1I7CB

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with methylglyoxal bis-(guanylhydrazone)
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 9
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i7cB01
1I7CB 3EPAB 3DZ6B 1JENB 3H0VB 3H0WB 1I79B 1MHMB 1I7BB 3DZ2B 3EPBB 3EP8B 1I72B 1I7MB 3EP6B 3EP9B 3DZ7B 3EP3B 3EP7B 5TVOB 3DZ4B 3DZ3B 3EP4B 3EP5B 3DZ5B
chains in the Genus database with same CATH superfamily
1I33A 3WGYA 4WNIA 1J0XO 1DC6A 3EPAB 3K2BA 5A04A 2O4UX 1E5QA 1RYEA 3LVFO 4MKXA 1GCUA 5C7IO 4MKZA 4YWJA 1GYQA 3HQ4O 4XQ9A 2R00C 3K9QO 4MIYA 1EVJA 1H6DA 1H6BA 2G17A 1DSSG 4TVBA 4GQAA 3PYXA 3E82A 3GNQA 3OA2A 3DZ6B 3RC7A 1U1IA 3E6AA 1T4BA 3EVNA 3TUTA 5KVQA 1GL3A 3O9ZA 4RL6A 1OBFO 3PQVA 1VM6A 4R5MA 5CEFA 3B1KA 3Q11A 1DIHA 5C7LO 1NQ5A 2CZCA 2IXAA 3Q1LA 2NQTA 1C3VA 1F06A 1VKNA 3DO5A 1LC0A 1FF9A 2X5KO 3CPSA 4O89A 1H9BA 1TA4A 3EPBB 3NTQA 3EP8B 3WGZA 1IHYA 2PKQP 1MB4A 1P1IA 3VOSA 1P1JA 5A03A 3UW3A 3DZ4B 3RC2A 1JKFA 3L0DA 2DUUA 1S7CA 1B7GO 3LC2O 4R3NA 1I32A 4XB2A 3NTOA 1QXSA 3Q2KA 3CINA 1GADO 3STHA 4MVJH 4IQ0A 1K3TA 5JW6A 5A05A 3IP3A 3EP9B 2DC1A 3PYMA 3Q2IA 4KOAA 3L4SO 4MJLA 3KV3O 4XQEA 3H9EO 3PWSA 1NX6A 1VSUA 2OZPA 4R5HA 4MVJA 4H3VA 1H93A 3L6OO 1PQUA 5EESA 4L8VA 3QVXA 3HXLA 1Q7GA 3E9MA 1ZH8A 3EP6B 3EZYA 4HADA 3KGDA 1QMIA 4MVJF 3WGQA 1Q2XA 5GZ3A 3QY9A 3V2UA 2I5PO 3QVWA 4CLQA 4K9DA 1NPTO 1EBUA 1ML3A 1LA2A 1E7MA 5A02A 3CMCO 1RM0A 3DMTC 3HNPA 3ZDFA 3K73O 1HDGO 3GFGA 1H94A 3DR3A 1H6AA 2DAPA 3E5RA 1I72B 4HKTA 4DPMA 1DC3A 1GR0A 4XQCA 3EP3B 4PG7A 4MVJM 3CEAA 3WYBA 1QMHA 4R54A 3VAZA 2PH5A 1E5LA 5JYEA 2VYVA 5JY6A 2VYVD 3IDSA 1P1HA 3B20A 2Q4EA 1XYGA 1PQPA 3BIOA 1UYJA 2DBVO 4R3WA 3DZ3B 2GD1O 1H9AA 1CF2O 1TVEA 2DPGA 3EC7A 3TV1A 3DZ5B 3RC9A 1DBVO 1IHXA 3HJAA 2EP7A 3WBBA 3LC7O 2NVWA 2YYYA 4N54A 2Q49A 3JSAA 4AK1A 1P9LA 1PU2A 3DB2A 3TUXA 3OQBA 1YWGO 4XB1A 3QVTA 4DPLA 5EIOA 1SZJG 5EINA 3KSZO 2BHLA 3QVSA 3BTUA 1YDWA 3DMTA 3GDOA 4MVJG 3F4LA 4LRSB 2B4RO 2EP5A 1JENB 3KSDO 4ZHSA 3NT2A 4PLPA 2VYND 2GZ3A 3PWKA 1H6CA 1E77A 3NTRA 3V5NA 3DZ7B 4O63O 2EJWA 1YL7A 1BRMA 4MVJI 1A7KA 3EP5B 1PS8A 3DAPA 1DC5A 3BTVA 3IJPA 3ZJXA 1P1KA 2G82A 1CERA 3LC1O 4EW6A 1T4DA 3IWDB 4INAA 1YL6A 1MC4A 1I79B 3OHSX 3U3XA 4XRGA 4DPKA 1RYDA 4LRTB 3RBVA 1YL5A 1P1FA 2CVOA 3EP4B 4II7A 1DRVA 3HSKA 3V1YA 2HKIA 3WGOA 4PG8A 2QZ9A 