3WX2A

Mouse cereblon thalidomide binding domain, native
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
108
structure length
108
Chain Sequence
GPTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
pubmed doi rcsb
molecule tags Metal binding protein
source organism Mus musculus
molecule keywords Protein cereblon
total genus 20
structure length 108
sequence length 108
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 3wx2A00
4TZ4C 2K8DA 3E0OA 3HCHA 4CI2B 3E0MA 3WX2A 4CI1B 3MAOA 4CI3B 4TZUA 4V2ZA 3HCJA 3CXKA 1L1DA 4TZCA 3CEZA 2KZNA 5AMHA 4V30A 3HCGA 3WX1A 3HCIA 4V31A 2KV1A 4V2YA
chains in the Genus database with same CATH superfamily
3GA3A 4TZ4C 2K8DA 5F98A 3E0OA 3HCHA 2HR9A 4CI2B 3E0MA 4A2XA 3LRRA 3WX2A 4BPBA 3NCUA 4CI1B 5F9FA 3MAOA 4CI3B 4TZUA 4V2ZA 2QFBA 1HXRA 3HCJA 2LVLA 4A2VA 3CXKA 1L1DA 4TZCA 5E3HA 3CEZA 2KZNA 2QFDA 3ZD6A 5F9HA 2RQBA 2YKGA 2FU5A 2RQAA 3OG8A 5AMHA 1YZ1A 1TXJA 2W4RA 3EBMA 3P3KA 1H7YA 3LRNA 2LOYA 4V30A 3HCGA 2KWBA 3DJMA 3WX1A 3HCIA 2RMJA 4V31A 1FWQA 2KV1A 1H6QA 4V2YA 3ZD7A 4AY2A 3FACA 3EQTA
chains in the Genus database with same CATH topology
4TZ4C 2K8DA 3E0OA 3HCHA 4CI2B 3E0MA 3WX2A 4CI1B 3MAOA 4CI3B 4TZUA 4V2ZA 3HCJA 3CXKA 1L1DA 4TZCA 3CEZA 2KZNA 5AMHA 4V30A 3HCGA 3WX1A 3HCIA 4V31A 2KV1A 4V2YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZ4 C;  2K8D A;  3E0O A;  3HCH A;  4CI2 B;  3E0M A;  3WX2 A;  4CI1 B;  3MAO A;  4CI3 B;  4TZU A;  4V2Z A;  3HCJ A;  3CXK A;  1L1D A;  4TZC A;  3CEZ A;  2KZN A;  5AMH A;  4V30 A;  3HCG A;  3WX1 A;  3HCI A;  4V31 A;  2KV1 A;  4V2Y A; 
#chains in the Genus database with same CATH topology
 3GA3 A;  4TZ4 C;  2K8D A;  5F98 A;  3E0O A;  3HCH A;  2HR9 A;  4CI2 B;  3E0M A;  4A2X A;  3LRR A;  3WX2 A;  4BPB A;  3NCU A;  4CI1 B;  5F9F A;  3MAO A;  4CI3 B;  4TZU A;  4V2Z A;  2QFB A;  1HXR A;  3HCJ A;  2LVL A;  4A2V A;  3CXK A;  1L1D A;  4TZC A;  5E3H A;  3CEZ A;  2KZN A;  2QFD A;  3ZD6 A;  5F9H A;  2RQB A;  2YKG A;  2FU5 A;  2RQA A;  3OG8 A;  5AMH A;  1YZ1 A;  1TXJ A;  2W4R A;  3EBM A;  3P3K A;  1H7Y A;  3LRN A;  2LOY A;  4V30 A;  3HCG A;  2KWB A;  3DJM A;  3WX1 A;  3HCI A;  2RMJ A;  4V31 A;  1FWQ A;  2KV1 A;  1H6Q A;  4V2Y A;  3ZD7 A;  4AY2 A;  3FAC A;  3EQT A; 
#chains in the Genus database with same CATH homology
 4TZ4 C;  2K8D A;  3E0O A;  3HCH A;  4CI2 B;  3E0M A;  3WX2 A;  4CI1 B;  3MAO A;  4CI3 B;  4TZU A;  4V2Z A;  3HCJ A;  3CXK A;  1L1D A;  4TZC A;  3CEZ A;  2KZN A;  5AMH A;  4V30 A;  3HCG A;  3WX1 A;  3HCI A;  4V31 A;  2KV1 A;  4V2Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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