3MK5A

Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase domain from mycobacterium tuberculosis with sulfate and zinc at ph 4.00
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
207
structure length
191
Chain Sequence
HMTRLDSVERAVADIAAGKAVIVIDDEDEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYTVTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for pH dependent monomer-dimer transition of 3,4-dihydroxy 2-butanone-4-phosphate synthase domain from Mycobacterium tuberculosis
pubmed doi rcsb
molecule keywords 3,4-dihydroxy-2-butanone 4-phosphate synthase
molecule tags Lyase
source organism Mycobacterium tuberculosis
total genus 61
structure length 191
sequence length 207
ec nomenclature ec 3.5.4.25: GTP cyclohydrolase II.
pdb deposition date 2010-04-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00926 DHBP_synthase 3,4-dihydroxy-2-butanone 4-phosphate synthase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.870.10 Alpha Beta Alpha-Beta Complex DHBP synthase DHBP synthase 3mk5A00
1JCUA 4P8EA 1K49A 2RISA 1G58A 4P77A 2RIUA 1SNNA 4E1BA 2MX1A 1TKUA 3MK5A 1HRUA 1K7JA 3MGZA 1K4PA 3LQUA 3AJEA 3LS6A 1PVYA 1IEZA 3H07A 4FFJA 4P8JA 4I14A 3L7VA 1K4LA 1G57A 1K4IA 4P6PA 1PVWA 4P6DA 1TKSA 1KK9A 1K4OA 3LRJA 3MIOA 4P6CA 2EQAA
chains in the Genus database with same CATH superfamily
1JCUA 4P8EA 1K49A 3TSPA 2RISA 1G58A 4P77A 3VTIA 3TTCA 3VEWA 2RIUA 1SNNA 3TSUA 4E1BA 2MX1A 1TKUA 3MK5A 3TTDA 1HRUA 1K7JA 3MGZA 3TTFA 1K4PA 3LQUA 3AJEA 3VESA 3LS6A 1PVYA 3VETA 1IEZA 3H07A 4FFJA 4P8JA 3VEOA 4I14A 3L7VA 1K4LA 3VF2A 1G57A 3VTHA 1K4IA 4P6PA 3VEZA 1PVWA 3TSQA 3VERA 4P6DA 1TKSA 1KK9A 1K4OA 3VEXA 3VF4A 3LRJA 3MIOA 4P6CA 3VENA 2EQAA
chains in the Genus database with same CATH topology
1JCUA 4P8EA 1K49A 3TSPA 2RISA 1G58A 4P77A 3VTIA 3TTCA 3VEWA 2RIUA 1SNNA 3TSUA 4E1BA 2MX1A 1TKUA 3MK5A 3TTDA 1HRUA 1K7JA 3MGZA 3TTFA 1K4PA 3LQUA 3AJEA 3VESA 3LS6A 1PVYA 3VETA 1IEZA 3H07A 4FFJA 4P8JA 3VEOA 4I14A 3L7VA 1K4LA 3VF2A 1G57A 3VTHA 1K4IA 4P6PA 3VEZA 1PVWA 3TSQA 3VERA 4P6DA 1TKSA 1KK9A 1K4OA 3VEXA 3VF4A 3LRJA 3MIOA 4P6CA 3VENA 2EQAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JCU A;  4P8E A;  1K49 A;  2RIS A;  1G58 A;  4P77 A;  2RIU A;  1SNN A;  4E1B A;  2MX1 A;  1TKU A;  3MK5 A;  1HRU A;  1K7J A;  3MGZ A;  1K4P A;  3LQU A;  3AJE A;  3LS6 A;  1PVY A;  1IEZ A;  3H07 A;  4FFJ A;  4P8J A;  4I14 A;  3L7V A;  1K4L A;  1G57 A;  1K4I A;  4P6P A;  1PVW A;  4P6D A;  1TKS A;  1KK9 A;  1K4O A;  3LRJ A;  3MIO A;  4P6C A;  2EQA A; 
#chains in the Genus database with same CATH topology
 1JCU A;  4P8E A;  1K49 A;  3TSP A;  2RIS A;  1G58 A;  4P77 A;  3VTI A;  3TTC A;  3VEW A;  2RIU A;  1SNN A;  3TSU A;  4E1B A;  2MX1 A;  1TKU A;  3MK5 A;  3TTD A;  1HRU A;  1K7J A;  3MGZ A;  3TTF A;  1K4P A;  3LQU A;  3AJE A;  3VES A;  3LS6 A;  1PVY A;  3VET A;  1IEZ A;  3H07 A;  4FFJ A;  4P8J A;  3VEO A;  4I14 A;  3L7V A;  1K4L A;  3VF2 A;  1G57 A;  3VTH A;  1K4I A;  4P6P A;  3VEZ A;  1PVW A;  3TSQ A;  3VER A;  4P6D A;  1TKS A;  1KK9 A;  1K4O A;  3VEX A;  3VF4 A;  3LRJ A;  3MIO A;  4P6C A;  3VEN A;  2EQA A; 
#chains in the Genus database with same CATH homology
 1JCU A;  4P8E A;  1K49 A;  3TSP A;  2RIS A;  1G58 A;  4P77 A;  3VTI A;  3TTC A;  3VEW A;  2RIU A;  1SNN A;  3TSU A;  4E1B A;  2MX1 A;  1TKU A;  3MK5 A;  3TTD A;  1HRU A;  1K7J A;  3MGZ A;  3TTF A;  1K4P A;  3LQU A;  3AJE A;  3VES A;  3LS6 A;  1PVY A;  3VET A;  1IEZ A;  3H07 A;  4FFJ A;  4P8J A;  3VEO A;  4I14 A;  3L7V A;  1K4L A;  3VF2 A;  1G57 A;  3VTH A;  1K4I A;  4P6P A;  3VEZ A;  1PVW A;  3TSQ A;  3VER A;  4P6D A;  1TKS A;  1KK9 A;  1K4O A;  3VEX A;  3VF4 A;  3LRJ A;  3MIO A;  4P6C A;  3VEN A;  2EQA A; 
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