4V30A

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with lenalidomide
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
molecule keywords CEREBLON ISOFORM 4
total genus 22
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v30A00
3HCIA 3HCJA 4TZ4C 3HCHA 3WX2A 3WX1A 2KZNA 4V2YA 3CEZA 3E0OA 5AMHA 3E0MA 4V30A 4CI1B 2KV1A 1L1DA 4CI2B 3HCGA 4TZUA 4V2ZA 3MAOA 4V31A 4TZCA 3CXKA 4CI3B 2K8DA
chains in the Genus database with same CATH superfamily
3EBMA 3LRNA 3HCIA 5F98A 3HCJA 3FACA 1HXRA 4TZ4C 4A2VA 1H6QA 3HCHA 3WX2A 3WX1A 3EQTA 2KZNA 3DJMA 2QFDA 3CEZA 4V2YA 5F9HA 2RMJA 2W4RA 3E0OA 5AMHA 4BPBA 2HR9A 3OG8A 4A2XA 3E0MA 2KWBA 4V30A 4CI1B 2LOYA 2KV1A 3GA3A 5E3HA 1TXJA 1L1DA 2QFBA 4CI2B 3ZD6A 5F9FA 1H7YA 3HCGA 4TZUA 4V2ZA 2RQAA 3MAOA 4V31A 3LRRA 2RQBA 4TZCA 3ZD7A 1FWQA 1YZ1A 3CXKA 2FU5A 4CI3B 2YKGA 3NCUA 2LVLA 4AY2A 2K8DA 3P3KA
chains in the Genus database with same CATH topology
3HCIA 3HCJA 4TZ4C 3HCHA 3WX2A 3WX1A 2KZNA 4V2YA 3CEZA 3E0OA 5AMHA 3E0MA 4V30A 4CI1B 2KV1A 1L1DA 4CI2B 3HCGA 4TZUA 4V2ZA 3MAOA 4V31A 4TZCA 3CXKA 4CI3B 2K8DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HCI A;  3HCJ A;  4TZ4 C;  3HCH A;  3WX2 A;  3WX1 A;  2KZN A;  4V2Y A;  3CEZ A;  3E0O A;  5AMH A;  3E0M A;  4V30 A;  4CI1 B;  2KV1 A;  1L1D A;  4CI2 B;  3HCG A;  4TZU A;  4V2Z A;  3MAO A;  4V31 A;  4TZC A;  3CXK A;  4CI3 B;  2K8D A; 
#chains in the Genus database with same CATH topology
 3EBM A;  3LRN A;  3HCI A;  5F98 A;  3HCJ A;  3FAC A;  1HXR A;  4TZ4 C;  4A2V A;  1H6Q A;  3HCH A;  3WX2 A;  3WX1 A;  3EQT A;  2KZN A;  3DJM A;  2QFD A;  3CEZ A;  4V2Y A;  5F9H A;  2RMJ A;  2W4R A;  3E0O A;  5AMH A;  4BPB A;  2HR9 A;  3OG8 A;  4A2X A;  3E0M A;  2KWB A;  4V30 A;  4CI1 B;  2LOY A;  2KV1 A;  3GA3 A;  5E3H A;  1TXJ A;  1L1D A;  2QFB A;  4CI2 B;  3ZD6 A;  5F9F A;  1H7Y A;  3HCG A;  4TZU A;  4V2Z A;  2RQA A;  3MAO A;  4V31 A;  3LRR A;  2RQB A;  4TZC A;  3ZD7 A;  1FWQ A;  1YZ1 A;  3CXK A;  2FU5 A;  4CI3 B;  2YKG A;  3NCU A;  2LVL A;  4AY2 A;  2K8D A;  3P3K A; 
#chains in the Genus database with same CATH homology
 3HCI A;  3HCJ A;  4TZ4 C;  3HCH A;  3WX2 A;  3WX1 A;  2KZN A;  4V2Y A;  3CEZ A;  3E0O A;  5AMH A;  3E0M A;  4V30 A;  4CI1 B;  2KV1 A;  1L1D A;  4CI2 B;  3HCG A;  4TZU A;  4V2Z A;  3MAO A;  4V31 A;  4TZC A;  3CXK A;  4CI3 B;  2K8D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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