4V31A

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with deoxyuridine
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
111
structure length
111
Chain Sequence
MVLAPGASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
molecule keywords CEREBLON ISOFORM 4
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
total genus 23
structure length 111
sequence length 111
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v31A00
5AMHA 3MAOA 3CEZA 4V2ZA 4CI1B 3HCIA 4V2YA 3E0OA 4CI3B 2KZNA 3CXKA 3HCGA 4V30A 4TZ4C 4V31A 2KV1A 3WX2A 3HCJA 3HCHA 1L1DA 4TZUA 3E0MA 4TZCA 2K8DA 3WX1A 4CI2B
chains in the Genus database with same CATH superfamily
5E3HA 5AMHA 1TXJA 3MAOA 3LRNA 3CEZA 1HXRA 2LVLA 4V2ZA 2W4RA 4CI1B 1H6QA 3EBMA 2YKGA 3HCIA 4V2YA 1H7YA 3DJMA 3E0OA 1YZ1A 4CI3B 3LRRA 2KZNA 3CXKA 3HCGA 2QFDA 2RQAA 4BPBA 3OG8A 2FU5A 1FWQA 5F9FA 5F9HA 4A2XA 4V30A 4TZ4C 4V31A 2KV1A 3WX2A 3ZD6A 3EQTA 2RQBA 3HCJA 3GA3A 3FACA 3HCHA 3NCUA 1L1DA 3P3KA 3E0MA 4TZUA 3ZD7A 2RMJA 4TZCA 2K8DA 3WX1A 4A2VA 4AY2A 2QFBA 2LOYA 2HR9A 5F98A 2KWBA 4CI2B
chains in the Genus database with same CATH topology
5AMHA 3MAOA 3CEZA 4V2ZA 4CI1B 3HCIA 4V2YA 3E0OA 4CI3B 2KZNA 3CXKA 3HCGA 4V30A 4TZ4C 4V31A 2KV1A 3WX2A 3HCJA 3HCHA 1L1DA 4TZUA 3E0MA 4TZCA 2K8DA 3WX1A 4CI2B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5AMH A;  3MAO A;  3CEZ A;  4V2Z A;  4CI1 B;  3HCI A;  4V2Y A;  3E0O A;  4CI3 B;  2KZN A;  3CXK A;  3HCG A;  4V30 A;  4TZ4 C;  4V31 A;  2KV1 A;  3WX2 A;  3HCJ A;  3HCH A;  1L1D A;  4TZU A;  3E0M A;  4TZC A;  2K8D A;  3WX1 A;  4CI2 B; 
#chains in the Genus database with same CATH topology
 5E3H A;  5AMH A;  1TXJ A;  3MAO A;  3LRN A;  3CEZ A;  1HXR A;  2LVL A;  4V2Z A;  2W4R A;  4CI1 B;  1H6Q A;  3EBM A;  2YKG A;  3HCI A;  4V2Y A;  1H7Y A;  3DJM A;  3E0O A;  1YZ1 A;  4CI3 B;  3LRR A;  2KZN A;  3CXK A;  3HCG A;  2QFD A;  2RQA A;  4BPB A;  3OG8 A;  2FU5 A;  1FWQ A;  5F9F A;  5F9H A;  4A2X A;  4V30 A;  4TZ4 C;  4V31 A;  2KV1 A;  3WX2 A;  3ZD6 A;  3EQT A;  2RQB A;  3HCJ A;  3GA3 A;  3FAC A;  3HCH A;  3NCU A;  1L1D A;  3P3K A;  3E0M A;  4TZU A;  3ZD7 A;  2RMJ A;  4TZC A;  2K8D A;  3WX1 A;  4A2V A;  4AY2 A;  2QFB A;  2LOY A;  2HR9 A;  5F98 A;  2KWB A;  4CI2 B; 
#chains in the Genus database with same CATH homology
 5AMH A;  3MAO A;  3CEZ A;  4V2Z A;  4CI1 B;  3HCI A;  4V2Y A;  3E0O A;  4CI3 B;  2KZN A;  3CXK A;  3HCG A;  4V30 A;  4TZ4 C;  4V31 A;  2KV1 A;  3WX2 A;  3HCJ A;  3HCH A;  1L1D A;  4TZU A;  3E0M A;  4TZC A;  2K8D A;  3WX1 A;  4CI2 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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