2AU3A

Crystal structure of the aquifex aeolicus primase (zinc binding and rna polymerase domains)
Total Genus 134
50100150200250300350400020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
403
structure length
403
Chain Sequence
MSSDIDELRREIDIVDVISEYLNLEKVGSNYRTNCPFHPDDTPSFYVSPSKQIFKCFGCGVGGDAIKFVSLYEDISYFEAALELAKRYGKKLDLEKISKDEKVYVALDRVCDFYRESLLKNREASEYVKSRGIDPKVARKFDLGYAPSSEALVKVLKENDLLEAYLETKNLLSPTKGVYRDLFLRRVVIPIKDPRGRVIGFGGRRIVEDKSPKYINSPDSRVFKKGENLFGLYEAKEYIKEEGFAILVEGYFDLLRLFSEGIRNVVAPLGTALTQNQANLLSKFTKKVYILYDGDDAGRKAMKSAIPLLLSAGVEVYPVYLPEGYDPDEFIKEFGKEELRRLINSSGELFETLIKTARENLEEKTREFRYYLGFISDGVRRFALASEFHTKYKVPMEILLMKI
50100150200250300350400400300200100
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (4-11)TI5 (93-96)AH4 (77-88)AH5 (99-120)EMPTYTI3 (49-52)AH2 (14-21)AH3 (65-73)S2 (30-33)S1 (25-27)TII'1 (27-30)TI1 (35-38)TIV1 (56-59)S3 (45-48)TI2 (48-51)S4 (53-56)S5 (62-63)AH7 (135-141)AH9 (161-167)TI9 (220-223)S6 (144-146)S8 (178-181)AH6 (122-131)S9 (186-192)TII2 (183-186)AH8 (149-159)TVIII1 (169-172)TI7 (181-184)S7 (171-175)TVIII3 (212-215)TI8 (193-196)AH10 (232-242)S10 (198-205)S11 (214-216)AH11 (251-260)3H1 (225-227)AH12 (275-283)S12 (229-230)S14 (265-268)TII3 (229-232)S13 (245-247)AH14 (327-334)TIV2 (268-271)S15 (287-291)S16 (315-319)AH13 (296-312)TII4 (322-325)AH17 (361-373)AH16 (349-356)3H2 (357-359)TVIII4 (375-378)AH18 (378-392)AH19 (396-400)TI4 (57-60)AH15 (336-345)Updating...
connected with : NaN
publication title Crosstalk between primase subunits can act to regulate primer synthesis in trans.
pubmed doi rcsb
molecule tags Transferase
source organism Aquifex aeolicus
molecule keywords DNA primase
total genus 134
structure length 403
sequence length 403
ec nomenclature ec 2.7.7.-:
pdb deposition date 2005-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01807 zf-CHC2 CHC2 zinc finger
A PF08275 Toprim_N DNA primase catalytic core, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.50.30 Mainly Alpha Up-down Bundle Pheromone ER-1 Pheromone ER-1 2au3A04
3.40.1360.10 Alpha Beta 3-Layer(aba) Sandwich Dna Topoisomerase Vi A Subunit; Chain: A, domain 2 Dna Topoisomerase Vi A Subunit; Chain: A, domain 2 2au3A03
3.90.580.10 Alpha Beta Alpha-Beta Complex DNA Primase; Chain A Zinc finger, CHC2-type domain 2au3A01
3.90.980.10 Alpha Beta Alpha-Beta Complex DNA primase DNAg catalytic core, N-terminal domain DNA primase, catalytic core, N-terminal domain 2au3A02
4O6OA 3B39A 4EDKA 1T6T1 3VDUA 4EDRA 1DD9A 2Q2EA 3VE5A 4EDGA 2ZBKA 1DDEA 2AU3A 1D0QA 1VDDA 1D3YA 5GUJA 4EDTA 4O6PB 4E2KA 4EDVA 4JCVA 4EE1A 1EQNA 3VDPA 2V1CA
chains in the Genus database with same CATH superfamily
4O6OA 3B39A 4EDKA 1T6T1 3VDUA 2NSWA 4EDRA 2KC6A 1DD9A 2Q2EA 3CU7A 2B39A 3VE5A 4EDGA 2KK2A 2I5RA 2NSVA 1DDEA 2AU3A 2V1CA 2ZBKA 1D0QA 1ERCA 1VDDA 2ERLA 1D3YA 5GUJA 4EDTA 2JMSA 4O6PB 4E2KA 2FCJA 4EDVA 4JCVA 3KLSA 4EE1A 1EQNA 3VDPA 2LMKA 3KXRA
chains in the Genus database with same CATH topology
4O6OA 3B39A 4EDKA 1T6T1 3VDUA 2NSWA 4EDRA 2KC6A 1DD9A 2Q2EA 3CU7A 2B39A 3VE5A 4EDGA 2KK2A 2NSVA 1DDEA 2AU3A 2V1CA 2ZBKA 1D0QA 1ERCA 1VDDA 2ERLA 1D3YA 5GUJA 4EDTA 2JMSA 4O6PB 4E2KA 4EDVA 4JCVA 3KLSA 4EE1A 1EQNA 3VDPA 2LMKA 3KXRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4O6O A;  3B39 A;  4EDK A;  1T6T 1;  3VDU A;  4EDR A;  1DD9 A;  2Q2E A;  3VE5 A;  4EDG A;  2ZBK A;  1DDE A;  2AU3 A;  1D0Q A;  1VDD A;  1D3Y A;  5GUJ A;  4EDT A;  4O6P B;  4E2K A;  4EDV A;  4JCV A;  4EE1 A;  1EQN A;  3VDP A;  2V1C A; 
#chains in the Genus database with same CATH topology
 4O6O A;  3B39 A;  4EDK A;  1T6T 1;  3VDU A;  2NSW A;  4EDR A;  2KC6 A;  1DD9 A;  2Q2E A;  3CU7 A;  2B39 A;  3VE5 A;  4EDG A;  2KK2 A;  2I5R A;  2NSV A;  1DDE A;  2AU3 A;  2V1C A;  2ZBK A;  1D0Q A;  1ERC A;  1VDD A;  2ERL A;  1D3Y A;  5GUJ A;  4EDT A;  2JMS A;  4O6P B;  4E2K A;  2FCJ A;  4EDV A;  4JCV A;  3KLS A;  4EE1 A;  1EQN A;  3VDP A;  2LMK A;  3KXR A; 
#chains in the Genus database with same CATH homology
 4O6O A;  3B39 A;  4EDK A;  1T6T 1;  3VDU A;  2NSW A;  4EDR A;  2KC6 A;  1DD9 A;  2Q2E A;  3CU7 A;  2B39 A;  3VE5 A;  4EDG A;  2KK2 A;  2NSV A;  1DDE A;  2AU3 A;  2V1C A;  2ZBK A;  1D0Q A;  1ERC A;  1VDD A;  2ERL A;  1D3Y A;  5GUJ A;  4EDT A;  2JMS A;  4O6P B;  4E2K A;  4EDV A;  4JCV A;  3KLS A;  4EE1 A;  1EQN A;  3VDP A;  2LMK A;  3KXR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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