4E2KA

The structure of the s. aureus dnag rna polymerase domain
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
321
structure length
319
Chain Sequence
SNADDLQMIEMHELIQEFYYYALTKTVEGEQALTYLQERGFTDALIKERGIGFAPDSSHFCHDFLQKKGYDIELAYEAGLLSRNEENFSYYDRFRNRIMFPLKNAQGRIVGYSGRTYTGQEPKYLNSPETPIFQKRKLLYNLDKARKSIRKLDEIVLLEGFMDVIKSDTAGLKNVVATMGTQLSDEHITFIRKLTSNITLMFDGDFAGSEATLKTGQHLLQQGLNVFVIQLPMDPDEYIGKYGNDAFTTFVKNDKKSFAHYKVSILKDEIAHNDLSYERYLKELSHDISLMKSSILQQKAINDVAPFFNVSPEQLANEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases.
pubmed doi rcsb
molecule keywords DNA primase
molecule tags Transferase
source organism Staphylococcus aureus
total genus 116
structure length 319
sequence length 321
ec nomenclature ec 2.7.7.-:
pdb deposition date 2012-03-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08275 Toprim_N DNA primase catalytic core, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.50.20 Mainly Alpha Up-down Bundle Pheromone ER-1 Pheromone ER-1 4e2kA03
3.40.1360.10 Alpha Beta 3-Layer(aba) Sandwich Dna Topoisomerase Vi A Subunit; Chain: A, domain 2 Dna Topoisomerase Vi A Subunit; Chain: A, domain 2 4e2kA02
3.90.980.10 Alpha Beta Alpha-Beta Complex DNA primase DNAg catalytic core, N-terminal domain DNA primase, catalytic core, N-terminal domain 4e2kA01
1EQNA 1VDDA 4EDTA 4O6PB 4JCVA 1D3YA 4E2KA 4EDRA 1DDEA 2AU3A 4EDGA 2Q2EA 4O6OA 1DD9A 1T6T1 3VDUA 4EE1A 4EDVA 3VDPA 3B39A 3VE5A 4EDKA 2ZBKA 5GUJA 2V1CA
chains in the Genus database with same CATH superfamily
2I5RA 1EQNA 1ERCA 1VDDA 2JMSA 4EDTA 2B39A 4JCVA 4O6PB 1D3YA 2NSVA 4E2KA 2NSWA 4EDRA 1DDEA 2FCJA 2AU3A 2KK2A 2LMKA 4EDGA 2Q2EA 2ERLA 1DD9A 4O6OA 1T6T1 3VDUA 4EE1A 3CU7A 4EDVA 3VDPA 3KXRA 3KLSA 2KC6A 3B39A 4EDKA 3VE5A 2ZBKA 5GUJA 2V1CA
chains in the Genus database with same CATH topology
1EQNA 1ERCA 1VDDA 2JMSA 4EDTA 2B39A 4JCVA 4O6PB 1D3YA 2NSVA 4E2KA 2NSWA 4EDRA 1DDEA 2AU3A 2KK2A 2LMKA 4EDGA 2Q2EA 2ERLA 1DD9A 4O6OA 1T6T1 3VDUA 4EE1A 3CU7A 4EDVA 3VDPA 3KXRA 3KLSA 2KC6A 3B39A 4EDKA 3VE5A 2ZBKA 5GUJA 2V1CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EQN A;  1VDD A;  4EDT A;  4O6P B;  4JCV A;  1D3Y A;  4E2K A;  4EDR A;  1DDE A;  2AU3 A;  4EDG A;  2Q2E A;  4O6O A;  1DD9 A;  1T6T 1;  3VDU A;  4EE1 A;  4EDV A;  3VDP A;  3B39 A;  3VE5 A;  4EDK A;  2ZBK A;  5GUJ A;  2V1C A; 
#chains in the Genus database with same CATH topology
 2I5R A;  1EQN A;  1ERC A;  1VDD A;  2JMS A;  4EDT A;  2B39 A;  4JCV A;  4O6P B;  1D3Y A;  2NSV A;  4E2K A;  2NSW A;  4EDR A;  1DDE A;  2FCJ A;  2AU3 A;  2KK2 A;  2LMK A;  4EDG A;  2Q2E A;  2ERL A;  1DD9 A;  4O6O A;  1T6T 1;  3VDU A;  4EE1 A;  3CU7 A;  4EDV A;  3VDP A;  3KXR A;  3KLS A;  2KC6 A;  3B39 A;  4EDK A;  3VE5 A;  2ZBK A;  5GUJ A;  2V1C A; 
#chains in the Genus database with same CATH homology
 1EQN A;  1ERC A;  1VDD A;  2JMS A;  4EDT A;  2B39 A;  4JCV A;  4O6P B;  1D3Y A;  2NSV A;  4E2K A;  2NSW A;  4EDR A;  1DDE A;  2AU3 A;  2KK2 A;  2LMK A;  4EDG A;  2Q2E A;  2ERL A;  1DD9 A;  4O6O A;  1T6T 1;  3VDU A;  4EE1 A;  3CU7 A;  4EDV A;  3VDP A;  3KXR A;  3KLS A;  2KC6 A;  3B39 A;  4EDK A;  3VE5 A;  2ZBK A;  5GUJ A;  2V1C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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