4V2ZA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pomalidomide
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule keywords CEREBLON ISOFORM 4
total genus 23
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2zA00
4TZCA 4TZ4C 3CEZA 3WX2A 4CI2B 2K8DA 4V31A 3WX1A 3MAOA 5AMHA 3CXKA 4CI3B 3E0MA 3HCIA 2KZNA 3E0OA 4V30A 4V2ZA 3HCGA 4V2YA 3HCHA 3HCJA 2KV1A 4CI1B 4TZUA 1L1DA
chains in the Genus database with same CATH superfamily
4TZCA 3P3KA 4TZ4C 3OG8A 5F9FA 2RQAA 3CEZA 4TZUA 3WX2A 4BPBA 4CI2B 2K8DA 4V31A 3WX1A 3EQTA 2LOYA 1HXRA 1FWQA 2HR9A 3FACA 3GA3A 3MAOA 3LRRA 2QFDA 3EBMA 1YZ1A 3ZD6A 3ZD7A 1H6QA 5AMHA 2FU5A 3CXKA 3DJMA 3E0MA 2RMJA 4CI3B 3HCIA 2KZNA 3LRNA 3E0OA 3NCUA 2YKGA 4V30A 2W4RA 2QFBA 4V2ZA 3HCGA 4A2XA 1H7YA 2RQBA 4V2YA 5F9HA 1TXJA 5F98A 3HCHA 4AY2A 3HCJA 5E3HA 4CI1B 2LVLA 2KV1A 4A2VA 1L1DA 2KWBA
chains in the Genus database with same CATH topology
4TZCA 4TZ4C 3CEZA 3WX2A 4CI2B 2K8DA 4V31A 3WX1A 3MAOA 5AMHA 3CXKA 4CI3B 3E0MA 3HCIA 2KZNA 3E0OA 4V30A 4V2ZA 3HCGA 4V2YA 3HCHA 3HCJA 2KV1A 4CI1B 4TZUA 1L1DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZC A;  4TZ4 C;  3CEZ A;  3WX2 A;  4CI2 B;  2K8D A;  4V31 A;  3WX1 A;  3MAO A;  5AMH A;  3CXK A;  4CI3 B;  3E0M A;  3HCI A;  2KZN A;  3E0O A;  4V30 A;  4V2Z A;  3HCG A;  4V2Y A;  3HCH A;  3HCJ A;  2KV1 A;  4CI1 B;  4TZU A;  1L1D A; 
#chains in the Genus database with same CATH topology
 4TZC A;  3P3K A;  4TZ4 C;  3OG8 A;  5F9F A;  2RQA A;  3CEZ A;  4TZU A;  3WX2 A;  4BPB A;  4CI2 B;  2K8D A;  4V31 A;  3WX1 A;  3EQT A;  2LOY A;  1HXR A;  1FWQ A;  2HR9 A;  3FAC A;  3GA3 A;  3MAO A;  3LRR A;  2QFD A;  3EBM A;  1YZ1 A;  3ZD6 A;  3ZD7 A;  1H6Q A;  5AMH A;  2FU5 A;  3CXK A;  3DJM A;  3E0M A;  2RMJ A;  4CI3 B;  3HCI A;  2KZN A;  3LRN A;  3E0O A;  3NCU A;  2YKG A;  4V30 A;  2W4R A;  2QFB A;  4V2Z A;  3HCG A;  4A2X A;  1H7Y A;  2RQB A;  4V2Y A;  5F9H A;  1TXJ A;  5F98 A;  3HCH A;  4AY2 A;  3HCJ A;  5E3H A;  4CI1 B;  2LVL A;  2KV1 A;  4A2V A;  1L1D A;  2KWB A; 
#chains in the Genus database with same CATH homology
 4TZC A;  4TZ4 C;  3CEZ A;  3WX2 A;  4CI2 B;  2K8D A;  4V31 A;  3WX1 A;  3MAO A;  5AMH A;  3CXK A;  4CI3 B;  3E0M A;  3HCI A;  2KZN A;  3E0O A;  4V30 A;  4V2Z A;  3HCG A;  4V2Y A;  3HCH A;  3HCJ A;  2KV1 A;  4CI1 B;  4TZU A;  1L1D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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