1I7CA

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with methylglyoxal bis-(guanylhydrazone)
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
261
structure length
257
Chain Sequence
SMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAGYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 61
structure length 257
sequence length 261
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.90.10 Alpha Beta 4-Layer Sandwich S-adenosylmethionine decarboxylase S-adenosylmethionine decarboxylase 1i7cA00
3DZ3A 1I7BA 2IIIA 1I7CA 1MSVA 3EP4A 3EP3A 1JL0A 1I7MA 1MHMA 3EP9A 1TLUA 3EP7A 3H0WA 1I72A 3EP6A 3DZ5A 3H0VA 1JENA 3EPBA 3DZ2A 3EP5A 3DZ6A 1I79A 3EP8A 1VR7A 1TMIA 3DZ7A 3EPAA 3DZ4A 5TVOA
chains in the Genus database with same CATH superfamily
3DZ3A 1I7BA 2IIIA 1I7CA 1MSVA 3EP4A 3EP3A 1JL0A 1I7MA 1MHMA 3EP9A 1TLUA 3EP7A 3H0WA 1I72A 3EP6A 3DZ5A 3H0VA 1JENA 3EPBA 3DZ2A 3EP5A 3DZ6A 1I79A 3EP8A 1VR7A 1TMIA 3DZ7A 3EPAA 3DZ4A 5TVOA
chains in the Genus database with same CATH topology
3DZ7B 3EPAB 3DZ4B 3DZ3A 1I7BA 2IIIA 5TVOB 1I7CA 1MSVA 3EP4A 3EP3A 1JL0A 1I7MA 1MHMA 3EP9A 1TLUA 3EP7A 3H0WA 1I72A 3DZ3B 3EP6A 3DZ5A 1I7BB 3H0VA 1JENA 3EPBA 1I7CB 3DZ2A 3EP5A 3EP4B 3EP3B 1MHMB 1I7MB 3DZ6A 3EP9B 3EP7B 1I79A 3EP8A 3H0WB 3H0VB 1I72B 1VR7A 3DZ5B 3EP6B 1TMIA 1JENB 3DZ7A 3EPBB 3EPAA 3DZ2B 3DZ4A 3EP5B 3DZ6B 5TVOA 1I79B 3EP8B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DZ3 A;  1I7B A;  2III A;  1I7C A;  1MSV A;  3EP4 A;  3EP3 A;  1JL0 A;  1I7M A;  1MHM A;  3EP9 A;  1TLU A;  3EP7 A;  3H0W A;  1I72 A;  3EP6 A;  3DZ5 A;  3H0V A;  1JEN A;  3EPB A;  3DZ2 A;  3EP5 A;  3DZ6 A;  1I79 A;  3EP8 A;  1VR7 A;  1TMI A;  3DZ7 A;  3EPA A;  3DZ4 A;  5TVO A; 
#chains in the Genus database with same CATH topology
 3DZ3 A;  1I7B A;  2III A;  1I7C A;  1MSV A;  3EP4 A;  3EP3 A;  1JL0 A;  1I7M A;  1MHM A;  3EP9 A;  1TLU A;  3EP7 A;  3H0W A;  1I72 A;  3EP6 A;  3DZ5 A;  3H0V A;  1JEN A;  3EPB A;  3DZ2 A;  3EP5 A;  3DZ6 A;  1I79 A;  3EP8 A;  1VR7 A;  1TMI A;  3DZ7 A;  3EPA A;  3DZ4 A;  5TVO A; 
#chains in the Genus database with same CATH homology
 3DZ7 B;  3EPA B;  3DZ4 B;  3DZ3 A;  1I7B A;  2III A;  5TVO B;  1I7C A;  1MSV A;  3EP4 A;  3EP3 A;  1JL0 A;  1I7M A;  1MHM A;  3EP9 A;  1TLU A;  3EP7 A;  3H0W A;  1I72 A;  3DZ3 B;  3EP6 A;  3DZ5 A;  1I7B B;  3H0V A;  1JEN A;  3EPB A;  1I7C B;  3DZ2 A;  3EP5 A;  3EP4 B;  3EP3 B;  1MHM B;  1I7M B;  3DZ6 A;  3EP9 B;  3EP7 B;  1I79 A;  3EP8 A;  3H0W B;  3H0V B;  1I72 B;  1VR7 A;  3DZ5 B;  3EP6 B;  1TMI A;  1JEN B;  3DZ7 A;  3EPB B;  3EPA A;  3DZ2 B;  3DZ4 A;  3EP5 B;  3DZ6 B;  5TVO A;  1I79 B;  3EP8 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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