4V30A

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with lenalidomide
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
molecule keywords CEREBLON ISOFORM 4
total genus 22
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v30A00
4V31A 4V30A 2KZNA 3MAOA 3CXKA 3HCJA 3HCGA 3CEZA 3WX1A 3E0OA 3HCHA 4CI3B 4V2ZA 1L1DA 4CI2B 5AMHA 4V2YA 2KV1A 4TZ4C 4TZUA 3HCIA 3WX2A 2K8DA 3E0MA 4TZCA 4CI1B
chains in the Genus database with same CATH superfamily
4V31A 4V30A 2FU5A 3OG8A 3EQTA 2KZNA 4CI1B 4A2VA 1H6QA 3MAOA 5E3HA 2YKGA 5F9FA 3CXKA 4AY2A 2QFBA 3HCJA 3HCGA 3CEZA 3WX1A 3E0OA 4A2XA 3FACA 3HCHA 4CI3B 4V2ZA 1L1DA 3P3KA 4CI2B 5AMHA 2RQAA 3ZD7A 3EBMA 4V2YA 2QFDA 3NCUA 5F9HA 2RMJA 2KV1A 2LVLA 3HCIA 4TZUA 4TZ4C 2LOYA 1FWQA 1HXRA 2KWBA 2RQBA 3WX2A 2K8DA 4BPBA 3LRRA 1H7YA 1TXJA 3E0MA 5F98A 3ZD6A 3GA3A 2W4RA 1YZ1A 4TZCA 3LRNA 2HR9A 3DJMA
chains in the Genus database with same CATH topology
4V31A 4V30A 2KZNA 3MAOA 3CXKA 3HCJA 3HCGA 3CEZA 3WX1A 3E0OA 3HCHA 4CI3B 4V2ZA 1L1DA 4CI2B 5AMHA 4V2YA 2KV1A 4TZ4C 4TZUA 3HCIA 3WX2A 2K8DA 3E0MA 4TZCA 4CI1B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V31 A;  4V30 A;  2KZN A;  3MAO A;  3CXK A;  3HCJ A;  3HCG A;  3CEZ A;  3WX1 A;  3E0O A;  3HCH A;  4CI3 B;  4V2Z A;  1L1D A;  4CI2 B;  5AMH A;  4V2Y A;  2KV1 A;  4TZ4 C;  4TZU A;  3HCI A;  3WX2 A;  2K8D A;  3E0M A;  4TZC A;  4CI1 B; 
#chains in the Genus database with same CATH topology
 4V31 A;  4V30 A;  2FU5 A;  3OG8 A;  3EQT A;  2KZN A;  4CI1 B;  4A2V A;  1H6Q A;  3MAO A;  5E3H A;  2YKG A;  5F9F A;  3CXK A;  4AY2 A;  2QFB A;  3HCJ A;  3HCG A;  3CEZ A;  3WX1 A;  3E0O A;  4A2X A;  3FAC A;  3HCH A;  4CI3 B;  4V2Z A;  1L1D A;  3P3K A;  4CI2 B;  5AMH A;  2RQA A;  3ZD7 A;  3EBM A;  4V2Y A;  2QFD A;  3NCU A;  5F9H A;  2RMJ A;  2KV1 A;  2LVL A;  3HCI A;  4TZU A;  4TZ4 C;  2LOY A;  1FWQ A;  1HXR A;  2KWB A;  2RQB A;  3WX2 A;  2K8D A;  4BPB A;  3LRR A;  1H7Y A;  1TXJ A;  3E0M A;  5F98 A;  3ZD6 A;  3GA3 A;  2W4R A;  1YZ1 A;  4TZC A;  3LRN A;  2HR9 A;  3DJM A; 
#chains in the Genus database with same CATH homology
 4V31 A;  4V30 A;  2KZN A;  3MAO A;  3CXK A;  3HCJ A;  3HCG A;  3CEZ A;  3WX1 A;  3E0O A;  3HCH A;  4CI3 B;  4V2Z A;  1L1D A;  4CI2 B;  5AMH A;  4V2Y A;  2KV1 A;  4TZ4 C;  4TZU A;  3HCI A;  3WX2 A;  2K8D A;  3E0M A;  4TZC A;  4CI1 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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