4IQ8A 4P8RA 1TB4A 3MTJA 2GLXA 4BOYA 4MIOA 3PYLA 3MOIA 5M6DA 2GYYA 2PKRA 3IWBB 1GAEO 2I3AA 4GPD1 5C7OO 4QX6A 4WOJA 1OFGA 2FPNA 2BH9A 4NHEA 4DIBA 4L9RA 1I7CB 3M2TA 5BNTA 1TLTA 1LC3A 3BTSA 3WBFA 2B4TO 3DOCA 3RCBA 4MVJP 3UUWA 1RM3A 3C8MA 5EERA 1GPDG 5AVOA 5TVOB 1E7YA 3IWCB 3TW3A 4MVJE 1DRWA 1GD1O 1NVMB 3FHLA 2HO5A 1OZAA 5GZ6A 1DAPA 1J5PA 4LSMA 5A06A 5JYAA 3PZBA 3GPDG 5DDIP 5J9GA 4PG4A 2POQX 4XQGA 2PKQO 2Q22A 1DPGA 1I7BB 2YV3A 4MIEA 1QKIA 3OA0A 3QW2A 4ZICA 2I3GA 3I23A 3TZ6A 3DTYA 3WB9A 3RC1A 1VKOA 4XR4A 3PFWO 1JN0A 4YDRA 3RVDA 2P2SA 1GYPA 5AQ1A 1DC4A 4FB5A 2X0NA 1MHMB 1PR3A 3DBVO 2VYNA 1U8FO 4Z0HO 3DZ2B 1ZNQO 5JYFA 3Q0EA 1NQOA 1NWCA 3FD8A 1RM5A 4R51A 5T73A 3KUXA 4O59O 3E18A 3QV1A 1JKIA 1NWHA 1CRWG 4LGVA 4DBVO 1VSVA 2GZ1A 2GZ2A 3H0VB 2IXBA 3NT5A 3INGA 4GMFA 1H2HA 3PZRA 4GMGA 1NBOA 1DRUA 3C1AA 2R00A 3MZ0A 3EP7B 2AXQA 2H63A 2D2IA 2HJSA 4R4JA 4WNCA 4MINA 1YS4A 3ZCXA 4O8JA 3WYCA 3CIFA 1XEAA 1RM4A 4MVJD 3H0WB 3EUWA 2X5JO 5GZ1A 4JN6B 3NT4A 1VC2A 1ARZA 3B1JA 4R41A 1I7MB 4PG6A 4F3YA 1EBFA 2XF8A 1NQAO 3E1KA 2O48X 4PG5A 5KVSA 3ABIA
chains in the Genus database with same CATH topology
3DZ4A 1I7CB 3EP5A 5TVOA 3DZ5A 3EPAB 1I7CA 2IIIA 3EPAA 3DZ6B 1JENB 3H0VB 3H0WB 1I79B 1MHMB 1TMIA 1I7BB 1MSVA 1JENA 3H0WA 3DZ2B 3DZ6A 3H0VA 3EPBB 1I79A 1JL0A 1MHMA 3EP8B 1I72B 1I7MB 3EP6B 1I7BA 3DZ2A 3EP9B 3EPBA 3DZ7B 3EP3B 3EP8A 1I72A 3EP7B 3EP6A 5TVOB 3DZ4B 1I7MA 3DZ3B 3EP4B 3DZ7A 3EP3A 3EP9A 1TLUA 3EP5B 3EP7A 1VR7A 3DZ3A 3EP4A 3DZ5B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I7C B;  3EPA B;  3DZ6 B;  1JEN B;  3H0V B;  3H0W B;  1I79 B;  1MHM B;  1I7B B;  3DZ2 B;  3EPB B;  3EP8 B;  1I72 B;  1I7M B;  3EP6 B;  3EP9 B;  3DZ7 B;  3EP3 B;  3EP7 B;  5TVO B;  3DZ4 B;  3DZ3 B;  3EP4 B;  3EP5 B;  3DZ5 B; 
#chains in the Genus database with same CATH topology
 1I33 A;  3WGY A;  4WNI A;  1J0X O;  1DC6 A;  3EPA B;  3K2B A;  5A04 A;  2O4U X;  1E5Q A;  1RYE A;  3LVF O;  4MKX A;  1GCU A;  5C7I O;  4MKZ A;  4YWJ A;  1GYQ A;  3HQ4 O;  4XQ9 A;  2R00 C;  3K9Q O;  4MIY A;  1EVJ A;  1H6D A;  1H6B A;  2G17 A;  1DSS G;  4TVB A;  4GQA A;  3PYX A;  3E82 A;  3GNQ A;  3OA2 A;  3DZ6 B;  3RC7 A;  1U1I A;  3E6A A;  1T4B A;  3EVN A;  3TUT A;  5KVQ A;  1GL3 A;  3O9Z A;  4RL6 A;  1OBF O;  3PQV A;  1VM6 A;  4R5M A;  5CEF A;  3B1K A;  3Q11 