3K4FA

X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1h-1,2,4-triazol-1-yl)-2-butanone
Total Genus 80
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
214
structure length
214
Chain Sequence
PQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Heme Oxygenase Inhibition by 2-Oxy-substituted 1-Azolyl-4-phenylbutanes: Effect of Variation of the Azole Moiety. X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Heme oxygenase 1
total genus 80
structure length 214
sequence length 214
chains with identical sequence B
ec nomenclature ec 1.14.14.18: Heme oxygenase (biliverdin-producing).
pdb deposition date 2009-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01126 Heme_oxygenase Heme oxygenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.910.10 Mainly Alpha Up-down Bundle Heme Oxygenase; Chain A Heme oxygenase-like 3k4fA00
1WZDA 2F2GA 1OZWA 1WE1A 1XK1A 1UDDA 1T5PA 1XK0A 4WMHA 2RD3A 1S13A 1UBBA 4FN6A 4GOHA 1IW1A 3NO6A 1XK3A 4G8WA 1WOXA 3DDEA 1OYLA 1TYHA 1J2CA 1J02A 2QZCA 1S8CA 1SK7A 2A2OA 1N45A 1P3TA 1DVEA 2Q4XA 2Q32A 3HOKA 2QCXA 4MECA 5BTQA 3MOOA 1OTWA 1VGIA 1ULXA 4NY7A 1RCWA 1P3UA 1OYKA 1TO9B 1TWRA 2ZVUA 3I8RA 4G7PA 1OZRA 2GM8A 1IX4A 1WOWA 3I9TA 3HMLA 1IW0A 2A2MA 1RTWA 1OTVA 3OQLA 1OZEA 1WWMA 1WZFA 4GPHA 2GM7A 4G98A 1WNXA 2RGZA 4GPCA 4GPFA 4G99A 3B5PA 1XK2A 1YAFA 3TGMA 1J77A 4WX0A 3B5OA 1DVGA 1XJZA 3HNHA 3CZYA 4RAJA 1YAKA 3IBXA 1NI6A 3RM5A 3K4FA 4G8UA 3I9UA 3MVUA 4G8PA 4G7TA 2A6BA 2E7EA 3BJDA 1WZGA 1TO9A 4G7UA 1OZLA 1N3UA 3HLXA 1TWNA 4LQXA 4WWJA 1IRMA 1Z72A 4WD4A 4WWZA 2Z68A 2QPPA 2DY5A 1WNVA 1IX3A 4G7LA 1P3VA 1V8XA 1WOVA 1WNWA 1IVJA
chains in the Genus database with same CATH superfamily
1WZDA 2F2GA 1OZWA 1WE1A 1XK1A 1UDDA 1T5PA 1XK0A 4WMHA 2RD3A 1S13A 1UBBA 4FN6A 4GOHA 1IW1A 3NO6A 1XK3A 4G8WA 1WOXA 3DDEA 1OYLA 1TYHA 1J2CA 1J02A 2QZCA 1S8CA 1SK7A 2A2OA 1N45A 1P3TA 1DVEA 2Q4XA 2Q32A 3HOKA 2QCXA 4MECA 5BTQA 3MOOA 1OTWA 1VGIA 1ULXA 4NY7A 1RCWA 1P3UA 1OYKA 1TO9B 1TWRA 2ZVUA 3I8RA 4G7PA 1OZRA 2GM8A 1IX4A 1WOWA 3I9TA 3HMLA 1IW0A 2A2MA 1RTWA 1OTVA 3OQLA 1OZEA 1WWMA 1WZFA 4GPHA 2GM7A 4G98A 1WNXA 2RGZA 4GPCA 4GPFA 4G99A 3B5PA 1XK2A 1YAFA 3TGMA 1J77A 4WX0A 3B5OA 1DVGA 1XJZA 2LCUA 3HNHA 3CZYA 4RAJA 1YAKA 3IBXA 1NI6A 3RM5A 3K4FA 4G8UA 3I9UA 3MVUA 4G8PA 4G7TA 2A6BA 2E7EA 3BJDA 1WZGA 1TO9A 4G7UA 1OZLA 1N3UA 3HLXA 1TWNA 4LQXA 4WWJA 1IRMA 1Z72A 4WD4A 4WWZA 2Z68A 2QPPA 2DY5A 1WNVA 1IX3A 4G7LA 1P3VA 1V8XA 1WOVA 1WNWA 1IVJA
