2IK8B

Crystal structure of the heterodimeric complex of human rgs16 and activated gi alpha 1
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
120
structure length
120
Chain Sequence
SFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETRELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Guanine nucleotide-binding protein G(i), alpha-1 subunit
total genus 42
structure length 120
sequence length 120
chains with identical sequence D
ec nomenclature
pdb deposition date 2006-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2ik8B02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2ik8B01
1EZTA 2V4ZB 3NYOA 5HE1A 2IHDA 2IHBB 3NYNA 2OWIA 3PVUA 2EBZA 2JM5A 2BT2A 5HE2A 2BV1A 2OJ4A 2AF0A 3UZTA 4EKDB 5HE3A 4TNBA 1FQJB 2DLVA 2D9JA 1OMWA 4TNDA 3C7KB 4MK0A 5HE0A 4PNKA 1EZYA 3KRWA 1FQKB 2CRPA 2ODEB 3KRXA 1FQIA 1AGRE 3V5WA 3PSCA 1CMZA 2BCJA 2JNUA 3C7LA 3CIKA 5DO9B 3PVWA 1EMUA 1DK8A 2IK8B 2GTPC
chains in the Genus database with same CATH superfamily
1EZTA 2V4ZB 3NYOA 5HE1A 2IHDA 2IHBB 3NYNA 2OWIA 3PVUA 2EBZA 2JM5A 2BT2A 5HE2A 2BV1A 2OJ4A 2AF0A 3UZTA 4EKDB 5HE3A 3I5QA 4TNBA 1FQJB 2DLVA 2D9JA 1OMWA 4TNDA 3C7KB 4MK0A 5HE0A 4PNKA 1EZYA 3KRWA 5REQB 1FQKB 2CRPA 2ODEB 3KRXA 4HTEA 1FQIA 1AGRE 3V5WA 3PSCA 1CMZA 3QYFA 2BCJA 2JNUA 3C7LA 3CIKA 5DO9B 3PVWA 1EMUA 1DK8A 2IK8B 2GTPC
chains in the Genus database with same CATH topology
1EZTA 2V4ZB 3NYOA 5HE1A 2IHDA 2IHBB 3NYNA 2OWIA 3PVUA 2EBZA 2JM5A 2BT2A 5HE2A 2BV1A 2OJ4A 2AF0A 3UZTA 4EKDB 5HE3A 4TNBA 1FQJB 2DLVA 2D9JA 1OMWA 4TNDA 3C7KB 4MK0A 5HE0A 4PNKA 1EZYA 3KRWA 5REQB 1FQKB 2CRPA 2ODEB 3KRXA 1FQIA 1AGRE 3V5WA 3PSCA 1CMZA 3QYFA 2BCJA 2JNUA 3C7LA 3CIKA 5DO9B 3PVWA 1EMUA 1DK8A 2IK8B 2GTPC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EZT A;  2V4Z B;  3NYO A;  5HE1 A;  2IHD A;  2IHB B;  3NYN A;  2OWI A;  3PVU A;  2EBZ A;  2JM5 A;  2BT2 A;  5HE2 A;  2BV1 A;  2OJ4 A;  2AF0 A;  3UZT A;  4EKD B;  5HE3 A;  4TNB A;  1FQJ B;  2DLV A;  2D9J A;  1OMW A;  4TND A;  3C7K B;  4MK0 A;  5HE0 A;  4PNK A;  1EZY A;  3KRW A;  1FQK B;  2CRP A;  2ODE B;  3KRX A;  1FQI A;  1AGR E;  3V5W A;  3PSC A;  1CMZ A;  2BCJ A;  2JNU A;  3C7L A;  3CIK A;  5DO9 B;  3PVW A;  1EMU A;  1DK8 A;  2IK8 B;  2GTP C; 
#chains in the Genus database with same CATH topology
 1EZT A;  2V4Z B;  3NYO A;  5HE1 A;  2IHD A;  2IHB B;  3NYN A;  2OWI A;  3PVU A;  2EBZ A;  2JM5 A;  2BT2 A;  5HE2 A;  2BV1 A;  2OJ4 A;  2AF0 A;  3UZT A;  4EKD B;  5HE3 A;  3I5Q A;  4TNB A;  1FQJ B;  2DLV A;  2D9J A;  1OMW A;  4TND A;  3C7K B;  4MK0 A;  5HE0 A;  4PNK A;  1EZY A;  3KRW A;  5REQ B;  1FQK B;  2CRP A;  2ODE B;  3KRX A;  4HTE A;  1FQI A;  1AGR E;  3V5W A;  3PSC A;  1CMZ A;  3QYF A;  2BCJ A;  2JNU A;  3C7L A;  3CIK A;  5DO9 B;  3PVW A;  1EMU A;  1DK8 A;  2IK8 B;  2GTP C; 
#chains in the Genus database with same CATH homology
 1EZT A;  2V4Z B;  3NYO A;  5HE1 A;  2IHD A;  2IHB B;  3NYN A;  2OWI A;  3PVU A;  2EBZ A;  2JM5 A;  2BT2 A;  5HE2 A;  2BV1 A;  2OJ4 A;  2AF0 A;  3UZT A;  4EKD B;  5HE3 A;  4TNB A;  1FQJ B;  2DLV A;  2D9J A;  1OMW A;  4TND A;  3C7K B;  4MK0 A;  5HE0 A;  4PNK A;  1EZY A;  3KRW A;  5REQ B;  1FQK B;  2CRP A;  2ODE B;  3KRX A;  1FQI A;  1AGR E;  3V5W A;  3PSC A;  1CMZ A;  3QYF A;  2BCJ A;  2JNU A;  3C7L A;  3CIK A;  5DO9 B;  3PVW A;  1EMU A;  1DK8 A;  2IK8 B;  2GTP C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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