4V2ZA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pomalidomide
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
molecule keywords CEREBLON ISOFORM 4
total genus 23
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2zA00
2K8DA 3WX2A 3WX1A 4CI1B 1L1DA 3CEZA 2KZNA 4V2ZA 4CI2B 3HCJA 4TZCA 4TZUA 3CXKA 3HCIA 3MAOA 4TZ4C 3HCHA 4V2YA 4V31A 3E0MA 3E0OA 3HCGA 4V30A 2KV1A 5AMHA 4CI3B
chains in the Genus database with same CATH superfamily
3GA3A 2K8DA 2RMJA 3WX2A 3WX1A 4CI1B 5F9HA 2RQBA 1L1DA 3OG8A 2RQAA 3ZD7A 3CEZA 3EQTA 1TXJA 2LVLA 2KZNA 4V2ZA 4CI2B 4BPBA 3EBMA 2KWBA 3HCJA 5F9FA 3ZD6A 1HXRA 4TZCA 2FU5A 4TZUA 1H6QA 2LOYA 3P3KA 3CXKA 3HCIA 3MAOA 2HR9A 3HCHA 4TZ4C 1FWQA 4V2YA 3FACA 1YZ1A 4V31A 3LRNA 3E0MA 3E0OA 4A2VA 3HCGA 5F98A 3LRRA 4V30A 5E3HA 2KV1A 2W4RA 4A2XA 2QFDA 4AY2A 5AMHA 1H7YA 3NCUA 4CI3B 2YKGA 3DJMA 2QFBA
chains in the Genus database with same CATH topology
2K8DA 3WX2A 3WX1A 4CI1B 1L1DA 3CEZA 2KZNA 4V2ZA 4CI2B 3HCJA 4TZCA 4TZUA 3CXKA 3HCIA 3MAOA 4TZ4C 3HCHA 4V2YA 4V31A 3E0MA 3E0OA 3HCGA 4V30A 2KV1A 5AMHA 4CI3B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2K8D A;  3WX2 A;  3WX1 A;  4CI1 B;  1L1D A;  3CEZ A;  2KZN A;  4V2Z A;  4CI2 B;  3HCJ A;  4TZC A;  4TZU A;  3CXK A;  3HCI A;  3MAO A;  4TZ4 C;  3HCH A;  4V2Y A;  4V31 A;  3E0M A;  3E0O A;  3HCG A;  4V30 A;  2KV1 A;  5AMH A;  4CI3 B; 
#chains in the Genus database with same CATH topology
 3GA3 A;  2K8D A;  2RMJ A;  3WX2 A;  3WX1 A;  4CI1 B;  5F9H A;  2RQB A;  1L1D A;  3OG8 A;  2RQA A;  3ZD7 A;  3CEZ A;  3EQT A;  1TXJ A;  2LVL A;  2KZN A;  4V2Z A;  4CI2 B;  4BPB A;  3EBM A;  2KWB A;  3HCJ A;  5F9F A;  3ZD6 A;  1HXR A;  4TZC A;  2FU5 A;  4TZU A;  1H6Q A;  2LOY A;  3P3K A;  3CXK A;  3HCI A;  3MAO A;  2HR9 A;  3HCH A;  4TZ4 C;  1FWQ A;  4V2Y A;  3FAC A;  1YZ1 A;  4V31 A;  3LRN A;  3E0M A;  3E0O A;  4A2V A;  3HCG A;  5F98 A;  3LRR A;  4V30 A;  5E3H A;  2KV1 A;  2W4R A;  4A2X A;  2QFD A;  4AY2 A;  5AMH A;  1H7Y A;  3NCU A;  4CI3 B;  2YKG A;  3DJM A;  2QFB A; 
#chains in the Genus database with same CATH homology
 2K8D A;  3WX2 A;  3WX1 A;  4CI1 B;  1L1D A;  3CEZ A;  2KZN A;  4V2Z A;  4CI2 B;  3HCJ A;  4TZC A;  4TZU A;  3CXK A;  3HCI A;  3MAO A;  4TZ4 C;  3HCH A;  4V2Y A;  4V31 A;  3E0M A;  3E0O A;  3HCG A;  4V30 A;  2KV1 A;  5AMH A;  4CI3 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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