4TZCA

Crystal structure of murine cereblon in complex with thalidomide
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
106
structure length
91
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSLETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
molecule keywords Protein cereblon
molecule tags Ligase
source organism Mus musculus
total genus 20
structure length 91
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzcA00
3E0OA 4V31A 4TZCA 3MAOA 1L1DA 2KV1A 3WX1A 4CI1B 4TZ4C 3CEZA 4V2YA 3HCIA 3HCGA 3E0MA 2K8DA 4V2ZA 4CI3B 5AMHA 3WX2A 3CXKA 4CI2B 4TZUA 2KZNA 3HCHA 3HCJA 4V30A
chains in the Genus database with same CATH superfamily
3E0OA 4V31A 3ZD7A 3FACA 4TZCA 2YKGA 3OG8A 3MAOA 3LRNA 1L1DA 2KV1A 2FU5A 2LVLA 3WX1A 3P3KA 1FWQA 1YZ1A 4CI1B 4TZ4C 5F9HA 2HR9A 3DJMA 5F9FA 3NCUA 3ZD6A 3CEZA 4V2YA 2RQBA 3HCIA 3HCGA 2RQAA 2K8DA 2KWBA 1HXRA 2LOYA 3E0MA 4V2ZA 2QFDA 5AMHA 4CI3B 3LRRA 3WX2A 3CXKA 3GA3A 5E3HA 4CI2B 4TZUA 2KZNA 4BPBA 3HCHA 2RMJA 5F98A 1TXJA 3EQTA 3HCJA 4A2XA 2W4RA 4A2VA 1H7YA 2QFBA 3EBMA 1H6QA 4V30A 4AY2A
chains in the Genus database with same CATH topology
3E0OA 4V31A 4TZCA 3MAOA 1L1DA 2KV1A 3WX1A 4CI1B 4TZ4C 3CEZA 4V2YA 3HCIA 3HCGA 3E0MA 2K8DA 4V2ZA 4CI3B 5AMHA 3WX2A 3CXKA 4CI2B 4TZUA 2KZNA 3HCHA 3HCJA 4V30A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E0O A;  4V31 A;  4TZC A;  3MAO A;  1L1D A;  2KV1 A;  3WX1 A;  4CI1 B;  4TZ4 C;  3CEZ A;  4V2Y A;  3HCI A;  3HCG A;  3E0M A;  2K8D A;  4V2Z A;  4CI3 B;  5AMH A;  3WX2 A;  3CXK A;  4CI2 B;  4TZU A;  2KZN A;  3HCH A;  3HCJ A;  4V30 A; 
#chains in the Genus database with same CATH topology
 3E0O A;  4V31 A;  3ZD7 A;  3FAC A;  4TZC A;  2YKG A;  3OG8 A;  3MAO A;  3LRN A;  1L1D A;  2KV1 A;  2FU5 A;  2LVL A;  3WX1 A;  3P3K A;  1FWQ A;  1YZ1 A;  4CI1 B;  4TZ4 C;  5F9H A;  2HR9 A;  3DJM A;  5F9F A;  3NCU A;  3ZD6 A;  3CEZ A;  4V2Y A;  2RQB A;  3HCI A;  3HCG A;  2RQA A;  2K8D A;  2KWB A;  1HXR A;  2LOY A;  3E0M A;  4V2Z A;  2QFD A;  5AMH A;  4CI3 B;  3LRR A;  3WX2 A;  3CXK A;  3GA3 A;  5E3H A;  4CI2 B;  4TZU A;  2KZN A;  4BPB A;  3HCH A;  2RMJ A;  5F98 A;  1TXJ A;  3EQT A;  3HCJ A;  4A2X A;  2W4R A;  4A2V A;  1H7Y A;  2QFB A;  3EBM A;  1H6Q A;  4V30 A;  4AY2 A; 
#chains in the Genus database with same CATH homology
 3E0O A;  4V31 A;  4TZC A;  3MAO A;  1L1D A;  2KV1 A;  3WX1 A;  4CI1 B;  4TZ4 C;  3CEZ A;  4V2Y A;  3HCI A;  3HCG A;  3E0M A;  2K8D A;  4V2Z A;  4CI3 B;  5AMH A;  3WX2 A;  3CXK A;  4CI2 B;  4TZU A;  2KZN A;  3HCH A;  3HCJ A;  4V30 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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