1I7BB

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and covalently bound s-adenosylmethionine methyl ester
Total Genus 6
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 6
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i7bB01
3DZ7B 3EP6B 3EP9B 1I79B 3EPAB 3EPBB 1I7MB 1MHMB 1I7CB 5TVOB 1I7BB 3EP5B 3EP8B 3DZ2B 3EP7B 3EP4B 3EP3B 3H0WB 3H0VB 3DZ5B 3DZ6B 3DZ3B 1I72B 3DZ4B 1JENB
chains in the Genus database with same CATH superfamily
3GPDG 5JYAA 4L9RA 2I5PO 2BHLA 3LVFO 1TB4A 4MKZA 3GFGA 1VSVA 2PKRA 3DMTC 2O4UX 1P9LA 3KV3O 4O63O 4XQGA 2G82A 5TVOB 3KSZO 1IHXA 1J0XO 3EP3B 4XB2A 2B4TO 1JKIA 4MVJI 1VC2A 3UUWA 1H6BA 4YWJA 1RM0A 3BTSA 1HDGO 3C1AA 4FB5A 4XQCA 4R51A 3H9EO 3LC1O 4ZICA 2BH9A 1U1IA 1YDWA 1PQPA 3DMTA 2DUUA 4INAA 5AQ1A 2GZ1A 3EZYA 1PU2A 3OHSX 4GMFA 1I72B 1T4BA 3RCBA 3LC7O 3PWSA 1I79B 3M2TA 4MKXA 1PQUA 1CF2O 5JYEA 1H9AA 3KSDO 2DPGA 3Q2IA 5A03A 1P1FA 4AK1A 2H63A 2GZ2A 2YYYA 1JN0A 3F4LA 3ABIA 1H2HA 1B7GO 1H94A 1EBUA 1DSSG 1XEAA 4LGVA 3INGA 3HNPA 4DBVO 5EESA 2VYVD 3C8MA 4TVBA 2Q22A 3Q1LA 4R54A 4MIEA 3K9QO 3E6AA 1RM4A 1E7YA 4JN6B 3UW3A 5GZ1A 4R5HA 4DIBA 3EUWA 1DAPA 2R00C 3EP8B 3PQVA 3DZ2B 1T4DA 3PFWO 2EP5A 3E82A 3B20A 2AXQA 1DC3A 3DBVO 4II7A 3GDOA 3PYLA 3V2UA 3QV1A 1DC5A 4DPLA 3QW2A 3OA0A 1H6AA 1C3VA 5JW6A 5T73A 5EERA 4R41A 3IDSA 2DAPA 2P2SA 3PZRA 1P1IA 4XQEA 2R00A 3L4SO 1DBVO 4Z0HO 4R3WA 3DZ5B 4IQ8A 1GL3A 2CVOA 5C7LO 2DC1A 1XYGA 5C7IO 1NPTO 2D2IA 1NQ5A 1NQOA 4QX6A 3BTVA 3EP9B 1ML3A 1VKNA 1H6DA 3VOSA 3HJAA 2HJSA 1NWCA 3L6OO 4ZHSA 3NTQA 3EPAB 3EPBB 3TZ6A 1QXSA 3CMCO 1TLTA 1I7CB 1DC6A 1SZJG 1GR0A 3HXLA 3WYCA 3EP7B 3TUTA 3H0VB 3IP3A 3VAZA 1ZNQO 1S7CA 4PG6A 3FD8A 1GADO 3WB9A 1CERA 5A04A 1LC3A 5CEFA 1H9BA 2HKIA 3B1KA 5DDIP 2NQTA 4MIYA 1I7BB 3QVXA 4XRGA 3H0WB 4MVJF 1GAEO 1LA2A 1JENB 4L8VA 1OZAA 1QKIA 2DBVO 3EVNA 4LRSB 1YWGO 3OA2A 3NT5A 5JYFA 2Q49A 2X5KO 2B4RO 3CIFA 4N54A 4MVJD 1GD1O 5AVOA 5KVSA 3CPSA 3Q0EA 3TW3A 1NQAO 3LC2O 3RC2A 3E18A 4XB1A 3DZ3B 4RL6A 5EIOA 4LSMA 4O8JA 1QMHA 1FF9A 3RC9A 4DPMA 4CLQA 5M6DA 3E5RA 3RC7A 4PG7A 1NWHA 5EINA 3DB2A 3NT4A 1GYQA 5GZ6A 1TA4A 1K3TA 1DRWA 1DPGA 3PZBA 1EBFA 3WBBA 2YV3A 4MVJA 4MIOA 1E5LA 1H6CA 1JKFA 5A02A 1VM6A 4YDRA 2O48X 3E1KA 4XR4A 2OZPA 4MVJM 3DZ7B 3DR3A 3ZDFA 3EC7A 1E77A 5JY6A 1PR3A 1VSUA 1RYDA 3U3XA 2NVWA 1I32A 4MVJH 1IHYA 1H93A 4K9DA 