chains in the Genus database with same CATH topology
1WZDA 2F2GA 1OZWA 1WE1A 1XK1A 1UDDA 1T5PA 1XK0A 4WMHA 2RD3A 1S13A 1UBBA 4FN6A 4GOHA 1IW1A 3NO6A 1XK3A 4G8WA 1WOXA 3DDEA 1OYLA 1TYHA 1J2CA 1J02A 2QZCA 1S8CA 1SK7A 2A2OA 1N45A 1P3TA 1DVEA 2Q4XA 2Q32A 3HOKA 2QCXA 4MECA 5BTQA 3MOOA 1OTWA 1VGIA 1ULXA 4NY7A 1RCWA 1P3UA 1OYKA 1TO9B 1TWRA 2ZVUA 3I8RA 4G7PA 1OZRA 2GM8A 1IX4A 1WOWA 3I9TA 3HMLA 1IW0A 2A2MA 1RTWA 1OTVA 3OQLA 1OZEA 1WWMA 1WZFA 4GPHA 2GM7A 4G98A 1WNXA 2RGZA 4GPCA 4GPFA 4G99A 3B5PA 1XK2A 1YAFA 3TGMA 1J77A 4WX0A 3B5OA 1DVGA 1XJZA 3HNHA 3CZYA 4RAJA 1YAKA 3IBXA 1NI6A 3RM5A 3K4FA 4G8UA 3I9UA 3MVUA 4G8PA 4G7TA 2A6BA 2E7EA 3BJDA 1WZGA 1TO9A 4G7UA 1OZLA 1N3UA 3HLXA 1TWNA 4LQXA 4WWJA 1IRMA 1Z72A 4WD4A 4WWZA 2Z68A 2QPPA 2DY5A 1WNVA 1IX3A 4G7LA 1P3VA 1V8XA 1WOVA 1WNWA 1IVJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WZD A;  2F2G A;  1OZW A;  1WE1 A;  1XK1 A;  1UDD A;  1T5P A;  1XK0 A;  4WMH A;  2RD3 A;  1S13 A;  1UBB A;  4FN6 A;  4GOH A;  1IW1 A;  3NO6 A;  1XK3 A;  4G8W A;  1WOX A;  3DDE A;  1OYL A;  1TYH A;  1J2C A;  1J02 A;  2QZC A;  1S8C A;  1SK7 A;  2A2O A;  1N45 A;  1P3T A;  1DVE A;  2Q4X A;  2Q32 A;  3HOK A;  2QCX A;  4MEC A;  5BTQ A;  3MOO A;  1OTW A;  1VGI A;  1ULX A;  4NY7 A;  1RCW A;  1P3U A;  1OYK A;  1TO9 B;  1TWR A;  2ZVU A;  3I8R A;  4G7P A;  1OZR A;  2GM8 A;  1IX4 A;  1WOW A;  3I9T A;  3HML A;  1IW0 A;  2A2M A;  1RTW A;  1OTV A;  3OQL A;  1OZE A;  1WWM A;  1WZF A;  4GPH A;  2GM7 A;  4G98 A;  1WNX A;  2RGZ A;  4GPC A;  4GPF A;  4G99 A;  3B5P A;  1XK2 A;  1YAF A;  3TGM A;  1J77 A;  4WX0 A;  3B5O A;  1DVG A;  1XJZ A;  3HNH A;  3CZY A;  4RAJ A;  1YAK A;  3IBX A;  1NI6 A;  3RM5 A;  3K4F A;  4G8U A;  3I9U A;  3MVU A;  4G8P A;  4G7T A;  2A6B A;  2E7E A;  3BJD A;  1WZG A;  1TO9 A;  4G7U A;  1OZL A;  1N3U A;  3HLX A;  1TWN A;  4LQX A;  4WWJ A;  1IRM A;  1Z72 A;  4WD4 A;  4WWZ A;  2Z68 A;  2QPP A;  2DY5 A;  1WNV A;  1IX3 A;  4G7L A;  1P3V A;  1V8X A;  1WOV A;  1WNW A;  1IVJ A; 
#chains in the Genus database with same CATH topology
