4TZUA

Crystal structure of murine cereblon in complex with pomalidomide
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
106
structure length
90
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
molecule keywords Protein cereblon
molecule tags Ligase
source organism Mus musculus
total genus 18
structure length 90
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzuA00
4V2ZA 4TZ4C 4CI3B 4V31A 4CI1B 4TZUA 3HCJA 3WX1A 4V30A 3HCGA 2KV1A 4V2YA 1L1DA 3E0OA 4CI2B 3HCHA 3CEZA 2K8DA 3HCIA 4TZCA 3MAOA 3WX2A 5AMHA 3CXKA 2KZNA 3E0MA
chains in the Genus database with same CATH superfamily
3P3KA 3LRRA 4V2ZA 2RMJA 4AY2A 5F9FA 4TZ4C 1H7YA 3LRNA 4CI3B 3EBMA 4BPBA 4V31A 5F9HA 2KWBA 4CI1B 4TZUA 3HCJA 3GA3A 1YZ1A 3WX1A 2QFBA 2HR9A 4V30A 2KV1A 2RQAA 3HCGA 3ZD7A 3ZD6A 1TXJA 3E0OA 1L1DA 4V2YA 4CI2B 2QFDA 3FACA 3HCHA 3CEZA 2K8DA 2W4RA 4A2VA 2YKGA 5F98A 3DJMA 3HCIA 4A2XA 4TZCA 2LVLA 1H6QA 3MAOA 3EQTA 3NCUA 3OG8A 2LOYA 3WX2A 5AMHA 5E3HA 3CXKA 1FWQA 2RQBA 2KZNA 1HXRA 3E0MA 2FU5A
chains in the Genus database with same CATH topology
4V2ZA 4TZ4C 4CI3B 4V31A 4CI1B 4TZUA 3HCJA 3WX1A 4V30A 3HCGA 2KV1A 4V2YA 1L1DA 3E0OA 4CI2B 3HCHA 3CEZA 2K8DA 3HCIA 4TZCA 3MAOA 3WX2A 5AMHA 3CXKA 2KZNA 3E0MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V2Z A;  4TZ4 C;  4CI3 B;  4V31 A;  4CI1 B;  4TZU A;  3HCJ A;  3WX1 A;  4V30 A;  3HCG A;  2KV1 A;  4V2Y A;  1L1D A;  3E0O A;  4CI2 B;  3HCH A;  3CEZ A;  2K8D A;  3HCI A;  4TZC A;  3MAO A;  3WX2 A;  5AMH A;  3CXK A;  2KZN A;  3E0M A; 
#chains in the Genus database with same CATH topology
 3P3K A;  3LRR A;  4V2Z A;  2RMJ A;  4AY2 A;  5F9F A;  4TZ4 C;  1H7Y A;  3LRN A;  4CI3 B;  3EBM A;  4BPB A;  4V31 A;  5F9H A;  2KWB A;  4CI1 B;  4TZU A;  3HCJ A;  3GA3 A;  1YZ1 A;  3WX1 A;  2QFB A;  2HR9 A;  4V30 A;  2KV1 A;  2RQA A;  3HCG A;  3ZD7 A;  3ZD6 A;  1TXJ A;  3E0O A;  1L1D A;  4V2Y A;  4CI2 B;  2QFD A;  3FAC A;  3HCH A;  3CEZ A;  2K8D A;  2W4R A;  4A2V A;  2YKG A;  5F98 A;  3DJM A;  3HCI A;  4A2X A;  4TZC A;  2LVL A;  1H6Q A;  3MAO A;  3EQT A;  3NCU A;  3OG8 A;  2LOY A;  3WX2 A;  5AMH A;  5E3H A;  3CXK A;  1FWQ A;  2RQB A;  2KZN A;  1HXR A;  3E0M A;  2FU5 A; 
#chains in the Genus database with same CATH homology
 4V2Z A;  4TZ4 C;  4CI3 B;  4V31 A;  4CI1 B;  4TZU A;  3HCJ A;  3WX1 A;  4V30 A;  3HCG A;  2KV1 A;  4V2Y A;  1L1D A;  3E0O A;  4CI2 B;  3HCH A;  3CEZ A;  2K8D A;  3HCI A;  4TZC A;  3MAO A;  3WX2 A;  5AMH A;  3CXK A;  2KZN A;  3E0M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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