A;  1DIH A;  5C7L O;  1NQ5 A;  2CZC A;  2IXA A;  3Q1L A;  2NQT A;  1C3V A;  1F06 A;  1VKN A;  3DO5 A;  1LC0 A;  1FF9 A;  2X5K O;  3CPS A;  4O89 A;  1H9B A;  1TA4 A;  3EPB B;  3NTQ A;  3EP8 B;  3WGZ A;  1IHY A;  2PKQ P;  1MB4 A;  1P1I A;  3VOS A;  1P1J A;  5A03 A;  3UW3 A;  3DZ4 B;  3RC2 A;  1JKF A;  3L0D A;  2DUU A;  1S7C A;  1B7G O;  3LC2 O;  4R3N A;  1I32 A;  4XB2 A;  3NTO A;  1QXS A;  3Q2K A;  3CIN A;  1GAD O;  3STH A;  4MVJ H;  4IQ0 A;  1K3T A;  5JW6 A;  5A05 A;  3IP3 A;  3EP9 B;  2DC1 A;  3PYM A;  3Q2I A;  4KOA A;  3L4S O;  4MJL A;  3KV3 O;  4XQE A;  3H9E O;  3PWS A;  1NX6 A;  1VSU A;  2OZP A;  4R5H A;  4MVJ A;  4H3V A;  1H93 A;  3L6O O;  1PQU A;  5EES A;  4L8V A;  3QVX A;  3HXL A;  1Q7G A;  3E9M A;  1ZH8 A;  3EP6 B;  3EZY A;  4HAD A;  3KGD A;  1QMI A;  4MVJ F;  3WGQ A;  1Q2X A;  5GZ3 A;  3QY9 A;  3V2U A;  2I5P O;  3QVW A;  4CLQ A;  4K9D A;  1NPT O;  1EBU A;  1ML3 A;  1LA2 A;  1E7M A;  5A02 A;  3CMC O;  1RM0 A;  3DMT C;  3HNP A;  3ZDF A;  3K73 O;  1HDG O;  3GFG A;  1H94 A;  3DR3 A;  1H6A A;  2DAP A;  3E5R A;  1I72 B;  4HKT A;  4DPM A;  1DC3 A;  1GR0 A;  4XQC A;  3EP3 B;  4PG7 A;  4MVJ M;  3CEA A;  3WYB A;  1QMH A;  4R54 A;  3VAZ A;  2PH5 A;  1E5L A;  5JYE A;  2VYV A;  5JY6 A;  2VYV D;  3IDS A;  1P1H A;  3B20 A;  2Q4E A;  1XYG A;  1PQP A;  3BIO A;  1UYJ A;  2DBV O;  4R3W A;  3DZ3 B;  2GD1 O;  1H9A A;  1CF2 O;  1TVE A;  2DPG A;  3EC7 A;  3TV1 A;  3DZ5 B;  3RC9 A;  1DBV O;  1IHX A;  3HJA A;  2EP7 A;  3WBB A;  3LC7 O;  2NVW A;  2YYY A;  4N54 A;  2Q49 A;  3JSA A;  4AK1 A;  1P9L A;  1PU2 A;  3DB2 A;  3TUX A;  3OQB A;  1YWG O;  4XB1 A;  3QVT A;  4DPL A;  5EIO A;  1SZJ G;  5EIN A;  3KSZ O;  2BHL A;  3QVS A;  3BTU A;  1YDW A;  3DMT A;  3GDO A;  4MVJ G;  3F4L A;  4LRS B;  2B4R O;  2EP5 A;  1JEN B;  3KSD O;  4ZHS A;  3NT2 A;  4PLP A;  2VYN D;  2GZ3 A;  3PWK A;  1H6C A;  1E77 A;  3NTR A;  3V5N A;  3DZ7 B;  4O63 O;  2EJW A;  1YL7 A;  1BRM A;  4MVJ I;  1A7K A;  3EP5 B;  1PS8 A;  3DAP A;  1DC5 A;  3BTV A;  3IJP A;  3ZJX A;  1P1K A;  2G82 A;  1CER A;  3LC1 O;  4EW6 A;  1T4D A;  3IWD B;  4INA A;  1YL6 A;  1MC4 A;  1I79 B;  3OHS X;  3U3X A;  4XRG A;  4DPK A;  1RYD A;  4LRT B;  3RBV A;  1YL5 A;  1P1F A;  2CVO A;  3EP4 B;  4II7 A;  1DRV A;  3HSK A;  3V1Y A;  2HKI A;  3WGO A;  4PG8 A;  2QZ9 