4TZCA

Crystal structure of murine cereblon in complex with thalidomide
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
106
structure length
91
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSLETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
molecule keywords Protein cereblon
molecule tags Ligase
source organism Mus musculus
total genus 20
structure length 91
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzcA00
3MAOA 4CI2B 4CI1B 4V2YA 4TZCA 3HCIA 4TZUA 2KZNA 3CXKA 1L1DA 3E0MA 4V31A 3WX2A 3HCHA 5AMHA 4V30A 4V2ZA 4CI3B 3HCJA 2K8DA 3HCGA 4TZ4C 3WX1A 3CEZA 2KV1A 3E0OA
chains in the Genus database with same CATH superfamily
3MAOA 5F9FA 2QFBA 4CI2B 4CI1B 3GA3A 5F9HA 4V2YA 3ZD6A 4A2VA 2QFDA 3P3KA 2HR9A 3EQTA 4TZCA 3HCIA 2RMJA 4BPBA 2LOYA 4TZUA 2KZNA 2RQBA 1L1DA 3CXKA 3E0MA 4V31A 2W4RA 2FU5A 3FACA 3WX2A 5E3HA 1FWQA 3HCHA 2LVLA 5AMHA 3LRNA 1HXRA 3NCUA 4V30A 4A2XA 3EBMA 3LRRA 1H7YA 4V2ZA 4CI3B 2KWBA 3DJMA 3HCJA 1YZ1A 3ZD7A 3OG8A 2RQAA 2K8DA 2YKGA 3HCGA 4TZ4C 3WX1A 1TXJA 5F98A 1H6QA 4AY2A 3CEZA 2KV1A 3E0OA
chains in the Genus database with same CATH topology
3MAOA 4CI2B 4CI1B 4V2YA 4TZCA 3HCIA 4TZUA 2KZNA 3CXKA 1L1DA 3E0MA 4V31A 3WX2A 3HCHA 5AMHA 4V30A 4V2ZA 4CI3B 3HCJA 2K8DA 3HCGA 4TZ4C 3WX1A 3CEZA 2KV1A 3E0OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MAO A;  4CI2 B;  4CI1 B;  4V2Y A;  4TZC A;  3HCI A;  4TZU A;  2KZN A;  3CXK A;  1L1D A;  3E0M A;  4V31 A;  3WX2 A;  3HCH A;  5AMH A;  4V30 A;  4V2Z A;  4CI3 B;  3HCJ A;  2K8D A;  3HCG A;  4TZ4 C;  3WX1 A;  3CEZ A;  2KV1 A;  3E0O A; 
#chains in the Genus database with same CATH topology
 3MAO A;  5F9F A;  2QFB A;  4CI2 B;  4CI1 B;  3GA3 A;  5F9H A;  4V2Y A;  3ZD6 A;  4A2V A;  2QFD A;  3P3K A;  2HR9 A;  3EQT A;  4TZC A;  3HCI A;  2RMJ A;  4BPB A;  2LOY A;  4TZU A;  2KZN A;  2RQB A;  1L1D A;  3CXK A;  3E0M A;  4V31 A;  2W4R A;  2FU5 A;  3FAC A;  3WX2 A;  5E3H A;  1FWQ A;  3HCH A;  2LVL A;  5AMH A;  3LRN A;  1HXR A;  3NCU A;  4V30 A;  4A2X A;  3EBM A;  3LRR A;  1H7Y A;  4V2Z A;  4CI3 B;  2KWB A;  3DJM A;  3HCJ A;  1YZ1 A;  3ZD7 A;  3OG8 A;  2RQA A;  2K8D A;  2YKG A;  3HCG A;  4TZ4 C;  3WX1 A;  1TXJ A;  5F98 A;  1H6Q A;  4AY2 A;  3CEZ A;  2KV1 A;  3E0O A; 
#chains in the Genus database with same CATH homology
 3MAO A;  4CI2 B;  4CI1 B;  4V2Y A;  4TZC A;  3HCI A;  4TZU A;  2KZN A;  3CXK A;  1L1D A;  3E0M A;  4V31 A;  3WX2 A;  3HCH A;  5AMH A;  4V30 A;  4V2Z A;  4CI3 B;  3HCJ A;  2K8D A;  3HCG A;  4TZ4 C;  3WX1 A;  3CEZ A;  2KV1 A;  3E0O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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