5IO1A

Crystal structure of recombinant human z alpha-1-antitrypsin
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
371
structure length
365
Chain Sequence
NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDKKGCELEAIPRSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Alpha-1-antitrypsin
publication title Molecular Mechanism of Z alpha 1-Antitrypsin Deficiency
pubmed doi rcsb
source organism Homo sapiens
total genus 100
structure length 365
sequence length 371
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-03-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 5io1A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 5io1A01
4C41A 1NQ9I 2ARRA 4AQHA 1QLPA 4P0FA 2RIWA 5CDXA 1OC0A 1K9OI 3CWLA 4AU3A 1JVQI 3DY0A 4DY0A 2QUGA 4Y40A 1EZXA 1JMOA 3PB1I 1E03I 4BB2A 3EOXA 3NDDA 4AU4A 4ROBA 3F02A 2ACHA 1YXAA 3CWMA 3KCGI 2VH4A 1XQGA 2D26A 2B5TI 1WZ9A 1PSIA 1DB2A 2WXXA 4Y3KA 3OZQA 1BR8I 3EVJI 1QMBA 1JRRA 2H4QA 2WXZA 2OL2A 2WY1A 1A7CA 1E05I 2VDXA 1R1LI 1JJOC 4PYWA 1MTPA 2B4XI 2PEFA 1LK6I 2HI9A 1ATUA 2H4PA 5EI0A 4ROAA 4DY7C 4RO9A 1TB6I 1XU8A 2B4XL 2H4RA 1QMNA 4IF8A 3STOA 3CAAA 1AS4A 2WY0C 3DRMA 1UHGA 1OPHA 4CAAA 1DZGI 2XN5A 3LW2A 2ZNHA 1C5GA 2ARQA 1D5SA 3Q03A 3ZHAA 4C49A 4AU3B 1DVMA 1C8OA 1BY7A 3T1PA 1DZGL 1OO8A 1OVAC 2HIJI 2VDYA 2XN6A 3H5CA 1HP7A 7APIA 3B9FI 3Q02A 1OVAB 2DUTA 3NDAA 1OYHI 1DZHI 2HIJL 2WXWA 4G8RA 2WXYC 4ZK0A 3PZFA 9APIA 2V95A 4GA7A 1E04I 1JTIA 4G8OA 1IZ2A 4AU2A 4X30A 1F0CA 3F5NA 4AJUA 1OYHL 1DZHL 1SEKA 2RIVA 4AFXA 5HGCA 5BRRI 2BEHI 1DVNA 5CDZA 1LJ5A 2GD4C 2XN3A 2CEOA 1ATHA 3F1SA 2PEEA 2ZV6A 4R9IA 5IO1A 9PAIA 1KCTA 2BEHL 2R9YA 3VVJA 1IMVA 1T1FA 1JMJA 5C98A 3LE2A 2WXZC 1XQJA 1HLEA 1LQ8A 3NE4A 3R4LA 4P0OA 4YIAA 4EB1I 4DTEA 1AZXI 3UT3A 1M93B 8APIA 1ATTA 1ANTI 2ANTI 4ZK3A 4RSQA 1OVAA 5CE0A 2XN7A 3NDFA 3FGQA 4EB1L 5INWA 3CVMA 4AJTA 2OAYA 1B3KA 3DRUA 4KDSA 1SNGA 4IC0A 3DLWA 1SR5A
chains in the Genus database with same CATH superfamily
