3HOKA

X-ray crystal structure of human heme oxygenase-1 with (2r, 4s)-2-[2-(4-chlorophenyl)ethyl]-2-[(1h-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
214
structure length
214
Chain Sequence
PQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Heme oxygenase 1
total genus 76
structure length 214
sequence length 214
chains with identical sequence B
ec nomenclature ec 1.14.14.18: Heme oxygenase (biliverdin-producing).
pdb deposition date 2009-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01126 Heme_oxygenase Heme oxygenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.910.10 Mainly Alpha Up-down Bundle Heme Oxygenase; Chain A Heme oxygenase-like 3hokA00
3RM5A 3B5PA 1OYLA 4RAJA 1OTWA 4G99A 1DVGA 1V8XA 2F2GA 1P3TA 1NI6A 1OZLA 1IW0A 1SK7A 3MVUA 1IVJA 3DDEA 3K4FA 1WE1A 1ULXA 3MOOA 1WOXA 1WNXA 3I8RA 2A2OA 1TYHA 2DY5A 4G98A 2Q32A 2GM8A 4G8PA 2A6BA 4GOHA 4WWZA 1J77A 3I9TA 1J02A 1TO9B 1OZWA 1WZGA 1WOWA 1UBBA 1S13A 1IRMA 1IW1A 1OZRA 2E7EA 4WX0A 1OTVA 1OYKA 4G7TA 4FN6A 3OQLA 1WWMA 4GPHA 1P3VA 2QCXA 3IBXA 4GPCA 4G8WA 1OZEA 3I9UA 1WNWA 3HOKA 2RGZA 3NO6A 3BJDA 2Z68A 3HMLA 4LQXA 1VGIA 1IX4A 1Z72A 3TGMA 1P3UA 5BTQA 1XK3A 1UDDA 3CZYA 4NY7A 4WMHA 2RD3A 3HLXA 4G7PA 3B5OA 1WZDA 1YAKA 1IX3A 1N45A 2A2MA 4G7UA 1RCWA 2QPPA 1RTWA 1WNVA 4WD4A 4MECA 1T5PA 4G7LA 1TO9A 1S8CA 1XK0A 3HNHA 1XJZA 1TWNA 1YAFA 1TWRA 1N3UA 1WOVA 1XK1A 1DVEA 1XK2A 2GM7A 4GPFA 2ZVUA 1WZFA 2QZCA 1J2CA 2Q4XA 4WWJA 4G8UA
chains in the Genus database with same CATH superfamily
3RM5A 3B5PA 1OYLA 4RAJA 1OTWA 4G99A 1DVGA 1V8XA 2F2GA 1P3TA 1NI6A 1OZLA 1IW0A 1SK7A 3MVUA 1IVJA 3DDEA 3K4FA 1WE1A 1ULXA 3MOOA 1WOXA 1WNXA 3I8RA 2A2OA 1TYHA 2DY5A 4G98A 2Q32A 2GM8A 4G8PA 2A6BA 4GOHA 4WWZA 1J77A 3I9TA 1J02A 1TO9B 1OZWA 1WZGA 1WOWA 1UBBA 1S13A 1IRMA 1IW1A 1OZRA 2E7EA 4WX0A 1OTVA 1OYKA 4G7TA 4FN6A 3OQLA 1WWMA 2LCUA 4GPHA 1P3VA 2QCXA 3IBXA 4GPCA 4G8WA 1OZEA 3I9UA 1WNWA 3HOKA 2RGZA 3NO6A 3BJDA 2Z68A 3HMLA 4LQXA 1VGIA 1IX4A 1Z72A 3TGMA 1P3UA 5BTQA 1XK3A 1UDDA 3CZYA 4NY7A 4WMHA 2RD3A 3HLXA 4G7PA 3B5OA 1WZDA 1YAKA 1IX3A 1N45A 2A2MA 4G7UA 1RCWA 2QPPA 1RTWA 1WNVA 4WD4A 4MECA 1T5PA 4G7LA 1TO9A 1S8CA 1XK0A 3HNHA 1XJZA 1TWNA 1YAFA 1TWRA 1N3UA 1WOVA 1XK1A 1DVEA 1XK2A 2GM7A 4GPFA 2ZVUA 1WZFA 2QZCA 1J2CA 2Q4XA 4WWJA 4G8UA
