5AMHA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, trigonal crystal form
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
106
structure length
106
Chain Sequence
GASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Dynamics of the Cereblon Ligand Binding Domain.
pubmed doi rcsb
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
molecule keywords CEREBLON ISOFORM 4
total genus 21
structure length 106
sequence length 106
ec nomenclature
pdb deposition date 2015-03-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 5amhA00
3E0OA 2KV1A 4CI2B 2K8DA 3HCIA 4TZUA 4V2ZA 3MAOA 4V31A 3HCJA 4V2YA 3CXKA 1L1DA 3CEZA 3HCHA 3HCGA 4TZ4C 3WX2A 3E0MA 3WX1A 4CI3B 4V30A 2KZNA 5AMHA 4CI1B 4TZCA
chains in the Genus database with same CATH superfamily
3E0OA 2KV1A 4CI2B 3NCUA 2QFBA 4AY2A 2FU5A 5F98A 3P3KA 2QFDA 2K8DA 3EBMA 1H6QA 3HCIA 5F9HA 4A2VA 3EQTA 2LOYA 4TZUA 1YZ1A 4V2ZA 3ZD6A 3MAOA 3FACA 4V31A 5E3HA 1TXJA 3LRRA 5F9FA 3HCJA 4V2YA 3CXKA 4A2XA 1H7YA 2RQBA 1L1DA 1FWQA 2HR9A 2KWBA 3CEZA 3DJMA 3HCHA 3HCGA 4TZ4C 3WX2A 3E0MA 3WX1A 4CI3B 4V30A 2KZNA 3OG8A 1HXRA 3LRNA 2RMJA 2LVLA 4BPBA 5AMHA 4CI1B 2YKGA 2W4RA 3ZD7A 2RQAA 4TZCA 3GA3A
chains in the Genus database with same CATH topology
3E0OA 2KV1A 4CI2B 2K8DA 3HCIA 4TZUA 4V2ZA 3MAOA 4V31A 3HCJA 4V2YA 3CXKA 1L1DA 3CEZA 3HCHA 3HCGA 4TZ4C 3WX2A 3E0MA 3WX1A 4CI3B 4V30A 2KZNA 5AMHA 4CI1B 4TZCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E0O A;  2KV1 A;  4CI2 B;  2K8D A;  3HCI A;  4TZU A;  4V2Z A;  3MAO A;  4V31 A;  3HCJ A;  4V2Y A;  3CXK A;  1L1D A;  3CEZ A;  3HCH A;  3HCG A;  4TZ4 C;  3WX2 A;  3E0M A;  3WX1 A;  4CI3 B;  4V30 A;  2KZN A;  5AMH A;  4CI1 B;  4TZC A; 
#chains in the Genus database with same CATH topology
 3E0O A;  2KV1 A;  4CI2 B;  3NCU A;  2QFB A;  4AY2 A;  2FU5 A;  5F98 A;  3P3K A;  2QFD A;  2K8D A;  3EBM A;  1H6Q A;  3HCI A;  5F9H A;  4A2V A;  3EQT A;  2LOY A;  4TZU A;  1YZ1 A;  4V2Z A;  3ZD6 A;  3MAO A;  3FAC A;  4V31 A;  5E3H A;  1TXJ A;  3LRR A;  5F9F A;  3HCJ A;  4V2Y A;  3CXK A;  4A2X A;  1H7Y A;  2RQB A;  1L1D A;  1FWQ A;  2HR9 A;  2KWB A;  3CEZ A;  3DJM A;  3HCH A;  3HCG A;  4TZ4 C;  3WX2 A;  3E0M A;  3WX1 A;  4CI3 B;  4V30 A;  2KZN A;  3OG8 A;  1HXR A;  3LRN A;  2RMJ A;  2LVL A;  4BPB A;  5AMH A;  4CI1 B;  2YKG A;  2W4R A;  3ZD7 A;  2RQA A;  4TZC A;  3GA3 A; 
#chains in the Genus database with same CATH homology
 3E0O A;  2KV1 A;  4CI2 B;  2K8D A;  3HCI A;  4TZU A;  4V2Z A;  3MAO A;  4V31 A;  3HCJ A;  4V2Y A;  3CXK A;  1L1D A;  3CEZ A;  3HCH A;  3HCG A;  4TZ4 C;  3WX2 A;  3E0M A;  3WX1 A;  4CI3 B;  4V30 A;  2KZN A;  5AMH A;  4CI1 B;  4TZC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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