3CZYA

Crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1h-imidazol-1-yl)ethanone
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
214
structure length
214
Chain Sequence
PQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Heme oxygenase 1
total genus 84
structure length 214
sequence length 214
chains with identical sequence B
ec nomenclature ec 1.14.14.18: Heme oxygenase (biliverdin-producing).
pdb deposition date 2008-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01126 Heme_oxygenase Heme oxygenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.910.10 Mainly Alpha Up-down Bundle Heme Oxygenase; Chain A Heme oxygenase-like 3czyA00
2A2OA 1WOWA 3DDEA 3MOOA 2RD3A 1P3UA 1TO9A 1Z72A 1IX4A 2E7EA 1J02A 2DY5A 3BJDA 1OYKA 3HOKA 3I8RA 1WZFA 2A6BA 1NI6A 4G8PA 1IRMA 3HLXA 4LQXA 1WNWA 3TGMA 4MECA 1N3UA 1IW1A 1XK1A 1TWRA 4GPFA 1UDDA 1TO9B 1S13A 1WOVA 1DVGA 1TWNA 2Z68A 1WZDA 2F2GA 2RGZA 3HMLA 3I9UA 1YAKA 1OZLA 1J77A 3HNHA 1ULXA 2Q4XA 2ZVUA 2GM8A 1UBBA 1OTVA 4NY7A 1SK7A 4GPCA 1WNVA 4RAJA 1IW0A 1V8XA 1XK0A 4WMHA 3IBXA 2QCXA 3OQLA 4WWZA 4G7LA 1RTWA 3K4FA 4G7TA 3B5PA 1DVEA 2QZCA 1IVJA 4FN6A 4WD4A 2Q32A 4G7UA 1YAFA 1VGIA 2A2MA 3I9TA 3MVUA 5BTQA 1XJZA 4G98A 4G7PA 1OYLA 4G8WA 1WZGA 2GM7A 1OZWA 1WNXA 1OTWA 1S8CA 1P3VA 1WOXA 3B5OA 1WWMA 2QPPA 4G8UA 4G99A 4GOHA 1T5PA 3RM5A 1WE1A 4WX0A 1J2CA 1OZEA 3NO6A 1XK3A 1RCWA 1N45A 1XK2A 4WWJA 1OZRA 1TYHA 1IX3A 4GPHA 3CZYA 1P3TA
chains in the Genus database with same CATH superfamily
2A2OA 1WOWA 3DDEA 2LCUA 3MOOA 2RD3A 1P3UA 1TO9A 1Z72A 1IX4A 2E7EA 1J02A 2DY5A 3BJDA 1OYKA 3HOKA 3I8RA 1WZFA 2A6BA 1NI6A 4G8PA 1IRMA 3HLXA 4LQXA 1WNWA 3TGMA 4MECA 1N3UA 1IW1A 1XK1A 1TWRA 4GPFA 1UDDA 1TO9B 1S13A 1WOVA 1DVGA 1TWNA 2Z68A 1WZDA 2F2GA 2RGZA 3HMLA 3I9UA 1YAKA 1OZLA 1J77A 3HNHA 1ULXA 2Q4XA 2GM8A 1UBBA 1OTVA 2ZVUA 4NY7A 1SK7A 4GPCA 1WNVA 4RAJA 1IW0A 1V8XA 1XK0A 4WMHA 3IBXA 2QCXA 3OQLA 4WWZA 4G7LA 1RTWA 3K4FA 4G7TA 3B5PA 1DVEA 2QZCA 1IVJA 4FN6A 4WD4A 2Q32A 4G7UA 1YAFA 1VGIA 2A2MA 3I9TA 3MVUA 5BTQA 1XJZA 4G98A 4G7PA 1OYLA 4G8WA 1WZGA 2GM7A 1OZWA 1WNXA 1OTWA 1S8CA 1P3VA 1WOXA 3B5OA 1WWMA 2QPPA 4G8UA 4G99A 4GOHA 1T5PA 3RM5A 1WE1A 4WX0A 1J2CA 1OZEA 3NO6A 1XK3A 1RCWA 1N45A 1XK2A 4WWJA 1OZRA 1TYHA 1IX3A 4GPHA 3CZYA 1P3TA
