1I79B

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and covalently bound 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
Total Genus 7
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
7
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 7
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i79B01
5TVOB 1I72B 1JENB 3DZ3B 3EP8B 3EP5B 3EPBB 1I79B 3EP4B 3EP9B 1I7CB 3DZ4B 3DZ2B 3H0VB 3H0WB 3EP6B 3EP3B 1I7MB 3EPAB 3DZ6B 1MHMB 3DZ5B 3EP7B 1I7BB 3DZ7B
chains in the Genus database with same CATH superfamily
4HADA 3ZDFA 2O48X 1GPDG 4PG4A 3HQ4O 1DC5A 4KOAA 1PQPA 3DZ4B 3INGA 5C7LO 3HJAA 1E77A 2BHLA 1IHYA 3EP3B 1UYJA 4MVJP 4XQ9A 3H9EO 1E5LA 1U1IA 2POQX 5C7OO 3LC2O 4ZICA 1OZAA 2GD1O 1I7BB 5C7IO 2VYVA 4XQGA 5T73A 1E7MA 4R51A 4LGVA 1CRWG 3ABIA 3WBFA 2PH5A 3LC7O 3GNQA 2EP7A 4MVJI 1DAPA 3ZCXA 3RVDA 4PG5A 3EPAB 1DPGA 1NQOA 4XRGA 3E5RA 4IQ8A 4XQEA 4TVBA 1VC2A 4MVJA 3KGDA 5GZ3A 1GAEO 5TVOB 4DPLA 2GZ1A 3E6AA 4R3NA 4R54A 3K9QO 1DRVA 2NVWA 3DZ2B 3OA0A 5A02A 1DIHA 1YL6A 1QMHA 1TVEA 1RM4A 3F4LA 4R5MA 1H9AA 1NVMB 2I3GA 3V2UA 3WYCA 4RL6A 2IXAA 5EERA 1NX6A 3I23A 3WBBA 4GMFA 1T4DA 1NQAO 5GZ6A 3QVWA 3K73O 1TLTA 3OHSX 4DIBA 2VYND 5KVSA 4R41A 1H2HA 3TUTA 5EINA 3DO5A 3NT5A 2X5KO 1QXSA 1Q7GA 2DC1A 1J0XO 2X5JO 3BTUA 3DBVO 1ZNQO 4JN6B 1RM3A 1PQUA 5JW6A 3DMTA 4Z0HO 3B1KA 3C8MA 5BNTA 2FPNA 1P1KA 4NHEA 1RYEA 2XF8A 3EP5B 2GYYA 2DPGA 5JY6A 3NT2A 2EJWA 3IP3A 3TZ6A 4MIOA 4WNCA 1NWHA 1LC0A 3RC1A 1YL7A 3U3XA 1NBOA 1YL5A 1GL3A 4H3VA 3KUXA 3EP7B 3NT4A 3Q2KA 4MVJF 1H94A 3QW2A 1LA2A 3BTVA 3ZJXA 3MTJA 1DBVO 1E5QA 3QVXA 3L0DA 2PKRA 1DRWA 2I3AA 4XQCA 3MZ0A 3PYMA 1RM0A 5CEFA 2IXBA 3DZ5B 1H6DA 1OBFO 3WYBA 3RC2A 5M6DA 3WB9A 1DSSG 1H6AA 3B20A 3PQVA 4MIYA 1P1HA 3KV3O 3Q2IA 3JSAA 1OFGA 4O63O 1VKOA 2CVOA 1VSVA 3OQBA 2DBVO 3NTQA 1C3VA 5AQ1A 1CF2O 4O8JA 4PG7A 3CINA 1ARZA 2D2IA 4R3WA 3L6OO 3NTRA 3DR3A 1GD1O 3CIFA 3IWCB 3V1YA 5AVOA 3H0WB 3PWKA 2EP5A 2DAPA 4GPD1 3E82A 3VAZA 1DC4A 5J9GA 1PS8A 4MVJD 1GYPA 3CPSA 1A7KA 3DZ6B 3TUXA 3HNPA 1XEAA 3EZYA 3PZRA 4MVJE 5EESA 1YWGO 3RC9A 1GADO 1NQ5A 1P1IA 2B4RO 2VYNA 3O9ZA 4YWJA 3EC7A 3PWSA 2BH9A 1DC3A 3UW3A 3TV1A 1LC3A 2R00C 1U8FO 2YYYA 5EIOA 1EBFA 1JENB 3KSDO 4LRSB 1P9LA 3EP8B 3EPBB 1B7GO 5JYEA 1YDWA 1ML3A 2NQTA 1P1JA 3EP9B 3GDOA 3NTOA 2YV3A 1ZH8A 5A04A 1GCUA 1H9BA 3IDSA 4MJLA 3WGOA 3IWBB 5JYAA 4F3YA 