4V2ZA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pomalidomide
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule keywords CEREBLON ISOFORM 4
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
total genus 23
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2zA00
3WX2A 4V2YA 3CXKA 4TZ4C 4V2ZA 3HCJA 2KZNA 2K8DA 3MAOA 3WX1A 4CI3B 4V30A 3CEZA 4CI1B 3E0OA 4CI2B 3HCGA 4V31A 2KV1A 3HCIA 3HCHA 3E0MA 4TZUA 1L1DA 4TZCA 5AMHA
chains in the Genus database with same CATH superfamily
3WX2A 4V2YA 3ZD6A 3OG8A 2HR9A 3LRNA 2RQBA 3CXKA 1H6QA 4TZ4C 4BPBA 4V2ZA 3NCUA 3HCJA 2KZNA 2K8DA 4A2XA 3MAOA 4A2VA 3EQTA 3WX1A 2RQAA 4CI3B 2W4RA 1TXJA 1YZ1A 4V30A 4AY2A 3FACA 2QFBA 4TZCA 4CI1B 3LRRA 3E0OA 2KWBA 2QFDA 4CI2B 3HCGA 5E3HA 1FWQA 3DJMA 3P3KA 2FU5A 4V31A 2YKGA 2KV1A 5F98A 3HCIA 2LVLA 1HXRA 3HCHA 3GA3A 1H7YA 3E0MA 3ZD7A 5F9FA 2LOYA 2RMJA 4TZUA 5F9HA 1L1DA 3CEZA 3EBMA 5AMHA
chains in the Genus database with same CATH topology
3WX2A 4V2YA 3CXKA 4TZ4C 4V2ZA 3HCJA 2KZNA 2K8DA 3MAOA 3WX1A 4CI3B 4V30A 3CEZA 4CI1B 3E0OA 4CI2B 3HCGA 4V31A 2KV1A 3HCIA 3HCHA 3E0MA 4TZUA 1L1DA 4TZCA 5AMHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WX2 A;  4V2Y A;  3CXK A;  4TZ4 C;  4V2Z A;  3HCJ A;  2KZN A;  2K8D A;  3MAO A;  3WX1 A;  4CI3 B;  4V30 A;  3CEZ A;  4CI1 B;  3E0O A;  4CI2 B;  3HCG A;  4V31 A;  2KV1 A;  3HCI A;  3HCH A;  3E0M A;  4TZU A;  1L1D A;  4TZC A;  5AMH A; 
#chains in the Genus database with same CATH topology
 3WX2 A;  4V2Y A;  3ZD6 A;  3OG8 A;  2HR9 A;  3LRN A;  2RQB A;  3CXK A;  1H6Q A;  4TZ4 C;  4BPB A;  4V2Z A;  3NCU A;  3HCJ A;  2KZN A;  2K8D A;  4A2X A;  3MAO A;  4A2V A;  3EQT A;  3WX1 A;  2RQA A;  4CI3 B;  2W4R A;  1TXJ A;  1YZ1 A;  4V30 A;  4AY2 A;  3FAC A;  2QFB A;  4TZC A;  4CI1 B;  3LRR A;  3E0O A;  2KWB A;  2QFD A;  4CI2 B;  3HCG A;  5E3H A;  1FWQ A;  3DJM A;  3P3K A;  2FU5 A;  4V31 A;  2YKG A;  2KV1 A;  5F98 A;  3HCI A;  2LVL A;  1HXR A;  3HCH A;  3GA3 A;  1H7Y A;  3E0M A;  3ZD7 A;  5F9F A;  2LOY A;  2RMJ A;  4TZU A;  5F9H A;  1L1D A;  3CEZ A;  3EBM A;  5AMH A; 
#chains in the Genus database with same CATH homology
 3WX2 A;  4V2Y A;  3CXK A;  4TZ4 C;  4V2Z A;  3HCJ A;  2KZN A;  2K8D A;  3MAO A;  3WX1 A;  4CI3 B;  4V30 A;  3CEZ A;  4CI1 B;  3E0O A;  4CI2 B;  3HCG A;  4V31 A;  2KV1 A;  3HCI A;  3HCH A;  3E0M A;  4TZU A;  1L1D A;  4TZC A;  5AMH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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