chains in the Genus database with same CATH topology
2A2OA 1WOWA 3DDEA 3MOOA 2RD3A 1P3UA 1TO9A 1Z72A 1IX4A 2E7EA 1J02A 2DY5A 3BJDA 1OYKA 3HOKA 3I8RA 1WZFA 2A6BA 1NI6A 4G8PA 1IRMA 3HLXA 4LQXA 1WNWA 3TGMA 4MECA 1N3UA 1IW1A 1XK1A 1TWRA 4GPFA 1UDDA 1TO9B 1S13A 1WOVA 1DVGA 1TWNA 2Z68A 1WZDA 2F2GA 2RGZA 3HMLA 3I9UA 1YAKA 1OZLA 1J77A 3HNHA 1ULXA 2Q4XA 2ZVUA 2GM8A 1UBBA 1OTVA 4NY7A 1SK7A 4GPCA 1WNVA 4RAJA 1IW0A 1V8XA 1XK0A 4WMHA 3IBXA 2QCXA 3OQLA 4WWZA 4G7LA 1RTWA 3K4FA 4G7TA 3B5PA 1DVEA 2QZCA 1IVJA 4FN6A 4WD4A 2Q32A 4G7UA 1YAFA 1VGIA 2A2MA 3I9TA 3MVUA 5BTQA 1XJZA 4G98A 4G7PA 1OYLA 4G8WA 1WZGA 2GM7A 1OZWA 1WNXA 1OTWA 1S8CA 1P3VA 1WOXA 3B5OA 1WWMA 2QPPA 4G8UA 4G99A 4GOHA 1T5PA 3RM5A 1WE1A 4WX0A 1J2CA 1OZEA 3NO6A 1XK3A 1RCWA 1N45A 1XK2A 4WWJA 1OZRA 1TYHA 1IX3A 4GPHA 3CZYA 1P3TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A2O A;  1WOW A;  3DDE A;  3MOO A;  2RD3 A;  1P3U A;  1TO9 A;  1Z72 A;  1IX4 A;  2E7E A;  1J02 A;  2DY5 A;  3BJD A;  1OYK A;  3HOK A;  3I8R A;  1WZF A;  2A6B A;  1NI6 A;  4G8P A;  1IRM A;  3HLX A;  4LQX A;  1WNW A;  3TGM A;  4MEC A;  1N3U A;  1IW1 A;  1XK1 A;  1TWR A;  4GPF A;  1UDD A;  1TO9 B;  1S13 A;  1WOV A;  1DVG A;  1TWN A;  2Z68 A;  1WZD A;  2F2G A;  2RGZ A;  3HML A;  3I9U A;  1YAK A;  1OZL A;  1J77 A;  3HNH A;  1ULX A;  2Q4X A;  2ZVU A;  2GM8 A;  1UBB A;  1OTV A;  4NY7 A;  1SK7 A;  4GPC A;  1WNV A;  4RAJ A;  1IW0 A;  1V8X A;  1XK0 A;  4WMH A;  3IBX A;  2QCX A;  3OQL A;  4WWZ A;  4G7L A;  1RTW A;  3K4F A;  4G7T A;  3B5P A;  1DVE A;  2QZC A;  1IVJ A;  4FN6 A;  4WD4 A;  2Q32 A;  4G7U A;  1YAF A;  1VGI A;  2A2M A;  3I9T A;  3MVU A;  5BTQ A;  1XJZ A;  4G98 A;  4G7P A;  1OYL A;  4G8W A;  1WZG A;  2GM7 A;  1OZW A;  1WNX A;  1OTW A;  1S8C A;  1P3V A;  1WOX A;  3B5O A;  1WWM A;  2QPP A;  4G8U A;  4G99 A;  4GOH A;  1T5P A;  3RM5 A;  1WE1 A;  4WX0 A;  1J2C A;  1OZE A;  3NO6 A;  1XK3 A;  1RCW A;  1N45 A;  1XK2 A;  4WWJ A;  1OZR A;  1TYH A;  1IX3 A;  4GPH A;  3CZY A;  1P3T A; 
#chains in the Genus database with same CATH topology
