5AMHA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, trigonal crystal form
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
106
structure length
106
Chain Sequence
GASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Dynamics of the Cereblon Ligand Binding Domain.
pubmed doi rcsb
molecule keywords CEREBLON ISOFORM 4
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
total genus 21
structure length 106
sequence length 106
ec nomenclature
pdb deposition date 2015-03-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 5amhA00
3HCIA 2K8DA 3HCHA 3CXKA 4V2YA 2KZNA 3HCJA 5AMHA 4CI3B 4TZCA 3WX2A 3MAOA 4CI2B 3HCGA 4V2ZA 4V31A 4TZUA 3CEZA 3WX1A 3E0MA 2KV1A 1L1DA 4CI1B 4TZ4C 4V30A 3E0OA
chains in the Genus database with same CATH superfamily
5F9FA 4A2XA 3EBMA 2RQBA 3HCIA 2K8DA 1H6QA 3ZD7A 4BPBA 3NCUA 2KWBA 3HCHA 3EQTA 2YKGA 3DJMA 3P3KA 5F98A 3OG8A 3CXKA 4V2YA 5F9HA 2KZNA 2QFDA 3FACA 3HCJA 5AMHA 4CI3B 4TZCA 2RQAA 3WX2A 3MAOA 4CI2B 3ZD6A 3HCGA 4V2ZA 4V31A 2HR9A 4TZUA 3CEZA 3WX1A 3GA3A 1TXJA 5E3HA 2W4RA 3E0MA 2KV1A 1YZ1A 1L1DA 1HXRA 4CI1B 2FU5A 3LRNA 2RMJA 3LRRA 4AY2A 3E0OA 4TZ4C 2LOYA 4A2VA 4V30A 2LVLA 1H7YA 1FWQA 2QFBA
chains in the Genus database with same CATH topology
3HCIA 2K8DA 3HCHA 3CXKA 4V2YA 2KZNA 3HCJA 5AMHA 4CI3B 4TZCA 3WX2A 3MAOA 4CI2B 3HCGA 4V2ZA 4V31A 4TZUA 3CEZA 3WX1A 3E0MA 2KV1A 1L1DA 4CI1B 4TZ4C 4V30A 3E0OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HCI A;  2K8D A;  3HCH A;  3CXK A;  4V2Y A;  2KZN A;  3HCJ A;  5AMH A;  4CI3 B;  4TZC A;  3WX2 A;  3MAO A;  4CI2 B;  3HCG A;  4V2Z A;  4V31 A;  4TZU A;  3CEZ A;  3WX1 A;  3E0M A;  2KV1 A;  1L1D A;  4CI1 B;  4TZ4 C;  4V30 A;  3E0O A; 
#chains in the Genus database with same CATH topology
 5F9F A;  4A2X A;  3EBM A;  2RQB A;  3HCI A;  2K8D A;  1H6Q A;  3ZD7 A;  4BPB A;  3NCU A;  2KWB A;  3HCH A;  3EQT A;  2YKG A;  3DJM A;  3P3K A;  5F98 A;  3OG8 A;  3CXK A;  4V2Y A;  5F9H A;  2KZN A;  2QFD A;  3FAC A;  3HCJ A;  5AMH A;  4CI3 B;  4TZC A;  2RQA A;  3WX2 A;  3MAO A;  4CI2 B;  3ZD6 A;  3HCG A;  4V2Z A;  4V31 A;  2HR9 A;  4TZU A;  3CEZ A;  3WX1 A;  3GA3 A;  1TXJ A;  5E3H A;  2W4R A;  3E0M A;  2KV1 A;  1YZ1 A;  1L1D A;  1HXR A;  4CI1 B;  2FU5 A;  3LRN A;  2RMJ A;  3LRR A;  4AY2 A;  3E0O A;  4TZ4 C;  2LOY A;  4A2V A;  4V30 A;  2LVL A;  1H7Y A;  1FWQ A;  2QFB A; 
#chains in the Genus database with same CATH homology
 3HCI A;  2K8D A;  3HCH A;  3CXK A;  4V2Y A;  2KZN A;  3HCJ A;  5AMH A;  4CI3 B;  4TZC A;  3WX2 A;  3MAO A;  4CI2 B;  3HCG A;  4V2Z A;  4V31 A;  4TZU A;  3CEZ A;  3WX1 A;  3E0M A;  2KV1 A;  1L1D A;  4CI1 B;  4TZ4 C;  4V30 A;  3E0O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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