4TZUA

Crystal structure of murine cereblon in complex with pomalidomide
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
106
structure length
90
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
source organism Mus musculus
publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
molecule keywords Protein cereblon
total genus 18
structure length 90
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzuA00
3HCHA 3MAOA 4TZCA 3CXKA 4V31A 1L1DA 4V30A 4TZUA 3E0MA 4TZ4C 3E0OA 3HCIA 3CEZA 2KZNA 3HCGA 4CI2B 3WX1A 2KV1A 3WX2A 4V2ZA 3HCJA 4CI1B 5AMHA 2K8DA 4V2YA 4CI3B
chains in the Genus database with same CATH superfamily
3HCHA 3MAOA 4TZCA 3ZD7A 3CXKA 4V31A 1L1DA 4AY2A 2W4RA 4V30A 5F98A 2HR9A 2QFBA 4TZUA 4A2XA 3E0MA 2RQBA 4TZ4C 3FACA 3E0OA 1TXJA 3GA3A 2LOYA 3HCIA 1H7YA 1YZ1A 3CEZA 2KZNA 3HCGA 4CI2B 1FWQA 3WX1A 3ZD6A 3OG8A 2RMJA 3EBMA 3LRRA 2FU5A 3DJMA 2KV1A 3WX2A 4BPBA 5F9FA 4V2ZA 1HXRA 2RQAA 3HCJA 2YKGA 2LVLA 5E3HA 2QFDA 3P3KA 4A2VA 3EQTA 1H6QA 3LRNA 4CI1B 5AMHA 5F9HA 2KWBA 3NCUA 2K8DA 4V2YA 4CI3B
chains in the Genus database with same CATH topology
3HCHA 3MAOA 4TZCA 3CXKA 4V31A 1L1DA 4V30A 4TZUA 3E0MA 4TZ4C 3E0OA 3HCIA 3CEZA 2KZNA 3HCGA 4CI2B 3WX1A 2KV1A 3WX2A 4V2ZA 3HCJA 4CI1B 5AMHA 2K8DA 4V2YA 4CI3B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HCH A;  3MAO A;  4TZC A;  3CXK A;  4V31 A;  1L1D A;  4V30 A;  4TZU A;  3E0M A;  4TZ4 C;  3E0O A;  3HCI A;  3CEZ A;  2KZN A;  3HCG A;  4CI2 B;  3WX1 A;  2KV1 A;  3WX2 A;  4V2Z A;  3HCJ A;  4CI1 B;  5AMH A;  2K8D A;  4V2Y A;  4CI3 B; 
#chains in the Genus database with same CATH topology
 3HCH A;  3MAO A;  4TZC A;  3ZD7 A;  3CXK A;  4V31 A;  1L1D A;  4AY2 A;  2W4R A;  4V30 A;  5F98 A;  2HR9 A;  2QFB A;  4TZU A;  4A2X A;  3E0M A;  2RQB A;  4TZ4 C;  3FAC A;  3E0O A;  1TXJ A;  3GA3 A;  2LOY A;  3HCI A;  1H7Y A;  1YZ1 A;  3CEZ A;  2KZN A;  3HCG A;  4CI2 B;  1FWQ A;  3WX1 A;  3ZD6 A;  3OG8 A;  2RMJ A;  3EBM A;  3LRR A;  2FU5 A;  3DJM A;  2KV1 A;  3WX2 A;  4BPB A;  5F9F A;  4V2Z A;  1HXR A;  2RQA A;  3HCJ A;  2YKG A;  2LVL A;  5E3H A;  2QFD A;  3P3K A;  4A2V A;  3EQT A;  1H6Q A;  3LRN A;  4CI1 B;  5AMH A;  5F9H A;  2KWB A;  3NCU A;  2K8D A;  4V2Y A;  4CI3 B; 
#chains in the Genus database with same CATH homology
 3HCH A;  3MAO A;  4TZC A;  3CXK A;  4V31 A;  1L1D A;  4V30 A;  4TZU A;  3E0M A;  4TZ4 C;  3E0O A;  3HCI A;  3CEZ A;  2KZN A;  3HCG A;  4CI2 B;  3WX1 A;  2KV1 A;  3WX2 A;  4V2Z A;  3HCJ A;  4CI1 B;  5AMH A;  2K8D A;  4V2Y A;  4CI3 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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