2DUUA 3MOIA 1S7CA 3RBVA 5A03A 3HSKA 3E18A 1I79B 1I33A 4K9DA 1RM5A 2X0NA 1E7YA 4BOYA 1H93A 4L9RA 1GR0A 4EW6A 4GQAA 3CMCO 1MB4A 3L4SO 1MC4A 3DB2A 3QY9A 3GFGA 3PYLA 3IJPA 1F06A 4CLQA 1TA4A 3LC1O 2CZCA 2P2SA 3PZBA 3VOSA 2HO5A 4LSMA 1QKIA 3GPDG 3HXLA 5JYFA 4R5HA 5A06A 1Q2XA 1JN0A 2B4TO 3IWDB 2VYVD 2G82A 1VSUA 3RCBA 4MVJH 3RC7A 3DZ7B 1YS4A 2Q22A 1I72B 1VKNA 3BTSA 4DPKA 4ZHSA 3BIOA 3V5NA 4N54A 3Q0EA 4R4JA 1RYDA 3H0VB 4FB5A 1PR3A 3UUWA 3LVFO 4MKZA 4O59O 4YDRA 2Q4EA 3FD8A 1I7MB 3TW3A 1VM6A 1EVJA 2PKQP 3B1JA 4LRTB 5A05A 4MVJG 1DRUA 3QVTA 5DDIP 4MKXA 1JKFA 1J5PA 3E1KA 3KSZO 3PFWO 3EUWA 1JKIA 2O4UX 1BRMA 3DZ3B 3STHA 4HKTA 1H6BA 5GZ1A 2I5PO 3DAPA 1DC6A 1FF9A 2HJSA 4II7A 2PKQO 1QMIA 1GYQA 3M2TA 4GMGA 4DBVO 1NPTO 1NWCA 2GZ2A 2Q49A 3DOCA 4PG8A 1PU2A 4XB1A 3WGZA 3DMTC 3EP4B 3OA2A 4MINA 4INAA 3EVNA 1I7CB 4PLPA 3K2BA 3PYXA 1HDGO 4XR4A 1T4BA 1XYGA 1TB4A 3QV1A 3Q1LA 2R00A 4DPMA 4QX6A 3QVSA 1SZJG 3E9MA 1EBUA 3DTYA 1P1FA 4L8VA 2HKIA 4WNIA 3CEAA 2OZPA 2GLXA 2GZ3A 2H63A 2AXQA 4PG6A 4WOJA 1K3TA 3C1AA 3FHLA 1CERA 3Q11A 3WGQA 4O89A 5KVQA 4XB2A 2G17A 2QZ9A 1IHXA 4MIEA 3EP6B 4MVJM 4IQ0A 3WGYA 4P8RA 1MHMB 1I32A 4AK1A 1H6CA
chains in the Genus database with same CATH topology
1I72A 5TVOB 1TLUA 1I72B 1JENB 3DZ3A 3EP8A 3EP4A 3EP5A 3DZ3B 3EPBA 3EP8B 1I79A 3EP5B 3EPBB 1TMIA 1I79B 3EP4B 3EP9A 1I7CA 3DZ4A 3EP9B 3DZ2A 1I7CB 3H0VA 3DZ4B 3DZ2B 3H0VB 3H0WA 3EP6A 1JL0A 3H0WB 3EP3A 1I7MA 3EP6B 5TVOA 3EP3B 1I7MB 3EPAA 2IIIA 3EPAB 3DZ6A 1VR7A 3DZ6B 1MHMA 3DZ5A 3EP7A 1MHMB 3DZ5B 3EP7B 1I7BA 3DZ7A 1I7BB 1MSVA 3DZ7B 1JENA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TVO B;  1I72 B;  1JEN B;  3DZ3 B;  3EP8 B;  3EP5 B;  3EPB B;  1I79 B;  3EP4 B;  3EP9 B;  1I7C B;  3DZ4 B;  3DZ2 B;  3H0V B;  3H0W B;  3EP6 B;  3EP3 B;  1I7M B;  3EPA B;  3DZ6 B;  1MHM B;  3DZ5 B;  3EP7 B;  1I7B B;  3DZ7 B; 
#chains in the Genus database with same CATH topology
 4HAD A;  3ZDF A;  2O48 X;  1GPD G;  4PG4 A;  3HQ4 O;  1DC5 A;  4KOA A;  1PQP A;  3DZ4 B;  3ING A;  5C7L O;  3HJA A;  1E77 A;  2BHL A;  1IHY A;  3EP3 B;  1UYJ A;  4MVJ P;  4XQ9 A;  3H9E O;  1E5L A;  1U1I A;  2POQ X;  5C7O O;  3LC2 O;  4ZIC A;  1OZA A;  2GD1 O;  1I7B B;  5C7I O;  2VYV A;  4XQG A;  5T73 A;  1E7M A;  4R51 A;  4LGV A;  1CRW G;  3ABI A;  3WBF A;  2PH5 A;  3LC7 O;  3GNQ A;  2EP7 A;  4MVJ I;  1DAP