODE B;  3CIK A;  5DO9 B;  3C7L A;  4EKD B;  3C7K B;  4PNK A;  1FQJ B;  2JM5 A;  1OMW A;  2V4Z B;  1EZY A;  1FQI A;  2IHB B;  3UZT A;  3NYN A;  1FQK B;  2CRP A;  4MK0 A;  1AGR E;  2AF0 A;  2IK8 B;  3KRX A;  3PVU A;  4TND A;  2BT2 A;  3KRW A;  5HE1 A;  2JNU A;  1EMU A;  5HE0 A;  2OJ4 A;  3PVW A;  5HE3 A;  2D9J A;  1EZT A;  1CMZ A;  2IHD A;  2DLV A;  5HE2 A;  3V5W A;  3PSC A;  2GTP C;  1DK8 A;  2BCJ A;  2EBZ A;  2BV1 A;  3NYO A;  4TNB A; 
#chains in the Genus database with same CATH topology
 2OWI A;  2ODE B;  3CIK A;  5DO9 B;  3C7L A;  4EKD B;  3C7K B;  4PNK A;  1FQJ B;  2JM5 A;  5REQ B;  1OMW A;  2V4Z B;  1EZY A;  1FQI A;  2IHB B;  3UZT A;  3NYN A;  1FQK B;  2CRP A;  4MK0 A;  1AGR E;  2AF0 A;  2IK8 B;  3KRX A;  3PVU A;  4TND A;  2BT2 A;  3KRW A;  5HE1 A;  2JNU A;  1EMU A;  5HE0 A;  2OJ4 A;  3PVW A;  5HE3 A;  2D9J A;  1EZT A;  1CMZ A;  2IHD A;  2DLV A;  5HE2 A;  3V5W A;  3PSC A;  2GTP C;  3QYF A;  1DK8 A;  2BCJ A;  2EBZ A;  3I5Q A;  2BV1 A;  3NYO A;  4HTE A;  4TNB A; 
#chains in the Genus database with same CATH homology
 2OWI A;  2ODE B;  3CIK A;  5DO9 B;  3C7L A;  4EKD B;  3C7K B;  4PNK A;  1FQJ B;  2JM5 A;  5REQ B;  1OMW A;  2V4Z B;  1EZY A;  1FQI A;  2IHB B;  3UZT A;  3NYN A;  1FQK B;  2CRP A;  4MK0 A;  1AGR E;  2AF0 A;  2IK8 B;  3KRX A;  3PVU A;  4TND A;  2BT2 A;  3KRW A;  5HE1 A;  2JNU A;  1EMU A;  5HE0 A;  2OJ4 A;  3PVW A;  5HE3 A;  2D9J A;  1EZT A;  1CMZ A;  2IHD A;  2DLV A;  5HE2 A;  3V5W A;  3PSC A;  2GTP C;  3QYF A;  1DK8 A;  2BCJ A;  2EBZ A;  2BV1 A;  3NYO A;  4TNB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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