4V2YA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
molecule keywords CEREBLON ISOFORM 4
total genus 25
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2yA00
4V2ZA 4V30A 4TZ4C 2KZNA 2KV1A 3CEZA 4V31A 4CI1B 3CXKA 3E0MA 3WX1A 4CI2B 3HCGA 4CI3B 3HCIA 3HCJA 4TZUA 3E0OA 4V2YA 3HCHA 3MAOA 4TZCA 1L1DA 2K8DA 3WX2A 5AMHA
chains in the Genus database with same CATH superfamily
4V2ZA 4V30A 4TZ4C 3GA3A 2KZNA 4BPBA 5F9FA 2LVLA 2KV1A 2RMJA 3ZD7A 3CEZA 4V31A 2W4RA 4CI1B 5F98A 1FWQA 3CXKA 1H6QA 3E0MA 4A2XA 1HXRA 3WX1A 4CI2B 3NCUA 3HCGA 2QFDA 4CI3B 2YKGA 1YZ1A 3ZD6A 3HCIA 3HCJA 2FU5A 4TZUA 2RQBA 3E0OA 2QFBA 3EBMA 3HCHA 3MAOA 4V2YA 4TZCA 3FACA 4A2VA 2LOYA 2K8DA 1L1DA 1TXJA 5E3HA 3LRNA 5F9HA 2RQAA 4AY2A 1H7YA 3LRRA 2KWBA 3P3KA 3DJMA 3WX2A 5AMHA 3EQTA 2HR9A 3OG8A
chains in the Genus database with same CATH topology
4V2ZA 4V30A 4TZ4C 2KZNA 2KV1A 3CEZA 4V31A 4CI1B 3CXKA 3E0MA 3WX1A 4CI2B 3HCGA 4CI3B 3HCIA 3HCJA 4TZUA 3E0OA 4V2YA 3HCHA 3MAOA 4TZCA 1L1DA 2K8DA 3WX2A 5AMHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V2Z A;  4V30 A;  4TZ4 C;  2KZN A;  2KV1 A;  3CEZ A;  4V31 A;  4CI1 B;  3CXK A;  3E0M A;  3WX1 A;  4CI2 B;  3HCG A;  4CI3 B;  3HCI A;  3HCJ A;  4TZU A;  3E0O A;  4V2Y A;  3HCH A;  3MAO A;  4TZC A;  1L1D A;  2K8D A;  3WX2 A;  5AMH A; 
#chains in the Genus database with same CATH topology
 4V2Z A;  4V30 A;  4TZ4 C;  3GA3 A;  2KZN A;  4BPB A;  5F9F A;  2LVL A;  2KV1 A;  2RMJ A;  3ZD7 A;  3CEZ A;  4V31 A;  2W4R A;  4CI1 B;  5F98 A;  1FWQ A;  3CXK A;  1H6Q A;  3E0M A;  4A2X A;  1HXR A;  3WX1 A;  4CI2 B;  3NCU A;  3HCG A;  2QFD A;  4CI3 B;  2YKG A;  1YZ1 A;  3ZD6 A;  3HCI A;  3HCJ A;  2FU5 A;  4TZU A;  2RQB A;  3E0O A;  2QFB A;  3EBM A;  3HCH A;  3MAO A;  4V2Y A;  4TZC A;  3FAC A;  4A2V A;  2LOY A;  2K8D A;  1L1D A;  1TXJ A;  5E3H A;  3LRN A;  5F9H A;  2RQA A;  4AY2 A;  1H7Y A;  3LRR A;  2KWB A;  3P3K A;  3DJM A;  3WX2 A;  5AMH A;  3EQT A;  2HR9 A;  3OG8 A; 
#chains in the Genus database with same CATH homology
 4V2Z A;  4V30 A;  4TZ4 C;  2KZN A;  2KV1 A;  3CEZ A;  4V31 A;  4CI1 B;  3CXK A;  3E0M A;  3WX1 A;  4CI2 B;  3HCG A;  4CI3 B;  3HCI A;  3HCJ A;  4TZU A;  3E0O A;  4V2Y A;  3HCH A;  3MAO A;  4TZC A;  1L1D A;  2K8D A;  3WX2 A;  5AMH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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