1I7CA

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with methylglyoxal bis-(guanylhydrazone)
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
261
structure length
257
Chain Sequence
SMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAGYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 61
structure length 257
sequence length 261
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.90.10 Alpha Beta 4-Layer Sandwich S-adenosylmethionine decarboxylase S-adenosylmethionine decarboxylase 1i7cA00
3EP5A 3DZ3A 3EP3A 3DZ5A 3DZ7A 3EPBA 3H0WA 3DZ4A 3EP4A 1I79A 1I7CA 1I72A 1TMIA 1JENA 1MHMA 3DZ6A 3EP7A 1I7MA 3EPAA 1I7BA 3EP9A 3EP8A 3DZ2A 1JL0A 3H0VA 1MSVA 3EP6A 5TVOA 1TLUA 1VR7A 2IIIA
chains in the Genus database with same CATH superfamily
3EP5A 3DZ3A 3EP3A 3DZ5A 3DZ7A 3EPBA 3H0WA 3DZ4A 3EP4A 1I79A 1I7CA 1I72A 1TMIA 1JENA 1MHMA 3DZ6A 3EP7A 1I7MA 3EPAA 1I7BA 3EP9A 3EP8A 3DZ2A 1JL0A 3H0VA 1MSVA 3EP6A 5TVOA 1TLUA 1VR7A 2IIIA
chains in the Genus database with same CATH topology
1MHMB 3DZ3A 3EP5A 1JENB 3DZ6B 3EPAB 1I7BB 1I7MB 3EP8B 3EP3A 3DZ5A 3DZ7A 3EP9B 3EPBA 3DZ4A 3H0WA 3EP4A 1I79A 1I7CA 1I72A 1TMIA 3DZ2B 1JENA 1MHMA 3DZ6A 3EP7A 1I7MA 3H0VB 3EP6B 3EPAA 1I7BA 3EP9A 3EP8A 5TVOB 3EP5B 3DZ3B 3DZ2A 1JL0A 3EP3B 3DZ7B 3EPBB 3H0VA 1MSVA 3DZ4B 3EP6A 3DZ5B 3H0WB 3EP4B 5TVOA 1I79B 1TLUA 1VR7A 2IIIA 1I72B 1I7CB 3EP7B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EP5 A;  3DZ3 A;  3EP3 A;  3DZ5 A;  3DZ7 A;  3EPB A;  3H0W A;  3DZ4 A;  3EP4 A;  1I79 A;  1I7C A;  1I72 A;  1TMI A;  1JEN A;  1MHM A;  3DZ6 A;  3EP7 A;  1I7M A;  3EPA A;  1I7B A;  3EP9 A;  3EP8 A;  3DZ2 A;  1JL0 A;  3H0V A;  1MSV A;  3EP6 A;  5TVO A;  1TLU A;  1VR7 A;  2III A; 
#chains in the Genus database with same CATH topology
 3EP5 A;  3DZ3 A;  3EP3 A;  3DZ5 A;  3DZ7 A;  3EPB A;  3H0W A;  3DZ4 A;  3EP4 A;  1I79 A;  1I7C A;  1I72 A;  1TMI A;  1JEN A;  1MHM A;  3DZ6 A;  3EP7 A;  1I7M A;  3EPA A;  1I7B A;  3EP9 A;  3EP8 A;  3DZ2 A;  1JL0 A;  3H0V A;  1MSV A;  3EP6 A;  5TVO A;  1TLU A;  1VR7 A;  2III A; 
#chains in the Genus database with same CATH homology
 1MHM B;  3DZ3 A;  3EP5 A;  1JEN B;  3DZ6 B;  3EPA B;  1I7B B;  1I7M B;  3EP8 B;  3EP3 A;  3DZ5 A;  3DZ7 A;  3EP9 B;  3EPB A;  3DZ4 A;  3H0W A;  3EP4 A;  1I79 A;  1I7C A;  1I72 A;  1TMI A;  3DZ2 B;  1JEN A;  1MHM A;  3DZ6 A;  3EP7 A;  1I7M A;  3H0V B;  3EP6 B;  3EPA A;  1I7B A;  3EP9 A;  3EP8 A;  5TVO B;  3EP5 B;  3DZ3 B;  3DZ2 A;  1JL0 A;  3EP3 B;  3DZ7 B;  3EPB B;  3H0V A;  1MSV A;  3DZ4 B;  3EP6 A;  3DZ5 B;  3H0W B;  3EP4 B;  5TVO A;  1I79 B;  1TLU A;  1VR7 A;  2III A;  1I72 B;  1I7C B;  3EP7 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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