 1WZD A;  2F2G A;  1OZW A;  1WE1 A;  1XK1 A;  1UDD A;  1T5P A;  1XK0 A;  4WMH A;  2RD3 A;  1S13 A;  1UBB A;  4FN6 A;  4GOH A;  1IW1 A;  3NO6 A;  1XK3 A;  4G8W A;  1WOX A;  3DDE A;  1OYL A;  1TYH A;  1J2C A;  1J02 A;  2QZC A;  1S8C A;  1SK7 A;  2A2O A;  1N45 A;  1P3T A;  1DVE A;  2Q4X A;  2Q32 A;  3HOK A;  2QCX A;  4MEC A;  5BTQ A;  3MOO A;  1OTW A;  1VGI A;  1ULX A;  4NY7 A;  1RCW A;  1P3U A;  1OYK A;  1TO9 B;  1TWR A;  2ZVU A;  3I8R A;  4G7P A;  1OZR A;  2GM8 A;  1IX4 A;  1WOW A;  3I9T A;  3HML A;  1IW0 A;  2A2M A;  1RTW A;  1OTV A;  3OQL A;  1OZE A;  1WWM A;  1WZF A;  4GPH A;  2GM7 A;  4G98 A;  1WNX A;  2RGZ A;  4GPC A;  4GPF A;  4G99 A;  3B5P A;  1XK2 A;  1YAF A;  3TGM A;  1J77 A;  4WX0 A;  3B5O A;  1DVG A;  1XJZ A;  2LCU A;  3HNH A;  3CZY A;  4RAJ A;  1YAK A;  3IBX A;  1NI6 A;  3RM5 A;  3K4F A;  4G8U A;  3I9U A;  3MVU A;  4G8P A;  4G7T A;  2A6B A;  2E7E A;  3BJD A;  1WZG A;  1TO9 A;  4G7U A;  1OZL A;  1N3U A;  3HLX A;  1TWN A;  4LQX A;  4WWJ A;  1IRM A;  1Z72 A;  4WD4 A;  4WWZ A;  2Z68 A;  2QPP A;  2DY5 A;  1WNV A;  1IX3 A;  4G7L A;  1P3V A;  1V8X A;  1WOV A;  1WNW A;  1IVJ A; 
#chains in the Genus database with same CATH homology
 1WZD A;  2F2G A;  1OZW A;  1WE1 A;  1XK1 A;  1UDD A;  1T5P A;  1XK0 A;  4WMH A;  2RD3 A;  1S13 A;  1UBB A;  4FN6 A;  4GOH A;  1IW1 A;  3NO6 A;  1XK3 A;  4G8W A;  1WOX A;  3DDE A;  1OYL A;  1TYH A;  1J2C A;  1J02 A;  2QZC A;  1S8C A;  1SK7 A;  2A2O A;  1N45 A;  1P3T A;  1DVE A;  2Q4X A;  2Q32 A;  3HOK A;  2QCX A;  4MEC A;  5BTQ A;  3MOO A;  1OTW A;  1VGI A;  1ULX A;  4NY7 A;  1RCW A;  1P3U A;  1OYK A;  1TO9 B;  1TWR A;  2ZVU A;  3I8R A;  4G7P A;  1OZR A;  2GM8 A;  1IX4 A;  1WOW A;  3I9T A;  3HML A;  1IW0 A;  2A2M A;  1RTW A;  1OTV A;  3OQL A;  1OZE A;  1WWM A;  1WZF A;  4GPH A;  2GM7 A;  4G98 A;  1WNX A;  2RGZ A;  4GPC A;  4GPF A;  4G99 A;  3B5P A;  1XK2 A;  1YAF A;  3TGM A;  1J77 A;  4WX0 A;  3B5O A;  1DVG A;  1XJZ A;  3HNH A;  3CZY A;  4RAJ A;  1YAK A;  3IBX A;  1NI6 A;  3RM5 A;  3K4F A;  4G8U A;  3I9U A;  3MVU A;  4G8P A;  4G7T A;  2A6B A;  2E7E A;  3BJD A;  1WZG A;  1TO9 A;  4G7U A;  1OZL A;  1N3U A;  3HLX A;  1TWN A;  4LQX A;  4WWJ A;  1IRM A;  1Z72 A;  4WD4 A;  4WWZ A;  2Z68 A;  2QPP A;  2DY5 A;  1WNV A;  1IX3 A;  4G7L A;  1P3V A;  1V8X A;  1WOV A;  1WNW A;  1IVJ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...