3HOKA

X-ray crystal structure of human heme oxygenase-1 with (2r, 4s)-2-[2-(4-chlorophenyl)ethyl]-2-[(1h-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
214
structure length
214
Chain Sequence
PQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Heme oxygenase 1
total genus 76
structure length 214
sequence length 214
chains with identical sequence B
ec nomenclature ec 1.14.14.18: Heme oxygenase (biliverdin-producing).
pdb deposition date 2009-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01126 Heme_oxygenase Heme oxygenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.910.10 Mainly Alpha Up-down Bundle Heme Oxygenase; Chain A Heme oxygenase-like 3hokA00
1OZEA 1V8XA 1WOXA 1DVEA 1UBBA 1N3UA 1WWMA 2RGZA 4GOHA 1IW0A 4G98A 1J77A 4G99A 2Q32A 3HMLA 1TO9A 3HLXA 1P3VA 1OZWA 4G8WA 3B5PA 2Z68A 3HNHA 4WWJA 1OTWA 1XJZA 2RD3A 4GPCA 1IX4A 3IBXA 4WD4A 1WNXA 1IX3A 1OYLA 4GPHA 1Z72A 1VGIA 4G7PA 3I8RA 1S8CA 1OZRA 3BJDA 4G8PA 1WE1A 2ZVUA 1J02A 1IVJA 1TO9B 3NO6A 4G7UA 1YAFA 1XK2A 2F2GA 3I9UA 4MECA 3OQLA 4WX0A 3MOOA 1ULXA 3CZYA 1WNVA 1TYHA 4RAJA 1P3UA 1N45A 2GM8A 1OYKA 1WOWA 1P3TA 1YAKA 4WMHA 2QPPA 2A2OA 1S13A 2A6BA 2DY5A 4FN6A 1XK1A 3TGMA 4LQXA 3B5OA 1WNWA 1XK0A 4G7TA 5BTQA 2QCXA 1TWNA 4WWZA 1XK3A 2E7EA 2Q4XA 1T5PA 1WZDA 3HOKA 1IRMA 3MVUA 1SK7A 3K4FA 1TWRA 1OZLA 3DDEA 1OTVA 1RTWA 2A2MA 4NY7A 4GPFA 1WZFA 2QZCA 3I9TA 1WOVA 1IW1A 4G7LA 3RM5A 1WZGA 1NI6A 2GM7A 1J2CA 1UDDA 1RCWA 4G8UA 1DVGA
chains in the Genus database with same CATH superfamily
1OZEA 1V8XA 1WOXA 1DVEA 1UBBA 1N3UA 1WWMA 2RGZA 4GOHA 1IW0A 4G98A 1J77A 4G99A 2Q32A 3HMLA 1TO9A 3HLXA 1P3VA 1OZWA 4G8WA 3B5PA 2Z68A 3HNHA 4WWJA 1OTWA 1XJZA 2RD3A 4GPCA 1IX4A 3IBXA 4WD4A 1WNXA 1IX3A 1OYLA 4GPHA 1Z72A 1VGIA 4G7PA 3I8RA 1S8CA 1OZRA 3BJDA 4G8PA 1WE1A 2ZVUA 2LCUA 1J02A 1IVJA 1TO9B 3NO6A 4G7UA 1YAFA 1XK2A 2F2GA 3I9UA 4MECA 3OQLA 4WX0A 3MOOA 1ULXA 3CZYA 1WNVA 1TYHA 4RAJA 1P3UA 1N45A 2GM8A 1OYKA 1WOWA 1P3TA 1YAKA 4WMHA 2QPPA 2A2OA 1S13A 2A6BA 2DY5A 4FN6A 1XK1A 3TGMA 4LQXA 3B5OA 1WNWA 1XK0A 4G7TA 5BTQA 2QCXA 1TWNA 4WWZA 1XK3A 2E7EA 2Q4XA 1T5PA 1WZDA 3HOKA 1IRMA 3MVUA 1SK7A 3K4FA 1TWRA 1OZLA 3DDEA 1OTVA 1RTWA 2A2MA 4NY7A 4GPFA 1WZFA 2QZCA 3I9TA 1WOVA 1IW1A 4G7LA 3RM5A 1WZGA 1NI6A 2GM7A 1J2CA 1UDDA 1RCWA 4G8UA 1DVGA
