3HOKA

X-ray crystal structure of human heme oxygenase-1 with (2r, 4s)-2-[2-(4-chlorophenyl)ethyl]-2-[(1h-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
214
structure length
214
Chain Sequence
PQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Heme oxygenase 1
total genus 76
structure length 214
sequence length 214
chains with identical sequence B
ec nomenclature ec 1.14.14.18: Heme oxygenase (biliverdin-producing).
pdb deposition date 2009-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01126 Heme_oxygenase Heme oxygenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.910.10 Mainly Alpha Up-down Bundle Heme Oxygenase; Chain A Heme oxygenase-like 3hokA00
2Z68A 4G7LA 1RCWA 2A2MA 1OZRA 3OQLA 3HMLA 3TGMA 1WZDA 2QCXA 3RM5A 2QZCA 4G7PA 4G8WA 1Z72A 4G7UA 1WNWA 4WWZA 1OTWA 4GPFA 4RAJA 3I9TA 1P3UA 1YAFA 2DY5A 1IW1A 2F2GA 1P3TA 1XK3A 1TO9B 1XJZA 1IX3A 1RTWA 4WMHA 1UBBA 1WOXA 1N45A 2QPPA 4G7TA 4G98A 1WE1A 3B5PA 1WZGA 3BJDA 1XK0A 1TYHA 1WOWA 3B5OA 4MECA 1UDDA 1WNVA 2Q4XA 3MVUA 1VGIA 5BTQA 1OTVA 3HOKA 3CZYA 1OYLA 1SK7A 2A2OA 3HNHA 1OZEA 4LQXA 1V8XA 1OYKA 2GM8A 2GM7A 2RD3A 3K4FA 4GPCA 1IVJA 1IRMA 1NI6A 1DVGA 4WX0A 1T5PA 1IX4A 1DVEA 1WOVA 4GOHA 3DDEA 1N3UA 1S13A 1WNXA 1S8CA 4G8UA 1IW0A 1P3VA 1TO9A 4G99A 3NO6A 1YAKA 1TWNA 1TWRA 1WWMA 1J77A 2RGZA 1OZWA 3MOOA 3IBXA 4NY7A 4G8PA 1OZLA 1XK1A 3I9UA 2Q32A 3HLXA 4WD4A 4WWJA 4GPHA 1WZFA 1XK2A 4FN6A 1J2CA 3I8RA 2A6BA 1ULXA 1J02A 2E7EA 2ZVUA
chains in the Genus database with same CATH superfamily
2Z68A 4G7LA 1RCWA 2A2MA 1OZRA 3OQLA 3HMLA 3TGMA 1WZDA 2QCXA 3RM5A 2QZCA 4G7PA 4G8WA 1Z72A 4G7UA 1WNWA 4WWZA 1OTWA 4GPFA 4RAJA 3I9TA 1P3UA 1YAFA 2DY5A 1IW1A 2F2GA 1P3TA 1XK3A 1TO9B 1XJZA 2LCUA 1IX3A 1RTWA 4WMHA 1UBBA 1WOXA 1N45A 2QPPA 4G7TA 4G98A 1WE1A 3B5PA 1WZGA 3BJDA 1XK0A 1TYHA 1WOWA 3B5OA 4MECA 1UDDA 1WNVA 2Q4XA 3MVUA 1VGIA 5BTQA 1OTVA 3HOKA 3CZYA 1OYLA 1SK7A 2A2OA 3HNHA 1OZEA 4LQXA 1V8XA 1OYKA 2GM8A 2GM7A 2RD3A 3K4FA 4GPCA 1IVJA 1IRMA 1NI6A 1DVGA 4WX0A 1T5PA 1IX4A 1DVEA 1WOVA 4GOHA 3DDEA 1N3UA 1S13A 1WNXA 1S8CA 4G8UA 1IW0A 1P3VA 1TO9A 4G99A 3NO6A 1YAKA 1TWNA 1TWRA 1WWMA 1J77A 2RGZA 1OZWA 3MOOA 3IBXA 4NY7A 4G8PA 1OZLA 1XK1A 3I9UA 2Q32A 3HLXA 4WD4A 4WWJA 4GPHA 1WZFA 1XK2A 4FN6A 1J2CA 3I8RA 2A6BA 1ULXA 1J02A 2E7EA 2ZVUA