1GYPA 2GLXA 4PG4A 3ZJXA 3TUXA 4HKTA 3Q11A 3PYMA 3DOCA 3WYBA 2VYND 1E5QA 5A06A 3STHA 3RVDA 3TV1A 3V1YA 2QZ9A 1LC0A 4H3VA 1RYEA 4P8RA 2Q4EA 5GZ3A 4BOYA 1OFGA 2XF8A 1P1KA 3DZ4B 1EVJA 1DRVA 3NTOA 3MOIA 1MC4A 3IWDB 5KVQA 2VYNA 4O59O 2EP7A 1NVMB 2IXAA 2POQX 3WGYA 1QMIA 3BTUA 3PYXA 1MB4A 2PH5A 3DO5A 4GMGA 4XQ9A 5C7OO 4HADA 1I33A 5J9GA 3HQ4O 1YS4A 1CRWG 1J5PA 3E9MA 2G17A 3QY9A 3L0DA 3MZ0A 4PLPA 2GD1O 3BIOA 1NX6A 3CINA 4R3NA 3B1JA 4MJLA 1DIHA 1I7MB 1UYJA 4PG5A 1YL6A 1YL7A 2I3GA 2X0NA 2PKQP 1F06A 3KGDA 4WNIA 2GYYA 1YL5A 3QVWA 4MINA 3V5NA 1GPDG 4IQ0A 3K2BA 3WGQA 1VKOA 3I23A 4O89A 2FPNA 1P1HA 3WGOA 4PG8A 3WBFA 1OBFO 4DPKA 1MHMB 2IXBA 3QVSA 1P1JA 4KOAA 3EP5B 1U8FO 3NT2A 3RBVA 1Q7GA 3DTYA 3ZCXA 2EJWA 4MVJE 1BRMA 3EP6B 4LRTB 2CZCA 3QVTA 4WNCA 4F3YA 3MTJA 5BNTA 1A7KA 3HSKA 4EW6A 4NHEA 2GZ3A 1Q2XA 2I3AA 1PS8A 3PWKA 3DAPA 4GQAA 5A05A 1NBOA 4R4JA 1DRUA 4R5MA 1GCUA 3FHLA 3KUXA 3IJPA 3K73O 1ZH8A 2HO5A 4GPD1 3CEAA 1RM5A 3OQBA 1E7MA 2VYVA 3NTRA 3WGZA 4MVJP 3IWCB 1TVEA 2X5JO 1ARZA 3GNQA 3JSAA 3RC1A 4WOJA 3EP4B 2PKQO 1DC4A 1RM3A 3Q2KA 3DZ6B 3O9ZA 3IWBB 4MVJG
chains in the Genus database with same CATH topology
1TLUA 3DZ5A 3DZ3A 1I72A 1JL0A 3DZ4A 3DZ7B 3DZ6A 1JENA 1TMIA 3DZ7A 3EP6B 3EP9B 1I79B 3EP6A 3EP9A 1I79A 3H0WA 3EPAB 3EPBB 1I7MB 1MHMB 1I7CB 1VR7A 5TVOB 3EPBA 3EPAA 1I7BB 1I7MA 1MHMA 3EP5B 3EP8B 2IIIA 5TVOA 1MSVA 1I7BA 1I7CA 3DZ2B 3EP7B 3EP4B 3EP5A 3EP8A 3EP3B 3H0WB 3H0VB 3DZ5B 3DZ6B 3DZ3B 1I72B 3DZ2A 3DZ4B 3EP4A 3EP7A 3EP3A 1JENB 3H0VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DZ7 B;  3EP6 B;  3EP9 B;  1I79 B;  3EPA B;  3EPB B;  1I7M B;  1MHM B;  1I7C B;  5TVO B;  1I7B B;  3EP5 B;  3EP8 B;  3DZ2 B;  3EP7 B;  3EP4 B;  3EP3 B;  3H0W B;  3H0V B;  3DZ5 B;  3DZ6 B;  3DZ3 B;  1I72 B;  3DZ4 B;  1JEN B; 
#chains in the Genus database with same CATH topology
 3GPD G;  5JYA A;  4L9R A;  2I5P O;  2BHL A;  3LVF O;  1TB4 A;  4MKZ A;  3GFG A;  1VSV A;  2PKR A;  3DMT C;  2O4U X;  1P9L A;  3KV3 O;  4O63 O;  4XQG A;  2G82 A;  5TVO B;  3KSZ O;  1IHX A;  1J0X O;  3EP3 B;  4XB2 A;  2B4T O;  1JKI A;  4MVJ I;  1VC2 A;  3UUW A;  1H6B A;  4YWJ A;  1RM0 A;  3BTS A;  1HDG O;  3C1A A;  4FB5 A;  4XQC A;  4R51 A;  3H9E O;  3LC1 O;  4ZIC A;  2BH9 A;  1U1I A;  1YDW A;  1PQP A;  3DMT A;  2DUU A;  4INA A;  5AQ1 A;  2GZ1 A;  