chains in the Genus database with same CATH topology
1OZEA 1V8XA 1WOXA 1DVEA 1UBBA 1N3UA 1WWMA 2RGZA 4GOHA 1IW0A 4G98A 1J77A 4G99A 2Q32A 3HMLA 1TO9A 3HLXA 1P3VA 1OZWA 4G8WA 3B5PA 2Z68A 3HNHA 4WWJA 1OTWA 1XJZA 2RD3A 4GPCA 1IX4A 3IBXA 4WD4A 1WNXA 1IX3A 1OYLA 4GPHA 1Z72A 1VGIA 4G7PA 3I8RA 1S8CA 1OZRA 3BJDA 4G8PA 1WE1A 2ZVUA 1J02A 1IVJA 1TO9B 3NO6A 4G7UA 1YAFA 1XK2A 2F2GA 3I9UA 4MECA 3OQLA 4WX0A 3MOOA 1ULXA 3CZYA 1WNVA 1TYHA 4RAJA 1P3UA 1N45A 2GM8A 1OYKA 1WOWA 1P3TA 1YAKA 4WMHA 2QPPA 2A2OA 1S13A 2A6BA 2DY5A 4FN6A 1XK1A 3TGMA 4LQXA 3B5OA 1WNWA 1XK0A 4G7TA 5BTQA 2QCXA 1TWNA 4WWZA 1XK3A 2E7EA 2Q4XA 1T5PA 1WZDA 3HOKA 1IRMA 3MVUA 1SK7A 3K4FA 1TWRA 1OZLA 3DDEA 1OTVA 1RTWA 2A2MA 4NY7A 4GPFA 1WZFA 2QZCA 3I9TA 1WOVA 1IW1A 4G7LA 3RM5A 1WZGA 1NI6A 2GM7A 1J2CA 1UDDA 1RCWA 4G8UA 1DVGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OZE A;  1V8X A;  1WOX A;  1DVE A;  1UBB A;  1N3U A;  1WWM A;  2RGZ A;  4GOH A;  1IW0 A;  4G98 A;  1J77 A;  4G99 A;  2Q32 A;  3HML A;  1TO9 A;  3HLX A;  1P3V A;  1OZW A;  4G8W A;  3B5P A;  2Z68 A;  3HNH A;  4WWJ A;  1OTW A;  1XJZ A;  2RD3 A;  4GPC A;  1IX4 A;  3IBX A;  4WD4 A;  1WNX A;  1IX3 A;  1OYL A;  4GPH A;  1Z72 A;  1VGI A;  4G7P A;  3I8R A;  1S8C A;  1OZR A;  3BJD A;  4G8P A;  1WE1 A;  2ZVU A;  1J02 A;  1IVJ A;  1TO9 B;  3NO6 A;  4G7U A;  1YAF A;  1XK2 A;  2F2G A;  3I9U A;  4MEC A;  3OQL A;  4WX0 A;  3MOO A;  1ULX A;  3CZY A;  1WNV A;  1TYH A;  4RAJ A;  1P3U A;  1N45 A;  2GM8 A;  1OYK A;  1WOW A;  1P3T A;  1YAK A;  4WMH A;  2QPP A;  2A2O A;  1S13 A;  2A6B A;  2DY5 A;  4FN6 A;  1XK1 A;  3TGM A;  4LQX A;  3B5O A;  1WNW A;  1XK0 A;  4G7T A;  5BTQ A;  2QCX A;  1TWN A;  4WWZ A;  1XK3 A;  2E7E A;  2Q4X A;  1T5P A;  1WZD A;  3HOK A;  1IRM A;  3MVU A;  1SK7 A;  3K4F A;  1TWR A;  1OZL A;  3DDE A;  1OTV A;  1RTW A;  2A2M A;  4NY7 A;  4GPF A;  1WZF A;  2QZC A;  3I9T A;  1WOV A;  1IW1 A;  4G7L A;  3RM5 A;  1WZG A;  1NI6 A;  2GM7 A;  1J2C A;  1UDD A;  1RCW A;  4G8U A;  1DVG A; 
#chains in the Genus database with same CATH topology
