5AMHA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, trigonal crystal form
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
106
structure length
106
Chain Sequence
GASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Dynamics of the Cereblon Ligand Binding Domain.
pubmed doi rcsb
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
molecule keywords CEREBLON ISOFORM 4
total genus 21
structure length 106
sequence length 106
ec nomenclature
pdb deposition date 2015-03-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 5amhA00
4V30A 3E0MA 4CI3B 3CEZA 3WX1A 4TZCA 4V2YA 4V2ZA 2KV1A 4CI2B 1L1DA 2KZNA 2K8DA 3HCIA 5AMHA 3WX2A 3MAOA 3HCJA 4CI1B 4V31A 3CXKA 3E0OA 4TZ4C 3HCGA 4TZUA 3HCHA
chains in the Genus database with same CATH superfamily
4V30A 1H6QA 3OG8A 3E0MA 4CI3B 3CEZA 5F98A 3WX1A 2QFBA 2KWBA 2RQBA 3NCUA 4TZCA 3LRNA 2YKGA 5E3HA 2RQAA 2HR9A 2W4RA 4V2YA 4V2ZA 2LVLA 3P3KA 3FACA 2KV1A 4CI2B 4A2XA 1L1DA 3EBMA 2KZNA 3ZD6A 5F9HA 3GA3A 2RMJA 2K8DA 3HCIA 1FWQA 2QFDA 5AMHA 3WX2A 1YZ1A 3DJMA 2FU5A 3MAOA 1TXJA 5F9FA 4BPBA 2LOYA 4A2VA 3EQTA 3HCJA 4AY2A 4CI1B 1H7YA 4V31A 3LRRA 3CXKA 3E0OA 4TZ4C 3HCGA 3ZD7A 1HXRA 4TZUA 3HCHA
chains in the Genus database with same CATH topology
4V30A 3E0MA 4CI3B 3CEZA 3WX1A 4TZCA 4V2YA 4V2ZA 2KV1A 4CI2B 1L1DA 2KZNA 2K8DA 3HCIA 5AMHA 3WX2A 3MAOA 3HCJA 4CI1B 4V31A 3CXKA 3E0OA 4TZ4C 3HCGA 4TZUA 3HCHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V30 A;  3E0M A;  4CI3 B;  3CEZ A;  3WX1 A;  4TZC A;  4V2Y A;  4V2Z A;  2KV1 A;  4CI2 B;  1L1D A;  2KZN A;  2K8D A;  3HCI A;  5AMH A;  3WX2 A;  3MAO A;  3HCJ A;  4CI1 B;  4V31 A;  3CXK A;  3E0O A;  4TZ4 C;  3HCG A;  4TZU A;  3HCH A; 
#chains in the Genus database with same CATH topology
 4V30 A;  1H6Q A;  3OG8 A;  3E0M A;  4CI3 B;  3CEZ A;  5F98 A;  3WX1 A;  2QFB A;  2KWB A;  2RQB A;  3NCU A;  4TZC A;  3LRN A;  2YKG A;  5E3H A;  2RQA A;  2HR9 A;  2W4R A;  4V2Y A;  4V2Z A;  2LVL A;  3P3K A;  3FAC A;  2KV1 A;  4CI2 B;  4A2X A;  1L1D A;  3EBM A;  2KZN A;  3ZD6 A;  5F9H A;  3GA3 A;  2RMJ A;  2K8D A;  3HCI A;  1FWQ A;  2QFD A;  5AMH A;  3WX2 A;  1YZ1 A;  3DJM A;  2FU5 A;  3MAO A;  1TXJ A;  5F9F A;  4BPB A;  2LOY A;  4A2V A;  3EQT A;  3HCJ A;  4AY2 A;  4CI1 B;  1H7Y A;  4V31 A;  3LRR A;  3CXK A;  3E0O A;  4TZ4 C;  3HCG A;  3ZD7 A;  1HXR A;  4TZU A;  3HCH A; 
#chains in the Genus database with same CATH homology
 4V30 A;  3E0M A;  4CI3 B;  3CEZ A;  3WX1 A;  4TZC A;  4V2Y A;  4V2Z A;  2KV1 A;  4CI2 B;  1L1D A;  2KZN A;  2K8D A;  3HCI A;  5AMH A;  3WX2 A;  3MAO A;  3HCJ A;  4CI1 B;  4V31 A;  3CXK A;  3E0O A;  4TZ4 C;  3HCG A;  4TZU A;  3HCH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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