3EZY A;  1PU2 A;  3OHS X;  4GMF A;  1I72 B;  1T4B A;  3RCB A;  3LC7 O;  3PWS A;  1I79 B;  3M2T A;  4MKX A;  1PQU A;  1CF2 O;  5JYE A;  1H9A A;  3KSD O;  2DPG A;  3Q2I A;  5A03 A;  1P1F A;  4AK1 A;  2H63 A;  2GZ2 A;  2YYY A;  1JN0 A;  3F4L A;  3ABI A;  1H2H A;  1B7G O;  1H94 A;  1EBU A;  1DSS G;  1XEA A;  4LGV A;  3ING A;  3HNP A;  4DBV O;  5EES A;  2VYV D;  3C8M A;  4TVB A;  2Q22 A;  3Q1L A;  4R54 A;  4MIE A;  3K9Q O;  3E6A A;  1RM4 A;  1E7Y A;  4JN6 B;  3UW3 A;  5GZ1 A;  4R5H A;  4DIB A;  3EUW A;  1DAP A;  2R00 C;  3EP8 B;  3PQV A;  3DZ2 B;  1T4D A;  3PFW O;  2EP5 A;  3E82 A;  3B20 A;  2AXQ A;  1DC3 A;  3DBV O;  4II7 A;  3GDO A;  3PYL A;  3V2U A;  3QV1 A;  1DC5 A;  4DPL A;  3QW2 A;  3OA0 A;  1H6A A;  1C3V A;  5JW6 A;  5T73 A;  5EER A;  4R41 A;  3IDS A;  2DAP A;  2P2S A;  3PZR A;  1P1I A;  4XQE A;  2R00 A;  3L4S O;  1DBV O;  4Z0H O;  4R3W A;  3DZ5 B;  4IQ8 A;  1GL3 A;  2CVO A;  5C7L O;  2DC1 A;  1XYG A;  5C7I O;  1NPT O;  2D2I A;  1NQ5 A;  1NQO A;  4QX6 A;  3BTV A;  3EP9 B;  1ML3 A;  1VKN A;  1H6D A;  3VOS A;  3HJA A;  2HJS A;  1NWC A;  3L6O O;  4ZHS A;  3NTQ A;  3EPA B;  3EPB B;  3TZ6 A;  1QXS A;  3CMC O;  1TLT A;  1I7C B;  1DC6 A;  1SZJ G;  1GR0 A;  3HXL A;  3WYC A;  3EP7 B;  3TUT A;  3H0V B;  3IP3 A;  3VAZ A;  1ZNQ O;  1S7C A;  4PG6 A;  3FD8 A;  1GAD O;  3WB9 A;  1CER A;  5A04 A;  1LC3 A;  5CEF A;  1H9B A;  2HKI A;  3B1K A;  5DDI P;  2NQT A;  4MIY A;  1I7B B;  3QVX A;  4XRG A;  3H0W B;  4MVJ F;  1GAE O;  1LA2 A;  1JEN B;  4L8V A;  1OZA A;  1QKI A;  2DBV O;  3EVN A;  4LRS B;  1YWG O;  3OA2 A;  3NT5 A;  5JYF A;  2Q49 A;  2X5K O;  2B4R O;  3CIF A;  4N54 A;  4MVJ D;  1GD1 O;  5AVO A;  5KVS A;  3CPS A;  3Q0E A;  3TW3 A;  1NQA O;  3LC2 O;  3RC2 A;  3E18 A;  4XB1 A;  3DZ3 B;  4RL6 A;  5EIO A;  4LSM A;  4O8J A;  1QMH A;  1FF9 A;  3RC9 A;  4DPM A;  4CLQ A;  5M6D A;  3E5R A;  3RC7 A;  4PG7 A;  1NWH A;  5EIN A;  3DB2 A;  3NT4 A;  1GYQ A;  5GZ6 A;  1TA4 A;  1K3T A;  1DRW A;  1DPG A;  3PZB A;  1EBF A;  3WBB A;  2YV3 A;  4MVJ A;  4MIO A;  1E5L A;  1H6C A;  1JKF A;  5A02 A;  1VM6 A;  4YDR A;  2O48 X;  3E1K A;  4XR4 A;  2OZP A;  4MVJ M;  3DZ7 B;  3DR3 A;  3ZDF A;  3EC7 A;  1E77 A;  5JY6 A;  1PR3 A;  1VSU A;  1RYD A;  3U3X A;  2NVW A;  1I32 A;  4MVJ H;  1IHY A;  1H93 A;  4K9D A;  1GYP A;  2GLX A;  4PG4 A;  3ZJX A;  3TUX A;  4HKT A;  3Q11 A;  3PYM A;  3DOC A;  3WYB A;  2VYN D;  1E5Q A;  5A06 A;  3STH A;  3RVD A;  3TV1 A;  3V1Y A;  2QZ9 A;  1LC0 A;  4H3V A;  1RYE A;  4P8R A;  2Q4E A;  5GZ3 A;  4BOY A;  1OFG A;  2XF8 A;  1P1K A;  3DZ4 B;  1EVJ A;  1DRV A;  3NTO A;  3MOI A;  1MC4 A;  3IWD B;  5KVQ A;  2VYN A;  4O59 O;  2EP7 A;  1NVM B;  2IXA A;  2POQ X;  3WGY A;  1QMI A;  3BTU A;  3PYX A;  1MB4 A;  2PH5 A;  3DO5 A;  4GMG A;  4XQ9 A;  5C7O O;  4HAD A;  1I33 A;  5J9G A;  3HQ4 O;  1YS4 A;  1CRW G;  1J5P A;  3E9M A;  2G17 A;  3QY9 A;  3L0D A;  3MZ0 A;  4PLP A;  2GD1 O;  3BIO A;  1NX6 A;  3CIN A;  4R3N A;  3B1J A;  4MJL A;  1DIH A;  1I7M B;  1UYJ A;  4PG5 A;  1YL6 A;  1YL7 A;  2I3G A;  2X0N A;  2PKQ P;  1F06 A;  3KGD A;  4WNI A;  2GYY A;  1YL5 A;  3QVW A;  4MIN A;  3V5N A;  1GPD G;  4IQ0 A;  3K2B A;  3WGQ A;  1VKO A;  3I23 A;  4O89 A;  2FPN A;  1P1H A;  3WGO A;  4PG8 A;  3WBF A;  1OBF O;  4DPK A;  1MHM B;  2IXB A;  3QVS A;  1P1J A;  4KOA A;  3EP5 B;  1U8F O;  3NT2 A;  3RBV A;  1Q7G A;  3DTY A;  3ZCX A;  2EJW A;  4MVJ E;  1BRM A;  3EP6 B;  4LRT B;  2CZC A;  3QVT A;  4WNC A;  4F3Y A;  3MTJ A;  5BNT A;  1A7K A;  3HSK A;  4EW6 A;  4NHE A;  2GZ3 A;  1Q2X A;  2I3A A;  1PS8 A;  3PWK A;  3DAP A;  4GQA A;  5A05 A;  1NBO A;  4R4J A;  1DRU A;  4R5M A;  1GCU A;  3FHL A;  3KUX A;  3IJP A;  3K73 O;  1ZH8 A;  2HO5 A;  4GPD 1;  3CEA A;  1RM5 A;  3OQB A;  1E7M A;  2VYV A;  3NTR A;  3WGZ A;  4MVJ P;  3IWC B;  1TVE A;  2X5J O;  1ARZ A;  3GNQ A;  3JSA A;  3RC1 A;  4WOJ A;  3EP4 B;  2PKQ O;  1DC4 A;  1RM3 A;  3Q2K A;  3DZ6 B;  3O9Z A;  3IWB B;  4MVJ G; 
#chains in the Genus database with same CATH homology
 1TLU A;  3DZ5 A;  3DZ3 A;  1I72 A;  1JL0 A;  3DZ4 A;  3DZ7 B;  3DZ6 A;  1JEN A;  1TMI A;  3DZ7 A;  3EP6 B;  3EP9 B;  1I79 B;  3EP6 A;  3EP9 A;  1I79 A;  3H0W A;  3EPA B;  3EPB B;  1I7M B;  1MHM B;  1I7C B;  1VR7 A;  5TVO B;  3EPB A;  3EPA A;  1I7B B;  1I7M A;  1MHM A;  3EP5 B;  3EP8 B;  2III A;  5TVO A;  1MSV A;  1I7B A;  1I7C A;  3DZ2 B;  3EP7 B;  3EP4 B;  3EP5 A;  3EP8 A;  3EP3 B;  3H0W B;  3H0V B;  3DZ5 B;  3DZ6 B;  3DZ3 B;  1I72 B;  3DZ2 A;  3DZ4 B;  3EP4 A;  3EP7 A;  3EP3 A;  1JEN B;  3H0V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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