 1OZE A;  1V8X A;  1WOX A;  1DVE A;  1UBB A;  1N3U A;  1WWM A;  2RGZ A;  4GOH A;  1IW0 A;  4G98 A;  1J77 A;  4G99 A;  2Q32 A;  3HML A;  1TO9 A;  3HLX A;  1P3V A;  1OZW A;  4G8W A;  3B5P A;  2Z68 A;  3HNH A;  4WWJ A;  1OTW A;  1XJZ A;  2RD3 A;  4GPC A;  1IX4 A;  3IBX A;  4WD4 A;  1WNX A;  1IX3 A;  1OYL A;  4GPH A;  1Z72 A;  1VGI A;  4G7P A;  3I8R A;  1S8C A;  1OZR A;  3BJD A;  4G8P A;  1WE1 A;  2ZVU A;  2LCU A;  1J02 A;  1IVJ A;  1TO9 B;  3NO6 A;  4G7U A;  1YAF A;  1XK2 A;  2F2G A;  3I9U A;  4MEC A;  3OQL A;  4WX0 A;  3MOO A;  1ULX A;  3CZY A;  1WNV A;  1TYH A;  4RAJ A;  1P3U A;  1N45 A;  2GM8 A;  1OYK A;  1WOW A;  1P3T A;  1YAK A;  4WMH A;  2QPP A;  2A2O A;  1S13 A;  2A6B A;  2DY5 A;  4FN6 A;  1XK1 A;  3TGM A;  4LQX A;  3B5O A;  1WNW A;  1XK0 A;  4G7T A;  5BTQ A;  2QCX A;  1TWN A;  4WWZ A;  1XK3 A;  2E7E A;  2Q4X A;  1T5P A;  1WZD A;  3HOK A;  1IRM A;  3MVU A;  1SK7 A;  3K4F A;  1TWR A;  1OZL A;  3DDE A;  1OTV A;  1RTW A;  2A2M A;  4NY7 A;  4GPF A;  1WZF A;  2QZC A;  3I9T A;  1WOV A;  1IW1 A;  4G7L A;  3RM5 A;  1WZG A;  1NI6 A;  2GM7 A;  1J2C A;  1UDD A;  1RCW A;  4G8U A;  1DVG A; 
#chains in the Genus database with same CATH homology
 1OZE A;  1V8X A;  1WOX A;  1DVE A;  1UBB A;  1N3U A;  1WWM A;  2RGZ A;  4GOH A;  1IW0 A;  4G98 A;  1J77 A;  4G99 A;  2Q32 A;  3HML A;  1TO9 A;  3HLX A;  1P3V A;  1OZW A;  4G8W A;  3B5P A;  2Z68 A;  3HNH A;  4WWJ A;  1OTW A;  1XJZ A;  2RD3 A;  4GPC A;  1IX4 A;  3IBX A;  4WD4 A;  1WNX A;  1IX3 A;  1OYL A;  4GPH A;  1Z72 A;  1VGI A;  4G7P A;  3I8R A;  1S8C A;  1OZR A;  3BJD A;  4G8P A;  1WE1 A;  2ZVU A;  1J02 A;  1IVJ A;  1TO9 B;  3NO6 A;  4G7U A;  1YAF A;  1XK2 A;  2F2G A;  3I9U A;  4MEC A;  3OQL A;  4WX0 A;  3MOO A;  1ULX A;  3CZY A;  1WNV A;  1TYH A;  4RAJ A;  1P3U A;  1N45 A;  2GM8 A;  1OYK A;  1WOW A;  1P3T A;  1YAK A;  4WMH A;  2QPP A;  2A2O A;  1S13 A;  2A6B A;  2DY5 A;  4FN6 A;  1XK1 A;  3TGM A;  4LQX A;  3B5O A;  1WNW A;  1XK0 A;  4G7T A;  5BTQ A;  2QCX A;  1TWN A;  4WWZ A;  1XK3 A;  2E7E A;  2Q4X A;  1T5P A;  1WZD A;  3HOK A;  1IRM A;  3MVU A;  1SK7 A;  3K4F A;  1TWR A;  1OZL A;  3DDE A;  1OTV A;  1RTW A;  2A2M A;  4NY7 A;  4GPF A;  1WZF A;  2QZC A;  3I9T A;  1WOV A;  1IW1 A;  4G7L A;  3RM5 A;  1WZG A;  1NI6 A;  2GM7 A;  1J2C A;  1UDD A;  1RCW A;  4G8U A;  1DVG A; 
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