A;  3ZCX A;  3RVD A;  4PG5 A;  3EPA B;  1DPG A;  1NQO A;  4XRG A;  3E5R A;  4IQ8 A;  4XQE A;  4TVB A;  1VC2 A;  4MVJ A;  3KGD A;  5GZ3 A;  1GAE O;  5TVO B;  4DPL A;  2GZ1 A;  3E6A A;  4R3N A;  4R54 A;  3K9Q O;  1DRV A;  2NVW A;  3DZ2 B;  3OA0 A;  5A02 A;  1DIH A;  1YL6 A;  1QMH A;  1TVE A;  1RM4 A;  3F4L A;  4R5M A;  1H9A A;  1NVM B;  2I3G A;  3V2U A;  3WYC A;  4RL6 A;  2IXA A;  5EER A;  1NX6 A;  3I23 A;  3WBB A;  4GMF A;  1T4D A;  1NQA O;  5GZ6 A;  3QVW A;  3K73 O;  1TLT A;  3OHS X;  4DIB A;  2VYN D;  5KVS A;  4R41 A;  1H2H A;  3TUT A;  5EIN A;  3DO5 A;  3NT5 A;  2X5K O;  1QXS A;  1Q7G A;  2DC1 A;  1J0X O;  2X5J O;  3BTU A;  3DBV O;  1ZNQ O;  4JN6 B;  1RM3 A;  1PQU A;  5JW6 A;  3DMT A;  4Z0H O;  3B1K A;  3C8M A;  5BNT A;  2FPN A;  1P1K A;  4NHE A;  1RYE A;  2XF8 A;  3EP5 B;  2GYY A;  2DPG A;  5JY6 A;  3NT2 A;  2EJW A;  3IP3 A;  3TZ6 A;  4MIO A;  4WNC A;  1NWH A;  1LC0 A;  3RC1 A;  1YL7 A;  3U3X A;  1NBO A;  1YL5 A;  1GL3 A;  4H3V A;  3KUX A;  3EP7 B;  3NT4 A;  3Q2K A;  4MVJ F;  1H94 A;  3QW2 A;  1LA2 A;  3BTV A;  3ZJX A;  3MTJ A;  1DBV O;  1E5Q A;  3QVX A;  3L0D A;  2PKR A;  1DRW A;  2I3A A;  4XQC A;  3MZ0 A;  3PYM A;  1RM0 A;  5CEF A;  2IXB A;  3DZ5 B;  1H6D A;  1OBF O;  3WYB A;  3RC2 A;  5M6D A;  3WB9 A;  1DSS G;  1H6A A;  3B20 A;  3PQV A;  4MIY A;  1P1H A;  3KV3 O;  3Q2I A;  3JSA A;  1OFG A;  4O63 O;  1VKO A;  2CVO A;  1VSV A;  3OQB A;  2DBV O;  3NTQ A;  1C3V A;  5AQ1 A;  1CF2 O;  4O8J A;  4PG7 A;  3CIN A;  1ARZ A;  2D2I A;  4R3W A;  3L6O O;  3NTR A;  3DR3 A;  1GD1 O;  3CIF A;  3IWC B;  3V1Y A;  5AVO A;  3H0W B;  3PWK A;  2EP5 A;  2DAP A;  4GPD 1;  3E82 A;  3VAZ A;  1DC4 A;  5J9G A;  1PS8 A;  4MVJ D;  1GYP A;  3CPS A;  1A7K A;  3DZ6 B;  3TUX A;  3HNP A;  1XEA A;  3EZY A;  3PZR A;  4MVJ E;  5EES A;  1YWG O;  3RC9 A;  1GAD O;  1NQ5 A;  1P1I A;  2B4R O;  2VYN A;  3O9Z A;  4YWJ A;  3EC7 A;  3PWS A;  2BH9 A;  1DC3 A;  3UW3 A;  3TV1 A;  1LC3 A;  2R00 C;  1U8F O;  2YYY A;  5EIO A;  1EBF A;  1JEN B;  3KSD O;  4LRS B;  1P9L A;  3EP8 B;  3EPB B;  1B7G O;  5JYE A;  1YDW A;  1ML3 A;  2NQT A;  1P1J A;  3EP9 B;  3GDO A;  3NTO A;  2YV3 A;  1ZH8 A;  5A04 A;  1GCU A;  1H9B A;  3IDS A;  4MJL A;  3WGO A;  3IWB B;  5JYA A;  4F3Y A;  2DUU A;  3MOI A;  1S7C A;  3RBV A;  5A03 A;  3HSK A;  3E18 A;  1I79 B;  1I33 A;  4K9D