3WX2A

Mouse cereblon thalidomide binding domain, native
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
108
structure length
108
Chain Sequence
GPTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
pubmed doi rcsb
molecule keywords Protein cereblon
molecule tags Metal binding protein
source organism Mus musculus
total genus 20
structure length 108
sequence length 108
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 3wx2A00
2K8DA 3HCGA 3HCHA 4V2ZA 4TZ4C 4V2YA 2KZNA 2KV1A 3CEZA 3HCIA 3MAOA 1L1DA 3WX1A 3CXKA 4CI1B 3E0MA 4V31A 5AMHA 4V30A 4TZUA 3E0OA 4CI2B 4CI3B 3WX2A 4TZCA 3HCJA
chains in the Genus database with same CATH superfamily
2QFBA 1YZ1A 3ZD7A 1H6QA 4A2VA 4BPBA 1H7YA 2FU5A 2K8DA 3HCHA 3HCGA 4AY2A 4V2ZA 1FWQA 4TZ4C 4V2YA 3GA3A 3EQTA 1HXRA 2W4RA 2YKGA 3ZD6A 2RMJA 2KV1A 3CEZA 5F9FA 2RQAA 3DJMA 3HCIA 3MAOA 4TZCA 1L1DA 2QFDA 2LOYA 3WX1A 3CXKA 2KWBA 2HR9A 3E0MA 4CI1B 4A2XA 5E3HA 4V31A 5AMHA 2LVLA 1TXJA 5F9HA 5F98A 4V30A 4TZUA 3E0OA 4CI2B 3FACA 3NCUA 4CI3B 3EBMA 3LRNA 3OG8A 3LRRA 3WX2A 2RQBA 2KZNA 3P3KA 3HCJA
chains in the Genus database with same CATH topology
2K8DA 3HCGA 3HCHA 4V2ZA 4TZ4C 4V2YA 2KZNA 2KV1A 3CEZA 3HCIA 3MAOA 1L1DA 3WX1A 3CXKA 4CI1B 3E0MA 4V31A 5AMHA 4V30A 4TZUA 3E0OA 4CI2B 4CI3B 3WX2A 4TZCA 3HCJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2K8D A;  3HCG A;  3HCH A;  4V2Z A;  4TZ4 C;  4V2Y A;  2KZN A;  2KV1 A;  3CEZ A;  3HCI A;  3MAO A;  1L1D A;  3WX1 A;  3CXK A;  4CI1 B;  3E0M A;  4V31 A;  5AMH A;  4V30 A;  4TZU A;  3E0O A;  4CI2 B;  4CI3 B;  3WX2 A;  4TZC A;  3HCJ A; 
#chains in the Genus database with same CATH topology
 2QFB A;  1YZ1 A;  3ZD7 A;  1H6Q A;  4A2V A;  4BPB A;  1H7Y A;  2FU5 A;  2K8D A;  3HCH A;  3HCG A;  4AY2 A;  4V2Z A;  1FWQ A;  4TZ4 C;  4V2Y A;  3GA3 A;  3EQT A;  1HXR A;  2W4R A;  2YKG A;  3ZD6 A;  2RMJ A;  2KV1 A;  3CEZ A;  5F9F A;  2RQA A;  3DJM A;  3HCI A;  3MAO A;  4TZC A;  1L1D A;  2QFD A;  2LOY A;  3WX1 A;  3CXK A;  2KWB A;  2HR9 A;  3E0M A;  4CI1 B;  4A2X A;  5E3H A;  4V31 A;  5AMH A;  2LVL A;  1TXJ A;  5F9H A;  5F98 A;  4V30 A;  4TZU A;  3E0O A;  4CI2 B;  3FAC A;  3NCU A;  4CI3 B;  3EBM A;  3LRN A;  3OG8 A;  3LRR A;  3WX2 A;  2RQB A;  2KZN A;  3P3K A;  3HCJ A; 
#chains in the Genus database with same CATH homology
 2K8D A;  3HCG A;  3HCH A;  4V2Z A;  4TZ4 C;  4V2Y A;  2KZN A;  2KV1 A;  3CEZ A;  3HCI A;  3MAO A;  1L1D A;  3WX1 A;  3CXK A;  4CI1 B;  3E0M A;  4V31 A;  5AMH A;  4V30 A;  4TZU A;  3E0O A;  4CI2 B;  4CI3 B;  3WX2 A;  4TZC A;  3HCJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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