A;  4IQ8 A;  4P8R A;  1TB4 A;  3MTJ A;  2GLX A;  4BOY A;  4MIO A;  3PYL A;  3MOI A;  5M6D A;  2GYY A;  2PKR A;  3IWB B;  1GAE O;  2I3A A;  4GPD 1;  5C7O O;  4QX6 A;  4WOJ A;  1OFG A;  2FPN A;  2BH9 A;  4NHE A;  4DIB A;  4L9R A;  1I7C B;  3M2T A;  5BNT A;  1TLT A;  1LC3 A;  3BTS A;  3WBF A;  2B4T O;  3DOC A;  3RCB A;  4MVJ P;  3UUW A;  1RM3 A;  3C8M A;  5EER A;  1GPD G;  5AVO A;  5TVO B;  1E7Y A;  3IWC B;  3TW3 A;  4MVJ E;  1DRW A;  1GD1 O;  1NVM B;  3FHL A;  2HO5 A;  1OZA A;  5GZ6 A;  1DAP A;  1J5P A;  4LSM A;  5A06 A;  5JYA A;  3PZB A;  3GPD G;  5DDI P;  5J9G A;  4PG4 A;  2POQ X;  4XQG A;  2PKQ O;  2Q22 A;  1DPG A;  1I7B B;  2YV3 A;  4MIE A;  1QKI A;  3OA0 A;  3QW2 A;  4ZIC A;  2I3G A;  3I23 A;  3TZ6 A;  3DTY A;  3WB9 A;  3RC1 A;  1VKO A;  4XR4 A;  3PFW O;  1JN0 A;  4YDR A;  3RVD A;  2P2S A;  1GYP A;  5AQ1 A;  1DC4 A;  4FB5 A;  2X0N A;  1MHM B;  1PR3 A;  3DBV O;  2VYN A;  1U8F O;  4Z0H O;  3DZ2 B;  1ZNQ O;  5JYF A;  3Q0E A;  1NQO A;  1NWC A;  3FD8 A;  1RM5 A;  4R51 A;  5T73 A;  3KUX A;  4O59 O;  3E18 A;  3QV1 A;  1JKI A;  1NWH A;  1CRW G;  4LGV A;  4DBV O;  1VSV A;  2GZ1 A;  2GZ2 A;  3H0V B;  2IXB A;  3NT5 A;  3ING A;  4GMF A;  1H2H A;  3PZR A;  4GMG A;  1NBO A;  1DRU A;  3C1A A;  2R00 A;  3MZ0 A;  3EP7 B;  2AXQ A;  2H63 A;  2D2I A;  2HJS A;  4R4J A;  4WNC A;  4MIN A;  1YS4 A;  3ZCX A;  4O8J A;  3WYC A;  3CIF A;  1XEA A;  1RM4 A;  4MVJ D;  3H0W B;  3EUW A;  2X5J O;  5GZ1 A;  4JN6 B;  3NT4 A;  1VC2 A;  1ARZ A;  3B1J A;  4R41 A;  1I7M B;  4PG6 A;  4F3Y A;  1EBF A;  2XF8 A;  1NQA O;  3E1K A;  2O48 X;  4PG5 A;  5KVS A;  3ABI A; 
#chains in the Genus database with same CATH homology
 3DZ4 A;  1I7C B;  3EP5 A;  5TVO A;  3DZ5 A;  3EPA B;  1I7C A;  2III A;  3EPA A;  3DZ6 B;  1JEN B;  3H0V B;  3H0W B;  1I79 B;  1MHM B;  1TMI A;  1I7B B;  1MSV A;  1JEN A;  3H0W A;  3DZ2 B;  3DZ6 A;  3H0V A;  3EPB B;  1I79 A;  1JL0 A;  1MHM A;  3EP8 B;  1I72 B;  1I7M B;  3EP6 B;  1I7B A;  3DZ2 A;  3EP9 B;  3EPB A;  3DZ7 B;  3EP3 B;  3EP8 A;  1I72 A;  3EP7 B;  3EP6 A;  5TVO B;  3DZ4 B;  1I7M A;  3DZ3 B;  3EP4 B;  3DZ7 A;  3EP3 A;  3EP9 A;  1TLU A;  3EP5 B;  3EP7 A;  1VR7 A;  3DZ3 A;  3EP4 A;  3DZ5 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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