A;  1RM5 A;  2X0N A;  1E7Y A;  4BOY A;  1H93 A;  4L9R A;  1GR0 A;  4EW6 A;  4GQA A;  3CMC O;  1MB4 A;  3L4S O;  1MC4 A;  3DB2 A;  3QY9 A;  3GFG A;  3PYL A;  3IJP A;  1F06 A;  4CLQ A;  1TA4 A;  3LC1 O;  2CZC A;  2P2S A;  3PZB A;  3VOS A;  2HO5 A;  4LSM A;  1QKI A;  3GPD G;  3HXL A;  5JYF A;  4R5H A;  5A06 A;  1Q2X A;  1JN0 A;  2B4T O;  3IWD B;  2VYV D;  2G82 A;  1VSU A;  3RCB A;  4MVJ H;  3RC7 A;  3DZ7 B;  1YS4 A;  2Q22 A;  1I72 B;  1VKN A;  3BTS A;  4DPK A;  4ZHS A;  3BIO A;  3V5N A;  4N54 A;  3Q0E A;  4R4J A;  1RYD A;  3H0V B;  4FB5 A;  1PR3 A;  3UUW A;  3LVF O;  4MKZ A;  4O59 O;  4YDR A;  2Q4E A;  3FD8 A;  1I7M B;  3TW3 A;  1VM6 A;  1EVJ A;  2PKQ P;  3B1J A;  4LRT B;  5A05 A;  4MVJ G;  1DRU A;  3QVT A;  5DDI P;  4MKX A;  1JKF A;  1J5P A;  3E1K A;  3KSZ O;  3PFW O;  3EUW A;  1JKI A;  2O4U X;  1BRM A;  3DZ3 B;  3STH A;  4HKT A;  1H6B A;  5GZ1 A;  2I5P O;  3DAP A;  1DC6 A;  1FF9 A;  2HJS A;  4II7 A;  2PKQ O;  1QMI A;  1GYQ A;  3M2T A;  4GMG A;  4DBV O;  1NPT O;  1NWC A;  2GZ2 A;  2Q49 A;  3DOC A;  4PG8 A;  1PU2 A;  4XB1 A;  3WGZ A;  3DMT C;  3EP4 B;  3OA2 A;  4MIN A;  4INA A;  3EVN A;  1I7C B;  4PLP A;  3K2B A;  3PYX A;  1HDG O;  4XR4 A;  1T4B A;  1XYG A;  1TB4 A;  3QV1 A;  3Q1L A;  2R00 A;  4DPM A;  4QX6 A;  3QVS A;  1SZJ G;  3E9M A;  1EBU A;  3DTY A;  1P1F A;  4L8V A;  2HKI A;  4WNI A;  3CEA A;  2OZP A;  2GLX A;  2GZ3 A;  2H63 A;  2AXQ A;  4PG6 A;  4WOJ A;  1K3T A;  3C1A A;  3FHL A;  1CER A;  3Q11 A;  3WGQ A;  4O89 A;  5KVQ A;  4XB2 A;  2G17 A;  2QZ9 A;  1IHX A;  4MIE A;  3EP6 B;  4MVJ M;  4IQ0 A;  3WGY A;  4P8R A;  1MHM B;  1I32 A;  4AK1 A;  1H6C A; 
#chains in the Genus database with same CATH homology
 1I72 A;  5TVO B;  1TLU A;  1I72 B;  1JEN B;  3DZ3 A;  3EP8 A;  3EP4 A;  3EP5 A;  3DZ3 B;  3EPB A;  3EP8 B;  1I79 A;  3EP5 B;  3EPB B;  1TMI A;  1I79 B;  3EP4 B;  3EP9 A;  1I7C A;  3DZ4 A;  3EP9 B;  3DZ2 A;  1I7C B;  3H0V A;  3DZ4 B;  3DZ2 B;  3H0V B;  3H0W A;  3EP6 A;  1JL0 A;  3H0W B;  3EP3 A;  1I7M A;  3EP6 B;  5TVO A;  3EP3 B;  1I7M B;  3EPA A;  2III A;  3EPA B;  3DZ6 A;  1VR7 A;  3DZ6 B;  1MHM A;  3DZ5 A;  3EP7 A;  1MHM B;  3DZ5 B;  3EP7 B;  1I7B A;  3DZ7 A;  1I7B B;  1MSV A;  3DZ7 B;  1JEN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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