4C41A 1NQ9I 2ARRA 4AQHA 1QLPA 4P0FA 2RIWA 5CDXA 1OC0A 1K9OI 3CWLA 4AU3A 1JVQI 3DY0A 4DY0A 2QUGA 4Y40A 1EZXA 1JMOA 3PB1I 1E03I 4BB2A 3EOXA 3NDDA 4AU4A 4ROBA 3F02A 2ACHA 1YXAA 3CWMA 3KCGI 2VH4A 1XQGA 2D26A 2B5TI 1WZ9A 1PSIA 1DB2A 2WXXA 4Y3KA 3OZQA 1BR8I 3EVJI 1QMBA 1JRRA 2H4QA 2WXZA 2OL2A 2WY1A 1A7CA 1E05I 2VDXA 1R1LI 1JJOC 4PYWA 1MTPA 2B4XI 2PEFA 1LK6I 2HI9A 1ATUA 2H4PA 5EI0A 4ROAA 4DY7C 4RO9A 1TB6I 1XU8A 2B4XL 2H4RA 1QMNA 4IF8A 3STOA 3CAAA 1AS4A 2WY0C 3DRMA 1UHGA 1OPHA 4CAAA 1DZGI 2XN5A 3LW2A 2ZNHA 1C5GA 2ARQA 1D5SA 3Q03A 3ZHAA 4C49A 4AU3B 1DVMA 1C8OA 1BY7A 3T1PA 1DZGL 1OO8A 1OVAC 2HIJI 2VDYA 2XN6A 3H5CA 1HP7A 7APIA 3B9FI 3Q02A 1OVAB 2DUTA 3NDAA 1OYHI 1DZHI 2HIJL 2WXWA 4G8RA 2WXYC 4ZK0A 3PZFA 9APIA 2V95A 4GA7A 1E04I 1JTIA 4G8OA 1IZ2A 4AU2A 4X30A 1F0CA 3F5NA 4AJUA 1OYHL 1DZHL 1SEKA 2RIVA 4AFXA 5HGCA 5BRRI 2BEHI 1DVNA 5CDZA 1LJ5A 2GD4C 2XN3A 2CEOA 1ATHA 3F1SA 2PEEA 2ZV6A 4R9IA 5IO1A 9PAIA 1KCTA 2BEHL 2R9YA 3VVJA 1IMVA 1T1FA 1JMJA 5C98A 3LE2A 2WXZC 1XQJA 1HLEA 1LQ8A 3NE4A 3R4LA 4P0OA 4YIAA 4EB1I 4DTEA 1AZXI 3UT3A 1M93B 8APIA 1ATTA 1ANTI 2ANTI 4ZK3A 4RSQA 1OVAA 5CE0A 2XN7A 3NDFA 3FGQA 4EB1L 5INWA 3CVMA 4AJTA 2OAYA 1B3KA 3DRUA 4KDSA 1SNGA 4IC0A 3DLWA 1SR5A
chains in the Genus database with same CATH topology
4C41A 1NQ9I 2ARRA 4AQHA 1QLPA 4P0FA 2RIWA 5CDXA 1OC0A 1K9OI 3CWLA 4AU3A 1JVQI 3DY0A 4DY0A 2QUGA 4Y40A 1EZXA 1JMOA 3PB1I 1E03I 4BB2A 3EOXA 3NDDA 4AU4A 4ROBA 3F02A 2ACHA 1YXAA 3CWMA 3KCGI 2VH4A 1XQGA 2D26A 2B5TI 1WZ9A 1PSIA 1DB2A 2WXXA 4Y3KA 3OZQA 1BR8I 3EVJI 1QMBA 1JRRA 2H4QA 2WXZA 2OL2A 2WY1A 1A7CA 1E05I 2VDXA 1R1LI 1JJOC 4PYWA 1MTPA 2B4XI 2PEFA 1LK6I 2HI9A 1ATUA 2H4PA 5EI0A 4ROAA 4DY7C 4RO9A 1TB6I 1XU8A 2B4XL 2H4RA 1QMNA 4IF8A 3STOA 3CAAA 1AS4A 2WY0C 3DRMA 1UHGA 1OPHA 4CAAA 1DZGI 2XN5A 3LW2A 2ZNHA 1C5GA 2ARQA 1D5SA 3Q03A 3ZHAA 4C49A 4AU3B 1DVMA 1C8OA 1BY7A 3T1PA 1DZGL 1OO8A 1OVAC 2HIJI 2VDYA 2XN6A 3H5CA 1HP7A 7APIA 3B9FI 3Q02A 1OVAB 2DUTA 3NDAA 1OYHI 1DZHI 2HIJL 2WXWA 4G8RA 2WXYC 4ZK0A 3PZFA 9APIA 2V95A 4GA7A 1E04I 1JTIA 4G8OA 1IZ2A 4AU2A 4X30A 1F0CA 3F5NA 4AJUA 1OYHL 1DZHL 1SEKA 2RIVA 4AFXA 5HGCA 5BRRI 