2V4ZB

The crystal structure of the human g-protein subunit alpha (gnai3) in complex with an engineered regulator of g-protein signaling type 2 domain (rgs2)
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
128
structure length
122
Chain Sequence
PSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFSEENIEFWLACEDFKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNATSGCFTTAQKRVYSLMENDSYPRFLKSEFYQDLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2).
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords GUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA
total genus 41
structure length 122
sequence length 128
ec nomenclature
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2v4zB02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2v4zB01
2JNUA 2OJ4A 2DLVA 5HE0A 3V5WA 1AGRE 1FQKB 4TNDA 1EZYA 4TNBA 1EMUA 5HE2A 2OWIA 2EBZA 3PVWA 5DO9B 3PVUA 2V4ZB 2BCJA 3UZTA 1FQJB 1FQIA 4MK0A 4PNKA 3C7LA 3KRXA 3NYOA 2GTPC 1EZTA 3KRWA 5HE3A 2CRPA 2ODEB 3PSCA 2IHDA 2AF0A 3NYNA 2D9JA 2BT2A 5HE1A 1DK8A 2IK8B 1OMWA 1CMZA 2JM5A 2BV1A 3C7KB 4EKDB 3CIKA 2IHBB
chains in the Genus database with same CATH superfamily
2JNUA 2OJ4A 2DLVA 5HE0A 3V5WA 1AGRE 1FQKB 4TNDA 1EZYA 4HTEA 4TNBA 1EMUA 5HE2A 2OWIA 2EBZA 3PVWA 5DO9B 3PVUA 2V4ZB 2BCJA 3UZTA 1FQJB 1FQIA 4MK0A 4PNKA 3C7LA 3KRXA 3NYOA 3QYFA 2GTPC 1EZTA 3KRWA 5HE3A 2CRPA 2ODEB 3PSCA 2IHDA 3I5QA 2AF0A 3NYNA 2D9JA 2BT2A 5HE1A 1DK8A 2IK8B 1OMWA 1CMZA 2JM5A 2BV1A 3C7KB 4EKDB 5REQB 3CIKA 2IHBB
chains in the Genus database with same CATH topology
2JNUA 2OJ4A 2DLVA 5HE0A 3V5WA 1AGRE 1FQKB 4TNDA 1EZYA 4TNBA 1EMUA 5HE2A 2OWIA 2EBZA 3PVWA 5DO9B 3PVUA 2V4ZB 2BCJA 3UZTA 1FQJB 1FQIA 4MK0A 4PNKA 3C7LA 3KRXA 3NYOA 3QYFA 2GTPC 1EZTA 3KRWA 5HE3A 2CRPA 2ODEB 3PSCA 2IHDA 2AF0A 3NYNA 2D9JA 2BT2A 5HE1A 1DK8A 2IK8B 1OMWA 1CMZA 2JM5A 2BV1A 3C7KB 4EKDB 5REQB 3CIKA 2IHBB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JNU A;  2OJ4 A;  2DLV A;  5HE0 A;  3V5W A;  1AGR E;  1FQK B;  4TND A;  1EZY A;  4TNB A;  1EMU A;  5HE2 A;  2OWI A;  2EBZ A;  3PVW A;  5DO9 B;  3PVU A;  2V4Z B;  2BCJ A;  3UZT A;  1FQJ B;  1FQI A;  4MK0 A;  4PNK A;  3C7L A;  3KRX A;  3NYO A;  2GTP C;  1EZT A;  3KRW A;  5HE3 A;  2CRP A;  2ODE B;  3PSC A;  2IHD A;  2AF0 A;  3NYN A;  2D9J A;  2BT2 A;  5HE1 A;  1DK8 A;  2IK8 B;  1OMW A;  1CMZ A;  2JM5 A;  2BV1 A;  3C7K B;  4EKD B;  3CIK A;  2IHB B; 
#chains in the Genus database with same CATH topology
 2JNU A;  2OJ4 A;  2DLV A;  5HE0 A;  3V5W A;  1AGR E;  1FQK B;  4TND A;  1EZY A;  4HTE A;  4TNB A;  1EMU A;  5HE2 A;  2OWI A;  2EBZ A;  3PVW A;  5DO9 B;  3PVU A;  2V4Z B;  2BCJ A;  3UZT A;  1FQJ B;  1FQI A;  4MK0 A;  4PNK A;  3C7L A;  3KRX A;  3NYO A;  3QYF A;  2GTP C;  1EZT A;  3KRW A;  5HE3 A;  2CRP A;  2ODE B;  3PSC A;  2IHD A;  3I5Q A;  2AF0 A;  3NYN A;  2D9J A;  2BT2 A;  5HE1 A;  1DK8 A;  2IK8 B;  1OMW A;  1CMZ A;  2JM5 A;  2BV1 A;  3C7K B;  4EKD B;  5REQ B;  3CIK A;  2IHB B; 
#chains in the Genus database with same CATH homology
 2JNU A;  2OJ4 A;  2DLV A;  5HE0 A;  3V5W A;  1AGR E;  1FQK B;  4TND A;  1EZY A;  4TNB A;  1EMU A;  5HE2 A;  2OWI A;  2EBZ A;  3PVW A;  5DO9 B;  3PVU A;  2V4Z B;  2BCJ A;  3UZT A;  1FQJ B;  1FQI A;  4MK0 A;  4PNK A;  3C7L A;  3KRX A;  3NYO A;  3QYF A;  2GTP C;  1EZT A;  3KRW A;  5HE3 A;  2CRP A;  2ODE B;  3PSC A;  2IHD A;  2AF0 A;  3NYN A;  2D9J A;  2BT2 A;  5HE1 A;  1DK8 A;  2IK8 B;  1OMW A;  1CMZ A;  2JM5 A;  2BV1 A;  3C7K B;  4EKD B;  5REQ B;  3CIK A;  2IHB B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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