5AMHA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, trigonal crystal form
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
106
structure length
106
Chain Sequence
GASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords CEREBLON ISOFORM 4
publication title Structural Dynamics of the Cereblon Ligand Binding Domain.
pubmed doi rcsb
source organism Magnetospirillum gryphiswaldense
total genus 21
structure length 106
sequence length 106
ec nomenclature
pdb deposition date 2015-03-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 5amhA00
3MAOA 2KV1A 1L1DA 3HCHA 4CI1B 4V2ZA 3HCIA 4CI3B 4TZUA 3CXKA 4TZCA 3CEZA 4V31A 3WX1A 3WX2A 4V30A 4TZ4C 2K8DA 4CI2B 3E0OA 3E0MA 4V2YA 3HCGA 2KZNA 3HCJA 5AMHA
chains in the Genus database with same CATH superfamily
3MAOA 2FU5A 1L1DA 2KV1A 3HCHA 4CI1B 2LVLA 4V2ZA 3HCIA 3GA3A 2QFDA 4CI3B 4A2XA 4TZUA 2RQAA 3CXKA 2RQBA 5F9HA 4TZCA 3CEZA 3DJMA 4V31A 4AY2A 1TXJA 3ZD6A 5F9FA 3EQTA 3LRRA 3LRNA 3WX1A 3P3KA 1HXRA 3WX2A 1YZ1A 4V30A 3ZD7A 5F98A 2RMJA 3FACA 4A2VA 4TZ4C 3OG8A 2K8DA 3EBMA 4CI2B 2HR9A 1H7YA 2LOYA 3E0OA 5E3HA 2QFBA 3E0MA 4V2YA 2YKGA 1H6QA 2W4RA 1FWQA 3HCGA 4BPBA 3NCUA 2KZNA 2KWBA 3HCJA 5AMHA
chains in the Genus database with same CATH topology
3MAOA 2KV1A 1L1DA 3HCHA 4CI1B 4V2ZA 3HCIA 4CI3B 4TZUA 3CXKA 4TZCA 3CEZA 4V31A 3WX1A 3WX2A 4V30A 4TZ4C 2K8DA 4CI2B 3E0OA 3E0MA 4V2YA 3HCGA 2KZNA 3HCJA 5AMHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MAO A;  2KV1 A;  1L1D A;  3HCH A;  4CI1 B;  4V2Z A;  3HCI A;  4CI3 B;  4TZU A;  3CXK A;  4TZC A;  3CEZ A;  4V31 A;  3WX1 A;  3WX2 A;  4V30 A;  4TZ4 C;  2K8D A;  4CI2 B;  3E0O A;  3E0M A;  4V2Y A;  3HCG A;  2KZN A;  3HCJ A;  5AMH A; 
#chains in the Genus database with same CATH topology
 3MAO A;  2FU5 A;  1L1D A;  2KV1 A;  3HCH A;  4CI1 B;  2LVL A;  4V2Z A;  3HCI A;  3GA3 A;  2QFD A;  4CI3 B;  4A2X A;  4TZU A;  2RQA A;  3CXK A;  2RQB A;  5F9H A;  4TZC A;  3CEZ A;  3DJM A;  4V31 A;  4AY2 A;  1TXJ A;  3ZD6 A;  5F9F A;  3EQT A;  3LRR A;  3LRN A;  3WX1 A;  3P3K A;  1HXR A;  3WX2 A;  1YZ1 A;  4V30 A;  3ZD7 A;  5F98 A;  2RMJ A;  3FAC A;  4A2V A;  4TZ4 C;  3OG8 A;  2K8D A;  3EBM A;  4CI2 B;  2HR9 A;  1H7Y A;  2LOY A;  3E0O A;  5E3H A;  2QFB A;  3E0M A;  4V2Y A;  2YKG A;  1H6Q A;  2W4R A;  1FWQ A;  3HCG A;  4BPB A;  3NCU A;  2KZN A;  2KWB A;  3HCJ A;  5AMH A; 
#chains in the Genus database with same CATH homology
 3MAO A;  2KV1 A;  1L1D A;  3HCH A;  4CI1 B;  4V2Z A;  3HCI A;  4CI3 B;  4TZU A;  3CXK A;  4TZC A;  3CEZ A;  4V31 A;  3WX1 A;  3WX2 A;  4V30 A;  4TZ4 C;  2K8D A;  4CI2 B;  3E0O A;  3E0M A;  4V2Y A;  3HCG A;  2KZN A;  3HCJ A;  5AMH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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