2JM5A

Solution structure of the rgs domain from human rgs18
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
134
structure length
134
Chain Sequence
SMVSPEEAVKWGESFDKLLSHRDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule keywords Regulator of G-protein signaling 18
molecule tags Signaling protein
source organism Homo sapiens
total genus 50
structure length 134
sequence length 134
ec nomenclature
pdb deposition date 2006-10-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2jm5A02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2jm5A01
1FQJB 4MK0A 3C7LA 2BT2A 2DLVA 3KRWA 4PNKA 1FQKB 2IK8B 4EKDB 2EBZA 2IHBB 1FQIA 1OMWA 2JNUA 1EZYA 3PVUA 1EMUA 3CIKA 3PSCA 2V4ZB 3UZTA 1AGRE 3NYOA 3V5WA 2OWIA 2JM5A 5HE2A 2AF0A 2BV1A 5HE3A 3C7KB 3NYNA 2OJ4A 3KRXA 4TNBA 2D9JA 5HE1A 1DK8A 2IHDA 2ODEB 3PVWA 1CMZA 2BCJA 1EZTA 5HE0A 2GTPC 2CRPA 4TNDA 5DO9B
chains in the Genus database with same CATH superfamily
1FQJB 4MK0A 3C7LA 2BT2A 2DLVA 3KRWA 4PNKA 1FQKB 2IK8B 4EKDB 2EBZA 2IHBB 1FQIA 1OMWA 2JNUA 3I5QA 3PVUA 1EMUA 3CIKA 3PSCA 2V4ZB 3UZTA 1EZYA 1AGRE 3NYOA 3V5WA 2OWIA 3QYFA 2JM5A 5HE2A 2AF0A 2BV1A 5HE3A 3C7KB 3NYNA 2OJ4A 3KRXA 4TNBA 2D9JA 5HE1A 1DK8A 2IHDA 2ODEB 3PVWA 4HTEA 1CMZA 2BCJA 1EZTA 5REQB 5HE0A 2GTPC 2CRPA 4TNDA 5DO9B
chains in the Genus database with same CATH topology
1FQJB 4MK0A 3C7LA 2BT2A 2DLVA 3KRWA 4PNKA 1FQKB 2IK8B 4EKDB 2EBZA 2IHBB 1FQIA 1OMWA 2JNUA 1EZYA 3PVUA 1EMUA 3CIKA 3PSCA 2V4ZB 3UZTA 1AGRE 3NYOA 3V5WA 2OWIA 3QYFA 2JM5A 5HE2A 2AF0A 2BV1A 5HE3A 3C7KB 3NYNA 2OJ4A 3KRXA 4TNBA 2D9JA 5HE1A 1DK8A 2IHDA 2ODEB 3PVWA 1CMZA 2BCJA 1EZTA 5REQB 5HE0A 2GTPC 2CRPA 4TNDA 5DO9B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FQJ B;  4MK0 A;  3C7L A;  2BT2 A;  2DLV A;  3KRW A;  4PNK A;  1FQK B;  2IK8 B;  4EKD B;  2EBZ A;  2IHB B;  1FQI A;  1OMW A;  2JNU A;  1EZY A;  3PVU A;  1EMU A;  3CIK A;  3PSC A;  2V4Z B;  3UZT A;  1AGR E;  3NYO A;  3V5W A;  2OWI A;  2JM5 A;  5HE2 A;  2AF0 A;  2BV1 A;  5HE3 A;  3C7K B;  3NYN A;  2OJ4 A;  3KRX A;  4TNB A;  2D9J A;  5HE1 A;  1DK8 A;  2IHD A;  2ODE B;  3PVW A;  1CMZ A;  2BCJ A;  1EZT A;  5HE0 A;  2GTP C;  2CRP A;  4TND A;  5DO9 B; 
#chains in the Genus database with same CATH topology
 1FQJ B;  4MK0 A;  3C7L A;  2BT2 A;  2DLV A;  3KRW A;  4PNK A;  1FQK B;  2IK8 B;  4EKD B;  2EBZ A;  2IHB B;  1FQI A;  1OMW A;  2JNU A;  3I5Q A;  3PVU A;  1EMU A;  3CIK A;  3PSC A;  2V4Z B;  3UZT A;  1EZY A;  1AGR E;  3NYO A;  3V5W A;  2OWI A;  3QYF A;  2JM5 A;  5HE2 A;  2AF0 A;  2BV1 A;  5HE3 A;  3C7K B;  3NYN A;  2OJ4 A;  3KRX A;  4TNB A;  2D9J A;  5HE1 A;  1DK8 A;  2IHD A;  2ODE B;  3PVW A;  4HTE A;  1CMZ A;  2BCJ A;  1EZT A;  5REQ B;  5HE0 A;  2GTP C;  2CRP A;  4TND A;  5DO9 B; 
#chains in the Genus database with same CATH homology
 1FQJ B;  4MK0 A;  3C7L A;  2BT2 A;  2DLV A;  3KRW A;  4PNK A;  1FQK B;  2IK8 B;  4EKD B;  2EBZ A;  2IHB B;  1FQI A;  1OMW A;  2JNU A;  1EZY A;  3PVU A;  1EMU A;  3CIK A;  3PSC A;  2V4Z B;  3UZT A;  1AGR E;  3NYO A;  3V5W A;  2OWI A;  3QYF A;  2JM5 A;  5HE2 A;  2AF0 A;  2BV1 A;  5HE3 A;  3C7K B;  3NYN A;  2OJ4 A;  3KRX A;  4TNB A;  2D9J A;  5HE1 A;  1DK8 A;  2IHD A;  2ODE B;  3PVW A;  1CMZ A;  2BCJ A;  1EZT A;  5REQ B;  5HE0 A;  2GTP C;  2CRP A;  4TND A;  5DO9 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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