2BEHI 1DVNA 5CDZA 1LJ5A 2GD4C 2XN3A 2CEOA 1ATHA 3F1SA 2PEEA 2ZV6A 4R9IA 5IO1A 9PAIA 1KCTA 2BEHL 2R9YA 3VVJA 1IMVA 1T1FA 1JMJA 5C98A 3LE2A 2WXZC 1XQJA 1HLEA 1LQ8A 3NE4A 3R4LA 4P0OA 4YIAA 4EB1I 4DTEA 1AZXI 3UT3A 1M93B 8APIA 1ATTA 1ANTI 2ANTI 4ZK3A 4RSQA 1OVAA 5CE0A 2XN7A 3NDFA 3FGQA 4EB1L 5INWA 3CVMA 4AJTA 2OAYA 1B3KA 3DRUA 4KDSA 1SNGA 4IC0A 3DLWA 1SR5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C41 A;  1NQ9 I;  2ARR A;  4AQH A;  1QLP A;  4P0F A;  2RIW A;  5CDX A;  1OC0 A;  1K9O I;  3CWL A;  4AU3 A;  1JVQ I;  3DY0 A;  4DY0 A;  2QUG A;  4Y40 A;  1EZX A;  1JMO A;  3PB1 I;  1E03 I;  4BB2 A;  3EOX A;  3NDD A;  4AU4 A;  4ROB A;  3F02 A;  2ACH A;  1YXA A;  3CWM A;  3KCG I;  2VH4 A;  1XQG A;  2D26 A;  2B5T I;  1WZ9 A;  1PSI A;  1DB2 A;  2WXX A;  4Y3K A;  3OZQ A;  1BR8 I;  3EVJ I;  1QMB A;  1JRR A;  2H4Q A;  2WXZ A;  2OL2 A;  2WY1 A;  1A7C A;  1E05 I;  2VDX A;  1R1L I;  1JJO C;  4PYW A;  1MTP A;  2B4X I;  2PEF A;  1LK6 I;  2HI9 A;  1ATU A;  2H4P A;  5EI0 A;  4ROA A;  4DY7 C;  4RO9 A;  1TB6 I;  1XU8 A;  2B4X L;  2H4R A;  1QMN A;  4IF8 A;  3STO A;  3CAA A;  1AS4 A;  2WY0 C;  3DRM A;  1UHG A;  1OPH A;  4CAA A;  1DZG I;  2XN5 A;  3LW2 A;  2ZNH A;  1C5G A;  2ARQ A;  1D5S A;  3Q03 A;  3ZHA A;  4C49 A;  4AU3 B;  1DVM A;  1C8O A;  1BY7 A;  3T1P A;  1DZG L;  1OO8 A;  1OVA C;  2HIJ I;  2VDY A;  2XN6 A;  3H5C A;  1HP7 A;  7API A;  3B9F I;  3Q02 A;  1OVA B;  2DUT A;  3NDA A;  1OYH I;  1DZH I;  2HIJ L;  2WXW A;  4G8R A;  2WXY C;  4ZK0 A;  3PZF A;  9API A;  2V95 A;  4GA7 A;  1E04 I;  1JTI A;  4G8O A;  1IZ2 A;  4AU2 A;  4X30 A;  1F0C A;  3F5N A;  4AJU A;  1OYH L;  1DZH L;  1SEK A;  2RIV A;  4AFX A;  5HGC A;  5BRR I;  2BEH I;  1DVN A;  5CDZ A;  1LJ5 A;  2GD4 C;  2XN3 A;  2CEO A;  1ATH A;  3F1S A;  2PEE A;  2ZV6 A;  4R9I A;  5IO1 A;  9PAI A;  1KCT A;  2BEH L;  2R9Y A;  3VVJ A;  1IMV A;  1T1F A;  1JMJ A;  5C98 A;  3LE2 A;  2WXZ C;  1XQJ A;  1HLE A;  1LQ8 A;  3NE4 A;  3R4L A;  4P0O A;  4YIA A;  4EB1 I;  4DTE A;  1AZX I;  3UT3 A;  1M93 B;  8API A;  1ATT A;  1ANT I;  2ANT I;  4ZK3 A;  4RSQ A;  1OVA A;  5CE0 A;  2XN7 A;  3NDF A;  3FGQ A;  4EB1 L;  5INW A;  3CVM A;  4AJT A;  2OAY A;  1B3K A;  3DRU A;  4KDS A;  1SNG A;  4IC0 A;  3DLW A;  1SR5 A; 