 2A2O A;  1WOW A;  3DDE A;  2LCU A;  3MOO A;  2RD3 A;  1P3U A;  1TO9 A;  1Z72 A;  1IX4 A;  2E7E A;  1J02 A;  2DY5 A;  3BJD A;  1OYK A;  3HOK A;  3I8R A;  1WZF A;  2A6B A;  1NI6 A;  4G8P A;  1IRM A;  3HLX A;  4LQX A;  1WNW A;  3TGM A;  4MEC A;  1N3U A;  1IW1 A;  1XK1 A;  1TWR A;  4GPF A;  1UDD A;  1TO9 B;  1S13 A;  1WOV A;  1DVG A;  1TWN A;  2Z68 A;  1WZD A;  2F2G A;  2RGZ A;  3HML A;  3I9U A;  1YAK A;  1OZL A;  1J77 A;  3HNH A;  1ULX A;  2Q4X A;  2GM8 A;  1UBB A;  1OTV A;  2ZVU A;  4NY7 A;  1SK7 A;  4GPC A;  1WNV A;  4RAJ A;  1IW0 A;  1V8X A;  1XK0 A;  4WMH A;  3IBX A;  2QCX A;  3OQL A;  4WWZ A;  4G7L A;  1RTW A;  3K4F A;  4G7T A;  3B5P A;  1DVE A;  2QZC A;  1IVJ A;  4FN6 A;  4WD4 A;  2Q32 A;  4G7U A;  1YAF A;  1VGI A;  2A2M A;  3I9T A;  3MVU A;  5BTQ A;  1XJZ A;  4G98 A;  4G7P A;  1OYL A;  4G8W A;  1WZG A;  2GM7 A;  1OZW A;  1WNX A;  1OTW A;  1S8C A;  1P3V A;  1WOX A;  3B5O A;  1WWM A;  2QPP A;  4G8U A;  4G99 A;  4GOH A;  1T5P A;  3RM5 A;  1WE1 A;  4WX0 A;  1J2C A;  1OZE A;  3NO6 A;  1XK3 A;  1RCW A;  1N45 A;  1XK2 A;  4WWJ A;  1OZR A;  1TYH A;  1IX3 A;  4GPH A;  3CZY A;  1P3T A; 
#chains in the Genus database with same CATH homology
 2A2O A;  1WOW A;  3DDE A;  3MOO A;  2RD3 A;  1P3U A;  1TO9 A;  1Z72 A;  1IX4 A;  2E7E A;  1J02 A;  2DY5 A;  3BJD A;  1OYK A;  3HOK A;  3I8R A;  1WZF A;  2A6B A;  1NI6 A;  4G8P A;  1IRM A;  3HLX A;  4LQX A;  1WNW A;  3TGM A;  4MEC A;  1N3U A;  1IW1 A;  1XK1 A;  1TWR A;  4GPF A;  1UDD A;  1TO9 B;  1S13 A;  1WOV A;  1DVG A;  1TWN A;  2Z68 A;  1WZD A;  2F2G A;  2RGZ A;  3HML A;  3I9U A;  1YAK A;  1OZL A;  1J77 A;  3HNH A;  1ULX A;  2Q4X A;  2ZVU A;  2GM8 A;  1UBB A;  1OTV A;  4NY7 A;  1SK7 A;  4GPC A;  1WNV A;  4RAJ A;  1IW0 A;  1V8X A;  1XK0 A;  4WMH A;  3IBX A;  2QCX A;  3OQL A;  4WWZ A;  4G7L A;  1RTW A;  3K4F A;  4G7T A;  3B5P A;  1DVE A;  2QZC A;  1IVJ A;  4FN6 A;  4WD4 A;  2Q32 A;  4G7U A;  1YAF A;  1VGI A;  2A2M A;  3I9T A;  3MVU A;  5BTQ A;  1XJZ A;  4G98 A;  4G7P A;  1OYL A;  4G8W A;  1WZG A;  2GM7 A;  1OZW A;  1WNX A;  1OTW A;  1S8C A;  1P3V A;  1WOX A;  3B5O A;  1WWM A;  2QPP A;  4G8U A;  4G99 A;  4GOH A;  1T5P A;  3RM5 A;  1WE1 A;  4WX0 A;  1J2C A;  1OZE A;  3NO6 A;  1XK3 A;  1RCW A;  1N45 A;  1XK2 A;  4WWJ A;  1OZR A;  1TYH A;  1IX3 A;  4GPH A;  3CZY A;  1P3T A; 
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