chains in the Genus database with same CATH topology
2Z68A 4G7LA 1RCWA 2A2MA 1OZRA 3OQLA 3HMLA 3TGMA 1WZDA 2QCXA 3RM5A 2QZCA 4G7PA 4G8WA 1Z72A 4G7UA 1WNWA 4WWZA 1OTWA 4GPFA 4RAJA 3I9TA 1P3UA 1YAFA 2DY5A 1IW1A 2F2GA 1P3TA 1XK3A 1TO9B 1XJZA 1IX3A 1RTWA 4WMHA 1UBBA 1WOXA 1N45A 2QPPA 4G7TA 4G98A 1WE1A 3B5PA 1WZGA 3BJDA 1XK0A 1TYHA 1WOWA 3B5OA 4MECA 1UDDA 1WNVA 2Q4XA 3MVUA 1VGIA 5BTQA 1OTVA 3HOKA 3CZYA 1OYLA 1SK7A 2A2OA 3HNHA 1OZEA 4LQXA 1V8XA 1OYKA 2GM8A 2GM7A 2RD3A 3K4FA 4GPCA 1IVJA 1IRMA 1NI6A 1DVGA 4WX0A 1T5PA 1IX4A 1DVEA 1WOVA 4GOHA 3DDEA 1N3UA 1S13A 1WNXA 1S8CA 4G8UA 1IW0A 1P3VA 1TO9A 4G99A 3NO6A 1YAKA 1TWNA 1TWRA 1WWMA 1J77A 2RGZA 1OZWA 3MOOA 3IBXA 4NY7A 4G8PA 1OZLA 1XK1A 3I9UA 2Q32A 3HLXA 4WD4A 4WWJA 4GPHA 1WZFA 1XK2A 4FN6A 1J2CA 3I8RA 2A6BA 1ULXA 1J02A 2E7EA 2ZVUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Z68 A;  4G7L A;  1RCW A;  2A2M A;  1OZR A;  3OQL A;  3HML A;  3TGM A;  1WZD A;  2QCX A;  3RM5 A;  2QZC A;  4G7P A;  4G8W A;  1Z72 A;  4G7U A;  1WNW A;  4WWZ A;  1OTW A;  4GPF A;  4RAJ A;  3I9T A;  1P3U A;  1YAF A;  2DY5 A;  1IW1 A;  2F2G A;  1P3T A;  1XK3 A;  1TO9 B;  1XJZ A;  1IX3 A;  1RTW A;  4WMH A;  1UBB A;  1WOX A;  1N45 A;  2QPP A;  4G7T A;  4G98 A;  1WE1 A;  3B5P A;  1WZG A;  3BJD A;  1XK0 A;  1TYH A;  1WOW A;  3B5O A;  4MEC A;  1UDD A;  1WNV A;  2Q4X A;  3MVU A;  1VGI A;  5BTQ A;  1OTV A;  3HOK A;  3CZY A;  1OYL A;  1SK7 A;  2A2O A;  3HNH A;  1OZE A;  4LQX A;  1V8X A;  1OYK A;  2GM8 A;  2GM7 A;  2RD3 A;  3K4F A;  4GPC A;  1IVJ A;  1IRM A;  1NI6 A;  1DVG A;  4WX0 A;  1T5P A;  1IX4 A;  1DVE A;  1WOV A;  4GOH A;  3DDE A;  1N3U A;  1S13 A;  1WNX A;  1S8C A;  4G8U A;  1IW0 A;  1P3V A;  1TO9 A;  4G99 A;  3NO6 A;  1YAK A;  1TWN A;  1TWR A;  1WWM A;  1J77 A;  2RGZ A;  1OZW A;  3MOO A;  3IBX A;  4NY7 A;  4G8P A;  1OZL A;  1XK1 A;  3I9U A;  2Q32 A;  3HLX A;  4WD4 A;  4WWJ A;  4GPH A;  1WZF A;  1XK2 A;  4FN6 A;  1J2C A;  3I8R A;  2A6B A;  1ULX A;  1J02 A;  2E7E A;  2ZVU A; 
#chains in the Genus database with same CATH topology