#chains in the Genus database with same CATH topology
 4C41 A;  1NQ9 I;  2ARR A;  4AQH A;  1QLP A;  4P0F A;  2RIW A;  5CDX A;  1OC0 A;  1K9O I;  3CWL A;  4AU3 A;  1JVQ I;  3DY0 A;  4DY0 A;  2QUG A;  4Y40 A;  1EZX A;  1JMO A;  3PB1 I;  1E03 I;  4BB2 A;  3EOX A;  3NDD A;  4AU4 A;  4ROB A;  3F02 A;  2ACH A;  1YXA A;  3CWM A;  3KCG I;  2VH4 A;  1XQG A;  2D26 A;  2B5T I;  1WZ9 A;  1PSI A;  1DB2 A;  2WXX A;  4Y3K A;  3OZQ A;  1BR8 I;  3EVJ I;  1QMB A;  1JRR A;  2H4Q A;  2WXZ A;  2OL2 A;  2WY1 A;  1A7C A;  1E05 I;  2VDX A;  1R1L I;  1JJO C;  4PYW A;  1MTP A;  2B4X I;  2PEF A;  1LK6 I;  2HI9 A;  1ATU A;  2H4P A;  5EI0 A;  4ROA A;  4DY7 C;  4RO9 A;  1TB6 I;  1XU8 A;  2B4X L;  2H4R A;  1QMN A;  4IF8 A;  3STO A;  3CAA A;  1AS4 A;  2WY0 C;  3DRM A;  1UHG A;  1OPH A;  4CAA A;  1DZG I;  2XN5 A;  3LW2 A;  2ZNH A;  1C5G A;  2ARQ A;  1D5S A;  3Q03 A;  3ZHA A;  4C49 A;  4AU3 B;  1DVM A;  1C8O A;  1BY7 A;  3T1P A;  1DZG L;  1OO8 A;  1OVA C;  2HIJ I;  2VDY A;  2XN6 A;  3H5C A;  1HP7 A;  7API A;  3B9F I;  3Q02 A;  1OVA B;  2DUT A;  3NDA A;  1OYH I;  1DZH I;  2HIJ L;  2WXW A;  4G8R A;  2WXY C;  4ZK0 A;  3PZF A;  9API A;  2V95 A;  4GA7 A;  1E04 I;  1JTI A;  4G8O A;  1IZ2 A;  4AU2 A;  4X30 A;  1F0C A;  3F5N A;  4AJU A;  1OYH L;  1DZH L;  1SEK A;  2RIV A;  4AFX A;  5HGC A;  5BRR I;  2BEH I;  1DVN A;  5CDZ A;  1LJ5 A;  2GD4 C;  2XN3 A;  2CEO A;  1ATH A;  3F1S A;  2PEE A;  2ZV6 A;  4R9I A;  5IO1 A;  9PAI A;  1KCT A;  2BEH L;  2R9Y A;  3VVJ A;  1IMV A;  1T1F A;  1JMJ A;  5C98 A;  3LE2 A;  2WXZ C;  1XQJ A;  1HLE A;  1LQ8 A;  3NE4 A;  3R4L A;  4P0O A;  4YIA A;  4EB1 I;  4DTE A;  1AZX I;  3UT3 A;  1M93 B;  8API A;  1ATT A;  1ANT I;  2ANT I;  4ZK3 A;  4RSQ A;  1OVA A;  5CE0 A;  2XN7 A;  3NDF A;  3FGQ A;  4EB1 L;  5INW A;  3CVM A;  4AJT A;  2OAY A;  1B3K A;  3DRU A;  4KDS A;  1SNG A;  4IC0 A;  3DLW A;  1SR5 A; 
#chains in the Genus database with same CATH homology
 4C41 A;  1NQ9 I;  2ARR A;  4AQH A;  1QLP A;  4P0F A;  2RIW A;  5CDX A;  1OC0 A;  1K9O I;  3CWL A;  4AU3 A;  1JVQ I;  3DY0 A;  4DY0 A;  2QUG A;  4Y40 A;  1EZX A;  1JMO A;  3PB1 I;  1E03 I;  4BB2 A;  3EOX A;  3NDD A;  4AU4 A;  4ROB A;  3F02 A;  2ACH A;  1YXA A;  3CWM A;  3KCG I;  2VH4 A;  1XQG A;  2D26 A;  2B5T I;  1WZ9 A;  1PSI A;  1DB2 A;  2WXX A;  4Y3K A;  3OZQ A;  1BR8 I;  3EVJ I;  1QMB A;  1JRR A;  2H4Q A;  2WXZ A;  2OL2 A;  2WY1 A;  1A7C A;  1E05 I;  2VDX A;  1R1L I;  1JJO C;  4PYW A;  1MTP A;  2B4X I;  2PEF A;  1LK6 I;  2HI9 A;  1ATU A;  2H4P A;  5EI0 A;  4ROA A;  4DY7 C;  4RO9 A;  1TB6 I;  1XU8 A;  2B4X L;  2H4R A;  1QMN A;  4IF8 A;  3STO A;  3CAA A;  1AS4 A;  2WY0 C;  3DRM A;  1UHG A;  1OPH A;  4CAA A;  1DZG I;  2XN5 A;  3LW2 A;  2ZNH A;  1C5G A;  2ARQ A;  1D5S A;  3Q03 A;  3ZHA A;  4C49 A;  4AU3 B;  1DVM A;  1C8O A;  1BY7 A;  3T1P A;  1DZG L;  1OO8 A;  1OVA C;  2HIJ I;  2VDY A;  2XN6 A;  3H5C A;  1HP7 A;  7API A;  3B9F I;  3Q02 A;  1OVA B;  2DUT A;  3NDA A;  1OYH I;  1DZH I;  2HIJ L;  2WXW A;  4G8R A;  2WXY C;  4ZK0 A;  3PZF A;  9API A;  2V95 A;  4GA7 A;  1E04 I;  1JTI A;  4G8O A;  1IZ2 A;  4AU2 A;  4X30 A;  1F0C A;  3F5N A;  4AJU A;  1OYH L;  1DZH L;  1SEK A;  2RIV A;  4AFX A;  5HGC A;  5BRR I;  2BEH I;  1DVN A;  5CDZ A;  1LJ5 A;  2GD4 C;  2XN3 A;  2CEO A;  1ATH A;  3F1S A;  2PEE A;  2ZV6 A;  4R9I A;  5IO1 A;  9PAI A;  1KCT A;  2BEH L;  2R9Y A;  3VVJ A;  1IMV A;  1T1F A;  1JMJ A;  5C98 A;  3LE2 A;  2WXZ C;  1XQJ A;  1HLE A;  1LQ8 A;  3NE4 A;  3R4L A;  4P0O A;  4YIA A;  4EB1 I;  4DTE A;  1AZX I;  3UT3 A;  1M93 B;  8API A;  1ATT A;  1ANT I;  2ANT I;  4ZK3 A;  4RSQ A;  1OVA A;  5CE0 A;  2XN7 A;  3NDF A;  3FGQ A;  4EB1 L;  5INW A;  3CVM A;  4AJT A;  2OAY A;  1B3K A;  3DRU A;  4KDS A;  1SNG A;  4IC0 A;  3DLW A;  1SR5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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