4TZUA

Crystal structure of murine cereblon in complex with pomalidomide
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
106
structure length
90
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
molecule keywords Protein cereblon
molecule tags Ligase
source organism Mus musculus
total genus 18
structure length 90
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzuA00
2K8DA 3HCHA 3CXKA 3E0OA 3HCJA 2KZNA 3WX1A 3MAOA 1L1DA 4V2ZA 4CI3B 3HCGA 4V31A 4TZUA 3CEZA 5AMHA 4TZCA 4CI2B 4CI1B 3HCIA 4V2YA 3E0MA 3WX2A 4TZ4C 2KV1A 4V30A
chains in the Genus database with same CATH superfamily
2K8DA 3OG8A 3HCHA 3CXKA 3E0OA 4A2VA 1TXJA 3HCJA 3FACA 4A2XA 2KZNA 2KWBA 2RQBA 3ZD6A 1H6QA 3WX1A 2QFDA 5F9HA 2QFBA 3MAOA 5F98A 3LRRA 1YZ1A 1HXRA 1L1DA 4V2ZA 4CI3B 3DJMA 3HCGA 1FWQA 4V31A 3ZD7A 2YKGA 4TZUA 3EBMA 3CEZA 2LOYA 5AMHA 4TZCA 5F9FA 3LRNA 2W4RA 4CI2B 4CI1B 3HCIA 3P3KA 4V2YA 2LVLA 3EQTA 3E0MA 2RMJA 3WX2A 4TZ4C 3GA3A 3NCUA 2RQAA 5E3HA 2KV1A 4BPBA 4AY2A 2HR9A 1H7YA 2FU5A 4V30A
chains in the Genus database with same CATH topology
2K8DA 3HCHA 3CXKA 3E0OA 3HCJA 2KZNA 3WX1A 3MAOA 1L1DA 4V2ZA 4CI3B 3HCGA 4V31A 4TZUA 3CEZA 5AMHA 4TZCA 4CI2B 4CI1B 3HCIA 4V2YA 3E0MA 3WX2A 4TZ4C 2KV1A 4V30A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2K8D A;  3HCH A;  3CXK A;  3E0O A;  3HCJ A;  2KZN A;  3WX1 A;  3MAO A;  1L1D A;  4V2Z A;  4CI3 B;  3HCG A;  4V31 A;  4TZU A;  3CEZ A;  5AMH A;  4TZC A;  4CI2 B;  4CI1 B;  3HCI A;  4V2Y A;  3E0M A;  3WX2 A;  4TZ4 C;  2KV1 A;  4V30 A; 
#chains in the Genus database with same CATH topology
 2K8D A;  3OG8 A;  3HCH A;  3CXK A;  3E0O A;  4A2V A;  1TXJ A;  3HCJ A;  3FAC A;  4A2X A;  2KZN A;  2KWB A;  2RQB A;  3ZD6 A;  1H6Q A;  3WX1 A;  2QFD A;  5F9H A;  2QFB A;  3MAO A;  5F98 A;  3LRR A;  1YZ1 A;  1HXR A;  1L1D A;  4V2Z A;  4CI3 B;  3DJM A;  3HCG A;  1FWQ A;  4V31 A;  3ZD7 A;  2YKG A;  4TZU A;  3EBM A;  3CEZ A;  2LOY A;  5AMH A;  4TZC A;  5F9F A;  3LRN A;  2W4R A;  4CI2 B;  4CI1 B;  3HCI A;  3P3K A;  4V2Y A;  2LVL A;  3EQT A;  3E0M A;  2RMJ A;  3WX2 A;  4TZ4 C;  3GA3 A;  3NCU A;  2RQA A;  5E3H A;  2KV1 A;  4BPB A;  4AY2 A;  2HR9 A;  1H7Y A;  2FU5 A;  4V30 A; 
#chains in the Genus database with same CATH homology
 2K8D A;  3HCH A;  3CXK A;  3E0O A;  3HCJ A;  2KZN A;  3WX1 A;  3MAO A;  1L1D A;  4V2Z A;  4CI3 B;  3HCG A;  4V31 A;  4TZU A;  3CEZ A;  5AMH A;  4TZC A;  4CI2 B;  4CI1 B;  3HCI A;  4V2Y A;  3E0M A;  3WX2 A;  4TZ4 C;  2KV1 A;  4V30 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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