chains in the Genus database with same CATH topology
3RM5A 3B5PA 1OYLA 4RAJA 1OTWA 4G99A 1DVGA 1V8XA 2F2GA 1P3TA 1NI6A 1OZLA 1IW0A 1SK7A 3MVUA 1IVJA 3DDEA 3K4FA 1WE1A 1ULXA 3MOOA 1WOXA 1WNXA 3I8RA 2A2OA 1TYHA 2DY5A 4G98A 2Q32A 2GM8A 4G8PA 2A6BA 4GOHA 4WWZA 1J77A 3I9TA 1J02A 1TO9B 1OZWA 1WZGA 1WOWA 1UBBA 1S13A 1IRMA 1IW1A 1OZRA 2E7EA 4WX0A 1OTVA 1OYKA 4G7TA 4FN6A 3OQLA 1WWMA 4GPHA 1P3VA 2QCXA 3IBXA 4GPCA 4G8WA 1OZEA 3I9UA 1WNWA 3HOKA 2RGZA 3NO6A 3BJDA 2Z68A 3HMLA 4LQXA 1VGIA 1IX4A 1Z72A 3TGMA 1P3UA 5BTQA 1XK3A 1UDDA 3CZYA 4NY7A 4WMHA 2RD3A 3HLXA 4G7PA 3B5OA 1WZDA 1YAKA 1IX3A 1N45A 2A2MA 4G7UA 1RCWA 2QPPA 1RTWA 1WNVA 4WD4A 4MECA 1T5PA 4G7LA 1TO9A 1S8CA 1XK0A 3HNHA 1XJZA 1TWNA 1YAFA 1TWRA 1N3UA 1WOVA 1XK1A 1DVEA 1XK2A 2GM7A 4GPFA 2ZVUA 1WZFA 2QZCA 1J2CA 2Q4XA 4WWJA 4G8UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RM5 A;  3B5P A;  1OYL A;  4RAJ A;  1OTW A;  4G99 A;  1DVG A;  1V8X A;  2F2G A;  1P3T A;  1NI6 A;  1OZL A;  1IW0 A;  1SK7 A;  3MVU A;  1IVJ A;  3DDE A;  3K4F A;  1WE1 A;  1ULX A;  3MOO A;  1WOX A;  1WNX A;  3I8R A;  2A2O A;  1TYH A;  2DY5 A;  4G98 A;  2Q32 A;  2GM8 A;  4G8P A;  2A6B A;  4GOH A;  4WWZ A;  1J77 A;  3I9T A;  1J02 A;  1TO9 B;  1OZW A;  1WZG A;  1WOW A;  1UBB A;  1S13 A;  1IRM A;  1IW1 A;  1OZR A;  2E7E A;  4WX0 A;  1OTV A;  1OYK A;  4G7T A;  4FN6 A;  3OQL A;  1WWM A;  4GPH A;  1P3V A;  2QCX A;  3IBX A;  4GPC A;  4G8W A;  1OZE A;  3I9U A;  1WNW A;  3HOK A;  2RGZ A;  3NO6 A;  3BJD A;  2Z68 A;  3HML A;  4LQX A;  1VGI A;  1IX4 A;  1Z72 A;  3TGM A;  1P3U A;  5BTQ A;  1XK3 A;  1UDD A;  3CZY A;  4NY7 A;  4WMH A;  2RD3 A;  3HLX A;  4G7P A;  3B5O A;  1WZD A;  1YAK A;  1IX3 A;  1N45 A;  2A2M A;  4G7U A;  1RCW A;  2QPP A;  1RTW A;  1WNV A;  4WD4 A;  4MEC A;  1T5P A;  4G7L A;  1TO9 A;  1S8C A;  1XK0 A;  3HNH A;  1XJZ A;  1TWN A;  1YAF A;  1TWR A;  1N3U A;  1WOV A;  1XK1 A;  1DVE A;  1XK2 A;  2GM7 A;  4GPF A;  2ZVU A;  1WZF A;  2QZC A;  1J2C A;  2Q4X A;  4WWJ A;  4G8U A; 
#chains in the Genus database with same CATH topology
