4V30A

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with lenalidomide
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords CEREBLON ISOFORM 4
publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
source organism Magnetospirillum gryphiswaldense
total genus 22
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v30A00
4TZUA 4CI3B 3E0MA 3MAOA 4V31A 3HCIA 2KZNA 3HCGA 2K8DA 4V2ZA 5AMHA 3CXKA 4TZ4C 4TZCA 3E0OA 3WX2A 1L1DA 3WX1A 4V30A 4CI1B 2KV1A 4CI2B 3HCHA 4V2YA 3CEZA 3HCJA
chains in the Genus database with same CATH superfamily
1TXJA 4TZUA 2QFBA 3NCUA 4CI3B 4A2XA 3E0MA 3MAOA 3OG8A 2RQBA 2KWBA 4V31A 3GA3A 3EQTA 5F9HA 4BPBA 5F9FA 3HCIA 2LOYA 3DJMA 5F98A 2KZNA 3HCGA 2FU5A 3EBMA 1HXRA 2QFDA 3ZD6A 2K8DA 4V2ZA 2W4RA 1YZ1A 5AMHA 2YKGA 3CXKA 4TZ4C 4A2VA 4AY2A 3ZD7A 1FWQA 2LVLA 4TZCA 3E0OA 3WX2A 2RQAA 1L1DA 3WX1A 5E3HA 3FACA 3LRNA 4V30A 4CI1B 3LRRA 1H7YA 2KV1A 2RMJA 3P3KA 4CI2B 3CEZA 3HCHA 4V2YA 1H6QA 3HCJA 2HR9A
chains in the Genus database with same CATH topology
4TZUA 4CI3B 3E0MA 3MAOA 4V31A 3HCIA 2KZNA 3HCGA 2K8DA 4V2ZA 5AMHA 3CXKA 4TZ4C 4TZCA 3E0OA 3WX2A 1L1DA 3WX1A 4V30A 4CI1B 2KV1A 4CI2B 3HCHA 4V2YA 3CEZA 3HCJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZU A;  4CI3 B;  3E0M A;  3MAO A;  4V31 A;  3HCI A;  2KZN A;  3HCG A;  2K8D A;  4V2Z A;  5AMH A;  3CXK A;  4TZ4 C;  4TZC A;  3E0O A;  3WX2 A;  1L1D A;  3WX1 A;  4V30 A;  4CI1 B;  2KV1 A;  4CI2 B;  3HCH A;  4V2Y A;  3CEZ A;  3HCJ A; 
#chains in the Genus database with same CATH topology
 1TXJ A;  4TZU A;  2QFB A;  3NCU A;  4CI3 B;  4A2X A;  3E0M A;  3MAO A;  3OG8 A;  2RQB A;  2KWB A;  4V31 A;  3GA3 A;  3EQT A;  5F9H A;  4BPB A;  5F9F A;  3HCI A;  2LOY A;  3DJM A;  5F98 A;  2KZN A;  3HCG A;  2FU5 A;  3EBM A;  1HXR A;  2QFD A;  3ZD6 A;  2K8D A;  4V2Z A;  2W4R A;  1YZ1 A;  5AMH A;  2YKG A;  3CXK A;  4TZ4 C;  4A2V A;  4AY2 A;  3ZD7 A;  1FWQ A;  2LVL A;  4TZC A;  3E0O A;  3WX2 A;  2RQA A;  1L1D A;  3WX1 A;  5E3H A;  3FAC A;  3LRN A;  4V30 A;  4CI1 B;  3LRR A;  1H7Y A;  2KV1 A;  2RMJ A;  3P3K A;  4CI2 B;  3CEZ A;  3HCH A;  4V2Y A;  1H6Q A;  3HCJ A;  2HR9 A; 
#chains in the Genus database with same CATH homology
 4TZU A;  4CI3 B;  3E0M A;  3MAO A;  4V31 A;  3HCI A;  2KZN A;  3HCG A;  2K8D A;  4V2Z A;  5AMH A;  3CXK A;  4TZ4 C;  4TZC A;  3E0O A;  3WX2 A;  1L1D A;  3WX1 A;  4V30 A;  4CI1 B;  2KV1 A;  4CI2 B;  3HCH A;  4V2Y A;  3CEZ A;  3HCJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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