4V30A

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with lenalidomide
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
molecule keywords CEREBLON ISOFORM 4
total genus 22
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v30A00
2KV1A 3HCGA 1L1DA 3HCHA 2K8DA 2KZNA 4V2ZA 5AMHA 3MAOA 4TZ4C 4CI1B 3WX1A 3HCIA 3E0OA 4CI2B 4CI3B 4TZUA 4V30A 3WX2A 4TZCA 3CXKA 4V31A 3CEZA 3HCJA 3E0MA 4V2YA
chains in the Genus database with same CATH superfamily
2KV1A 3HCGA 2LOYA 3P3KA 2RQAA 3EBMA 1TXJA 1L1DA 2HR9A 3DJMA 4A2VA 3HCHA 2LVLA 2RQBA 2QFBA 2K8DA 2KZNA 3OG8A 4V2ZA 5F98A 5AMHA 3MAOA 4AY2A 2KWBA 3FACA 3EQTA 2FU5A 2W4RA 4TZ4C 4CI1B 3WX1A 3GA3A 3HCIA 5F9FA 1FWQA 3E0OA 4CI2B 3LRNA 3LRRA 3ZD6A 3NCUA 4CI3B 2YKGA 5F9HA 4TZUA 4V30A 2RMJA 3WX2A 4TZCA 4BPBA 1HXRA 2QFDA 1H7YA 1YZ1A 3ZD7A 3CXKA 4V31A 3CEZA 4A2XA 1H6QA 5E3HA 3HCJA 3E0MA 4V2YA
chains in the Genus database with same CATH topology
2KV1A 3HCGA 1L1DA 3HCHA 2K8DA 2KZNA 4V2ZA 5AMHA 3MAOA 4TZ4C 4CI1B 3WX1A 3HCIA 3E0OA 4CI2B 4CI3B 4TZUA 4V30A 3WX2A 4TZCA 3CXKA 4V31A 3CEZA 3HCJA 3E0MA 4V2YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KV1 A;  3HCG A;  1L1D A;  3HCH A;  2K8D A;  2KZN A;  4V2Z A;  5AMH A;  3MAO A;  4TZ4 C;  4CI1 B;  3WX1 A;  3HCI A;  3E0O A;  4CI2 B;  4CI3 B;  4TZU A;  4V30 A;  3WX2 A;  4TZC A;  3CXK A;  4V31 A;  3CEZ A;  3HCJ A;  3E0M A;  4V2Y A; 
#chains in the Genus database with same CATH topology
 2KV1 A;  3HCG A;  2LOY A;  3P3K A;  2RQA A;  3EBM A;  1TXJ A;  1L1D A;  2HR9 A;  3DJM A;  4A2V A;  3HCH A;  2LVL A;  2RQB A;  2QFB A;  2K8D A;  2KZN A;  3OG8 A;  4V2Z A;  5F98 A;  5AMH A;  3MAO A;  4AY2 A;  2KWB A;  3FAC A;  3EQT A;  2FU5 A;  2W4R A;  4TZ4 C;  4CI1 B;  3WX1 A;  3GA3 A;  3HCI A;  5F9F A;  1FWQ A;  3E0O A;  4CI2 B;  3LRN A;  3LRR A;  3ZD6 A;  3NCU A;  4CI3 B;  2YKG A;  5F9H A;  4TZU A;  4V30 A;  2RMJ A;  3WX2 A;  4TZC A;  4BPB A;  1HXR A;  2QFD A;  1H7Y A;  1YZ1 A;  3ZD7 A;  3CXK A;  4V31 A;  3CEZ A;  4A2X A;  1H6Q A;  5E3H A;  3HCJ A;  3E0M A;  4V2Y A; 
#chains in the Genus database with same CATH homology
 2KV1 A;  3HCG A;  1L1D A;  3HCH A;  2K8D A;  2KZN A;  4V2Z A;  5AMH A;  3MAO A;  4TZ4 C;  4CI1 B;  3WX1 A;  3HCI A;  3E0O A;  4CI2 B;  4CI3 B;  4TZU A;  4V30 A;  3WX2 A;  4TZC A;  3CXK A;  4V31 A;  3CEZ A;  3HCJ A;  3E0M A;  4V2Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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