2JM5A

Solution structure of the rgs domain from human rgs18
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
134
structure length
134
Chain Sequence
SMVSPEEAVKWGESFDKLLSHRDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
molecule keywords Regulator of G-protein signaling 18
molecule tags Signaling protein
source organism Homo sapiens
total genus 50
structure length 134
sequence length 134
ec nomenclature
pdb deposition date 2006-10-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2jm5A02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2jm5A01
2EBZA 5HE1A 2ODEB 5DO9B 3KRXA 3PVWA 3CIKA 4TNBA 2JM5A 5HE3A 3C7LA 2OJ4A 2AF0A 1OMWA 1EMUA 3KRWA 3PVUA 3C7KB 4MK0A 1EZYA 2BT2A 5HE0A 2IK8B 1CMZA 1EZTA 1AGRE 3NYOA 2GTPC 2JNUA 4PNKA 4TNDA 5HE2A 3V5WA 2D9JA 3UZTA 2BV1A 3PSCA 2V4ZB 2CRPA 1FQIA 4EKDB 3NYNA 1DK8A 2IHDA 1FQJB 2IHBB 1FQKB 2OWIA 2DLVA 2BCJA
chains in the Genus database with same CATH superfamily
2EBZA 5HE1A 2ODEB 5DO9B 3KRXA 3PVWA 3CIKA 4TNBA 2JM5A 5HE3A 3C7LA 2OJ4A 3I5QA 2AF0A 4HTEA 1OMWA 1EMUA 3KRWA 3PVUA 3C7KB 4MK0A 1EZYA 2BT2A 5HE0A 5REQB 2IK8B 1CMZA 1EZTA 1AGRE 3NYOA 2GTPC 2JNUA 4PNKA 4TNDA 5HE2A 3V5WA 2D9JA 3UZTA 2BV1A 3PSCA 2V4ZB 3QYFA 2CRPA 1FQIA 4EKDB 3NYNA 1DK8A 2IHDA 1FQJB 2IHBB 1FQKB 2OWIA 2DLVA 2BCJA
chains in the Genus database with same CATH topology
2EBZA 5HE1A 2ODEB 5DO9B 3KRXA 3PVWA 3CIKA 4TNBA 2JM5A 5HE3A 3C7LA 2OJ4A 2AF0A 1OMWA 1EMUA 3KRWA 3PVUA 3C7KB 4MK0A 1EZYA 2BT2A 5HE0A 5REQB 2IK8B 1CMZA 1EZTA 1AGRE 3NYOA 2GTPC 2JNUA 4PNKA 4TNDA 5HE2A 3V5WA 2D9JA 3UZTA 2BV1A 3PSCA 2V4ZB 3QYFA 2CRPA 1FQIA 4EKDB 3NYNA 1DK8A 2IHDA 1FQJB 2IHBB 1FQKB 2OWIA 2DLVA 2BCJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EBZ A;  5HE1 A;  2ODE B;  5DO9 B;  3KRX A;  3PVW A;  3CIK A;  4TNB A;  2JM5 A;  5HE3 A;  3C7L A;  2OJ4 A;  2AF0 A;  1OMW A;  1EMU A;  3KRW A;  3PVU A;  3C7K B;  4MK0 A;  1EZY A;  2BT2 A;  5HE0 A;  2IK8 B;  1CMZ A;  1EZT A;  1AGR E;  3NYO A;  2GTP C;  2JNU A;  4PNK A;  4TND A;  5HE2 A;  3V5W A;  2D9J A;  3UZT A;  2BV1 A;  3PSC A;  2V4Z B;  2CRP A;  1FQI A;  4EKD B;  3NYN A;  1DK8 A;  2IHD A;  1FQJ B;  2IHB B;  1FQK B;  2OWI A;  2DLV A;  2BCJ A; 
#chains in the Genus database with same CATH topology
 2EBZ A;  5HE1 A;  2ODE B;  5DO9 B;  3KRX A;  3PVW A;  3CIK A;  4TNB A;  2JM5 A;  5HE3 A;  3C7L A;  2OJ4 A;  3I5Q A;  2AF0 A;  4HTE A;  1OMW A;  1EMU A;  3KRW A;  3PVU A;  3C7K B;  4MK0 A;  1EZY A;  2BT2 A;  5HE0 A;  5REQ B;  2IK8 B;  1CMZ A;  1EZT A;  1AGR E;  3NYO A;  2GTP C;  2JNU A;  4PNK A;  4TND A;  5HE2 A;  3V5W A;  2D9J A;  3UZT A;  2BV1 A;  3PSC A;  2V4Z B;  3QYF A;  2CRP A;  1FQI A;  4EKD B;  3NYN A;  1DK8 A;  2IHD A;  1FQJ B;  2IHB B;  1FQK B;  2OWI A;  2DLV A;  2BCJ A; 
#chains in the Genus database with same CATH homology
 2EBZ A;  5HE1 A;  2ODE B;  5DO9 B;  3KRX A;  3PVW A;  3CIK A;  4TNB A;  2JM5 A;  5HE3 A;  3C7L A;  2OJ4 A;  2AF0 A;  1OMW A;  1EMU A;  3KRW A;  3PVU A;  3C7K B;  4MK0 A;  1EZY A;  2BT2 A;  5HE0 A;  5REQ B;  2IK8 B;  1CMZ A;  1EZT A;  1AGR E;  3NYO A;  2GTP C;  2JNU A;  4PNK A;  4TND A;  5HE2 A;  3V5W A;  2D9J A;  3UZT A;  2BV1 A;  3PSC A;  2V4Z B;  3QYF A;  2CRP A;  1FQI A;  4EKD B;  3NYN A;  1DK8 A;  2IHD A;  1FQJ B;  2IHB B;  1FQK B;  2OWI A;  2DLV A;  2BCJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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