 3RM5 A;  3B5P A;  1OYL A;  4RAJ A;  1OTW A;  4G99 A;  1DVG A;  1V8X A;  2F2G A;  1P3T A;  1NI6 A;  1OZL A;  1IW0 A;  1SK7 A;  3MVU A;  1IVJ A;  3DDE A;  3K4F A;  1WE1 A;  1ULX A;  3MOO A;  1WOX A;  1WNX A;  3I8R A;  2A2O A;  1TYH A;  2DY5 A;  4G98 A;  2Q32 A;  2GM8 A;  4G8P A;  2A6B A;  4GOH A;  4WWZ A;  1J77 A;  3I9T A;  1J02 A;  1TO9 B;  1OZW A;  1WZG A;  1WOW A;  1UBB A;  1S13 A;  1IRM A;  1IW1 A;  1OZR A;  2E7E A;  4WX0 A;  1OTV A;  1OYK A;  4G7T A;  4FN6 A;  3OQL A;  1WWM A;  2LCU A;  4GPH A;  1P3V A;  2QCX A;  3IBX A;  4GPC A;  4G8W A;  1OZE A;  3I9U A;  1WNW A;  3HOK A;  2RGZ A;  3NO6 A;  3BJD A;  2Z68 A;  3HML A;  4LQX A;  1VGI A;  1IX4 A;  1Z72 A;  3TGM A;  1P3U A;  5BTQ A;  1XK3 A;  1UDD A;  3CZY A;  4NY7 A;  4WMH A;  2RD3 A;  3HLX A;  4G7P A;  3B5O A;  1WZD A;  1YAK A;  1IX3 A;  1N45 A;  2A2M A;  4G7U A;  1RCW A;  2QPP A;  1RTW A;  1WNV A;  4WD4 A;  4MEC A;  1T5P A;  4G7L A;  1TO9 A;  1S8C A;  1XK0 A;  3HNH A;  1XJZ A;  1TWN A;  1YAF A;  1TWR A;  1N3U A;  1WOV A;  1XK1 A;  1DVE A;  1XK2 A;  2GM7 A;  4GPF A;  2ZVU A;  1WZF A;  2QZC A;  1J2C A;  2Q4X A;  4WWJ A;  4G8U A; 
#chains in the Genus database with same CATH homology
 3RM5 A;  3B5P A;  1OYL A;  4RAJ A;  1OTW A;  4G99 A;  1DVG A;  1V8X A;  2F2G A;  1P3T A;  1NI6 A;  1OZL A;  1IW0 A;  1SK7 A;  3MVU A;  1IVJ A;  3DDE A;  3K4F A;  1WE1 A;  1ULX A;  3MOO A;  1WOX A;  1WNX A;  3I8R A;  2A2O A;  1TYH A;  2DY5 A;  4G98 A;  2Q32 A;  2GM8 A;  4G8P A;  2A6B A;  4GOH A;  4WWZ A;  1J77 A;  3I9T A;  1J02 A;  1TO9 B;  1OZW A;  1WZG A;  1WOW A;  1UBB A;  1S13 A;  1IRM A;  1IW1 A;  1OZR A;  2E7E A;  4WX0 A;  1OTV A;  1OYK A;  4G7T A;  4FN6 A;  3OQL A;  1WWM A;  4GPH A;  1P3V A;  2QCX A;  3IBX A;  4GPC A;  4G8W A;  1OZE A;  3I9U A;  1WNW A;  3HOK A;  2RGZ A;  3NO6 A;  3BJD A;  2Z68 A;  3HML A;  4LQX A;  1VGI A;  1IX4 A;  1Z72 A;  3TGM A;  1P3U A;  5BTQ A;  1XK3 A;  1UDD A;  3CZY A;  4NY7 A;  4WMH A;  2RD3 A;  3HLX A;  4G7P A;  3B5O A;  1WZD A;  1YAK A;  1IX3 A;  1N45 A;  2A2M A;  4G7U A;  1RCW A;  2QPP A;  1RTW A;  1WNV A;  4WD4 A;  4MEC A;  1T5P A;  4G7L A;  1TO9 A;  1S8C A;  1XK0 A;  3HNH A;  1XJZ A;  1TWN A;  1YAF A;  1TWR A;  1N3U A;  1WOV A;  1XK1 A;  1DVE A;  1XK2 A;  2GM7 A;  4GPF A;  2ZVU A;  1WZF A;  2QZC A;  1J2C A;  2Q4X A;  4WWJ A;  4G8U A; 
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