4V30A

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with lenalidomide
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule keywords CEREBLON ISOFORM 4
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
total genus 22
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v30A00
4V2YA 3CEZA 4V2ZA 3CXKA 4TZCA 2KV1A 3E0OA 4CI3B 3HCGA 2KZNA 4TZUA 2K8DA 5AMHA 3HCIA 3MAOA 3WX2A 3E0MA 4CI1B 4V31A 3WX1A 4V30A 3HCHA 3HCJA 4TZ4C 4CI2B 1L1DA
chains in the Genus database with same CATH superfamily
4V2YA 2YKGA 3LRRA 3CEZA 5F9HA 1YZ1A 1H6QA 4V2ZA 2LOYA 3GA3A 1HXRA 2W4RA 3CXKA 2RQAA 4TZCA 2KV1A 2RMJA 3E0OA 4CI3B 2HR9A 3HCGA 2KZNA 3ZD7A 4AY2A 5F9FA 3DJMA 1TXJA 2K8DA 3P3KA 4TZUA 5AMHA 3HCIA 4BPBA 4A2XA 1H7YA 2RQBA 5E3HA 3EQTA 1FWQA 3MAOA 2QFBA 3WX2A 2KWBA 3E0MA 2FU5A 4CI1B 4V31A 3ZD6A 3WX1A 5F98A 4V30A 3HCHA 3LRNA 3HCJA 4TZ4C 4CI2B 2LVLA 2QFDA 3FACA 4A2VA 1L1DA 3OG8A 3NCUA 3EBMA
chains in the Genus database with same CATH topology
4V2YA 3CEZA 4V2ZA 3CXKA 4TZCA 2KV1A 3E0OA 4CI3B 3HCGA 2KZNA 4TZUA 2K8DA 5AMHA 3HCIA 3MAOA 3WX2A 3E0MA 4CI1B 4V31A 3WX1A 4V30A 3HCHA 3HCJA 4TZ4C 4CI2B 1L1DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V2Y A;  3CEZ A;  4V2Z A;  3CXK A;  4TZC A;  2KV1 A;  3E0O A;  4CI3 B;  3HCG A;  2KZN A;  4TZU A;  2K8D A;  5AMH A;  3HCI A;  3MAO A;  3WX2 A;  3E0M A;  4CI1 B;  4V31 A;  3WX1 A;  4V30 A;  3HCH A;  3HCJ A;  4TZ4 C;  4CI2 B;  1L1D A; 
#chains in the Genus database with same CATH topology
 4V2Y A;  2YKG A;  3LRR A;  3CEZ A;  5F9H A;  1YZ1 A;  1H6Q A;  4V2Z A;  2LOY A;  3GA3 A;  1HXR A;  2W4R A;  3CXK A;  2RQA A;  4TZC A;  2KV1 A;  2RMJ A;  3E0O A;  4CI3 B;  2HR9 A;  3HCG A;  2KZN A;  3ZD7 A;  4AY2 A;  5F9F A;  3DJM A;  1TXJ A;  2K8D A;  3P3K A;  4TZU A;  5AMH A;  3HCI A;  4BPB A;  4A2X A;  1H7Y A;  2RQB A;  5E3H A;  3EQT A;  1FWQ A;  3MAO A;  2QFB A;  3WX2 A;  2KWB A;  3E0M A;  2FU5 A;  4CI1 B;  4V31 A;  3ZD6 A;  3WX1 A;  5F98 A;  4V30 A;  3HCH A;  3LRN A;  3HCJ A;  4TZ4 C;  4CI2 B;  2LVL A;  2QFD A;  3FAC A;  4A2V A;  1L1D A;  3OG8 A;  3NCU A;  3EBM A; 
#chains in the Genus database with same CATH homology
 4V2Y A;  3CEZ A;  4V2Z A;  3CXK A;  4TZC A;  2KV1 A;  3E0O A;  4CI3 B;  3HCG A;  2KZN A;  4TZU A;  2K8D A;  5AMH A;  3HCI A;  3MAO A;  3WX2 A;  3E0M A;  4CI1 B;  4V31 A;  3WX1 A;  4V30 A;  3HCH A;  3HCJ A;  4TZ4 C;  4CI2 B;  1L1D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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