4V2ZA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pomalidomide
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule keywords CEREBLON ISOFORM 4
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
total genus 23
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2zA00
3CXKA 4V2ZA 3WX1A 5AMHA 3HCHA 4CI3B 3HCIA 3MAOA 3HCJA 4V30A 2KZNA 3CEZA 4CI1B 4V2YA 4TZ4C 2K8DA 4V31A 3E0OA 1L1DA 3HCGA 2KV1A 4CI2B 4TZCA 3E0MA 3WX2A 4TZUA
chains in the Genus database with same CATH superfamily
3OG8A 3EQTA 3CXKA 4V2ZA 3ZD6A 3WX1A 5AMHA 5F98A 3HCHA 4CI3B 2RQAA 3HCIA 3MAOA 3HCJA 4A2XA 1H6QA 4V30A 2KZNA 1FWQA 1HXRA 1YZ1A 3DJMA 2HR9A 3P3KA 4A2VA 2RQBA 5E3HA 3CEZA 3WX2A 4CI1B 5F9FA 2LOYA 4V2YA 5F9HA 4TZ4C 2YKGA 2K8DA 1TXJA 2QFBA 3EBMA 4V31A 2W4RA 3E0OA 1L1DA 3HCGA 2KV1A 4BPBA 3NCUA 4AY2A 2QFDA 2KWBA 2RMJA 3FACA 4CI2B 3LRNA 1H7YA 3GA3A 4TZCA 3LRRA 3E0MA 2FU5A 4TZUA 2LVLA 3ZD7A
chains in the Genus database with same CATH topology
3CXKA 4V2ZA 3WX1A 5AMHA 3HCHA 4CI3B 3HCIA 3MAOA 3HCJA 4V30A 2KZNA 3CEZA 4CI1B 4V2YA 4TZ4C 2K8DA 4V31A 3E0OA 1L1DA 3HCGA 2KV1A 4CI2B 4TZCA 3E0MA 3WX2A 4TZUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CXK A;  4V2Z A;  3WX1 A;  5AMH A;  3HCH A;  4CI3 B;  3HCI A;  3MAO A;  3HCJ A;  4V30 A;  2KZN A;  3CEZ A;  4CI1 B;  4V2Y A;  4TZ4 C;  2K8D A;  4V31 A;  3E0O A;  1L1D A;  3HCG A;  2KV1 A;  4CI2 B;  4TZC A;  3E0M A;  3WX2 A;  4TZU A; 
#chains in the Genus database with same CATH topology
 3OG8 A;  3EQT A;  3CXK A;  4V2Z A;  3ZD6 A;  3WX1 A;  5AMH A;  5F98 A;  3HCH A;  4CI3 B;  2RQA A;  3HCI A;  3MAO A;  3HCJ A;  4A2X A;  1H6Q A;  4V30 A;  2KZN A;  1FWQ A;  1HXR A;  1YZ1 A;  3DJM A;  2HR9 A;  3P3K A;  4A2V A;  2RQB A;  5E3H A;  3CEZ A;  3WX2 A;  4CI1 B;  5F9F A;  2LOY A;  4V2Y A;  5F9H A;  4TZ4 C;  2YKG A;  2K8D A;  1TXJ A;  2QFB A;  3EBM A;  4V31 A;  2W4R A;  3E0O A;  1L1D A;  3HCG A;  2KV1 A;  4BPB A;  3NCU A;  4AY2 A;  2QFD A;  2KWB A;  2RMJ A;  3FAC A;  4CI2 B;  3LRN A;  1H7Y A;  3GA3 A;  4TZC A;  3LRR A;  3E0M A;  2FU5 A;  4TZU A;  2LVL A;  3ZD7 A; 
#chains in the Genus database with same CATH homology
 3CXK A;  4V2Z A;  3WX1 A;  5AMH A;  3HCH A;  4CI3 B;  3HCI A;  3MAO A;  3HCJ A;  4V30 A;  2KZN A;  3CEZ A;  4CI1 B;  4V2Y A;  4TZ4 C;  2K8D A;  4V31 A;  3E0O A;  1L1D A;  3HCG A;  2KV1 A;  4CI2 B;  4TZC A;  3E0M A;  3WX2 A;  4TZU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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