2RQB | Genus

Total Genus 12

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	12
sequence length	135
structure length	135
Chain Sequence	GPLGSYKNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCLFSDED

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS pubmed doi rcsb
molecule keywords	Interferon-induced helicase C domain-containing protein 1
total genus	12
structure length	135
sequence length	135
ec nomenclature	ec 3.6.4.13: RNA helicase.
pdb deposition date	2009-03-17

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF11648	RIG-I_C-RD	C-terminal domain of RIG-I

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.170.150.30	Mainly Beta	Beta Complex	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A	2rqbA00

2RQBA 3ZD7A 2RMJA 2QFBA 3ZD6A 5E3HA 4A2VA 4A2XA 4AY2A 3LRNA 2QFDA 5F9FA 5F9HA 4BPBA 3OG8A 2W4RA 2RQAA 3GA3A 3LRRA 2YKGA 3EQTA 5F98A 3NCUA
chains in the Genus database with same CATH superfamily

1FWQA 3E0OA 4V2ZA 2RQBA 3EBMA 3ZD7A 2KV1A 4CI1B 2RMJA 3CXKA 3MAOA 3HCJA 2QFBA 4TZCA 4CI2B 2KZNA 3ZD6A 1L1DA 5E3HA 2K8DA 5AMHA 3HCHA 4A2VA 4V31A 4A2XA 3DJMA 4V30A 1H7YA 4AY2A 1YZ1A 3LRNA 1H6QA 4CI3B 2QFDA 3FACA 3HCGA 4TZ4C 2HR9A 3E0MA 3P3KA 5F9FA 4V2YA 5F9HA 4BPBA 1TXJA 3OG8A 2W4RA 2RQAA 3CEZA 3GA3A 3HCIA 2LOYA 2LVLA 4TZUA 3LRRA 3WX2A 3WX1A 2YKGA 3EQTA 2KWBA 5F98A 1HXRA 2FU5A 3NCUA
chains in the Genus database with same CATH topology

1FWQA 2RQBA 3EBMA 3ZD7A 2RMJA 2QFBA 3ZD6A 5E3HA 4A2VA 4A2XA 3DJMA 1H7YA 4AY2A 1YZ1A 3LRNA 1H6QA 2QFDA 3FACA 2HR9A 3P3KA 5F9FA 5F9HA 4BPBA 1TXJA 3OG8A 2W4RA 2RQAA 3GA3A 2LOYA 2LVLA 3LRRA 2YKGA 3EQTA 2KWBA 5F98A 1HXRA 2FU5A 3NCUA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 2RQB A;  3ZD7 A;  2RMJ A;  2QFB A;  3ZD6 A;  5E3H A;  4A2V A;  4A2X A;  4AY2 A;  3LRN A;  2QFD A;  5F9F A;  5F9H A;  4BPB A;  3OG8 A;  2W4R A;  2RQA A;  3GA3 A;  3LRR A;  2YKG A;  3EQT A;  5F98 A;  3NCU A; 
#chains in the Genus database with same CATH topology
 1FWQ A;  3E0O A;  4V2Z A;  2RQB A;  3EBM A;  3ZD7 A;  2KV1 A;  4CI1 B;  2RMJ A;  3CXK A;  3MAO A;  3HCJ A;  2QFB A;  4TZC A;  4CI2 B;  2KZN A;  3ZD6 A;  1L1D A;  5E3H A;  2K8D A;  5AMH A;  3HCH A;  4A2V A;  4V31 A;  4A2X A;  3DJM A;  4V30 A;  1H7Y A;  4AY2 A;  1YZ1 A;  3LRN A;  1H6Q A;  4CI3 B;  2QFD A;  3FAC A;  3HCG A;  4TZ4 C;  2HR9 A;  3E0M A;  3P3K A;  5F9F A;  4V2Y A;  5F9H A;  4BPB A;  1TXJ A;  3OG8 A;  2W4R A;  2RQA A;  3CEZ A;  3GA3 A;  3HCI A;  2LOY A;  2LVL A;  4TZU A;  3LRR A;  3WX2 A;  3WX1 A;  2YKG A;  3EQT A;  2KWB A;  5F98 A;  1HXR A;  2FU5 A;  3NCU A; 
#chains in the Genus database with same CATH homology
 1FWQ A;  2RQB A;  3EBM A;  3ZD7 A;  2RMJ A;  2QFB A;  3ZD6 A;  5E3H A;  4A2V A;  4A2X A;  3DJM A;  1H7Y A;  4AY2 A;  1YZ1 A;  3LRN A;  1H6Q A;  2QFD A;  3FAC A;  2HR9 A;  3P3K A;  5F9F A;  5F9H A;  4BPB A;  1TXJ A;  3OG8 A;  2W4R A;  2RQA A;  3GA3 A;  2LOY A;  2LVL A;  3LRR A;  2YKG A;  3EQT A;  2KWB A;  5F98 A;  1HXR A;  2FU5 A;  3NCU A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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2RQBA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations