3WX1A

Mouse cereblon thalidomide binding domain, selenomethionine derivative
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
108
structure length
108
Chain Sequence
GPTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
pubmed doi rcsb
molecule keywords Protein cereblon
molecule tags Metal binding protein
source organism Mus musculus
total genus 21
structure length 108
sequence length 108
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 3wx1A00
2KV1A 4V2YA 3HCIA 2KZNA 3CEZA 3HCHA 3E0OA 3HCGA 3WX1A 4CI3B 4CI1B 4V31A 3MAOA 3HCJA 1L1DA 4TZUA 3WX2A 4TZ4C 3E0MA 5AMHA 3CXKA 4V30A 4CI2B 2K8DA 4V2ZA 4TZCA
chains in the Genus database with same CATH superfamily
3ZD7A 2KV1A 4V2YA 3HCIA 2LVLA 2RQAA 1TXJA 2KZNA 3CEZA 3P3KA 3FACA 2YKGA 3HCHA 4BPBA 3E0OA 3HCGA 3ZD6A 1HXRA 4AY2A 3WX1A 4CI3B 4CI1B 3LRNA 2LOYA 5F9FA 2QFBA 4V31A 5F98A 1H7YA 1H6QA 2W4RA 3MAOA 2QFDA 5E3HA 3HCJA 3EBMA 1L1DA 1YZ1A 3OG8A 3NCUA 4TZUA 4A2XA 3DJMA 3WX2A 5F9HA 4A2VA 2FU5A 4TZ4C 3E0MA 3LRRA 5AMHA 3CXKA 2HR9A 4V30A 4CI2B 1FWQA 2K8DA 2RMJA 2RQBA 3GA3A 4V2ZA 3EQTA 4TZCA 2KWBA
chains in the Genus database with same CATH topology
2KV1A 4V2YA 3HCIA 2KZNA 3CEZA 3HCHA 3E0OA 3HCGA 3WX1A 4CI3B 4CI1B 4V31A 3MAOA 3HCJA 1L1DA 4TZUA 3WX2A 4TZ4C 3E0MA 5AMHA 3CXKA 4V30A 4CI2B 2K8DA 4V2ZA 4TZCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KV1 A;  4V2Y A;  3HCI A;  2KZN A;  3CEZ A;  3HCH A;  3E0O A;  3HCG A;  3WX1 A;  4CI3 B;  4CI1 B;  4V31 A;  3MAO A;  3HCJ A;  1L1D A;  4TZU A;  3WX2 A;  4TZ4 C;  3E0M A;  5AMH A;  3CXK A;  4V30 A;  4CI2 B;  2K8D A;  4V2Z A;  4TZC A; 
#chains in the Genus database with same CATH topology
 3ZD7 A;  2KV1 A;  4V2Y A;  3HCI A;  2LVL A;  2RQA A;  1TXJ A;  2KZN A;  3CEZ A;  3P3K A;  3FAC A;  2YKG A;  3HCH A;  4BPB A;  3E0O A;  3HCG A;  3ZD6 A;  1HXR A;  4AY2 A;  3WX1 A;  4CI3 B;  4CI1 B;  3LRN A;  2LOY A;  5F9F A;  2QFB A;  4V31 A;  5F98 A;  1H7Y A;  1H6Q A;  2W4R A;  3MAO A;  2QFD A;  5E3H A;  3HCJ A;  3EBM A;  1L1D A;  1YZ1 A;  3OG8 A;  3NCU A;  4TZU A;  4A2X A;  3DJM A;  3WX2 A;  5F9H A;  4A2V A;  2FU5 A;  4TZ4 C;  3E0M A;  3LRR A;  5AMH A;  3CXK A;  2HR9 A;  4V30 A;  4CI2 B;  1FWQ A;  2K8D A;  2RMJ A;  2RQB A;  3GA3 A;  4V2Z A;  3EQT A;  4TZC A;  2KWB A; 
#chains in the Genus database with same CATH homology
 2KV1 A;  4V2Y A;  3HCI A;  2KZN A;  3CEZ A;  3HCH A;  3E0O A;  3HCG A;  3WX1 A;  4CI3 B;  4CI1 B;  4V31 A;  3MAO A;  3HCJ A;  1L1D A;  4TZU A;  3WX2 A;  4TZ4 C;  3E0M A;  5AMH A;  3CXK A;  4V30 A;  4CI2 B;  2K8D A;  4V2Z A;  4TZC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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