4TZCA

Crystal structure of murine cereblon in complex with thalidomide
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
106
structure length
91
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSLETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
source organism Mus musculus
publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
molecule keywords Protein cereblon
total genus 20
structure length 91
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzcA00
4V31A 3HCJA 4V2ZA 3HCHA 4TZ4C 3HCGA 4V2YA 4CI1B 3E0OA 4TZCA 4TZUA 3WX2A 3CXKA 3HCIA 3WX1A 3E0MA 2KZNA 3MAOA 2KV1A 4CI2B 4CI3B 5AMHA 1L1DA 2K8DA 3CEZA 4V30A
chains in the Genus database with same CATH superfamily
4V31A 1H7YA 4A2XA 3EQTA 3HCJA 4V2ZA 3HCHA 4TZ4C 3HCGA 3LRRA 2QFBA 3ZD7A 2RQBA 2RMJA 2LVLA 5F98A 3ZD6A 2LOYA 4V2YA 1HXRA 4CI1B 3LRNA 3OG8A 3E0OA 4TZCA 3NCUA 5F9FA 2KWBA 4TZUA 2W4RA 3CXKA 3EBMA 3WX2A 3HCIA 3WX1A 3E0MA 2KZNA 1YZ1A 1TXJA 2RQAA 3MAOA 4A2VA 2KV1A 5E3HA 1FWQA 4CI2B 3FACA 2HR9A 5AMHA 4CI3B 2FU5A 1L1DA 3P3KA 3DJMA 2K8DA 3GA3A 3CEZA 2QFDA 4BPBA 5F9HA 4AY2A 4V30A 1H6QA 2YKGA
chains in the Genus database with same CATH topology
4V31A 3HCJA 4V2ZA 3HCHA 4TZ4C 3HCGA 4V2YA 4CI1B 3E0OA 4TZCA 4TZUA 3WX2A 3CXKA 3HCIA 3WX1A 3E0MA 2KZNA 3MAOA 2KV1A 4CI2B 4CI3B 5AMHA 1L1DA 2K8DA 3CEZA 4V30A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V31 A;  3HCJ A;  4V2Z A;  3HCH A;  4TZ4 C;  3HCG A;  4V2Y A;  4CI1 B;  3E0O A;  4TZC A;  4TZU A;  3WX2 A;  3CXK A;  3HCI A;  3WX1 A;  3E0M A;  2KZN A;  3MAO A;  2KV1 A;  4CI2 B;  4CI3 B;  5AMH A;  1L1D A;  2K8D A;  3CEZ A;  4V30 A; 
#chains in the Genus database with same CATH topology
 4V31 A;  1H7Y A;  4A2X A;  3EQT A;  3HCJ A;  4V2Z A;  3HCH A;  4TZ4 C;  3HCG A;  3LRR A;  2QFB A;  3ZD7 A;  2RQB A;  2RMJ A;  2LVL A;  5F98 A;  3ZD6 A;  2LOY A;  4V2Y A;  1HXR A;  4CI1 B;  3LRN A;  3OG8 A;  3E0O A;  4TZC A;  3NCU A;  5F9F A;  2KWB A;  4TZU A;  2W4R A;  3CXK A;  3EBM A;  3WX2 A;  3HCI A;  3WX1 A;  3E0M A;  2KZN A;  1YZ1 A;  1TXJ A;  2RQA A;  3MAO A;  4A2V A;  2KV1 A;  5E3H A;  1FWQ A;  4CI2 B;  3FAC A;  2HR9 A;  5AMH A;  4CI3 B;  2FU5 A;  1L1D A;  3P3K A;  3DJM A;  2K8D A;  3GA3 A;  3CEZ A;  2QFD A;  4BPB A;  5F9H A;  4AY2 A;  4V30 A;  1H6Q A;  2YKG A; 
#chains in the Genus database with same CATH homology
 4V31 A;  3HCJ A;  4V2Z A;  3HCH A;  4TZ4 C;  3HCG A;  4V2Y A;  4CI1 B;  3E0O A;  4TZC A;  4TZU A;  3WX2 A;  3CXK A;  3HCI A;  3WX1 A;  3E0M A;  2KZN A;  3MAO A;  2KV1 A;  4CI2 B;  4CI3 B;  5AMH A;  1L1D A;  2K8D A;  3CEZ A;  4V30 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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