 2Z68 A;  4G7L A;  1RCW A;  2A2M A;  1OZR A;  3OQL A;  3HML A;  3TGM A;  1WZD A;  2QCX A;  3RM5 A;  2QZC A;  4G7P A;  4G8W A;  1Z72 A;  4G7U A;  1WNW A;  4WWZ A;  1OTW A;  4GPF A;  4RAJ A;  3I9T A;  1P3U A;  1YAF A;  2DY5 A;  1IW1 A;  2F2G A;  1P3T A;  1XK3 A;  1TO9 B;  1XJZ A;  2LCU A;  1IX3 A;  1RTW A;  4WMH A;  1UBB A;  1WOX A;  1N45 A;  2QPP A;  4G7T A;  4G98 A;  1WE1 A;  3B5P A;  1WZG A;  3BJD A;  1XK0 A;  1TYH A;  1WOW A;  3B5O A;  4MEC A;  1UDD A;  1WNV A;  2Q4X A;  3MVU A;  1VGI A;  5BTQ A;  1OTV A;  3HOK A;  3CZY A;  1OYL A;  1SK7 A;  2A2O A;  3HNH A;  1OZE A;  4LQX A;  1V8X A;  1OYK A;  2GM8 A;  2GM7 A;  2RD3 A;  3K4F A;  4GPC A;  1IVJ A;  1IRM A;  1NI6 A;  1DVG A;  4WX0 A;  1T5P A;  1IX4 A;  1DVE A;  1WOV A;  4GOH A;  3DDE A;  1N3U A;  1S13 A;  1WNX A;  1S8C A;  4G8U A;  1IW0 A;  1P3V A;  1TO9 A;  4G99 A;  3NO6 A;  1YAK A;  1TWN A;  1TWR A;  1WWM A;  1J77 A;  2RGZ A;  1OZW A;  3MOO A;  3IBX A;  4NY7 A;  4G8P A;  1OZL A;  1XK1 A;  3I9U A;  2Q32 A;  3HLX A;  4WD4 A;  4WWJ A;  4GPH A;  1WZF A;  1XK2 A;  4FN6 A;  1J2C A;  3I8R A;  2A6B A;  1ULX A;  1J02 A;  2E7E A;  2ZVU A; 
#chains in the Genus database with same CATH homology
 2Z68 A;  4G7L A;  1RCW A;  2A2M A;  1OZR A;  3OQL A;  3HML A;  3TGM A;  1WZD A;  2QCX A;  3RM5 A;  2QZC A;  4G7P A;  4G8W A;  1Z72 A;  4G7U A;  1WNW A;  4WWZ A;  1OTW A;  4GPF A;  4RAJ A;  3I9T A;  1P3U A;  1YAF A;  2DY5 A;  1IW1 A;  2F2G A;  1P3T A;  1XK3 A;  1TO9 B;  1XJZ A;  1IX3 A;  1RTW A;  4WMH A;  1UBB A;  1WOX A;  1N45 A;  2QPP A;  4G7T A;  4G98 A;  1WE1 A;  3B5P A;  1WZG A;  3BJD A;  1XK0 A;  1TYH A;  1WOW A;  3B5O A;  4MEC A;  1UDD A;  1WNV A;  2Q4X A;  3MVU A;  1VGI A;  5BTQ A;  1OTV A;  3HOK A;  3CZY A;  1OYL A;  1SK7 A;  2A2O A;  3HNH A;  1OZE A;  4LQX A;  1V8X A;  1OYK A;  2GM8 A;  2GM7 A;  2RD3 A;  3K4F A;  4GPC A;  1IVJ A;  1IRM A;  1NI6 A;  1DVG A;  4WX0 A;  1T5P A;  1IX4 A;  1DVE A;  1WOV A;  4GOH A;  3DDE A;  1N3U A;  1S13 A;  1WNX A;  1S8C A;  4G8U A;  1IW0 A;  1P3V A;  1TO9 A;  4G99 A;  3NO6 A;  1YAK A;  1TWN A;  1TWR A;  1WWM A;  1J77 A;  2RGZ A;  1OZW A;  3MOO A;  3IBX A;  4NY7 A;  4G8P A;  1OZL A;  1XK1 A;  3I9U A;  2Q32 A;  3HLX A;  4WD4 A;  4WWJ A;  4GPH A;  1WZF A;  1XK2 A;  4FN6 A;  1J2C A;  3I8R A;  2A6B A;  1ULX A;  1J02 A;  2E7E A;  2ZVU A; 
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